CNS T-cell lymphoma: an under-recognized entity?


:The incidence of CNS lymphoma has increased significantly in the past 30 years, primarily in the elderly and immunocompromised. While T-cell lymphomas comprise 15-20% of systemic lymphomas, they comprise less than 4% of primary CNS lymphomas, suggesting that they may be under-recognized compared to their systemic counterparts. To investigate this, we studied brain biopsies from three patients who were diagnosed with T-cell lymphoma confined to the brain. They had enhancing lesions by MRI, arising in the cerebellum and brainstem in one and temporal lobe in two. We compared these to biopsies from three patients who had reactive lymphoid infiltrates and who had clinical signs/symptoms and radiographic findings that were indistinguishable from the lymphoma group. Biopsies from both the lymphoma group and reactive group showed considerable cytomorphologic heterogeneity. Although one lymphoma case contained large atypical cells, the other two contained small, mature lymphocytes within a heterogeneous infiltrate of neoplastic and reactive inflammatory cells. Surface marker aberrancies were present in two lymphoma cases, but this alone could not reliably diagnose T-cell lymphoma. The proliferation index was not useful for differentiating lymphoma from reactive infiltrates. In five of the six cases the diagnosis was most influenced by clonality studies for T-cell receptor-gamma gene rearrangements. We conclude that because of the high degree of overlap in cytomorphologic and immunophenotypic features between T-cell lymphoma and reactive infiltrates, T-cell lymphoma may not be recognized unless studies for T-cell receptor gene rearrangements are performed for CNS lesions composed of a polymorphous but predominantly T-cell infiltrate.


Acta Neuropathol


Acta neuropathologica


Dulai MS,Park CY,Howell WD,Smyth LT,Desai M,Carter DM,Vogel H




Has Abstract


2008-03-01 00:00:00












  • The membrane attack complex of complement mediates peripheral nervous system demyelination in vitro.

    abstract::The present study used cocultures of rat dorsal root ganglia (DRG) and peritoneal macrophages to define the role of activated complement components during demyelination. The complement cascade was activated in vitro by treatment of the cultures with natural rat serum and lipopolysaccharides. Complement activation was ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Brück W,Brück Y,Diederich U,Piddlesden SJ

    更新日期:1995-01-01 00:00:00

  • Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia.

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    journal_title:Acta neuropathologica

    pub_type: 杂志文章


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  • miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease.

    abstract::MicroRNAs are recognized as important regulators of many facets of physiological brain function while also being implicated in the pathogenesis of several neurological disorders. Dysregulation of miR155 is widely reported across a variety of neurodegenerative conditions, including Alzheimer's disease (AD), Parkinson's...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


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    journal_title:Acta neuropathologica

    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Acta neuropathologica

    pub_type: 杂志文章


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    更新日期:2020-05-01 00:00:00

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    journal_title:Acta neuropathologica

    pub_type: 杂志文章


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    journal_title:Acta neuropathologica

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    更新日期:1987-01-01 00:00:00

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    journal_title:Acta neuropathologica

    pub_type: 杂志文章


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    更新日期:2013-12-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1999-03-01 00:00:00

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    journal_title:Acta neuropathologica

    pub_type: 杂志文章


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    journal_title:Acta neuropathologica

    pub_type: 杂志文章


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  • Immunohistochemical study on the distribution of alpha and beta subunits of S-100 protein in brain tumors.

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    journal_title:Acta neuropathologica

    pub_type: 杂志文章


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    journal_title:Acta neuropathologica

    pub_type: 杂志文章


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    更新日期:1992-01-01 00:00:00