Abstract：
:Vasa vasorum are adventitial vessels that play a role in pathogenesis of atherosclerosis, aneurysm, vasculitides, and graft vascular disease. The existence of vasa vasorum in human intracranial arteries is not yet well defined. The specific aims of this study are to determine whether the human intracranial arteries have vasa vasorum, whether their existence is related to the thickness of tunica media as is in systemic vessels, and whether they are acquired in reaction to pathological conditions, such as atherosclerosis and arterial occlusion. Human intracranial internal carotid (i-ICA), vertebral (i-VA), basilar (BA) and middle cerebral arteries (MCA) from adults, children and newborns were examined. Systemic vessels of comparable medial thickness were used as controls. Immunohistochemical staining for Factor VIII and CD 31 was used to identify the endothelial cells. Human intracranial arteries in neonates, children and adults do not have vasa vasorum, although their medial thickness is comparable to their systemic counterparts with vasa vasorum. Only in adults did the proximal intracranial segments of i-ICA and i-VA reveal a few vasa vasorum-like vessels with unusually large diameter. They were more frequently seen in atherosclerosis and thrombotic but again limited to the proximal segments of i-ICA and i-VA. Completely obstructed bilateral carotid arteries in a child with sickle cell disorder revealed a rich adventitial neovascularization in the proximal intracranial part of the vessel. It is not yet known whether obstruction of the distal segments may create similar neovascularizations. Adventitial neovascularizations seen in the proximal i-ICA and i-VA may represent a focal intracranial extension of the vascular pathologies involving the extracranial segments of major cerebral arteries.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Aydin Fdoi
10.1007/s004010050856subject
Has Abstractpub_date
1998-07-01 00:00:00pages
22-8issue
1eissn
0001-6322issn
1432-0533journal_volume
96pub_type
杂志文章abstract：:The spatial patterns of diffuse, primitive, classic (cored) and compact (burnt-out) subtypes of beta/A4 deposits were studied in coronal sections of the frontal lobe and hippocampus, including the adjacent gyri, in nine cases of Alzheimer's disease (AD). If the more mature deposits were derived from the diffuse deposi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00454896
更新日期：1993-01-01 00:00:00
abstract：:Abnormal TDP-43 aggregation is a prominent feature in the neuropathology of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. Mutations in TARDBP, the gene encoding TDP-43, cause some cases of ALS. The normal function of TDP-43 remains incompletely understood. To better understand TDP-43 biolo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-010-0659-0
更新日期：2010-04-01 00:00:00
abstract：:Primary extradural ependymomas are rare neoplasms usually of the myxopapillary type. Reports on malignant primary extradural ependymal tumors are exceptionally rare. We here report on a 3-year-old boy with Schinzel-Giedion syndrome (SGS), who presented with lumbar spina bifida occulta and a progressive extraspinal les...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0179-0
更新日期：2007-03-01 00:00:00
abstract：:Defects of major histocompatibility complex (MHC) class I antigen-processing machinery (APM) components have been shown to contribute to immune escape of malignant cells. We investigated the expression of APM components in astrocytomas without detectable defects in HLA class I antigen expression and correlated it with...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0231-8
更新日期：2007-08-01 00:00:00
abstract：:Induction of differentiation is an attractive approach to the management of infiltrative tumors such as malignant glioma. Here, we report that lovastatin and phenylacetate induce apoptosis, but fail to induce differentiation, in malignant glioma cell lines and untransformed rat astrocytes. Lovastatin and phenylacetate...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000254
更新日期：2001-03-01 00:00:00
abstract：:A 1-year-old male chinchilla with a 2-week history of conjunctivitis suffered subsequently from neurological signs comprising seizures, disorientation, recumbency and apathy. After 3 weeks of progressive central nervous disease the animal was killed in view of the poor prognosis. A non-suppurative meningitis and polio...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0597-6
更新日期：2002-12-01 00:00:00
abstract：:A case of 14-year-old girl is reported in whom an alveolar rhabdomyosarcoma occurred in the soft tissues of the left forearm 4 years prior to death. Despite extensive surgery as well as chemotherapy and radiotherapy the tumor recurred locally and produced extensive metastases including a metastasis to the brain. Cereb...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687824
