Abstract：
:Hyper- and hypothyroidism repercussions on soma, nucleus and cytoplasm increases were studied by electron microscopy on 7-, 14-, 21-, and 35-day-old rats. Adult normal animals were compared with adult ones made hypothyroid until they were 35 days old. Also heat value restriction of food intake effects were compared with hypothyroid ones at 14 and 35 days. Hyperthyroidism accelerated the soma and cytoplasm size increase as early as 14 days, and the nucleus size increase as early as 21 days. It did not change the nucleo-cytoplasmic ratio (N/P) markedly, except that maximal value of this ratio was reached earlier than in normal animals. Heat value restriction of food intake led to a transitory soma size decrease at 14 days and a high nucleus size increase. This diet did not change markedly either cytoplasm size or N/P ratio value. Hypothyroidism slackened the rate of the soma, nucleus and cytoplasm size increase during the third postnatal week especially. Beyond, these structures went on increasing and their size became greater than normal in adult hypothyroid animals. N/P ratio was always superior to normal. Hypothyroidism led to a high volumetric and linear density of Purkinje cell soma glial surrounding. Hyperthyroidism caused a slight increase of these parameters which were not greatly changed by heat value restriction of food intake.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Rebière A,Dainat Jsubject
Has Abstractpub_date
1978-09-15 00:00:00pages
221-8issue
3eissn
0001-6322issn
1432-0533journal_volume
43pub_type
杂志文章abstract：:A case of Creutzfeldt-Jakob disease (CJD) with a rare mutation of the prion protein (PrP) gene (PRNP) at codon 208 (R208H) is described. By comparison with two preceding reports, the case described here displayed two distinct biochemical and neuropathological features. Western blot analysis of brain homogenates showed...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0978-0
更新日期：2005-04-01 00:00:00
abstract：:Conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer's disease (LOAD). Mutations and/or differential expression of microglial specific receptors such as TREM2, CD33, and CR3 have been associated wi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1737-3
更新日期：2017-11-01 00:00:00
abstract：:Pick's disease is characterized morphologically by severe atrophy of the frontal and temporal lobes and the presence in the cerebral cortex of degenerative neuronal lesions referred to as Pick bodies. In the present study, we analyzed the regional and laminar distribution of Pick bodies in a series of 16 Pick's diseas...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00296179
更新日期：1994-01-01 00:00:00
abstract：:Neuropeptides have turned out to be promising new parameters, in addition to the routinely performed histochemical diagnosis, of Hirschsprung's disease (HD). Studies of the peptidergic innervation of the affected intestinal segment of patients with HD have demonstrated a marked reduction in the density of several neur...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0613-x
更新日期：2003-01-01 00:00:00
abstract：:The pathological changes in the nucleus basalis of Meynert (nbM) in 10 autopsied cases with Pick's disease were studied in comparison with 15 age-matched controls. Both the number and density of nerve cells and the degree of fibrillary gliosis were examined at the anterior, intermediate, and posterior divisions of the...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687402
更新日期：1989-01-01 00:00:00
abstract：:This study tests the effects of chronic electrostimulation on denervated/reinnervated skeletal muscle in producing an optimal restoration of size and mechanical and histochemical properties. We compared tibialis anterior muscles in four groups of rats: in unoperated control (C) and 10 weeks following nerve lesion with...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0035-2
更新日期：2006-06-01 00:00:00
abstract：:We have obtained a cDNA fragment to human glial fibrillary acidic protein (GFAP) by immunoscreening a lambda gt11 human brain cDNA library with antibody to bovine GFAP. The highly homologous nucleotide sequence of this clone with that of the mouse GFAP enabled the identification of this cDNA as one encoding GFAP. As t...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687396
更新日期：1989-01-01 00:00:00
abstract：:Continuous intrathecal infusion of N-methyl-D-aspartate (NMDA) at the level of the lumbar enlargement of the spinal cord in middle-aged rats produced dose-dependent toxicity of spinal cord neuronal systems. Toxicity was enhanced by coadministration of glycine, but was significantly reduced when NMDA was co-administere...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00662631
