当前位置： SCI文献检索 > ACTA NEUROPATHOLOGICA期刊下所有文献 > Correlation of morphologic brain lesions with physiologic alterations and blood-brain barrier impairment in 3-nitropropionic acid toxicity in rats.

Correlation of morphologic brain lesions with physiologic alterations and blood-brain barrier impairment in 3-nitropropionic acid toxicity in rats.

Abstract：

:3-Nitropropionic acid (NPA), a toxin which irreversibly inhibits the Krebs cycle enzyme succinate dehydrogenase, causes severe neurologic disease and a specific pattern of morphologic brain damage when given subcutaneously to rats. To determine whether hypotension or hypoxemia were necessary for development of morphologic brain lesions in NPA neurotoxicity, systemic blood pressure and arterial blood gases were measured in NPA-intoxicated rats. The extent and distribution of albumin extravasation was examined by immunohistochemistry, and was compared to the extent and severity of morphological injury in the caudate-putamen. Neither hypotension nor hypoxemia were necessary for the development of morphologic injury in the brains of NPA-intoxicated rats. In fact, intoxicated rats had significantly higher systolic blood pressure and arterial blood oxygen than did controls. Arterial bicarbonate and pH were significantly lower in intoxicated rats than controls, however, suggesting that acidosis may be involved in the pathogenesis of NPA toxicity. When morphologic injury was severe, albumin extravasation was extensive occupying approximately 30%-80% of the lesion area in the caudate-putamen of NPA-intoxicated rats. When morphologic injury was mild, albumin extravasation was absent, or limited to small cuffs around individual capillaries (less than 1% of the lesion area). There was no leakage of albumin in the cerebral cortex, which was resistant to morphologic injury. It was concluded that leakage of protein-rich fluid into cerebral parenchyma from blood-brain barrier impairment is not responsible for the initiation of morphologic injury in NPA toxicity, but may contribute to the severity of injury later in the evolution of brain lesions.

journal_name

Acta Neuropathol

journal_title

Acta neuropathologica

authors

Hamilton BF,Gould DH

doi

10.1007/BF00688340

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

67-74

issue

1

eissn

0001-6322

issn

1432-0533

journal_volume

74

pub_type

杂志文章

相关文献

ACTA NEUROPATHOLOGICA文献大全
  • Schwann cell differentiation in Charcot-Marie-Tooth disease type 1A (CMT1A): normal number of myelinating Schwann cells in young CMT1A patients and neural cell adhesion molecule expression in onion bulbs.

    abstract：:Charcot-Marie-Tooth disease type 1A (CMT1A) is a common hereditary demyelinating neuropathy caused by a duplication of the gene for the myelin protein PMP22, resulting in overexpression of PMP22 in young patients. Although genetically well defined, the pathogenesis of the hereditary demyelinating neuropathy CMT1A is s...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s004010050712

    authors： Hanemann CO,Gabreëls-Festen AA,Stoll G,Müller HW

    更新日期：1997-10-01 00:00:00

  • Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain.

    abstract：:Fifteen cases of Down syndrome between age 25-59 years were examined neuropathologically. A variety of histological methods were used to identify plaques and neurofibrillary tangles (NFT). All cases had some plaques or NFT, but their density was generally not high before the age of 40 years. Plaques and NFT tended to ...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/BF00687256

    authors： Motte J,Williams RS

    更新日期：1989-01-01 00:00:00

  • Evidence for tangential migration disturbances in human lissencephaly resulting from a defect in LIS1, DCX and ARX genes.

    abstract：:During corticogenesis, neurons adopt different migration pathways to reach their final position. The precursors of pyramidal neurons migrate radially, whereas most of the GABA-containing interneurons are generated in the ventral telencephalon and migrate tangentially into the neocortex. Then, they use a radial migrati...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-010-0692-z

    authors： Marcorelles P,Laquerrière A,Adde-Michel C,Marret S,Saugier-Veber P,Beldjord C,Friocourt G

