About demyelinating properties of humoral antibodies in experimental allergic encephalomyelitis. In vivo and in vitro studies.

abstract：:Plaque-type deposition of prion protein (PrP) in the brain has been extremely rare in sporadic Creutzfeldt-Jakob disease patients with methionine homozygosity at polymorphic codon 129 of the PrP gene and type 1 abnormal isoform of PrP (sCJD-MM1). Here we report three sCJD-MM1 patients who showed prominent PrP-positive...

journal_title：Acta neuropathologica

authors： Kobayashi A,Arima K,Ogawa M,Murata M,Fukuda T,Kitamoto T

更新日期：2008-11-01 00:00:00

abstract：:The distribution of apolipoprotein E (ApoE) was studied in the brain tissue of cases of the amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam, locally known as lytico bodig disease (LB), and compared with cases of Alzheimer's disease (AD) and normal brain tissue. In both LB and AD, strong ApoE immuno...

journal_title：Acta neuropathologica

authors： Schwab C,Steele JC,Akiyama H,McGeer PL

更新日期：1996-10-01 00:00:00

abstract：:Head and neck paragangliomas, rare neoplasms of the paraganglia composed of nests of neurosecretory and glial cells embedded in vascular stroma, provide a remarkable example of organoid tumor architecture. To identify genes and pathways commonly deregulated in head and neck paraganglioma, we integrated high-density ge...

journal_title：Acta neuropathologica

authors： Cama A,Verginelli F,Lotti LV,Napolitano F,Morgano A,D'Orazio A,Vacca M,Perconti S,Pepe F,Romani F,Vitullo F,di Lella F,Visone R,Mannelli M,Neumann HP,Raiconi G,Paties C,Moschetta A,Tagliaferri R,Veronese A,Sanna M

更新日期：2013-10-01 00:00:00

abstract：:Pyroglutamylated amyloid-β (pE(3)-Aβ) has been suggested to play a major role in Alzheimer's disease (AD) pathogenesis as amyloid-β (Aβ) oligomers containing pE(3)-Aβ might initiate tau-dependent cytotoxicity. We aimed to further elucidate the associations among pE(3)-Aβ, full-length Aβ and hyperphosphorylated tau (HP...

journal_title：Acta neuropathologica

authors： Mandler M,Walker L,Santic R,Hanson P,Upadhaya AR,Colloby SJ,Morris CM,Thal DR,Thomas AJ,Schneeberger A,Attems J

更新日期：2014-07-01 00:00:00

abstract：:A study of a muscle biopsy has provided evidence of storage involvement of the skeletal muscle fibres in Fabry's disease. In the endothelial cells of the capillaries, the inclusions were more abundant and pleomorphic. Muscle satellite cells were spared. In the sensory nerve biopsy, the perineurial and endothelial cell...

journal_title：Acta neuropathologica

authors： Tomé FM,Fardeau M,Lenoir G

更新日期：1977-06-15 00:00:00

abstract：:Oral administration of N-[4-(3-ethoxy-2-hydropropoxy)phenyl] acrylamide (EHA) induced selective granule cell destruction in the granular layer of the cerebellar cortex together with neurological signs, such as delayed righting reflex, gait or truncal ataxia, and convulsion. Neuropathologically, it caused multifocal gr...

journal_title：Acta neuropathologica

authors： Tanaka G,Okeda R

更新日期：2000-04-01 00:00:00

abstract：:Structural proteins of cultured neurofibromatosis (NF) tumor and skin cells were studied with reference to control skin fibroblasts. In polyacrylamide gel electrophoresis (PAGE)/fluorography the banding patterns of the cell lysates were markedly similar. NF tumor cells, however, produced a 60 kD band with a stronger a...

journal_title：Acta neuropathologica

authors： Peltonen J,Näntö-Salonen K,Aho HJ,Kouri T,Virtanen I,Penttinen R

更新日期：1984-01-01 00:00:00

abstract：:Ectopic neurons have been detected in the hippocampus of postnatal hooded rats aged 5-24 days. These rats were exposed to methylazoxymethanol acetate (MAMac) during foetal development by injecting the mother rats with this neurotoxin. At birth, the hippocampus of rats exposed to MAMac showed a normal cytoarchitecture;...

journal_title：Acta neuropathologica

authors： Singh SC

更新日期：1977-10-10 00:00:00

abstract：:Motor neuron disease (MND) may be complicated by frontotemporal dementia and/or an extrapyramidal movement disorder. Several studies have identified the pathological substrate for dementia in MND as being ubiquitin-immunoreactive inclusions and dystrophic neurites in the extramotor neocortex and hippocampus. Although ...

journal_title：Acta neuropathologica

authors： Mackenzie IR,Feldman H

更新日期：2004-04-01 00:00:00

abstract：:Synucleinopathies, such as Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are defined by the presence of α-synuclein (αSYN) aggregates throughout the nervous system but diverge from one another with regard to their clinical and pathological phenotype. The recent generatio...

journal_title：Acta neuropathologica

authors： Van der Perren A,Gelders G,Fenyi A,Bousset L,Brito F,Peelaerts W,Van den Haute C,Gentleman S,Melki R,Baekelandt V

