Abstract：
:Neurons of Area 11 in the fronto-orbital cortex of 18 unselected AIDS brains are analyzed by means of stereology. Neurological abnormalities including dementing symptoms were described in eight patients. Neuropathology diagnosed human immunodeficiency virus (HIV)-specific changes in four, and diffuse poliodystrophy in eight brains. The majority (71.4%) of these brains was immunoreactive for HIV antigens when tested by immunocytochemistry. A significant loss of neurons is found as compared to normal controls. Neuronal density in AIDS brains is reduced by 18%, and the perikaryon volume fractions is reduced by 31%. Although only speculation on pathogenesis of this neuronal loss is possible at present, it may represent a part of the pathomorphological substrate of AIDS-related dementia. Moreover, it confirms by quantitative means damage to the cerebral cortex in AIDS which has been described only qualitatively as diffuse poliodystrophy.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Ketzler S,Weis S,Haug H,Budka Hdoi
10.1007/BF00294228subject
Has Abstractpub_date
1990-01-01 00:00:00pages
92-4issue
1eissn
0001-6322issn
1432-0533journal_volume
80pub_type
杂志文章abstract：:Evidence of misfolded wild-type superoxide dismutase 1 (SOD1) has been detected in spinal cords of sporadic ALS (sALS) patients, suggesting an etiological relationship to SOD1-associated familial ALS (fALS). Given that there are currently a number of promising therapies under development that target SOD1, it is of cri...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-016-1623-4
更新日期：2016-12-01 00:00:00
abstract：:Progressive myopathy developed in two women who consumed ipecac syrup containing emetine hydrochloride to induce vomiting as part of their anorexia nervosa. Muscle biopsy specimens were characterized by severe disruption of the sarcomeres. The ultrastructural spectrum extended from "Z-band streaming" to the formation ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686202
更新日期：1988-01-01 00:00:00
abstract：:Gerstmann-Sträussler-Scheinker disease (GSS) is a hereditary transmissible spongiform encephalopathy associated with prion protein gene mutation P102L. The age of onset is roughly restricted to around the sixth decade; however, it is unclear whether the disease-specific pathology of GSS is already evident in the pre-c...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0697-y
更新日期：2003-07-01 00:00:00
abstract：:VM mice were inoculated by intracerebral and intraperitoneal routes with brain homogenates containing the 87V strain of scrapie. The distribution and numbers of plaques were found for the parietal cortex, cingulate cortex, corpus callosum and hippocampus/dentate in coronal sections cut at the level of the thalamus and...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688311
更新日期：1986-01-01 00:00:00
abstract：:A 17 year-old male, who was mentally and bodily retarded from the age of 7 years. At the age of 16 years, several neurological signs appeared. Pathologically, there was widespread myelin loss and tissue sponginess in the white matter of the cerebrum and cerebellum, bilaterally and symmetrically. A great many Alzheimer...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Six medulloblastomas were studied by electron microscopy. Two features were found which seem to be constant and essential characteristics of medulloblastoma. First, cell junctions are abundant between tumor cells. These are mostly desmosome-like but other, closer junctions, were also seen. Second, the capillary endoth...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685966
更新日期：1975-10-27 00:00:00
abstract：:Human adenovirus type 12 (Ad 12) was inoculated intraperitoneally, intrapleurally, intramuscularly or subcutaneously into newborn rodents. Tumors developed preferentially in the peritoneal cavities in 93.9% of the hamsters and 82.6% of the mice, but none in rats; in contrast to the high incidence of brain tumors in ra...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687575
更新日期：1989-01-01 00:00:00
abstract：:Immunohistochemical analysis of inflammatory cell density and infiltrate subpopulations in 42 meningiomas was performed. Evaluation of infiltrating cell density was carried out by cell counting. Meningothelial and fibroblastic meningiomas contained an average of 3% mononuclear cells; the few lymphocytes were localized...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294381
更新日期：1989-01-01 00:00:00
abstract：:Gliomas induced in the rat by transplacental administration of ethylnitrosourea (ENU) are intensely immunoreactive for vimentin and scarcely for glial fibrillary acidic protein (GFAP). Since tumoral transformation takes place during the late fetal and early postnatal period, the sequential expression of the two glial ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00227665
更新日期：1992-01-01 00:00:00
abstract：:Wistar rats were given intravenous (i.v.) horseradish peroxidase (HRP) in saline in doses commonly used to study vascular permeability and the blood-brain barrier. Samples of blood were taken from conscious animals via indwelling catheters at intervals up to 6 h after the HRP injection. Plasma concentrations of adreno...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687945
更新日期：1986-01-01 00:00:00
abstract：:Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) can typically be categorized into one of four distinct histopathologic patterns of TDP-43 pathology, types A to D. The strength of this histopathologic classification lies in the association between FTLD-TDP subtypes and various clinical and genetic f...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1679-9
更新日期：2017-07-01 00:00:00
abstract：:A 79-year-old woman had a 10-year history of dementia, initially presenting as non-fluent aphasia. Magnetic resonance imaging showed frontal atrophy (left greater than right) and hyperintense foci within white matter. Neuropathologically, there was severe frontal atrophy due to cortical neuronal loss with spongy chang...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0719-9
更新日期：2003-08-01 00:00:00
abstract：:A histochemical study is reported of regional differences of the lipid storage in a case of Niemann-Pick disease (NPD) type C. Besides tissues known to be affected (reticulo-endothelium, hepatocytes, nervous system), storage was demonstrated in adrenal cortical spongiocytes, sweat glands, renal glomerular and tubular ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688393
更新日期：1975-12-19 00:00:00
