Abstract:
:A woman of 22 years developed heavy pain in the neck and arms with weakness and paresthesia. She died two days after a myelography which was normal. At autopsy an enterogenous extra- and intra-medullary cyst of the cervical cord (C3, C4) was found. In addition the cervical cord apart from the cyst and the uppermost thoracic cord presented central clefts which were filled with mucilage. These findings are named mucomyelia and have not been reported previously.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Pilz P,Fischbach R,Brenneis Mdoi
10.1007/BF00691967subject
Has Abstractpub_date
1977-11-28 00:00:00pages
277-8issue
3eissn
0001-6322issn
1432-0533journal_volume
40pub_type
杂志文章abstract::Remyelination in multiple sclerosis (MS) lesions often remains incomplete despite the presence of oligodendrocyte progenitor cells (OPCs). Amongst other factors, successful remyelination depends on the phagocytic clearance of myelin debris. However, the proteins in myelin debris that act as potent and selective inhibi...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-015-1521-1
更新日期:2016-02-01 00:00:00
abstract::A description is given of three cases of ganglioneuromas, which originated from ganglia of the sympathetic chain of hamsters. Other reports of such tumors in this species are reviewed and the literature relative to hamster ganglioneuromas presented. In addition, the possible genesis of origin from adult ganglion cells...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00696794
更新日期:1975-10-01 00:00:00
abstract::The central distal axonopathy induced in dogs by the administration of high doses of clioquinol is contrasted with the central-peripheral distal axonopathy precipitated by intoxication with 2,5-hexanedione. Mature, pure-bred Beagle dogs received a daily oral dose of 400 mg/kg of clioquinol for up to 7 months, or 1 ml ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00690549
更新日期:1979-08-01 00:00:00
abstract::This article highlights the features that connect prion diseases with other cerebral amyloidoses and how these relate to neurodegeneration, with focus on tau phosphorylation. It also discusses similarities between prion disease and Alzheimer's disease: mechanisms of amyloid formation, neurotoxicity, pathways involved ...
journal_title:Acta neuropathologica
pub_type: 杂志文章,评审
doi:10.1007/s00401-010-0691-0
更新日期:2011-01-01 00:00:00
abstract::Fifteen cases of Down syndrome between age 25-59 years were examined neuropathologically. A variety of histological methods were used to identify plaques and neurofibrillary tangles (NFT). All cases had some plaques or NFT, but their density was generally not high before the age of 40 years. Plaques and NFT tended to ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00687256
更新日期:1989-01-01 00:00:00
abstract::This ultrastructural study deals with the synapses of primary dendrites of the anterior horn neurons in the lower lumbar spinal cords of seven patients with amyotrophic lateral sclerosis (ALS) who had mild neuronal depletion. Specimens from seven age-matched, neurologically normal individuals served as controls. In ea...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010050426
更新日期:1996-01-01 00:00:00
abstract::X-linked lissencephaly with abnormal genitalia (XLAG) is a rare disorder caused by mutations in the aristaless-related homeobox (ARX) gene, located on Xp22.13. Arx-null mice show loss of tangential migration of GABAergic interneurons, presumably being related to caudal ganglionic eminence tangential migration. In the ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-008-0382-2
更新日期:2008-10-01 00:00:00
abstract::Primary cortical and hippocampal neuronal cultures submitted to brief histotoxic hypoxia suffer delayed neuronal death after 24 h [Uto et al. (1995) J Neurochem 64: 2185-2192]. In this study the ultrastructural changes were monitored during the first 6 h following 5-min histotoxic hypoxia induced by exposure to 100 mi...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010050559
更新日期:1996-12-01 00:00:00
abstract::Histamine dihydrochloride (10 micrograms of 500 micrograms/ml) was infused during 1 min into the lateral cerebral ventricle of rats, which resulted in a significant stimulation of pinocytosis in the endothelial cells. Systemic injections of mepyramine or metiamide could not prevent this activation. In contrast, raniti...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00686387
更新日期:1988-01-01 00:00:00
abstract::Wolfram syndrome or DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is a neurodegenerative disorder characterized by diabetes mellitus and optic atrophy as well as diabetes insipidus and deafness in many cases. We report the post-mortem neuropathologic findings of a patient with Wolfram syn...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-009-0546-8
更新日期:2009-09-01 00:00:00
abstract::Polyclonal antibodies directed towards synaptophysin were raised against a synthesised peptide corresponding to amino acids 246 to 260 of the human synaptophysin sequence. The antibodies, when applied for immunocytochemical staining, showed a staining pattern identical to that of the commercially available monoclonal ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00293325
更新日期:1994-01-01 00:00:00
abstract::Foetal rat brain reaggregate cultures have been employed to investigate the morphological changes associated with the neurotoxic action of ethylcholine mustard aziridinium (ECMA). In a companion study we provided evidence for apparent selective cholinergic neurotoxicity. Exposure of 9-day-old cultures to 12.5 microM E...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00334882
更新日期:1993-01-01 00:00:00
abstract::HTLV-III-like particles were observed within a cell process surrounded by a myelin sheath, in the brain of a 4-year-old boy with AIDS encephalopathy. Similar particles were also observed in the mononuclear macrophage-like cells. ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00686627
更新日期:1987-01-01 00:00:00
abstract::Neuronal accumulation of oligomeric amyloid-beta (Alphabeta) is considered the proximal cause of neuronal demise in Alzheimer disease (AD) patients. Blood-borne macrophages might reduce Abeta stress to neurons by immigration into the brain and phagocytosis of Alphabeta. We tested migration and export across a blood-br...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-008-0481-0
