Degeneration of non-myelinated axons in the rat sciatic nerve following lysolecithin injection.

abstract：:Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here, we report on DNA methylation-based central nervous system (CNS) tumor diagnostics conducted in our institution between the years 2015 and 2018....

journal_title：Acta neuropathologica

authors： Capper D,Stichel D,Sahm F,Jones DTW,Schrimpf D,Sill M,Schmid S,Hovestadt V,Reuss DE,Koelsche C,Reinhardt A,Wefers AK,Huang K,Sievers P,Ebrahimi A,Schöler A,Teichmann D,Koch A,Hänggi D,Unterberg A,Platten M,Wick

更新日期：2018-08-01 00:00:00

abstract：:Round granulated body (RGB) and eosinophilic hyaline droplets (EHDs) have been described as cytoplasmic inclusions of certain astrocytic tumors. In the previous literature, however, these inclusions have been described using various terms or regarded as nosologically the same entity. Light microscopically, RGB appeare...

journal_title：Acta neuropathologica

authors： Hitotsumatsu T,Iwaki T,Fukui M,Tateishi J

更新日期：1994-01-01 00:00:00

abstract：:Muscle biopsy samples from five patients with cytoplasmic body myopathy (CBM) were investigated by immunohistochemical (antibodies to desmin, actin, dystrophin, spectrin, alpha actinin and utrophin), immunoelectron microscopic (antibodies to desmin, actin and dystrophin) and biochemical (desmin, dystrophin, actin and ...

journal_title：Acta neuropathologica

authors： Caron A,Viader F,Lechevalier B,Chapon F

更新日期：1995-01-01 00:00:00

abstract：:Three cases of spinal tanycytic ependymoma are reported, a man aged 45 years and two women aged 36 and 55 years. Each patient developed gradual paraparesis over a few months prior to admission. Magnetic resonance imaging showed an enhancing, well-circumscribed tumor in the spinal cord in each case. Histologically, the...

journal_title：Acta neuropathologica

authors： Kawano N,Yagishita S,Oka H,Utsuki S,Kobayashi I,Suzuki S,Tachibana S,Fujii K

更新日期：2001-01-01 00:00:00

abstract：:The effect of the cytokine, colony stimulating factor-1 (CSF-1), on neuronal survival in cerebral cortex ischemic lesion was determined. Ischemic lesions were made in C3H/HeJ mice by disrupting blood vessels that penetrate the cerebral cortex from the pial-vascular plexus. Recombinant human colony stimulating factor 1...

journal_title：Acta neuropathologica

authors： Berezovskaya O,Maysinger D,Fedoroff S

更新日期：1996-11-01 00:00:00

abstract：:We describe the clinical and neuropathological findings of three unrelated autopsy cases of MELAS harboring the A3243G transition in the mitochondrial DNA (mtDNA). Using immunohistochemical techniques, we studied the expression of several subunits of the respiratory chain in various brain regions from the same cases. ...

journal_title：Acta neuropathologica

authors： Sparaco M,Simonati A,Cavallaro T,Bartolomei L,Grauso M,Piscioli F,Morelli L,Rizzuto N

更新日期：2003-09-01 00:00:00

abstract：:In this study, we used immunohistochemistry to screen for alpha-synuclein pathology in the brains of 241 individuals without clinical evidence of neurologic disease, and discovered 36 cases (15%) with incidental Lewy bodies (LBs) and one case, a 96-year-old woman (0.4%), with inclusions similar to those seen in multip...

journal_title：Acta neuropathologica

authors： Fujishiro H,Ahn TB,Frigerio R,DelleDonne A,Josephs KA,Parisi JE,Eric Ahlskog J,Dickson DW

更新日期：2008-09-01 00:00:00

abstract：:Oral administration of N-[4-(3-ethoxy-2-hydropropoxy)phenyl] acrylamide (EHA) induced selective granule cell destruction in the granular layer of the cerebellar cortex together with neurological signs, such as delayed righting reflex, gait or truncal ataxia, and convulsion. Neuropathologically, it caused multifocal gr...

journal_title：Acta neuropathologica

authors： Tanaka G,Okeda R

更新日期：2000-04-01 00:00:00

abstract：:Neuronal and glial cytoplasmic inclusions (NCIs and GCIs), which contain alpha-synuclein as a major component, are characteristic cytopathological features of multiple system atrophy (MSA). We report MSA of 19 years' duration in a 73-year-old woman. Her initial symptom was parkinsonism, with dementia appearing about 8...

journal_title：Acta neuropathologica

authors： Piao YS,Hayashi S,Hasegawa M,Wakabayashi K,Yamada M,Yoshimoto M,Ishikawa A,Iwatsubo T,Takahashi H

更新日期：2001-03-01 00:00:00

abstract：:Peroxidase-labeled lectins were used for detection of specific monosaccharide residues in amyloid plaques in brains of scrapie-infected mice. The lectins tested recognize the following residues: beta-D-galactosyl (Ricinus communis agglutinin 120, RCA-1), alpha-D-galactosyl and alpha-D-galactopyranoside (Bandeirea simp...