更新日期：1985-01-01 00:00:00
abstract：:Spinal and bulbar muscular atrophy (SBMA) is an inherited neuromuscular disease caused by expansion of a polyglutamine (polyQ) tract in the androgen receptor (AR). SBMA is triggered by the interaction between polyQ-AR and its natural ligands, testosterone and dihydrotestosterone (DHT). SBMA is characterized by the los...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1122-9
更新日期：2013-07-01 00:00:00
abstract：:The colonic enteric nervous system was investigated in autopsy specimens from 12 patients with familial amyloidotic neuropathy (FAP) and 9 controls. The infiltration of amyloid deposits in the enteric nervous system was studied by double staining for amyloid and nerve elements. The myenteric plexus was immunostained f...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051050
更新日期：1999-07-01 00:00:00
abstract：:Inflammatory myopathy with abundant macrophages (IMAM) and dermatomyositis (DM) are considered to represent related disorders, since they share inflammatory infiltrates and skin alterations. In order to get more insight into these disorders, we addressed the cellular composition of the inflammatory infiltrates in musc...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-009-0570-8
更新日期：2009-12-01 00:00:00
abstract：:The original version of this article unfortunately contained a typesetting error in Fig 3c. The corrected Fig. 3 is given in the following page. ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00401-019-02115-8
更新日期：2020-02-01 00:00:00
abstract：:Localization of organ-specific brain antigens in the central nervous system of the rat has been studied by means of indirect immunofluorescence. Rabbit antiserum against homogenate of rat brain, previously absorbed with normal serum and homogenates of rat organs (kidney, liver, spleen), reacted with the water-soluble ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00703316
更新日期：1977-08-16 00:00:00
abstract：:We have developed a functional vegetative model by an 18-min clamping of the ascending aorta combined with a bypass formation between the aorta to right atrium and the aorta to femoral vein. Complete global brain ischemia (CGBI) induced for 18 min with this model provided the following distinct advantages: cardiopulmo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294614
更新日期：1990-01-01 00:00:00
abstract：:VM mice were inoculated by intracerebral and intraperitoneal routes with brain homogenates containing the 87V strain of scrapie. The distribution and numbers of plaques were found for the parietal cortex, cingulate cortex, corpus callosum and hippocampus/dentate in coronal sections cut at the level of the thalamus and...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688311
更新日期：1986-01-01 00:00:00
abstract：:This report illustrates a case of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) masquerading as neurofibromatosis due to multifocal enlargements of spinal nerve roots. The patient initially complained of intermittent numbness of the hands and leg weakness at age 62. Nerve conduction velocities were ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0616-7
更新日期：2003-02-01 00:00:00
abstract：:In an autopsy case of the sporadic juvenile ALS (a 17-year-old girl) intracytoplasmic inclusions are found in the upper and lower motor neurons and in nerve cells of the dentate nucleus, pontine nucleus, brain stem reticular formation, substantia nigra, thalamus, globus pallidus and others. Histochemically they contai...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691069
更新日期：1978-12-15 00:00:00
abstract：:Specific pathological hallmarks have been described in amyotrophic lateral sclerosis (ALS), which include motor neuronal loss, Bunina bodies (BBs) and skein like inclusions (SLIs). We investigated the relation between these three lesions in the cervical and lumbar anterior horns and the hypoglossal nuclei of 20 ALS pa...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-001-0507-3
更新日期：2002-06-01 00:00:00
abstract：:Alzheimer's disease (AD) is a major cause of dementia. Characteristic neuropathological features of AD include neurofibrillary tangles, senile plaques, amyloid angiopathy and microvascular atrophy. The ultra-structure of the microvascular atrophy in AD and its pathogenetic significance have not been defined. This repo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050386
更新日期：1996-01-01 00:00:00
abstract：:Primary cortical and hippocampal neuronal cultures submitted to brief histotoxic hypoxia suffer delayed neuronal death after 24 h [Uto et al. (1995) J Neurochem 64: 2185-2192]. In this study the ultrastructural changes were monitored during the first 6 h following 5-min histotoxic hypoxia induced by exposure to 100 mi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050559
