Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy).

abstract：:In Alzheimer's disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. Clinical progression is tightly linked to the progressive spread of Tau pathology throughout the brain, and several lines of evidence ...

journal_title：Acta neuropathologica

authors： Courade JP,Angers R,Mairet-Coello G,Pacico N,Tyson K,Lightwood D,Munro R,McMillan D,Griffin R,Baker T,Starkie D,Nan R,Westwood M,Mushikiwabo ML,Jung S,Odede G,Sweeney B,Popplewell A,Burgess G,Downey P,Citron M

更新日期：2018-11-01 00:00:00

abstract：:Granulovacuolar degeneration (GVD) is a common feature in Alzheimer's disease (AD). The occurrence of GVD is closely associated with that of neurofibrillary tangles (NFTs) and GVD is even considered to be a pre-NFT stage in the disease process of AD. Currently, the composition of GVD bodies, the mechanisms associated ...

journal_title：Acta neuropathologica

authors： Hondius DC,Koopmans F,Leistner C,Pita-Illobre D,Peferoen-Baert RM,Marbus F,Paliukhovich I,Li KW,Rozemuller AJM,Hoozemans JJM,Smit AB

更新日期：2021-01-25 00:00:00

abstract：:A simple and reproducible method for cryopreservation of brain tissue from patients with Alzheimer's disease is described. Fresh brain slices (1 cm thick) obtained less than 6 h postmortem are placed in sealed plastic bags, sandwiched between 0.3-cm-thick aluminium sheets, and frozen by placing the entire "sandwich" b...

journal_title：Acta neuropathologica

authors： Nochlin D,Mackenzie AP,Bryant EM,Norwood TH,Sumi SM

更新日期：1993-01-01 00:00:00

abstract：:Glioblastoma (GBM), the most common malignant brain tumor, is among the most lethal neoplasms, with a median survival of approximately 1 year. Prognosis is poor since GBMs possess a strong migratory and highly invasive potential, making complete surgical resection impossible. Reduced expression of carboxypeptidase E (...

journal_title：Acta neuropathologica

authors： Höring E,Harter PN,Seznec J,Schittenhelm J,Bühring HJ,Bhattacharyya S,von Hattingen E,Zachskorn C,Mittelbronn M,Naumann U

更新日期：2012-07-01 00:00:00

abstract：:Mineralization in the wall of central nervous system blood vessels is sporadically encountered in aged horses and cattle as in man, generally as an age-related change. This phenomenon has not to date been located in the meninges in dogs or cats. The present study reports a retrospective histological examination of 50 ...

journal_title：Acta neuropathologica

authors： Mandara MT

更新日期：2003-03-01 00:00:00

abstract：:In comparison to the levels in age and gender-matched controls, reduced levels of pathological amyloid-β protein in cerebrospinal fluid routinely precede the onset of Alzheimer's disease-related symptoms by several years, whereas elevated soluble abnormal tau fractions (phosphorylated tau, total tau protein) in cerebr...

journal_title：Acta neuropathologica

authors： Braak H,Zetterberg H,Del Tredici K,Blennow K

更新日期：2013-11-01 00:00:00

abstract：:Four of seven patients with nemaline myopathy had severe, rapidly progressing symptoms. These four showed an increase in acid phosphatase activity in muscle fibers demonstrated by histochemistry and cathepsin B&L activity by biochemical measurement. On electron microscopy, nemaline bodies, occasionally disorganized my...

journal_title：Acta neuropathologica

authors： Nonaka I,Ishiura S,Arahata K,Ishibashi-Ueda H,Maruyama T,Ii K

更新日期：1989-01-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed the question of whether or not sequential distribution patterns can be recognized for PS...

journal_title：Acta neuropathologica

authors： Kovacs GG,Lukic MJ,Irwin DJ,Arzberger T,Respondek G,Lee EB,Coughlin D,Giese A,Grossman M,Kurz C,McMillan CT,Gelpi E,Compta Y,van Swieten JC,Laat LD,Troakes C,Al-Sarraj S,Robinson JL,Roeber S,Xie SX,Lee VM,Trojan

更新日期：2020-08-01 00:00:00

abstract：:Entorhinal cortex displays a distinctive organization in layer II and forms small elevations on its surface called entorhinal verrucae. In Alzheimer's disease, the verrucae disappear due to neurofibrillary tangle formation and neuronal death. Isosurface models were reconstructed from high-resolution ex vivo MRI volume...

journal_title：Acta neuropathologica

authors： Augustinack JC,Huber KE,Postelnicu GM,Kakunoori S,Wang R,van der Kouwe AJ,Wald LL,Stein TD,Frosch MP,Fischl B

更新日期：2012-01-01 00:00:00

abstract：:In the nerve tissue with proliferating macroglia cells were observed a lowered oxygen consumption, an increased aerobic glycolysis and alanine formation and a higher alanine aminotransferase and glutamate dehydrogenase activity than in the control tissue in the homogenates and in the cell sap fraction. The substrate s...