更新日期:2009-02-01 00:00:00
abstract::Gelatinase A is an enzyme capable of cleaving soluble beta-amyloid protein (beta AP), and may function as an alpha-secretase to produce secretory forms of amyloid precursor protein. We examined gelatinase A immunoreactivity in the brains and posterior roots of neurologically normal, lacunar stroke, Alzheimer disease (...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00309334
更新日期:1995-01-01 00:00:00
abstract::The character of the silver positive reticulin network was analyzed with immunofluorescence and immunoperoxidase methods in an intra vitam diagnosed case of primary brain lymphoma. The network was shown to contain connective tissue proteins rich in hexose-sugars, such as type III collagen (classical "reticulin"), basa...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00690962
更新日期:1985-01-01 00:00:00
abstract::A large series of central and peripheral nervous system tumors was studied for the presence of glial fibrillary acidic protein (GFAP) and gamma-enolase (neuron-specific enolase, NSE), using specific monoclonal antibodies (mAbs). Occurrence in and specificity of GFAP to glial and mixed tumors was confirmed and depended...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00687791
更新日期:1988-01-01 00:00:00
abstract::Monosodium-L-glutamate given subcutaneously to pregnant rats caused acute necrosis of the acetylcholinesterase-positive neurons in the area postrema. The same effect has been observed in the area postrema of fetal rats. The process of neuronal cell death and the elimination of debris by microglia cells proved to be si...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00686787
更新日期:1987-01-01 00:00:00
abstract::In chronic granulomatous disease (CGD) enzyme-deficient neutrophils and mononuclear cells lack the respiratory burst required for biocidal activity. Recurrent infections lead to granulomas in various organs but brain lesions are rare. In the present case, a 23-year-old male with numerous infections since early childho...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00293469
更新日期:1991-01-01 00:00:00
abstract::Muscle biopsy samples from five patients with cytoplasmic body myopathy (CBM) were investigated by immunohistochemical (antibodies to desmin, actin, dystrophin, spectrin, alpha actinin and utrophin), immunoelectron microscopic (antibodies to desmin, actin and dystrophin) and biochemical (desmin, dystrophin, actin and ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00294314
更新日期:1995-01-01 00:00:00
abstract::Numerous families exhibiting both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have been described, and although many of these have been shown to harbour a repeat expansion in C9ORF72, several C9ORF72-negative FTD-ALS families remain. We performed neuropathological and genetic analysis of a la...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-013-1078-9
更新日期:2013-04-01 00:00:00
abstract::An autopsy case of unclassifiable presenil dementia is reported. The outstanding pathological findings were as follows; 1. presence of senile plaques, neurofibrillary changes, Pick bodies, Hirano bodies, granulovacuolar degeneration of neurons, etc. 2. numerous Lewy bodies in the brain stem and diencephalon, 3. peculi...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00685366
更新日期:1976-11-15 00:00:00
abstract::The brain tissue obtained from ninety-five cognitively unimpaired subjects, with ages ranging from 22 to 50 years upon death, were immunohistochemically assessed for neurodegenerative changes, i.e., hyperphosphorylated tau (HPτ) and β-amyloid (Aβ) pathology in predilection neuroanatomical areas. HPτ pathology was obse...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-011-0906-z
更新日期:2012-01-01 00:00:00
abstract::This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive con...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00227818
更新日期:1992-01-01 00:00:00
abstract::A cerebral biopsy was performed in a 39-year-old male patient with subacute paraparesis who later developed severe dementia and moderate cerebellar involvement. The histological examination showed a marked neuronal loss, severe neurofibrillary degeneration, and a great number of senile plaques. No PAS-positive plaques...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00703200
更新日期:1983-01-01 00:00:00
abstract::Conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer's disease (LOAD). Mutations and/or differential expression of microglial specific receptors such as TREM2, CD33, and CR3 have been associated wi...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-017-1737-3
更新日期:2017-11-01 00:00:00
abstract::The histological and ultrastructural findings of subacute spongiform encephalopathy (SSE) are described in the cerebral cortex and basal ganglia of a homosexual patient who died with acquired immune deficiency syndrome (AIDS). It is suggested that SSE, beside the diffuse AIDS leukoencephalopathy, might be another morp...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00687217
更新日期:1987-01-01 00:00:00
abstract::Observations have been made on the structure of the paranodal region at nodes of Ranvier in the sural nerve of patients with diabetic sensory polyneuropathy. The structure of the paranodes was examined with particular attention to the definition and assessment of axoglial dysjunction, which has been claimed to be a ch...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010050569
更新日期:1996-12-01 00:00:00
abstract::This study tests the effects of chronic electrostimulation on denervated/reinnervated skeletal muscle in producing an optimal restoration of size and mechanical and histochemical properties. We compared tibialis anterior muscles in four groups of rats: in unoperated control (C) and 10 weeks following nerve lesion with...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-006-0035-2
更新日期:2006-06-01 00:00:00
abstract::Immunohistochemical studies of monoamine neurons were performed to evaluate toxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on young adult mice and compare them with those of their offspring. Mice, 9-11 weeks old (C57BL/6J), injected subcutaneously with a large dose of MPTP (17 mg/kg per day) duri...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00294662
更新日期:1989-01-01 00:00:00