更新日期：1990-01-01 00:00:00
abstract：:Induction of differentiation is an attractive approach to the management of infiltrative tumors such as malignant glioma. Here, we report that lovastatin and phenylacetate induce apoptosis, but fail to induce differentiation, in malignant glioma cell lines and untransformed rat astrocytes. Lovastatin and phenylacetate...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000254
更新日期：2001-03-01 00:00:00
abstract：:The diagnosis of infantile neuro-axonal dystrophy (INAD) in a 5-year-old patient was confirmed by the ultrastructural study of neuromuscular, skin and conjunctival biopsy specimens. Abnormal networks of smooth membranous, lamellar and tubular profiles were found in presynaptic terminals and in conjunctival and dermal ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00702677
更新日期：1979-03-15 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) and adult onset X-linked recessive bulbospinal muscular atrophy (SPMA), constituting the category of adult onset form of motor neuron disease, were analyzed on motor nerve roots. The results of morphometric analysis on ventral spinal roots (VSR) of all spinal segments from ALS and S...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691322
更新日期：1981-01-01 00:00:00
abstract：:A 9-year-old male patient developed a germ cell tumor in the right basal ganglia which secreted beta-human chorionic gonadotropin (beta-HCG) and caused precocious puberty. Histology and immunohistochemical staining for placental alkaline phosphatase (PLAP), alpha-fetoprotein (alpha-FP), and beta-HCG showed a mixed pop...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687797
更新日期：1988-01-01 00:00:00
abstract：:A murine model of Tay-Sachs disease, the prototype of the GM2 gangliosidoses, was produced through the targeted disruption of the Hexa gene encoding the subunit of alpha-hexosaminidase A. The mice were completely devoid of beta-hexosaminidase A activity and accumulated GM2 ganglioside in the CNS in an age-dependent ma...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00309622
更新日期：1995-01-01 00:00:00
abstract：:In recent years, we have used a variety of tau immunological markers combined with the dye thiazin red (TR), an accurate marker to differentiate the fibrillar from the nonfibrillar state of both amyloid-beta and tau in Alzheimer's disease (AD). In this study, we used TR as a potential diagnostic marker of AD in frozen...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-008-0431-x
更新日期：2008-11-01 00:00:00
abstract：:The number and nucleolar volume of nerve cells within the nucleus basalis of Meynert, locus caeruleus, substantia nigra and dorsal raphe were examined in five patients with Huntington's chorea. No significant changes in nerve cell number were noted in any area in any patient and, although nucleolar volume was reduced ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687718
更新日期：1989-01-01 00:00:00
abstract：:Oral administration of N-[4-(3-ethoxy-2-hydropropoxy)phenyl] acrylamide (EHA) induced selective granule cell destruction in the granular layer of the cerebellar cortex together with neurological signs, such as delayed righting reflex, gait or truncal ataxia, and convulsion. Neuropathologically, it caused multifocal gr...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051133
更新日期：2000-04-01 00:00:00
abstract：:The peripheral immune system plays a critical role in aging and in the response to brain injury. Emerging data suggest inflammatory responses are exacerbated in older animals following ischemic stroke; however, our understanding of these age-related changes is poor. In this work, we demonstrate marked differences in t...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-018-1859-2
更新日期：2018-07-01 00:00:00
abstract：:Eleven atypical teratoid/rhabdoid tumors (AT/RT) and 121 primitive neuroectodermal tumors/medulloblastomas (PNET/MB) were included in this study for evaluation of the histopathological features of AT/RT and comparison between AT/RT and PNET/MB. Histopathological studies of AT/RT showed that in addition to the commonly...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051149
更新日期：2000-05-01 00:00:00
