Abstract:
:A 48-year-old man with dural arteriovenous malformation (AVM) is reported. Radiologically, the dural AVM was demonstrated mainly in the region of the left transverse sinus. Postmortem examination revealed dural AVM involving the bilateral transverse, superior sagittal and straight sinuses. In addition, numerous malformed venous vessels and extensive necrosis were observed mainly in the parenchyma of the brain stem and cerebellum. The present case suggests that dural AVMs may be associated with malformed venous vessels in the brain parenchyma.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Hinokuma K,Ohama E,Ikuta F,Tanimura K,Kameyama Sdoi
10.1007/BF00307635subject
Has Abstractpub_date
1990-01-01 00:00:00pages
656-9issue
6eissn
0001-6322issn
1432-0533journal_volume
80pub_type
杂志文章abstract::We present the neuropathological findings in a female patient with clinically definite multiple sclerosis (MS), who at autopsy had multifocal amyloid deposits in the white matter of the brain without other signs of amyloidosis. The patient had relapsing/remitting MS between the ages of 26 and 45, and during her last 1...
journal_title:Acta neuropathologica
pub_type: 杂志文章,评审
doi:10.1007/s004010050604
更新日期:1997-02-01 00:00:00
abstract::We studied three siblings and one unrelated patient with cerebrotendinous xanthomatosis (CTX). Of two unrelated patients, we examined biopsies of sural nerve, soleus muscle, and achilles tendon. We also performed neurophysiologic investigations. Another patient died, and a postmortem examination of both brain and spin...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688117
更新日期:1984-01-01 00:00:00
abstract::An unresolved issue in the study of demyelinating disease is whether blood-brain barrier damage is dependent upon the migration of inflammatory cells into the central nervous system (CNS). In a study of experimental autoimmune encephalomyelitis (EAE) in rabbits, a freeze-dried, paraffin-embedded tissue technique was e...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00692851
更新日期:1987-01-01 00:00:00
abstract::Double immunofluorescence for paired helical filament (PHF)-tau (AT8) and ubiquitin, enhanced by catalyzed reporter deposition amplification, was combined with thiazin red (TR), a fluorochrome, which has an affinity to fibrillary structures such as neurofibrillary tangles (NFTs). After recording these triple-fluoresce...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010000306
更新日期:2001-06-01 00:00:00
abstract::A histopathological study was carried out on the brains of eight ex-boxers (ages 56 to 83) using conventional histological staining methods and immunocytochemistry with antibodies to amyloid beta-protein and the PHF-related tau protein. All cases showed a large number of tau-immunoreactive neurofibrillary tangles and ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00308813
更新日期:1991-01-01 00:00:00
abstract::Spinal and bulbar muscular atrophy (SBMA) is an inherited neuromuscular disease caused by expansion of a polyglutamine (polyQ) tract in the androgen receptor (AR). SBMA is triggered by the interaction between polyQ-AR and its natural ligands, testosterone and dihydrotestosterone (DHT). SBMA is characterized by the los...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-013-1122-9
更新日期:2013-07-01 00:00:00
abstract::We have previously shown that in the hippocampal formation of patients with acquired immunodeficiency syndrome (AIDS) there is neuronal atrophy, without cell loss. Because reductions in neuronal size are suggestive of associated neuritic alterations, we decided to study the dendritic trees of the main neuronal populat...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-003-0781-3
更新日期:2004-02-01 00:00:00
abstract::We report the case of an elderly woman with a history of headache, vomiting and dizziness while walking. On CT scans a mass was identified in the right cerebellar hemisphere exhibiting radiological characteristics of lipomatous tissue. Surgery revealed a compact lesion consisting of whitish-yellow tissue with a fatty ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00389504
更新日期:1994-01-01 00:00:00
abstract::Histochemical and electron microscopic studies were performed in an attempt to clarify the muscle pathology in an 18-year-old man with Fabry disease, showing proximal limb muscle atrophy, and his 52-year-old mother, who is a Fabry carrier with hypertrophic cardiomyopathy. Despite the relatively mild myopathic changes ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00296520
更新日期:1995-01-01 00:00:00
abstract::Defects of major histocompatibility complex (MHC) class I antigen-processing machinery (APM) components have been shown to contribute to immune escape of malignant cells. We investigated the expression of APM components in astrocytomas without detectable defects in HLA class I antigen expression and correlated it with...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-007-0231-8
更新日期:2007-08-01 00:00:00
abstract::Relatively little work has been done on the structural effects of organic lead in the central nervous system (CNS), although this form of lead may be a significant fraction of total brain lead. We tested a number of easily measured light-histological parameters of neuronal development in rats for sensitivity to (a) no...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00687338
更新日期:1984-01-01 00:00:00
abstract::Behaviour of biogenic amines was studied in the brains of Mongolian gerbils subjected to unilateral occlusion of the common carotid artery. Assays on the hemispheres ipsilateral to occlusion revealed in symptom-positive animals a progressive decrease in norepinephrine and dopamine, and an increase in serotonin through...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00685142
更新日期:1976-09-15 00:00:00
abstract::Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by an expanded trinucleotide CAG repeat in the gene coding for huntingtin. Deregulation of chromatin remodeling is linked to the pathogenesis of HD but the mechanism remains elusive. To identify what genes are deregulated by trimethyla...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-013-1103-z
更新日期:2013-05-01 00:00:00
abstract::This study was undertaken to elucidate, using the Golgi method, the neuropathological change in the brain of the macular mutant mouse, whose hemizygote (Ml/y) is considered to be a model of Menkes kinky hair disease (MKHD). The hemizygote mice gradually lost weight after 10 days of age and died with emaciation and sei...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00687266
