Abstract：
:The formation of oedema in peripheral nerves was studied in rats at intervals varying from 6 h to 14 days after transection of the right sciatic nerve. Samples were removed proximal and distal to the injury, and the degree of oedema was determined by a microgravimetric method and by measurements of the water content and of the fascicular area. Distal to the lesion, decreased density values indicating the presence of oedema were observed in samples examined after a survival period of 6 h-14 days. The water content and fascicular area were both increased in samples taken 24 h after injury. Fourteen days postinjury the water content had increased further. Proximal to the lesion, the water content and the fascicular area were increased in samples examined after a survival period of 24 h. Fourteen days after the injury, the increase in water content was even more pronounced. No changes were detected with the microgravimetric technique 6 and 24 h after the injury. Unexpectedly, animals surviving 14 days showed increased density values. The microgravimetric technique used is a valuable adjunctive method for quantitation of peripheral nerve oedema in the acute phase after a traumatic nerve injury. Later on, loss of axons and of myelin components, together with regenerative phenomena, influence the density values obtained. Quantitative methods for studying chronic peripheral nerve oedema should, therefore, be supplemented with other techniques.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Pettersson CA,Tengvar Cdoi
10.1007/BF00686069subject
Has Abstractpub_date
1986-01-01 00:00:00pages
177-84issue
3-4eissn
0001-6322issn
1432-0533journal_volume
70pub_type
杂志文章abstract：:Histopathological, immunocytochemical, and electron microscopical investigations were carried out in a man with a protracted history of spastic paraparesis, adrenal insufficiency and hypogonadism. Pathological findings were identical with those of the few previously reported cases of adrenomyeloneuropathy (AMN) includ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690750
更新日期：1980-01-01 00:00:00
abstract：:The nature and distribution of vascular changes in acute Wernicke's encephalopathy (WE) were analyzed in three autopsy cases. Lesions of the lateral vestibular nucleus of the medulla oblongata (three cases) and lateral ventricular wall (one case) were examined by reconstruction of 200 serial sections, and the capillar...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00307646
更新日期：1995-01-01 00:00:00
abstract：:The present study used cocultures of rat dorsal root ganglia (DRG) and peritoneal macrophages to define the role of activated complement components during demyelination. The complement cascade was activated in vitro by treatment of the cultures with natural rat serum and lipopolysaccharides. Complement activation was ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00318572
更新日期：1995-01-01 00:00:00
abstract：:A large series of central and peripheral nervous system tumors was studied for the presence of glial fibrillary acidic protein (GFAP) and gamma-enolase (neuron-specific enolase, NSE), using specific monoclonal antibodies (mAbs). Occurrence in and specificity of GFAP to glial and mixed tumors was confirmed and depended...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687791
更新日期：1988-01-01 00:00:00
abstract：:Brain slices are used extensively for biochemical, electrophysiological and molecular investigations. However, only the time frame for electrophysiological and biochemical investigations has as yet been defined. The goal of the present study was to investigate the time course of nuclear structure in live brain slices....