abstract：:In comparison to the levels in age and gender-matched controls, reduced levels of pathological amyloid-β protein in cerebrospinal fluid routinely precede the onset of Alzheimer's disease-related symptoms by several years, whereas elevated soluble abnormal tau fractions (phosphorylated tau, total tau protein) in cerebr...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-013-1139-0
更新日期：2013-11-01 00:00:00
abstract：:Old age is associated with a deficient recovery from stroke, but the cellular mechanisms underlying such phenomena are poorly understood. To address this issue, focal cerebral ischemia was produced by reversible occlusion of the right middle cerebral artery in 3- and 20-month-old male Sprague-Dawley rats. Aged rats sh...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0164-7
更新日期：2007-03-01 00:00:00
abstract：:A patient with mixed gonadal dysgenesis showed glove and stocking-type sensory impairment and slowing of motor and sensory nerve conduction. Sural nerve biopsy revealed minifascicular formation with decreased density of myelinated fibers. As far as we are aware, this is the first report of polyneuropathy with minifasc...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051085
更新日期：1999-09-01 00:00:00
abstract：:Although clinical and electrophysiological evidence indicates that the amygdaloid body plays an important role in the pathogenesis of temporal lobe epilepsy, there are very few detailed data on histopathological changes in this nucleus in epilepsy patients. In the present study we have examined the lateral nucleus of ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050658
更新日期：1997-06-01 00:00:00
abstract：:Transient forebrain ischemia produces a spatially and temporally selective pattern of neuronal degeneration in the hippocampal formation of the Mongolian gerbil. Ischemic neuronal death has been suggested to depend on the activation of excitatory hippocampal pathways that project to the vulnerable neurons. This idea w...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687758
更新日期：1989-01-01 00:00:00
abstract：:In the present study we assessed the neuroprotective effects of the pan-caspase inhibitor z-VAD.fmk [N-benzyloxycarbony-valine-alanine-aspartate-(OMe)-fluoromethylketone], and the caspase-3 inhibitor Ac-DEVD.CHO (acetyl-aspartate-chloromethylketone) in the double-lesion rat model of striatonigral degeneration (SND), t...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0931-2
更新日期：2005-02-01 00:00:00
abstract：:We examined the immunohistochemical localization of p35nck5a, the regulatory subunit of cyclin-dependent kinase 5 (cdk5), in brains obtained postmortem from patients with Parkinson's disease (PD) and controls. We found p35nck5a immunoreactivity in Lewy bodies (LB) in the substantia nigra, locus ceruleus, and neocortex...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050687
更新日期：1997-08-01 00:00:00
abstract：:Fifteen cases of mitochondrial myopathy, three cases of hereditary motor and sensory neuropathy (HMSN) VI, and 280 cases of neuropathies of different etiologies were examined by electron microscopy for the presence of mitochondrial abnormalities in the sural nerve. Altered mitochondrial were found in most cases of mit...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/BF00293381
更新日期：1991-01-01 00:00:00
abstract：:Activating beta-catenin mutations with aberrant cytoplasmic and nuclear protein accumulation are hallmarks of adamantinomatous craniopharyngiomas (adaCP). These tumours tend to be associated with unfavourable and occasionally disastrous sequelae, as they invade adjacent brain structures such as the hypothalamus. The p...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-010-0642-9
更新日期：2010-05-01 00:00:00
abstract：:Long-term epidemiological studies indicate that environmental factors play a causative role in high-incidence amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) in the western Pacific. An increased risk for disease is acquired in youth and remains for life. The low concentrations of calcium and magnesi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688211
更新日期：1989-01-01 00:00:00
abstract：:DICER1 syndrome is a rare tumor predisposition syndrome with manifestations that predominantly affect children and young adults. The syndrome is typically caused by heterozygous germline loss-of-function DICER1 alterations accompanied on the other allele by somatic missense mutations occurring at one of a few mutation...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-019-01997-y
更新日期：2020-04-01 00:00:00
abstract：:We report the case of an elderly woman with a history of headache, vomiting and dizziness while walking. On CT scans a mass was identified in the right cerebellar hemisphere exhibiting radiological characteristics of lipomatous tissue. Surgery revealed a compact lesion consisting of whitish-yellow tissue with a fatty ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00389504
更新日期：1994-01-01 00:00:00
abstract：:This report presents the ultrastructural nerve study of a patient with sensorimotor neuropathy by a shoe glue containing an association of n-hexane and methylethylketone. Giant axons, distended by microfilamentous proliferation typical of such cases of neuropathy, were found in significant amounts. An unusual histolog...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690990
更新日期：1981-01-01 00:00:00
abstract：:The original version of this article unfortunately contained a typesetting error in Fig 3c. The corrected Fig. 3 is given in the following page. ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00401-019-02115-8
更新日期：2020-02-01 00:00:00
abstract：:Histochemical and electron microscopic studies of the brains inclusive of the leptomeninges containing large blood vessels from 7 patients with mucopolysaccharidosis (MPS) I, II, IIIA and V showed marked increase in mesenchymal elements and the generalized presence of characteristic lesions around cerebral veins and a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690379
更新日期：1977-07-15 00:00:00
abstract：:A newly developed in vitro labeling method with bromodeoxyuridine (BrdU) identifies S phase cells in situ in freshly obtained surgical tissue of human brain tumors which is subsequently fixed and embedded in paraffin for BrdU immunovisualization. For the first time, the BrdU labeling index (LI) is successfully compare...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687579
更新日期：1989-01-01 00:00:00
abstract：:Isocitrate dehydrogenase 1 (IDH1) mutations are frequent in astrocytomas, oligoastrocytomas and oligodendrogliomas. We previously reported the generation of a mutation-specific antibody that specifically detects R132H mutated IDH1 protein (clone H09). Here, we investigate the feasibility of H09 immunohistochemistry to...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-010-0770-2
更新日期：2011-02-01 00:00:00
