Abstract：
:We studied the microscopic features of 137 cases of human cerebral infarct. In each case, the age of the lesion was determined by measuring the time elapsed between initial clinical presentation and date of surgery or death. Multiple microscopic variables were analyzed on hematoxylin and eosin-stained sections. There were 104 (76%) male and 33 (24%) female patients with a median age of 64 years. The location of the infarcts included 129 cerebral, 5 cerebellar, and 1 each in the pons, midbrain and medulla. The age of the lesions ranged from 1 day to 53 years. All lesions were single and varied from lacunes to large infarcts in the distribution of one or more cerebral arteries. Key histologic features of the proposed classification are as follows: (1) phase of acute neuronal injury (11 cases studied), age 1-2 days, characterized by the presence of neuronal changes, and spongiosis of the neuropil and absence of neuronal ferrugination, chronic inflammation, macrophages, neo-vascularization and cavitation; (2) phase of organization subdivided into: (a) phase of acute inflammation (31 cases), age 3-37 days, characterized by coagulative necrosis, and frequent acute inflammation, and (b) phase of chronic inflammation (57 cases), age 10 days-53 years, characterized by the presence or absence of coagulative necrosis, neuronal injury, red neurons, macrophages, mononuclear inflammatory cells, perivascular cuffing, cavitation, gliosis, spheroids; absence of neutrophils; and (3) phase of resorption (38 cases), age 26 days-23 years, characterized by absence of an inflammatory response. Neuronophagia is not a feature of cerebral infarcts.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Mena H,Cadavid D,Rushing EJdoi
10.1007/s00401-004-0918-zsubject
Has Abstractpub_date
2004-12-01 00:00:00pages
524-30issue
6eissn
0001-6322issn
1432-0533journal_volume
108pub_type
杂志文章abstract：:Morphometric observations have been made on the medial plantar division of the tibial nerve (MPD) and on the motor branches of the tibial nerve to the calf muscles (MBC) in rats ranging in age from weaning (3 weeks) to 12 months. Axon size, assessed by measurements of circumference and cross-sectional area, increased ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308712
更新日期：1990-01-01 00:00:00
abstract：:A quantitative technique involving serial sectioning and semiautomatic morphometric analysis was used to assess the severity of the reduction in size of the major brain structures in cerebral hemispheres of children congenitally infected with HIV-1. Cerebral hemispheres from 12 children (18-48 months of age) who died ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050594
更新日期：1997-02-01 00:00:00
abstract：:A description is given of three cases of ganglioneuromas, which originated from ganglia of the sympathetic chain of hamsters. Other reports of such tumors in this species are reviewed and the literature relative to hamster ganglioneuromas presented. In addition, the possible genesis of origin from adult ganglion cells...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00696794
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abstract：:Respiratory chain dysfunction leads to reactive oxygen species (ROS) generation with following oxidative stress and cellular damage. A histochemical and immunohistochemical study was performed on muscle biopsies from 17 patients with mitochondrial disease [chronic progressive external ophthalmoplegia (CPEO), mitochond...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100455
更新日期：2002-03-01 00:00:00
abstract：:Two distinct species of amyloid beta protein (A beta) with different carboxyl termini, A beta 40 and A beta 42(43), are deposited in plaques in the brains of patients with Alzheimer's disease and Down's syndrome. The relationship between these two forms of A beta and microglial cells was investigated in 16 subjects wi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294808
更新日期：1995-01-01 00:00:00
abstract：:Four melanin pigment-containing intracranial tumors were found in three Long-Evans rats in the course of experimental oncogenesis by transplacental ethylnitrosourea (ENU). One of them was a leptomeningeal melanoma. Aside from the presence of scattered melanin-pigmented cells, the other three had the typical histologic...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688941
更新日期：1976-05-18 00:00:00
abstract：:Although it is known that deletions or mutations of the SMN1 gene on chromosome 5 cause decreased levels of the SMN protein in subjects with proximal autosomal recessive spinal muscular atrophy (SMA), the exact sequence of pathological events leading to selective motoneuron cell death is not fully understood yet. In t...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-008-0411-1
更新日期：2008-09-01 00:00:00
abstract：:Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed the question of whether or not sequential distribution patterns can be recognized for PS...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-020-02158-2
更新日期：2020-08-01 00:00:00
abstract：:The accumulation of calcium in the hippocampal and thalamic vascular endothelium and the perivascular space was detected histochemically by means of the pyroantimonate technique 30, 60 and 120 min after systemic kainic acid administration. An increased number of calcium pyroantimonate deposits was found in the endothe...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685971
更新日期：1986-01-01 00:00:00
abstract：:The selective toxicity of silica dust for macrophages has been used to assess the role of these cells in experimental allergic neuritis (EAN). Inbred Lewis rats were inoculated with bovine dorsal roots in Freund's complete adjuvant (day 0). In two experiments, animals received 200 mg of silica dust in 1 cm3 of saline ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687614
更新日期：1984-01-01 00:00:00
abstract：:Myotubular myopathy and centronuclear myopathies (CNM) are congenital myopathies characterized by generalized muscle weakness and mislocalization of muscle fiber nuclei. Genetically distinct forms exist, and mutations in BIN1 were recently identified in autosomal recessive cases (ARCNM). Amphiphysins have been implica...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-010-0754-2
更新日期：2011-02-01 00:00:00
abstract：:Intracranial solitary fibrous tumors (SFTs) are typically dural-based, CD34-positive neoplasms of uncertain histogenesis. We examined ten cases of meninges obtained at autopsy from patients with no history of neurological illness, head trauma, or neurosurgical intervention, and ten cases of typical meningiomas with at...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100389