journal_title：Acta neuropathologica

authors： Szumanska G,Vorbrodt AW,Wisniewski HM

更新日期：1986-01-01 00:00:00

abstract：:The brain tissue obtained from ninety-five cognitively unimpaired subjects, with ages ranging from 22 to 50 years upon death, were immunohistochemically assessed for neurodegenerative changes, i.e., hyperphosphorylated tau (HPτ) and β-amyloid (Aβ) pathology in predilection neuroanatomical areas. HPτ pathology was obse...

journal_title：Acta neuropathologica

authors： Elobeid A,Soininen H,Alafuzoff I

更新日期：2012-01-01 00:00:00

abstract：:Oxidative stress has been implicated in the pathogenesis of a number of diseases including Alzheimer's disease (AD). The oxidative stress hypothesis of AD pathogenesis, in part, is based on beta-amyloid peptide (Abeta)-induced oxidative stress in both in vitro and in vivo studies. Oxidative modification of the protein...

journal_title：Acta neuropathologica

authors： Sultana R,Perluigi M,Butterfield DA

更新日期：2009-07-01 00:00:00

abstract：:The deficiency of the cholinergic cortical projection system arising in the different basal forebrain structures collectively referred to as nucleus basalis of Meynert complex is a constant finding in Alzheimer's disease, a disorder which is neuro-pathologically characterised by the appearance of three intracerebral f...

journal_title：Acta neuropathologica

authors： Arendt T,Taubert G,Bigl V,Arendt A

更新日期：1988-01-01 00:00:00

abstract：:Changes in immature rats in motor neurones after axotomy were studied by enzyme-histochemical methods. Increased activity of dehydrogenases in these neurones demonstrates enhanced metabolism and there was also increase of acid phosphatases. Decreased activity of acetylcholinesterase and indoxylacetate esterase in the ...

journal_title：Acta neuropathologica

authors： Maślińska D,Thomas E

更新日期：1975-12-30 00:00:00

abstract：:A model of hypothermic circulatory arrest with recovery has been developed in the newborn dog. Eleven puppies were anesthetized with halothane, paralyzed and artificially ventilated with 70% nitrous oxide -30% oxygen to paO2 > 60 mm Hg, paCO2 = 33-42 mm Hg and pHa = 7.35-7.42. Animals were surface cooled to 20 degrees...

journal_title：Acta neuropathologica

authors： Mujsce DJ,Towfighi J,Yager JY,Vannucci RC

更新日期：1993-01-01 00:00:00

abstract：:Cerebral capillaries in "overgrown" neural tissue of chick embryo brains ranging in age from 5-18 days of incubation were studied by means of electron microscopy. The vessels in the abnormal tissue showed more extensive and prolonged interdigitations and overlapping of adjacent endothelial cells than did those in norm...

journal_title：Acta neuropathologica

authors： Wilson DB,Finta LA,Bois RM

更新日期：1979-04-12 00:00:00

abstract：:The post-mortem diagnosis of lysosomal storage diseases can be confounded by the unavailability of suitable material. Here we report the diagnosis of GM1-gangliosidosis in a cross-bred dog, from which only formalin-fixed brain was available, by a combination of electron microscopy and the detection of elevated levels ...

journal_title：Acta neuropathologica

authors： Whitfield P,Johnson AW,Dunn KA,Delauche AJ,Winchester BG,Franklin RJ

更新日期：2000-10-01 00:00:00

abstract：:Brain metastases (BM) are common in cancer patients and are associated with high morbidity and poor prognosis, even after intensive multimodal therapy including resection, radiotherapy (stereotactic radiosurgery or whole brain radiotherapy) and chemotherapy. However, advances in the understanding of the pathobiology o...

journal_title：Acta neuropathologica

authors： Preusser M,Capper D,Ilhan-Mutlu A,Berghoff AS,Birner P,Bartsch R,Marosi C,Zielinski C,Mehta MP,Winkler F,Wick W,von Deimling A

更新日期：2012-02-01 00:00:00

abstract：:Proliferation indices and mean number of silver-stained nucleolar organizer region-associated proteins (Ag-NORs) are compared in 65 brain tumors, including 34 gliomas, 8 meningiomas, 17 metastatic tumors, and 6 other tumors. Immunocytochemical investigations include labeling with the monoclonal antibody Ki-67 which id...

journal_title：Acta neuropathologica

authors： Maier H,Morimura T,Ofner D,Hallbrucker C,Kitz K,Budka H

更新日期：1990-01-01 00:00:00

abstract：:Synemin is a member of the intermediate protein superfamily. Previous studies in avian and rodent skeletal and cardiac muscles have demonstrated that synemin localises at the Z-band, where it associates with desmin and alpha-actinin. In the present study, the distribution of synemin was examined using immunohistochemi...

journal_title：Acta neuropathologica

authors： Olivé M,Goldfarb L,Dagvadorj A,Sambuughin N,Paulin D,Li Z,Goudeau B,Vicart P,Ferrer I