abstract：:Using a photochemical method silver was demonstrated in the brains of 1-, 14-, and 45-day-old rats which had been exposed to silver on gestational days 18 and 19. In the brain tissue of new-born rats, silver was found in the lysosomes of neurons and astroglia. Minor changes in the anatomic distribution of silver were ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691995
更新日期：1983-01-01 00:00:00
abstract：:Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3.3) subgroups were c...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-012-0998-0
更新日期：2012-09-01 00:00:00
abstract：:The dynamics of cell-associated Concanavalin A (Con A) in astrocytes of the newborn rat (RNA), the rat glioma (AC), and the human glioblastoma (GB) were studied in vitro by fluorescence and electron microscopy. Con A receptors on the cell surface were seen usually as a continuous thin layer, and Con A accumulations in...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690804
更新日期：1982-01-01 00:00:00
abstract：:Proliferation indices and mean number of silver-stained nucleolar organizer region-associated proteins (Ag-NORs) are compared in 65 brain tumors, including 34 gliomas, 8 meningiomas, 17 metastatic tumors, and 6 other tumors. Immunocytochemical investigations include labeling with the monoclonal antibody Ki-67 which id...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308919
更新日期：1990-01-01 00:00:00
abstract：:Psammoma bodies at the perivascular area in five cases of meningioma were examined with the electron microscope. In general, meningocytic cells invest the outer aspect of blood vessels, which are constituted by multilayered basal laminae, collagen fibers, microfibrils, and pericytes. Remnants of degenerated cells are ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688693
更新日期：1985-01-01 00:00:00
abstract：:Altered levels of cerebrospinal fluid (CSF) peptides related to Alzheimer's disease (AD) are associated with pathologic AD diagnosis, although cognitively normal subjects can also have abnormal levels of these AD biomarkers. To identify novel CSF biomarkers that distinguish pathologically confirmed AD from cognitively...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-010-0667-0
更新日期：2010-06-01 00:00:00
abstract：:The formation of oedema in peripheral nerves was studied in rats at intervals varying from 6 h to 14 days after transection of the right sciatic nerve. Samples were removed proximal and distal to the injury, and the degree of oedema was determined by a microgravimetric method and by measurements of the water content a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686069
更新日期：1986-01-01 00:00:00
abstract：:Pregnant rats were administered a liquid diet containing 5% (w/v) ethanol between gestational days 10 and 21, and the brains of nine offspring were examined at 8 weeks of age. Two ethanol-treated offspring showed obvious hydrocephalus characterized by markedly enlarged lateral ventricles. Most of the other ethanol-tre...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0901-8
更新日期：2004-11-01 00:00:00
abstract：:Interstitial cells are isolated neurons located in the infracortical white matter that are known to express neuropeptides. Twenty-four cases selected for the absence, slight (Braak stages I-II), moderate (Braak stages III-IV), or serious degree (Braak stages V-VI) of cortical neurofibrillary pathology were studied for...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0551-7
更新日期：2002-10-01 00:00:00
abstract：:Investigations of the existence and distribution of muscle spindles and tendon organs in the human voluntary anal sphincter muscle in 53 cases of autopsy material from both female and male persons (age: 27th week of gestation to 81 years) brought forward the following results: Similar to animals, muscle spindles are f...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691860
更新日期：1984-01-01 00:00:00
abstract：:Collections of human postmortem brains gathered in brain banks have underpinned many significant developments in the understanding of central nervous system (CNS) disorders and continue to support current research. Unfortunately, the worldwide decline in postmortem examinations has had an adverse effect on research ti...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-008-0360-8
更新日期：2008-05-01 00:00:00
abstract：:The deficiency of the cholinergic cortical projection system arising in the different basal forebrain structures collectively referred to as nucleus basalis of Meynert complex is a constant finding in Alzheimer's disease, a disorder which is neuro-pathologically characterised by the appearance of three intracerebral f...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690530
更新日期：1988-01-01 00:00:00