    更新日期：2010-10-01 00:00:00

  • Neuronal accumulation of silver in brains of progeny from argyric rats.

    abstract：:Using a photochemical method silver was demonstrated in the brains of 1-, 14-, and 45-day-old rats which had been exposed to silver on gestational days 18 and 19. In the brain tissue of new-born rats, silver was found in the lysosomes of neurons and astroglia. Minor changes in the anatomic distribution of silver were ...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/BF00691995

    authors： Rungby J,Danscher G

    更新日期：1983-01-01 00:00:00

  • Chronic relapsing polyradiculoneuritis in a cat.

    abstract：:An 18 month old cat had a 6 month history of abnormal high stepping gait, ataxia, muscle twitching and loss of sensory perception. The clinical course was interrupted by several episodes of temporary remission. The essential pathological features were those of a polyradiculoneuritis with segmental demyelination, focal...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/BF00689561

    authors： Flecknell PA,Lucke VM

    更新日期：1978-01-19 00:00:00

  • Immunohistological investigation of mononuclear cell infiltrates in meningiomas.

    abstract：:Immunohistochemical analysis of inflammatory cell density and infiltrate subpopulations in 42 meningiomas was performed. Evaluation of infiltrating cell density was carried out by cell counting. Meningothelial and fibroblastic meningiomas contained an average of 3% mononuclear cells; the few lymphocytes were localized...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/BF00294381

    authors： Becker I,Roggendorf W

    更新日期：1989-01-01 00:00:00

  • Histochemical study of pituitary adenomas with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine labeling, and nucleolar organizer region counts.

    abstract：:The growth potential of 65 pituitary adenomas was determined by histochemical analysis with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine (BrdUdR) labeling, and counts of argyrophilic nucleolar organizer regions (Ag-NORs). The mean proliferating cell indices (PCIs) determined by Ki-67 an...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/BF00311392

    authors： Shibuya M,Saito F,Miwa T,Davis RL,Wilson CB,Hoshino T

    更新日期：1992-01-01 00:00:00

  • Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment.

    abstract：:A case of Creutzfeldt-Jakob disease (CJD) with a rare mutation of the prion protein (PrP) gene (PRNP) at codon 208 (R208H) is described. By comparison with two preceding reports, the case described here displayed two distinct biochemical and neuropathological features. Western blot analysis of brain homogenates showed...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-004-0978-0

    authors： Roeber S,Krebs B,Neumann M,Windl O,Zerr I,Grasbon-Frodl EM,Kretzschmar HA

    更新日期：2005-04-01 00:00:00

  • Constant involvement of the Betz cells and pyramidal tract in amyotrophic lateral sclerosis with dementia: a clinicopathological study of eight autopsy cases.

    abstract：:We investigated clinicopathologically pyramidal signs, including hyperreflexia, Babinski sign, and spasticity, and the involvement of the primary motor cortex and pyramidal tract, in eight Japanese autopsy cases of amyotrophic lateral sclerosis (ALS) with dementia. Pyramidal signs were observed in seven (88%) of the e...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-002-0543-7

    authors： Tsuchiya K,Ikeda K,Mimura M,Takahashi M,Miyazaki H,Anno M,Shiotsu H,Akabane H,Niizato K,Uchihara T,Tominaga I,Nakano I

    更新日期：2002-09-01 00:00:00

  • Acute toxoplasma myositis: an immunohistochemical and ultrastructural study.

    abstract：:The occurrence is reported of acute myositis in a man with meningoencephalitis due to toxoplasmosis. The ultrastructure and immunohistochemistry of a muscle biopsy of the patient were investigated. Toxoplasma organisms were not found in the muscle biopsy. The perivascular inflammatory cells in the muscle were mainly C...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/BF00334513

    authors： Matsubara S,Takamori M,Adachi H,Kida H

    更新日期：1990-01-01 00:00:00

  • Do human intracranial arteries lack vasa vasorum? A comparative immunohistochemical study of intracranial and systemic arteries.