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000317
更新日期：2001-05-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) and adult onset X-linked recessive bulbospinal muscular atrophy (SPMA), constituting the category of adult onset form of motor neuron disease, were analyzed on motor nerve roots. The results of morphometric analysis on ventral spinal roots (VSR) of all spinal segments from ALS and S...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691322
更新日期：1981-01-01 00:00:00
abstract：:The IgM fraction of normal swine serum (NSS) was found to adhere to human peripheral nerve myelin sheaths from randomly selected neuropathies and control nerves in electron microscopic immunocytochemical assays. The reaction could be blocked by preincubation with undiluted fetal calf serum (FCS), whereas endoneurial b...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688249
更新日期：1988-01-01 00:00:00
abstract：:This study tests the effects of chronic electrostimulation on denervated/reinnervated skeletal muscle in producing an optimal restoration of size and mechanical and histochemical properties. We compared tibialis anterior muscles in four groups of rats: in unoperated control (C) and 10 weeks following nerve lesion with...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0035-2
更新日期：2006-06-01 00:00:00
abstract：:Immunofluorescence and immunogold labelling were used to localise the 43-kDa dystrophin-associated glycoprotein (43DAG) of the dystrophin-glycoprotein complex in control and Duchenne muscular dystrophy (DMD) biopsies. In control muscle 43DAG was localised by immunofluorescence to the periphery of the fibre and, by imm...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00313603
更新日期：1994-01-01 00:00:00
abstract：:We describe features of a patient that broadens the clinical and pathological spectrum of neurofilament inclusion disease (NFID). The patient was a 52-year-old man with a 5--6 year history of progressive, asymmetrical spastic weakness of the upper and lower extremities; L-DOPA-unresponsive parkinsonism; and SPECT evid...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0974-4
更新日期：2005-04-01 00:00:00
abstract：:A limited cortical resection including the rolandic fissure and the pre- and postcentral cortical regions was carried out in a patient suffering from epilepsia partialis continua resistant to antiepileptic drugs. The histological examination revealed several foci of very large neurons distributed with no laminar organ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00299415
更新日期：1992-01-01 00:00:00
abstract：:Conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer's disease (LOAD). Mutations and/or differential expression of microglial specific receptors such as TREM2, CD33, and CR3 have been associated wi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1737-3
更新日期：2017-11-01 00:00:00
abstract：:Aim of the present study was to establish different immunohistochemical staining patterns for a subsequent comparison with those of primitive neuroectodermal (PNET) subsets, i.e. PNET-NOS (not otherwise specified) or PNET with focal neuronal, astrocytic or ependymal differentiation, to relate neoplastic to embryonal d...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00293385
更新日期：1991-01-01 00:00:00
abstract：:Neurons of Area 11 in the fronto-orbital cortex of 18 unselected AIDS brains are analyzed by means of stereology. Neurological abnormalities including dementing symptoms were described in eight patients. Neuropathology diagnosed human immunodeficiency virus (HIV)-specific changes in four, and diffuse poliodystrophy in...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294228
更新日期：1990-01-01 00:00:00
abstract：:Pleomorphic xanthoastrocytoma (PXA), a tumor most often presenting superficially over the cerebral hemisphere of young subjects, has certain morphological similarities to fibrous histiocytoma (or fibrous xanthoma) of the meninges and brain, namely the occurrence of lipid-laden neoplastic cells and, frequently, a dense...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691285
更新日期：1989-01-01 00:00:00
abstract：:Changes in morphology, behavior of the blood-brain barrier (BBB), regional cerebral blood flow (rCBF), and local cerebral glucose utilization (LCGU) were assessed and correlated in Mongolian gerbils following 5 min cerebral ischemia, produced by bilateral clamping of the common carotid arteries. The morphological chan...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691868
更新日期：1983-01-01 00:00:00
abstract：:VM mice were inoculated by intracerebral and intraperitoneal routes with brain homogenates containing the 87V strain of scrapie. The distribution and numbers of plaques were found for the parietal cortex, cingulate cortex, corpus callosum and hippocampus/dentate in coronal sections cut at the level of the thalamus and...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688311
更新日期：1986-01-01 00:00:00
abstract：:Involvement of the choroid plexus by lymphoma (Hodgkin) is a hitherto undescribed complication. We report herein the case of a 49-year-old man who developed, shortly before death, neurologic symptoms seemingly related to extensive involvement of choroid plexus and surrounding ventricular structures by lymphoma (Hodgki...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00692063
