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Distributions of amyloid plaques in four regions of the brains of mice infected with scrapie by intracerebral and intraperitoneal routes of injection.

Abstract：

:VM mice were inoculated by intracerebral and intraperitoneal routes with brain homogenates containing the 87V strain of scrapie. The distribution and numbers of plaques were found for the parietal cortex, cingulate cortex, corpus callosum and hippocampus/dentate in coronal sections cut at the level of the thalamus and stained with Masson's trichrome. For the intracerebrally injected animals, the greatest numbers were seen on the side of the brain that had been injected. In the four regions, they were most numerous in the corpus callosum and least numerous in the parietal cortex and hippocampus/dentate. Following an intraperitoneal injection, plaques were absent from the corpus callosum and, in the remaining three regions, they were less numerous than in intracerebrally injected animals, although their relative numbers were similar. The distribution of the plaques was suggestive of an initial passive spread of inoculum following intracerebral injection and a tendency for plaques to be associated with myelinated axon tracts.

journal_name

Acta Neuropathol

journal_title

Acta neuropathologica

authors

Gibson PH

doi

10.1007/BF00688311

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

322-5

issue

3-4

eissn

0001-6322

issn

1432-0533

journal_volume

69

pub_type

杂志文章

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