更新日期：2020-06-01 00:00:00

abstract：:The mechanism of inflammatory demyelination in canine distemper encephalitis (CDE) is uncertain but macrophages are thought to play an important effector role in this lesion. Serum and cerebrospinal fluid (CSF), containing anti-canine distemper virus and anti-myelin antibodies from dogs with CDE were tested for their ...

journal_title：Acta neuropathologica

authors： Griot C,Bürge T,Vandevelde M,Peterhans E

更新日期：1989-01-01 00:00:00

abstract：:Monosodium-L-glutamate given subcutaneously to pregnant rats caused acute necrosis of the acetylcholinesterase-positive neurons in the area postrema. The same effect has been observed in the area postrema of fetal rats. The process of neuronal cell death and the elimination of debris by microglia cells proved to be si...

journal_title：Acta neuropathologica

authors： Tóth L,Karcsu S,Feledi J,Kreutzberg GW

更新日期：1987-01-01 00:00:00

abstract：:Psammoma bodies in meningocytic whorls were investigated by electron microscopy. In some whorls, connective tissue fibers were seen and membrane-bound vesicles were contiguous to degenerated cells. Some small vesicles, 0.1 to 0.5 micron in diameter, were outlined by plasma membrane (matrix vesicles), other larger ones...

journal_title：Acta neuropathologica

authors： Kubota T,Yamashima T,Hasegawa M,Kida S,Hayashi M,Yamamoto S

更新日期：1986-01-01 00:00:00

abstract：:Among the various mechanisms proposed to explain the pathogenesis of cerebral lesions in human immunodeficiency virus (HIV)-induced encephalitis, a cytokine-mediated action has found most favour. Indeed, elevated expression of cytokines such as interleukin (IL)-1 and tumor necrosis factor-alpha (TNF-alpha), thought to...

journal_title：Acta neuropathologica

authors： An SF,Ciardi A,Giometto B,Scaravilli T,Gray F,Scaravilli F

更新日期：1996-01-01 00:00:00

abstract：:The present study investigated the expression of c-erbB-2 in 59 meningiomas, including different histological subtypes and anaplastic variants, by immunocytochemistry and molecular biological techniques. Immunohistochemistry using the monoclonal antibody FWP-51 directed against c-erbB-2-encoded oncoprotein gp185 demon...

journal_title：Acta neuropathologica

authors： Schlegel J,Ullrich B,Stumm G,Gass P,Harwerth IM,Hynes NE,Kiessling M

更新日期：1993-01-01 00:00:00

abstract：:Nine dogs with canine distemper encephalitis (CDE) were examined with immunological techniques including demonstration of antibodies against canine distemper virus (CDV) in the serum and against myelin basic protein (MBP) in serum and in CSF. Mitogen stimulation tests of lymphocytes were also done. The brains were exa...

journal_title：Acta neuropathologica

authors： Vandevelde M,Kristensen F,Kristensen B,Steck AJ,Kihm U

更新日期：1982-01-01 00:00:00

abstract：:We report a sporadic tauopathy of 6-year duration in a 76-year-old woman. Her initial symptoms were asymmetrical parkinsonism and muscle weakness, with apraxia appearing 2 years later. The brain showed frontal and temporal cerebral atrophy; severe neuronal loss and gliosis were observed in the precentral cortex (loss ...

journal_title：Acta neuropathologica

authors： Piao YS,Tan CF,Iwanaga K,Kakita A,Takano H,Nishizawa M,Lashley T,Revesz T,Lees A,de Silva R,Tsujihata M,Takahashi H

更新日期：2005-12-01 00:00:00

abstract：:Hyper- and hypothyroidism repercussions on soma, nucleus and cytoplasm increases were studied by electron microscopy on 7-, 14-, 21-, and 35-day-old rats. Adult normal animals were compared with adult ones made hypothyroid until they were 35 days old. Also heat value restriction of food intake effects were compared wi...

journal_title：Acta neuropathologica

authors： Rebière A,Dainat J

更新日期：1978-09-15 00:00:00

abstract：:The cytoskeletal properties and endogenous degradation of intermediate filaments in cultured human glioma cells (U-251MG) were studied using monoclonal antibodies in immunohistochemical and immunochemical methods. Both glial fibrillary acidic protein (GFAP)- and vimentin-antibodies gave a fibrillar cytoplasmic stainin...

journal_title：Acta neuropathologica

authors： Paetau A,Virtanen I

更新日期：1986-01-01 00:00:00

abstract：:Experimental allergic neuritis (EAN) was induced in normal and irradiated Lewis rats by passively transferring T cells sensitized to SP-26, a peptide fragment of P2 myelin protein. The recipients became sick 4-8 days post transfer and the degree of disability correlated directly with the dose of T cells. Smaller doses...