更新日期：1977-02-28 00:00:00
abstract：:Neuropeptides have turned out to be promising new parameters, in addition to the routinely performed histochemical diagnosis, of Hirschsprung's disease (HD). Studies of the peptidergic innervation of the affected intestinal segment of patients with HD have demonstrated a marked reduction in the density of several neur...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0613-x
更新日期：2003-01-01 00:00:00
abstract：:The diagnosis of infantile neuro-axonal dystrophy (INAD) in a 5-year-old patient was confirmed by the ultrastructural study of neuromuscular, skin and conjunctival biopsy specimens. Abnormal networks of smooth membranous, lamellar and tubular profiles were found in presynaptic terminals and in conjunctival and dermal ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00702677
更新日期：1979-03-15 00:00:00
abstract：:Knockout of genes encoding metabotropic glutamate receptor 5 (mGluR5) or its endogenous regulators, such as Norbin, induce a schizophrenia-like phenotype in rodents, suggesting dysregulation of mGluR5 in schizophrenia. Human genetic and pharmacological animal studies support this hypothesis, but no studies have explor...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-015-1411-6
更新日期：2015-07-01 00:00:00
abstract：:Mutations in the gene coding for Sequestosome 1 (SQSTM1) have been genetically associated with amyotrophic lateral sclerosis (ALS) and Paget disease of bone. In the present study, we analyzed the SQSTM1 coding sequence for mutations in an extended cohort of 1,808 patients with frontotemporal lobar degeneration (FTLD),...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-014-1298-7
更新日期：2014-09-01 00:00:00
abstract：:A unique pathological finding of astrocytes was observed in the brain of a 20-year-old man who had severe physical and mental retardation. The brain was malformed showing micropolygyria in several cortical areas. A large number of hypertrophic astrocytes with eosinophilic granular substances in their cytoplasm were fo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00427225
更新日期：1992-01-01 00:00:00
abstract：:There is evidence that physical activity is associated with decreased brain injury resulting from transient middle cerebral artery (MCA) occlusion. We investigated whether exercise could reduce stroke-induced brain inflammatory injury and its associated mediators. Sprague Dawley rats (3 months old) were subjected to 3...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0943-y
更新日期：2005-03-01 00:00:00
abstract：:Modern neuropathology serves a key function in the multidisciplinary management of brain tumor patients. Owing to the recent advancements in molecular neurooncology, the neuropathological assessment of brain tumors is no longer restricted to provide information on a tumor's histological type and malignancy grade, but ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-010-0736-4
更新日期：2010-11-01 00:00:00
abstract：:This study was undertaken to elucidate morphological changes in the synaptic area of the Purkinje cell dendritic spines when granule cells were decreased in number. The mice were injected s.c. with 30 mg/kg b.w. of cytosine arabinoside on days 2, 3, and 4, and on days 7, 8 and 9, and were designated as group I and gro...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685343
更新日期：1983-01-01 00:00:00
abstract：:The mechanism of inflammatory demyelination in canine distemper encephalitis (CDE) is uncertain but macrophages are thought to play an important effector role in this lesion. Serum and cerebrospinal fluid (CSF), containing anti-canine distemper virus and anti-myelin antibodies from dogs with CDE were tested for their ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688176
更新日期：1989-01-01 00:00:00
abstract：:A morphometric study of the basal nucleus of Meynert (bnM) has been performed in a 70-year-old man with a 4-year history of pathologically confirmed progressive supranuclear palsy (PSP). An important neuronal loss (52%) was demonstrated in the bnM. This finding has not been previously documented with morphometric meth...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00697397
更新日期：1983-01-01 00:00:00
abstract：:The incidence of CNS lymphoma has increased significantly in the past 30 years, primarily in the elderly and immunocompromised. While T-cell lymphomas comprise 15-20% of systemic lymphomas, they comprise less than 4% of primary CNS lymphomas, suggesting that they may be under-recognized compared to their systemic coun...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0338-y
更新日期：2008-03-01 00:00:00
abstract：:The activities of three enzymes of the hexose monophosphate pathway (HMP) were measured in frozen samples of rat cerebral cortex and ethylnitrosourea-induced tumors of the rat nervous system. Results show that in most tumors, adequate amounts of glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogena...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690440
更新日期：1978-03-15 00:00:00