更新日期:1987-01-01 00:00:00
abstract::APO2 ligand (APO2L)/TRAIL is a novel member of the tumor necrosis factor cytokine family and a potent inducer of apoptosis in tumor cell lines. We recently reported that APO2L is consistently expressed in low-grade astrocytomas, anaplastic astrocytomas, glioblastomas, and cell lines derived thereof, and that malignant...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/pl00007399
更新日期:2000-01-01 00:00:00
abstract::The fine structures of two pineal parenchymal neoplasms has been described. The tumors contained a predominance of small, poorly differentiated cells with prominent nuclei and scanty cytoplasm. These cells were similar to those found in medulloblastomas, primitive cerebral neuroectodermal tumors, and fetal cerebellum ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00699239
更新日期:1981-01-01 00:00:00
abstract::Foetal rat brain reaggregate cultures have been employed to investigate the morphological changes associated with the neurotoxic action of ethylcholine mustard aziridinium (ECMA). In a companion study we provided evidence for apparent selective cholinergic neurotoxicity. Exposure of 9-day-old cultures to 12.5 microM E...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00334882
更新日期:1993-01-01 00:00:00
abstract::The aim of the present work was to investigate whether nestin, a member of the intermediate filament family, is immunohistochemically expressed in the non-tumoral human hypophysis and pituitary neoplasms. Twenty-three normal pituitaries and 125 pituitary neoplasms were included. The tissues were formalin-fixed and par...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-006-0031-6
更新日期:2006-03-01 00:00:00
abstract::A complex neuropathological study of two cases of Niemann-Pick disease (NPD) type C (NPDC) revealed some novel features in the chemical pathology of the neuronal storage. Lipid histochemistry showed the presence of a lipid which met the criteria of a neuronal glycosphingolipid. Sphingomyelin (SM) was not detected in t...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00690966
更新日期:1985-01-01 00:00:00
abstract::Neuronal accumulation of oligomeric amyloid-beta (Alphabeta) is considered the proximal cause of neuronal demise in Alzheimer disease (AD) patients. Blood-borne macrophages might reduce Abeta stress to neurons by immigration into the brain and phagocytosis of Alphabeta. We tested migration and export across a blood-br...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-008-0481-0
更新日期:2009-02-01 00:00:00
abstract::The incidence of CNS lymphoma has increased significantly in the past 30 years, primarily in the elderly and immunocompromised. While T-cell lymphomas comprise 15-20% of systemic lymphomas, they comprise less than 4% of primary CNS lymphomas, suggesting that they may be under-recognized compared to their systemic coun...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-007-0338-y
更新日期:2008-03-01 00:00:00
abstract::Cyclooxygenases (COX, prostaglandin endoperoxide synthases, PGG/H synthases) are potent mediators of inflammation. While COX-1 is constitutively expressed in a wide range of tissues, COX-2 is cytokine inducible. Although COX-1 expression is observed in normal tissue, enhanced COX-2 expression has been attributed a key...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010051075
更新日期:1999-09-01 00:00:00
abstract::Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer's disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, rather than larger fibrillar aggregates that deposit in the forms of extrace...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-016-1546-0
更新日期:2016-04-01 00:00:00
abstract::The ontogenesis of Fc gamma receptors (FcR) and C3b/C4b receptors (CR1) was studied in peripheral nerves from ten fetuses aged from 20 to 38 weeks using immunohistochemical and functional assays. Monoclonal antibodies (mAbs) against FcR and CR1 stained nerve fibers at 10 weeks of gestation and the staining intensity i...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00294219
更新日期:1990-01-01 00:00:00
abstract::This paper examines the neuropathology of oxygen-glucose deprivation uncomplicated by stagnant conditions. Rabbit vagus nerves were pulled into a multi-compartment perfusion chamber, stimulated five times per second and deprived of energy by substituting nitrogen and deoxyglucose for oxygen and glucose in the Locke's ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00685378
更新日期:1982-01-01 00:00:00
abstract::3-Nitropropionic acid (NPA), a toxin which irreversibly inhibits the Krebs cycle enzyme succinate dehydrogenase, causes severe neurologic disease and a specific pattern of morphologic brain damage when given subcutaneously to rats. To determine whether hypotension or hypoxemia were necessary for development of morphol...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688340
更新日期:1987-01-01 00:00:00
abstract::Three cases of spinal tanycytic ependymoma are reported, a man aged 45 years and two women aged 36 and 55 years. Each patient developed gradual paraparesis over a few months prior to admission. Magnetic resonance imaging showed an enhancing, well-circumscribed tumor in the spinal cord in each case. Histologically, the...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010000265
更新日期:2001-01-01 00:00:00
abstract::Observations have been made on the structure of the paranodal region at nodes of Ranvier in the sural nerve of patients with diabetic sensory polyneuropathy. The structure of the paranodes was examined with particular attention to the definition and assessment of axoglial dysjunction, which has been claimed to be a ch...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010050569
更新日期:1996-12-01 00:00:00
abstract::Cornelia de Lange syndrome (CDLS) is a rare multisystemic malformative syndrome of uncertain etiology characterized by severe psychomotor and mental retardation. Here we report the neuropathological analysis of a 35-year-old patient who displayed the classical clinical symptomatology of CDLS. A congenital dysgenesis o...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-002-0562-4
更新日期:2002-09-01 00:00:00
abstract::This study was designed to compare the degree of reactive astrogliosis occurring around a puncture wound in the brain of normal rats and at different intervals after a similar puncture wound in rats with a portocaval anastomosis. The gliosis was evaluated by the number of astrocytes, the thickness of their processes a...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00310926
更新日期:1991-01-01 00:00:00