Abstract:
:Three female cats, littermates born from clinically normal parents, were examined at 8 to 10 weeks of age because of a slowly progressive posterior ataxia. Another cat from a previous litter from the same parents suffered from similar neurological symptoms. Histopathological examination of the nervous tissues of these animals revealed degeneration of axons and myelinopathy in a distal distribution pattern. Both peripheral nerves and central nervous system were involved. The central nervous system lesions were most prominent in the lateral pyramidal tracts of the spinal cord, the fasciculi gracili of the dorsal column in the cervical spinal cord and the cerebellar vermian white matter. In the PNS numerous degenerating nerve fibers were found in the sciatic nerves but not in the spinal nerve roots. Our findings show that these cats were suffering from a hereditary multisystem degeneration with a distribution pattern of the lesions suggestive of a distal axonopathy.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Moreau PM,Vallat JM,Hugon J,Leboutet MJ,Vandevelde Mdoi
10.1007/BF00293957subject
Has Abstractpub_date
1991-01-01 00:00:00pages
143-6issue
2eissn
0001-6322issn
1432-0533journal_volume
82pub_type
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