Abstract:
:Focal cerebral ischemia was induced by occlusion of the right middle cerebral artery in hypoglycemic, normoglycemic, as well as in acute and chronic diabetic rats. The brain damage was studied after 4 days. The volume of infarction was decreased in hypoglycemia (29 +/- 19 mm3 (mean +/- SD) versus 58 +/- 35 mm3, P less than 0.0046), unaltered in acute diabetes (61 +/- 45 mm3), and increased in chronic diabetes (91 +/- 22 mm3, P less than 0.0463). The cortex adjacent to the infarct showed selective neuronal injury affecting the cortical layers 2 and 3. The damage was enhanced by hypoglycemia and prevented in most of the diabetic animals. The findings indicate that different mechanisms cause infarction and selective neuronal injury outside infarcts, but that both are influenced by the plasma glucose concentration.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Nedergaard M,Diemer NHdoi
10.1007/BF00693778subject
Has Abstractpub_date
1987-01-01 00:00:00pages
131-7issue
2eissn
0001-6322issn
1432-0533journal_volume
73pub_type
杂志文章abstract::A monoclonal antibody, raised against extracts from Alzheimer brain, that recognizes a phosphorylated epitope in high molecular weight neurofilament proteins and tau proteins also immunostains Alzheimer neurofibrillary tangles, neurites in senile plaques and granulovacuolar degeneration. This result suggest that granu...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00686619
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00691701
更新日期:1977-08-31 00:00:00
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Acta neuropathologica
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doi:10.1007/BF00702677
更新日期:1979-03-15 00:00:00
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00687797
更新日期:1988-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00686163
更新日期:1975-12-30 00:00:00
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
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更新日期:2007-08-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688007
更新日期:1980-01-01 00:00:00
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journal_title:Acta neuropathologica
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更新日期:2011-02-01 00:00:00
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更新日期:2002-03-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00369452
更新日期:1993-01-01 00:00:00
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