更新日期：1996-12-01 00:00:00
abstract：:A patient with mixed gonadal dysgenesis showed glove and stocking-type sensory impairment and slowing of motor and sensory nerve conduction. Sural nerve biopsy revealed minifascicular formation with decreased density of myelinated fibers. As far as we are aware, this is the first report of polyneuropathy with minifasc...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051085
更新日期：1999-09-01 00:00:00
abstract：:The occurrence is reported of acute myositis in a man with meningoencephalitis due to toxoplasmosis. The ultrastructure and immunohistochemistry of a muscle biopsy of the patient were investigated. Toxoplasma organisms were not found in the muscle biopsy. The perivascular inflammatory cells in the muscle were mainly C...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00334513
更新日期：1990-01-01 00:00:00
abstract：:Amplification of the epidermal growth factor receptor (EGFR) gene is found in about 40% of glioblastomas (GBMs) but is rarely detected in GBM cell lines. We confirmed that the exceptional SKMG-3 GBM cell line retained amplified EGFR genes in vitro, and found that these sequences were concentrated on extra-chromosomal ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000332
更新日期：2001-06-01 00:00:00
abstract：:In 2011, genome-wide association studies implicated a polymorphism near CD33 as a genetic risk factor for Alzheimer's disease. This finding sparked interest in this member of the sialic acid-binding immunoglobulin-type lectin family which is linked to innate immunity. Subsequent studies found that CD33 is expressed in...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-019-02000-4
更新日期：2019-08-01 00:00:00
abstract：:The nuclei for the nerves of a dorsal (m. splenius) and a ventral (m. longus capitis) neck muscle of the rat were retrogradely labeled by applying horseradish peroxidase (HRP) to the respective cut muscle nerves. Motoneurons of both muscles were analyzed for their localization, diameter of perikarya, and area of dendr...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690368
更新日期：1981-01-01 00:00:00
abstract：:Underlying the Lambert-Eaton myasthenic syndrome (LEMS) is a decrease in the release of the neurotransmitter acetylcholine. Only few reports on light and transmission electron microscopical observations of motor endplates in LEMS are available and changes reported so far differ from those found in experimental blockin...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308480
更新日期：1992-01-01 00:00:00
abstract：:Aim of the present study was to establish different immunohistochemical staining patterns for a subsequent comparison with those of primitive neuroectodermal (PNET) subsets, i.e. PNET-NOS (not otherwise specified) or PNET with focal neuronal, astrocytic or ependymal differentiation, to relate neoplastic to embryonal d...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00293385
更新日期：1991-01-01 00:00:00
abstract：:A 48-year-old man with dural arteriovenous malformation (AVM) is reported. Radiologically, the dural AVM was demonstrated mainly in the region of the left transverse sinus. Postmortem examination revealed dural AVM involving the bilateral transverse, superior sagittal and straight sinuses. In addition, numerous malfor...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00307635
更新日期：1990-01-01 00:00:00
abstract：:Dysferlin is a newly identified sarcolemmal protein related to Miyoshi myopathy and limb-girdle muscular dystrophy. Although its function is still unknown, it is inferred from the presence of C2 domains and a transmembrane domain in its sequence that dysferlin may be expressed or located not only at the sarcolemma but...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0686-1
更新日期：2003-06-01 00:00:00
abstract：:A woman of 22 years developed heavy pain in the neck and arms with weakness and paresthesia. She died two days after a myelography which was normal. At autopsy an enterogenous extra- and intra-medullary cyst of the cervical cord (C3, C4) was found. In addition the cervical cord apart from the cyst and the uppermost th...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691967
更新日期：1977-11-28 00:00:00
abstract：:Little information is available regarding the morphological changes in the mitochondria in amyotrophic lateral sclerosis (ALS). In particular, mitochondrial changes in dorsal root ganglion cells have not yet been examined. We therefore conducted an electron microscopic examination of the mitochondria in dorsal root ga...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0299-1
更新日期：2007-12-01 00:00:00