journal_title：Acta neuropathologica

authors： Ruscák M,Hager H,Orlický J

更新日期：1976-03-15 00:00:00

abstract：:In this study we evaluated the relationship between polyglucosan bodies and peripheral nerve lesions. The biopsied sural nerve from a patient with late-onset chronic sensori-motor neuropathy showed many intra-axonal polyglucosan bodies and segmental demyelination/remyelination. The formation of Schwann cell hyperplasi...

journal_title：Acta neuropathologica

authors： Matsumuro K,Izumo S,Minauchi Y,Inose M,Higuchi I,Osame M

更新日期：1993-01-01 00:00:00

abstract：:A large series of central and peripheral nervous system tumors was studied for the presence of glial fibrillary acidic protein (GFAP) and gamma-enolase (neuron-specific enolase, NSE), using specific monoclonal antibodies (mAbs). Occurrence in and specificity of GFAP to glial and mixed tumors was confirmed and depended...

journal_title：Acta neuropathologica

authors： Cras P,Martin JJ,Gheuens J

更新日期：1988-01-01 00:00:00

abstract：:Three cases of spinal tanycytic ependymoma are reported, a man aged 45 years and two women aged 36 and 55 years. Each patient developed gradual paraparesis over a few months prior to admission. Magnetic resonance imaging showed an enhancing, well-circumscribed tumor in the spinal cord in each case. Histologically, the...

journal_title：Acta neuropathologica

authors： Kawano N,Yagishita S,Oka H,Utsuki S,Kobayashi I,Suzuki S,Tachibana S,Fujii K

更新日期：2001-01-01 00:00:00

abstract：:Activation of the MAPK signaling pathway has been shown to be a unifying molecular feature in pilocytic astrocytoma (PA). Genetically, tandem duplications at chromosome 7q34 resulting in KIAA1549-BRAF fusion genes constitute the most common mechanism identified to date. To elucidate alternative mechanisms of aberrant ...

journal_title：Acta neuropathologica

authors： Cin H,Meyer C,Herr R,Janzarik WG,Lambert S,Jones DT,Jacob K,Benner A,Witt H,Remke M,Bender S,Falkenstein F,Van Anh TN,Olbrich H,von Deimling A,Pekrun A,Kulozik AE,Gnekow A,Scheurlen W,Witt O,Omran H,Jabado N,C

更新日期：2011-06-01 00:00:00

abstract：:Keratan sulphate proteoglycan (KSPG) is a developmentally regulated barrier molecule, directing axonal growth during central nervous system (CNS) formation. The possible re-expression and functional significance of KSPG in preventing axon regeneration following spinal cord injury (SCI) is poorly understood. In the pre...

journal_title：Acta neuropathologica

authors： Krautstrunk M,Scholtes F,Martin D,Schoenen J,Schmitt AB,Plate D,Nacimiento W,Noth J,Brook GA

更新日期：2002-12-01 00:00:00

abstract：:A case of 14-year-old girl is reported in whom an alveolar rhabdomyosarcoma occurred in the soft tissues of the left forearm 4 years prior to death. Despite extensive surgery as well as chemotherapy and radiotherapy the tumor recurred locally and produced extensive metastases including a metastasis to the brain. Cereb...

journal_title：Acta neuropathologica

authors： Kleinert R,Beham A,Rosanelli G

更新日期：1985-01-01 00:00:00

abstract：:In our recent ultrastructural studies on synapses of the nucleus dorsalis, central cervical nucleus, and anterior horn of the spinal cord of the normal cat we happened to find spheroids and several types of axonal alterations. These spheroids were up to 39 micrometer in diameter. They were found in myelinated and unmy...

journal_title：Acta neuropathologica

authors： Saito K

更新日期：1980-01-01 00:00:00

abstract：:Impaired axonal transport of the fast or slow component has been reported in patients with sporadic amyotrophic lateral sclerosis (ALS), animal models for ALS, and familial ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) transgenic mice. However, little is known about the impairment of axonal transport in mutant S...

journal_title：Acta neuropathologica

authors： Sasaki S,Warita H,Abe K,Iwata M

更新日期：2005-07-01 00:00:00

abstract：:The incidence of CNS lymphoma has increased significantly in the past 30 years, primarily in the elderly and immunocompromised. While T-cell lymphomas comprise 15-20% of systemic lymphomas, they comprise less than 4% of primary CNS lymphomas, suggesting that they may be under-recognized compared to their systemic coun...

journal_title：Acta neuropathologica

authors： Dulai MS,Park CY,Howell WD,Smyth LT,Desai M,Carter DM,Vogel H

更新日期：2008-03-01 00:00:00

abstract：:Glucosylceramide lipidosis results from a defective lysosomal degradation of this glycolipid. Lipid degradation is controlled by two components, the enzyme beta-glucocerebrosidase and a sphingolipid activator protein. While most Gaucher cases are due to mutations within the gene that codes for the lysosomal enzyme, on...