    abstract：:Vasa vasorum are adventitial vessels that play a role in pathogenesis of atherosclerosis, aneurysm, vasculitides, and graft vascular disease. The existence of vasa vasorum in human intracranial arteries is not yet well defined. The specific aims of this study are to determine whether the human intracranial arteries ha...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s004010050856

    authors： Aydin F

    更新日期：1998-07-01 00:00:00

  • Lectin histochemistry of scrapie amyloid plaques.

    abstract：:Peroxidase-labeled lectins were used for detection of specific monosaccharide residues in amyloid plaques in brains of scrapie-infected mice. The lectins tested recognize the following residues: beta-D-galactosyl (Ricinus communis agglutinin 120, RCA-1), alpha-D-galactosyl and alpha-D-galactopyranoside (Bandeirea simp...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/BF00688295

    authors： Szumanska G,Vorbrodt AW,Wisniewski HM

    更新日期：1986-01-01 00:00:00

  • Primary parafalcine chondrosarcoma in a child.

    abstract：:Intracranial cartilaginous tumors are rare lesions, usually arising from the skull base in older individuals. We report the case of a 12-year-old girl with a low-grade type chondrosarcoma arising from the falx cerebri. To our knowledge this is the first such case reported in a child. She was treated with gross total s...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s004010050773

    authors： Gerszten PC,Pollack IF,Hamilton RL

    更新日期：1998-01-01 00:00:00

  • Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis.

    abstract：:Multiple sclerosis (MS) is the most frequent demyelinating disease in young adults and despite significant advances in immunotherapy, disease progression still cannot be prevented. Promotion of remyelination, an endogenous repair mechanism resulting in the formation of new myelin sheaths around demyelinated axons, rep...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-020-02217-8

    authors： Starost L,Lindner M,Herold M,Xu YKT,Drexler HCA,Heß K,Ehrlich M,Ottoboni L,Ruffini F,Stehling M,Röpke A,Thomas C,Schöler HR,Antel J,Winkler J,Martino G,Klotz L,Kuhlmann T

    更新日期：2020-11-01 00:00:00

  • Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons.

    abstract：:The recently identified GGGGCC repeat expansion in the noncoding region of C9ORF72 is the most common pathogenic mutation in patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). We generated a human neuronal model and investigated the pathological phenotypes of human neurons containing G...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-013-1149-y

    authors： Almeida S,Gascon E,Tran H,Chou HJ,Gendron TF,Degroot S,Tapper AR,Sellier C,Charlet-Berguerand N,Karydas A,Seeley WW,Boxer AL,Petrucelli L,Miller BL,Gao FB

    更新日期：2013-09-01 00:00:00

  • Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet.

    abstract：:Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by the expansion of a polyglutamine tract in the androgen receptor (AR). The mechanism by which expansion of polyglutamine in AR causes muscle atrophy is unknown. Here, we investigated pathological pathways underlying muscle atrophy in SBMA kn...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-016-1550-4

    authors： Rocchi A,Milioto C,Parodi S,Armirotti A,Borgia D,Pellegrini M,Urciuolo A,Molon S,Morbidoni V,Marabita M,Romanello V,Gatto P,Blaauw B,Bonaldo P,Sambataro F,Robins DM,Lieberman AP,Sorarù G,Vergani L,Sandri M,Pennuto

    更新日期：2016-07-01 00:00:00

  • Cognitive dysfunction in patients with amyotrophic lateral sclerosis is associated with spherical or crescent-shaped ubiquitinated intraneuronal inclusions in the parahippocampal gyrus and amygdala, but not in the neostriatum.

    abstract：:Skeins or skein-like inclusions, one of the two types of ubiquitinated intraneuronal inclusions in amyotrophic lateral sclerosis (ALS), in the neostriatum are not specific to the disease, but it has not yet been determined whether the other, spherical or crescent-shaped inclusions (SCI) are pathognomonic. To clarify t...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s004010100398

    authors： Kawashima T,Doh-ura K,Kikuchi H,Iwaki T

    更新日期：2001-11-01 00:00:00

  • Temporal lobe epilepsy with and without psychosis: exploration of hippocampal pathology including that in subpopulations of neurons defined by their content of immunoreactive calcium-binding proteins.