更新日期：2003-07-01 00:00:00

abstract：:In recent years, we have used a variety of tau immunological markers combined with the dye thiazin red (TR), an accurate marker to differentiate the fibrillar from the nonfibrillar state of both amyloid-beta and tau in Alzheimer's disease (AD). In this study, we used TR as a potential diagnostic marker of AD in frozen...

journal_title：Acta neuropathologica

authors： Luna-Muñoz J,Peralta-Ramirez J,Chávez-Macías L,Harrington CR,Wischik CM,Mena R

更新日期：2008-11-01 00:00:00

abstract：:Glucosylceramide lipidosis results from a defective lysosomal degradation of this glycolipid. Lipid degradation is controlled by two components, the enzyme beta-glucocerebrosidase and a sphingolipid activator protein. While most Gaucher cases are due to mutations within the gene that codes for the lysosomal enzyme, on...

journal_title：Acta neuropathologica

authors： Pàmpols T,Pineda M,Girós ML,Ferrer I,Cusi V,Chabás A,Sanmarti FX,Vanier MT,Christomanou H

更新日期：1999-01-01 00:00:00

abstract：:The isolated paired helical filaments (PHF) that occur in the neurofibrillary tangles of Alzheimer's disease were assayed to determine if they contained N-acetyl-glucosamine and N-acetyl-galactosamine residues. The enzyme-linked lectin assay was used to detect their total content in the PHF preparation. The assay empl...

journal_title：Acta neuropathologica

authors： Sparkman DR,Hill SJ,White CL 3rd

更新日期：1990-01-01 00:00:00

abstract：:The endothelial cells of three cases of cerebellar capillary hemangioblastoma were studied by means of electron microscopy. Crystalloid bodies, not previously described in the vessels of the central nervous system (CNS), were found in 5%-10% of the endothelial cells, more often in the capillaries with small irregular ...

journal_title：Acta neuropathologica

authors： Ho KL

更新日期：1985-01-01 00:00:00

abstract：:Aim of the present study was to establish different immunohistochemical staining patterns for a subsequent comparison with those of primitive neuroectodermal (PNET) subsets, i.e. PNET-NOS (not otherwise specified) or PNET with focal neuronal, astrocytic or ependymal differentiation, to relate neoplastic to embryonal d...

journal_title：Acta neuropathologica

authors： Kleinert R

更新日期：1991-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are endoproteases that have been implicated in the pathogenesis of inflammatory and vasculitic neuropathies. In systemic lupus erythematosus (SLE), a peripheral neuropathy is frequently seen that is thought to be caused by ischemic nerve damage due to vasculopathy and/or vasculitis of ...

journal_title：Acta neuropathologica

authors： Mawrin C,Brunn A,Röcken C,Schröder JM

更新日期：2003-04-01 00:00:00

abstract：:Microglia are long-living resident immune cells of the brain, which secure a stable chemical and physical microenvironment necessary for the proper functioning of the central nervous system (CNS). These highly dynamic cells continuously scan their environment for pathogens and possess the ability to react to damage-in...

journal_title：Acta neuropathologica

authors： Dudvarski Stankovic N,Teodorczyk M,Ploen R,Zipp F,Schmidt MHH

更新日期：2016-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is the most frequent demyelinating disease in young adults and despite significant advances in immunotherapy, disease progression still cannot be prevented. Promotion of remyelination, an endogenous repair mechanism resulting in the formation of new myelin sheaths around demyelinated axons, rep...

journal_title：Acta neuropathologica

authors： Starost L,Lindner M,Herold M,Xu YKT,Drexler HCA,Heß K,Ehrlich M,Ottoboni L,Ruffini F,Stehling M,Röpke A,Thomas C,Schöler HR,Antel J,Winkler J,Martino G,Klotz L,Kuhlmann T

更新日期：2020-11-01 00:00:00

abstract：:To investigate the pathogenetic role of human T lymphocyte virus type I (HTLV-I) in central nervous system disease, a rat model for HTLV-I-associated myelopathy/tropical spastic paraparesis, designated as HAM rat disease, has been established. Wistar-King-Aptekman-Hokudai strain rats with induced HTLV-I infection deve...

journal_title：Acta neuropathologica

authors： Kasai T,Ikeda H,Tomaru U,Yamashita I,Ohya O,Morita K,Wakisaka A,Matsuoka E,Moritoyo T,Hashimoto K,Higuchi I,Izumo S,Osame M,Yoshiki T

更新日期：1999-02-01 00:00:00

abstract：:It was earlier shown that bicuculline-induced status epilepticus gives rise to profound acute changes in the rat cerebral cortex, i.e. edema and neuronal alterations. In the present study, we explored to what extent interruption of the seizure activity reverses the changes observed. To that end, status epilepticus of ...

journal_title：Acta neuropathologica

authors： Söderfeldt B,Kalimo H,Olsson Y,Siesjö BK

更新日期：1983-01-01 00:00:00