journal_title：Acta neuropathologica

authors： Pàmpols T,Pineda M,Girós ML,Ferrer I,Cusi V,Chabás A,Sanmarti FX,Vanier MT,Christomanou H

更新日期：1999-01-01 00:00:00

abstract：:Human recombinant tumor necrosis factor-alpha (rTNF-alpha) was administered to normal Fischer 344 rats by stereotaxic intracerebral (IC) injection. Animals received a single injection of either 6 x 10(4) U rTNF-alpha or excipient in their right parietal lobe. Others received three consecutive daily injections of eithe...

journal_title：Acta neuropathologica

authors： Wright JL,Merchant RE

更新日期：1992-01-01 00:00:00

abstract：:Frontotemporal lobar degeneration is the term used to describe the non-Alzheimer clinical syndromes of frontotemporal dementia, semantic dementia and progressive non-fluent aphasia, regardless of the underlying neuropathological features. Considerable progress has been made in recent years in our understanding of the ...

journal_title：Acta neuropathologica

authors： Pickering-Brown SM

更新日期：2007-07-01 00:00:00

abstract：:A retrospective study of 450 consecutive AIDS autopsy cases (397 males, 53 females; mean age at death 38.4 years) in Vienna, Austria, between 1984 and 1999 compares the central nervous system (CNS) findings in three cohorts: 1984-1992 (190 cases), 1993-1995 (162 cases) and 1996-1999 (98 cases, after introduction of tr...

journal_title：Acta neuropathologica

authors： Jellinger KA,Setinek U,Drlicek M,Böhm G,Steurer A,Lintner F

更新日期：2000-08-01 00:00:00

abstract：:The nature and distribution of vascular changes in acute Wernicke's encephalopathy (WE) were analyzed in three autopsy cases. Lesions of the lateral vestibular nucleus of the medulla oblongata (three cases) and lateral ventricular wall (one case) were examined by reconstruction of 200 serial sections, and the capillar...

journal_title：Acta neuropathologica

authors： Okeda R,Taki K,Ikari R,Funata N

更新日期：1995-01-01 00:00:00

abstract：:In search of novel genes associated with glioma pathogenesis, we have previously shown frequent deletions of the KIAA1797/FOCAD gene in malignant gliomas, and a tumor suppressor function of the encoded focadhesin impacting proliferation and migration of glioma cells in vitro and in vivo. Here, we examined an associati...

journal_title：Acta neuropathologica

authors： Brand F,Förster A,Christians A,Bucher M,Thomé CM,Raab MS,Westphal M,Pietsch T,von Deimling A,Reifenberger G,Claus P,Hentschel B,Weller M,Weber RG

更新日期：2020-01-01 00:00:00

abstract：:The neuropathologic findings in the brain of a National Aeronautics and Space Administration (NASA) engineer, who died subsequent to nitrogen inhalation, are reported. Findings which are unusual in other forms of anoxia included relative preservation of neurons in the Sommer sector of the hippocampus and a pattern of ...

journal_title：Acta neuropathologica

authors： Hunter S,Ballinger WE Jr,Greer M

更新日期：1985-01-01 00:00:00

abstract：:Pilocytic astrocytomas (PAs) are the most common brain tumors in pediatric patients and can cause significant morbidity, including chronic neurological deficiencies. They are characterized by activating alterations in the mitogen-activated protein kinase pathway, but little else is known about their development. To ma...

journal_title：Acta neuropathologica

authors： Lambert SR,Witt H,Hovestadt V,Zucknick M,Kool M,Pearson DM,Korshunov A,Ryzhova M,Ichimura K,Jabado N,Fontebasso AM,Lichter P,Pfister SM,Collins VP,Jones DT

更新日期：2013-08-01 00:00:00

abstract：:A histopathological study was carried out on the brains of eight ex-boxers (ages 56 to 83) using conventional histological staining methods and immunocytochemistry with antibodies to amyloid beta-protein and the PHF-related tau protein. All cases showed a large number of tau-immunoreactive neurofibrillary tangles and ...

journal_title：Acta neuropathologica

authors： Tokuda T,Ikeda S,Yanagisawa N,Ihara Y,Glenner GG

更新日期：1991-01-01 00:00:00

abstract：:The brain of a 69-year-old man exhibited extensive granulomatous inflammation in the walls of arteries in the leptomeninges, associated with amyloid deposition in the media of the involved arteries. The extracranial arteries exhibited neither granulomatous inflammation nor amyloid deposition in their walls. ...

journal_title：Acta neuropathologica

authors： Shintaku M,Osawa K,Toki J,Maeda R,Nishiyama T

更新日期：1986-01-01 00:00:00

abstract：:Lysolecithin has been used in many studies to induce demyelination in peripheral nerves. In the present investigation lysolecithin (lysophosphatidyl choline) was injected into rat sciatic nerves at a dose of 2-3 microns of a 10 mg/ml solution in order to study the effects of this lipid on cellular elements other than ...

journal_title：Acta neuropathologica

authors： Mitchell J,Caren CA

更新日期：1982-01-01 00:00:00