    abstract：:We have investigated relationships between hippocampal/temporal lobe neuropathology and psychosis in subjects with temporal lobe epilepsy, paying particular attention to possible differences in density of hippocampal neurons immunoreactive for calcium-binding proteins. There was a trend for a greater prevalence of lef...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s004010051159

    authors： Suckling J,Roberts H,Walker M,Highley JR,Fenwick P,Oxbury J,Esiri MM

    更新日期：2000-05-01 00:00:00

  • Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas.

    abstract：:Intracranial germ cell tumors (iGCTs) are the second most common brain tumors among children under 14 in Japan. The World Health Organization classification recognizes several subtypes of iGCTs, which are conventionally subclassified into pure germinoma or non-germinomatous GCTs. Recent exhaustive genomic studies show...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-017-1673-2

    authors： Fukushima S,Yamashita S,Kobayashi H,Takami H,Fukuoka K,Nakamura T,Yamasaki K,Matsushita Y,Nakamura H,Totoki Y,Kato M,Suzuki T,Mishima K,Yanagisawa T,Mukasa A,Saito N,Kanamori M,Kumabe T,Tominaga T,Nagane M,Iuchi T

    更新日期：2017-03-01 00:00:00

  • Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.

    abstract：:In order to further evaluate the parameters whereby intracerebral administration of recombinant α-synuclein (αS) induces pathological phenotypes in mice, we conducted a series of studies where αS fibrils were injected into the brains of M83 (A53T) and M47 (E46K) αS transgenic (Tg) mice, and non-transgenic (nTg) mice. ...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-014-1268-0

    authors： Sacino AN,Brooks M,Thomas MA,McKinney AB,McGarvey NH,Rutherford NJ,Ceballos-Diaz C,Robertson J,Golde TE,Giasson BI

    更新日期：2014-05-01 00:00:00

  • Enzyme-histochemical studies of "retrograde" reaction in motor neurones of immature rats.

    abstract：:Changes in immature rats in motor neurones after axotomy were studied by enzyme-histochemical methods. Increased activity of dehydrogenases in these neurones demonstrates enhanced metabolism and there was also increase of acid phosphatases. Decreased activity of acetylcholinesterase and indoxylacetate esterase in the ...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/BF00686163

    authors： Maślińska D,Thomas E

    更新日期：1975-12-30 00:00:00

  • Peripheral and central distal axonopathy of suspected inherited origin in Birman cats.

    abstract：:Three female cats, littermates born from clinically normal parents, were examined at 8 to 10 weeks of age because of a slowly progressive posterior ataxia. Another cat from a previous litter from the same parents suffered from similar neurological symptoms. Histopathological examination of the nervous tissues of these...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/BF00293957

    authors： Moreau PM,Vallat JM,Hugon J,Leboutet MJ,Vandevelde M

    更新日期：1991-01-01 00:00:00

  • Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia.

    abstract：:Upon brain reperfusion following ischemia, there is widespread inhibition of neuronal protein synthesis that is due to phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha), which persists in selectively vulnerable neurons (SVNs) destined to die. Other investigators have shown that expression of mutant eI...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-003-0693-2

    authors： Page AB,Owen CR,Kumar R,Miller JM,Rafols JA,White BC,DeGracia DJ,Krause GS

    更新日期：2003-07-01 00:00:00

  • Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience.

    abstract：:Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here, we report on DNA methylation-based central nervous system (CNS) tumor diagnostics conducted in our institution between the years 2015 and 2018....