更新日期：2001-10-01 00:00:00
abstract：:A 48-year-old man with dural arteriovenous malformation (AVM) is reported. Radiologically, the dural AVM was demonstrated mainly in the region of the left transverse sinus. Postmortem examination revealed dural AVM involving the bilateral transverse, superior sagittal and straight sinuses. In addition, numerous malfor...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00307635
更新日期：1990-01-01 00:00:00
abstract：:Cryostat sections of 12 gliomas and of 3 peritumoral brain tissue samples were investigated for mononuclear cell infiltration by immunohistochemistry, concentrating on cells expressing monocyte/macrophage markers. Only low numbers of T cells were detected in the tumors, whereas in average 20%-30% of all cells present ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294647
更新日期：1990-01-01 00:00:00
abstract：:Intracerebral C6 glioma xenografts spontaneously develop centrally located necrotic regions that are bordered by densely packed neoplastic cells. Proliferative and metabolic heterogeneity in these perinecrotic regions were assessed by bromodeoxyuridine (BrdU) incorporation, by immunocytological and by histochemical an...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0803-1
更新日期：2004-03-01 00:00:00
abstract：:Essential mixed cryoglobulinemia, which can cause hypersensitivity vasculitis, was observed in five patients with peripheral neuropathy. Three cases presented with multifocal neuropathies and two cases with symmetrical polyneuropathy. One had cryoglobulinemia with IgM monoclonal gammopathy IgG polyclonal gammopathy, a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686206
更新日期：1988-01-01 00:00:00
abstract：:Peroxidase-labeled lectins were used for detection of specific monosaccharide residues in amyloid plaques in brains of scrapie-infected mice. The lectins tested recognize the following residues: beta-D-galactosyl (Ricinus communis agglutinin 120, RCA-1), alpha-D-galactosyl and alpha-D-galactopyranoside (Bandeirea simp...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688295
更新日期：1986-01-01 00:00:00
abstract：:The essential role of the cellular prion protein (PrPC) in prion disorders such as Creutzfeldt-Jakob disease is well documented. Moreover, evidence is accumulating that PrPC may act as a receptor for protein aggregates and transduce neurotoxic signals in more common neurodegenerative disorders, such as Alzheimer's dis...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-017-1790-y
更新日期：2018-02-01 00:00:00
abstract：:Four of seven patients with nemaline myopathy had severe, rapidly progressing symptoms. These four showed an increase in acid phosphatase activity in muscle fibers demonstrated by histochemistry and cathepsin B&L activity by biochemical measurement. On electron microscopy, nemaline bodies, occasionally disorganized my...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687709
更新日期：1989-01-01 00:00:00
abstract：:Accumulation of amyloid-β (Aβ) and neurofibrillary tangles in the brain, inflammation and synaptic and neuronal loss are some of the major neuropathological hallmarks of Alzheimer's disease (AD). While genetic mutations in amyloid precursor protein and presenilin-1 and -2 (PS1 and PS2) genes cause early-onset familial...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-012-1065-6
更新日期：2013-02-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-010-0770-2
更新日期：2011-02-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0543-7
更新日期：2002-09-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687041
更新日期：1986-01-01 00:00:00
abstract：:The brain of a 69-year-old man exhibited extensive granulomatous inflammation in the walls of arteries in the leptomeninges, associated with amyloid deposition in the media of the involved arteries. The extracranial arteries exhibited neither granulomatous inflammation nor amyloid deposition in their walls. ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686094
更新日期：1986-01-01 00:00:00
abstract：:Human recombinant tumor necrosis factor-alpha (rTNF-alpha) was administered to normal Fischer 344 rats by stereotaxic intracerebral (IC) injection. Animals received a single injection of either 6 x 10(4) U rTNF-alpha or excipient in their right parietal lobe. Others received three consecutive daily injections of eithe...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00304638
更新日期：1992-01-01 00:00:00
abstract：:Interstitial cells are isolated neurons located in the infracortical white matter that are known to express neuropeptides. Twenty-four cases selected for the absence, slight (Braak stages I-II), moderate (Braak stages III-IV), or serious degree (Braak stages V-VI) of cortical neurofibrillary pathology were studied for...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0551-7
更新日期：2002-10-01 00:00:00
abstract：:Multiple system atrophy (MSA) is characterized by the presence of distinctive glial cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein alpha-synuclein (aSyn) and the oligodendroglia-specific phosphoprotein TPPP/p25α. However, the role of oligodendroglial aSyn and p25α in the format...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-019-02014-y
更新日期：2019-09-01 00:00:00
abstract：:A woman of 36 was admitted to hospital because of griping abdominal pain which occurred especially during the night when turning in bed. She had a history of constipation and bloating since birth. Irrigoscopy revealed megacolon extending from the middle of the transverse colon to the rectum. A rectal biopsy excluded H...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688193
更新日期：1987-01-01 00:00:00
abstract：:A case of classic medulloblastoma that metastasized, despite the absence of local recurrence, to extraneural sites 7 years after treatment is reported. The metastases were, in contrast to the primary tumor, of large cell type and displayed abortive myogenic and, in one site, also rhabdoid differentiation. The primary ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-0986-8
更新日期：2005-05-01 00:00:00
abstract：:Impaired axonal transport of the fast or slow component has been reported in patients with sporadic amyotrophic lateral sclerosis (ALS), animal models for ALS, and familial ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) transgenic mice. However, little is known about the impairment of axonal transport in mutant S...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-1021-9
更新日期：2005-07-01 00:00:00