journal_title：Acta neuropathologica

authors： Hahn AF,Feasby TE,Lovgren D,Wilkie L

更新日期：1993-01-01 00:00:00

abstract：:In 54 cats experimental brain tumors were produced by xenotransplantation of the blastomatous glial cell clone RG2 into the internal capsule of the left hemisphere. Fifteen of these animals were treated with dexamethasone for 1 week and four animals for 2 h. The occurrence of glial fibrillary acidic (GFA) protein in t...

journal_title：Acta neuropathologica

authors： Szymas J,Hossmann KA

更新日期：1984-01-01 00:00:00

abstract：:Mutations of isocitrate dehydrogenase 1 (IDH1) gene are most common in glioma, arguably preceding all known genetic alterations during tumor development. IDH1 mutations nearly invariably target the enzymatic active site Arg132, giving rise to the predominant IDH1R132H. Cells harboring IDH1 R132H -heterozygous mutation...

journal_title：Acta neuropathologica

authors： Tiburcio PDB,Xiao B,Berg S,Asper S,Lyne S,Zhang Y,Zhu X,Yan H,Huang LE

更新日期：2018-02-01 00:00:00

abstract：:In a large series of 116 cortical resections for treatment of medically intractable epilepsy, 10 glial hamartomas and 11 neuronoglial malformative lesions were found. Glial hamartomas were astrocytic in 3 cases, oligodendrocytic in 6 and mixed oligoastrocytic in 1. Neuronoglial lesions corresponded to "focal cortical ...

journal_title：Acta neuropathologica

authors： Vital A,Marchal C,Loiseau H,Rougier A,Pedespan JM,Rivel J,Vital C

更新日期：1994-01-01 00:00:00

abstract：:Two young zebra siblings from consecutive pregnancies suffered from neurological disease, characterized by ventral deviation of the neck and tetraparesis which progressed to tetraplegia within a few weeks. On histological examination widespread neuronal degeneration was observed in the ventral horns of the spinal cord...

journal_title：Acta neuropathologica

authors： Higgins RJ,Vandevelde M,Hoff EJ,Jagar JE,Cork LC,Silberman MS

更新日期：1977-01-31 00:00:00

abstract：:The close correlation between abnormally low pre-mortem cerebrospinal fluid (CSF) concentrations of amyloid-β1-42 (Aβ(1-42)) and plaque burden measured by amyloid imaging as well as between pathologically increased levels of CSF tau and the extent of neurodegeneration measured by MRI has led to growing interest in usi...

journal_title：Acta neuropathologica

authors： Shaw LM,Vanderstichele H,Knapik-Czajka M,Figurski M,Coart E,Blennow K,Soares H,Simon AJ,Lewczuk P,Dean RA,Siemers E,Potter W,Lee VM,Trojanowski JQ,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2011-05-01 00:00:00

abstract：:Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild impact traumatic brain injury from contact sports. Recently, a consensus panel defined the pathognomonic lesion for CTE as accumulations of abnormally hyperphosphorylated tau (p-tau) in neurons (neurofibrillary tangle...

journal_title：Acta neuropathologica

authors： Shively SB,Edgerton SL,Iacono D,Purohit DP,Qu BX,Haroutunian V,Davis KL,Diaz-Arrastia R,Perl DP

更新日期：2017-03-01 00:00:00

abstract：:Altered levels of cerebrospinal fluid (CSF) peptides related to Alzheimer's disease (AD) are associated with pathologic AD diagnosis, although cognitively normal subjects can also have abnormal levels of these AD biomarkers. To identify novel CSF biomarkers that distinguish pathologically confirmed AD from cognitively...

journal_title：Acta neuropathologica

authors： Hu WT,Chen-Plotkin A,Arnold SE,Grossman M,Clark CM,Shaw LM,Pickering E,Kuhn M,Chen Y,McCluskey L,Elman L,Karlawish J,Hurtig HI,Siderowf A,Lee VM,Soares H,Trojanowski JQ

更新日期：2010-06-01 00:00:00

abstract：:There is evidence that apoptotic cell death mechanisms contribute to muscle fibre loss in dystrophinopathies, but little knowledge about the activators of the final degrading caspase cascade in muscle fibre apoptosis. As mitochondria-related activation of this caspase cascade, through e.g. APAF-1, could not be proven ...

journal_title：Acta neuropathologica

authors： Tews DS

更新日期：2005-02-01 00:00:00

abstract：:We have investigated relationships between hippocampal/temporal lobe neuropathology and psychosis in subjects with temporal lobe epilepsy, paying particular attention to possible differences in density of hippocampal neurons immunoreactive for calcium-binding proteins. There was a trend for a greater prevalence of lef...

journal_title：Acta neuropathologica

authors： Suckling J,Roberts H,Walker M,Highley JR,Fenwick P,Oxbury J,Esiri MM

更新日期：2000-05-01 00:00:00

abstract：:An 18 month old cat had a 6 month history of abnormal high stepping gait, ataxia, muscle twitching and loss of sensory perception. The clinical course was interrupted by several episodes of temporary remission. The essential pathological features were those of a polyradiculoneuritis with segmental demyelination, focal...

journal_title：Acta neuropathologica

authors： Flecknell PA,Lucke VM

更新日期：1978-01-19 00:00:00