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-018-1879-y

    authors： Capper D,Stichel D,Sahm F,Jones DTW,Schrimpf D,Sill M,Schmid S,Hovestadt V,Reuss DE,Koelsche C,Reinhardt A,Wefers AK,Huang K,Sievers P,Ebrahimi A,Schöler A,Teichmann D,Koch A,Hänggi D,Unterberg A,Platten M,Wick

    更新日期：2018-08-01 00:00:00

  • Pontocerebellar hypoplasia type 2: a neuropathological update.

    abstract：:Pontocerebellar hypoplasia type 2 (PCH-2; MIM 277470), an autosomal recessive neurodegeneration with fetal onset, was studied in six autopsies with ages at death ranging between 1 and 22 years. Three patients were distantly related. A case of olivopontocerebellar hypoplasia (OPCH; MIM 225753) was studied for compariso...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-007-0263-0

    authors： Barth PG,Aronica E,de Vries L,Nikkels PG,Scheper W,Hoozemans JJ,Poll-The BT,Troost D

    更新日期：2007-10-01 00:00:00

  • Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition.

    abstract：:Brain tumors are the most common solid tumors of childhood, and the genetic drivers and optimal therapeutic strategies for many of the different subtypes remain unknown. Here, we identify that bithalamic gliomas harbor frequent mutations in the EGFR oncogene, only rare histone H3 mutation (in contrast to their unilate...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-020-02155-5

    authors： Mondal G,Lee JC,Ravindranathan A,Villanueva-Meyer JE,Tran QT,Allen SJ,Barreto J,Gupta R,Doo P,Van Ziffle J,Onodera C,Devine P,Grenert JP,Samuel D,Li R,Metrock LK,Jin LW,Antony R,Alashari M,Cheshier S,Whipple NS,

    更新日期：2020-06-01 00:00:00

  • Cellular localization of prolactin-releasing peptide receptors in the human pituitary.

    abstract：:The recently identified prolactin (PRL)-releasing peptide (PrRP) is the first hypothalamic peptide hormone found to operate as a ligand of an orphan receptor that specifically stimulates PRL production from the pituitary gland. However, its other biological functions remain unknown. Using immunohistochemistry, we exam...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-003-0753-7

    authors： Abe T,Koga N,Tomita M,Tonoike T,Kushima M,Takahashi K,Sano Y,Taniyama M

    更新日期：2003-11-01 00:00:00

  • Lovastatin and phenylacetate induce apoptosis, but not differentiation, in human malignant glioma cells.

    abstract：:Induction of differentiation is an attractive approach to the management of infiltrative tumors such as malignant glioma. Here, we report that lovastatin and phenylacetate induce apoptosis, but fail to induce differentiation, in malignant glioma cell lines and untransformed rat astrocytes. Lovastatin and phenylacetate...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s004010000254

    authors： Schmidt F,Groscurth P,Kermer M,Dichgans J,Weller M

    更新日期：2001-03-01 00:00:00

  • In situ analysis of cell kinetics in human brain tumors. A comparative immunocytochemical study of S phase cells by a new in vitro bromodeoxyuridine-labeling technique, and of proliferating pool cells by monoclonal antibody Ki-67.

    abstract：:A newly developed in vitro labeling method with bromodeoxyuridine (BrdU) identifies S phase cells in situ in freshly obtained surgical tissue of human brain tumors which is subsequently fixed and embedded in paraffin for BrdU immunovisualization. For the first time, the BrdU labeling index (LI) is successfully compare...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/BF00687579

    authors： Morimura T,Kitz K,Budka H

    更新日期：1989-01-01 00:00:00

  • Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion.

    abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are relentlessly progressive neurodegenerative disorders with overlapping clinical, genetic and pathological features. Cytoplasmic inclusions of fused in sarcoma (FUS) are the hallmark of several forms of FTLD and ALS patients with mutati...

    journal_title：Acta neuropathologica

    pub_type： 杂志文章

    doi：10.1007/s00401-012-1043-z

    authors： Mitchell JC,McGoldrick P,Vance C,Hortobagyi T,Sreedharan J,Rogelj B,Tudor EL,Smith BN,Klasen C,Miller CC,Cooper JD,Greensmith L,Shaw CE

    更新日期：2013-02-01 00:00:00