Abstract：
:The endothelial cells of three cases of cerebellar capillary hemangioblastoma were studied by means of electron microscopy. Crystalloid bodies, not previously described in the vessels of the central nervous system (CNS), were found in 5%-10% of the endothelial cells, more often in the capillaries with small irregular lumens. They were not observed in the pericytes or stromal cells. They were round to polygonal, 0.5-1.0 micron in size and composed of substructural units of parallel thick and thin electron-dense lines with a periodicity of 180-220 A. They coexisted occasionally with Weibel-Palade bodies but shared no structural correlation with them. The nature and significance of these crystalloid bodies are as yet unknown. Their close association with pinocytic vesicles suggests that the substructural crystalline might be the result of reconstruction of absorbed material from either the vascular lumen or the interstitium. Their subsequent development, associated with lysosomal activity, into intracytoplasmic dense bodies is postulated. Since crystalloid bodies were found only in endothelial cells, particularly those active in proliferation, they may play a pathophysiologic role in relation to angiogenesis.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Ho KLdoi
10.1007/BF00688686subject
Has Abstractpub_date
1985-01-01 00:00:00pages
117-26issue
2eissn
0001-6322issn
1432-0533journal_volume
66pub_type
杂志文章abstract：:Continuous intrathecal infusion of N-methyl-D-aspartate (NMDA) at the level of the lumbar enlargement of the spinal cord in middle-aged rats produced dose-dependent toxicity of spinal cord neuronal systems. Toxicity was enhanced by coadministration of glycine, but was significantly reduced when NMDA was co-administere...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00662631
更新日期：1990-01-01 00:00:00
abstract：:Using a fluorescent antibody technique, sections of the brains of patients with senile dementia or Alzheimer's disease containing senile plaques were treated with rabbit antihuman immunoglobulins labelled with FITC (fluorescein isothiocyanate, BBL). The senile plaques and the cerebral amyloid angiopathy (drusige Entar...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00689569
更新日期：1975-08-11 00:00:00
abstract：:Flow cytofluorometric analysis was used to determine the distribution of the DNA content in cells from selected areas of normal human brain and in benign and malignant brain tumors. Propidium iodide was employed as DNA fluorochrome and the analysis was carried out on a suspension of single cells. Normal, nonstimulated...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00684802
更新日期：1979-04-12 00:00:00
abstract：:Based on the Kellie-Munro doctrine according to which the intracranial compartments--blood, brain, and CSF--are in a state of pressure and volume equilibrium, we examined if traumatic lesions of the liquor absorption passages could change the intracranial pressure (ICP). Therefore, we reviewed the arachnoid villi and ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691896
更新日期：1979-02-15 00:00:00
abstract：:Exercise intolerance associated with myalgias, muscle cramps or myoglobinuria may be associated with a dystrophinopathy. A search for abnormal dystrophin expression (using immunohistochemistry, immunoblot and DNA analysis) was carried out in a series of 15 patients. They were selected because they presented exercise i...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050671
更新日期：1997-07-01 00:00:00
abstract：:Alpha-synuclein (alphaS) and ubiquitin (Ub) are shared constituents of glial cytoplasmic inclusions (GCIs) and Lewy bodies (LBs), both composed of fibrillary structures. Staining profiles of GCIs were investigated with triple immunofluorescence involving immunostaining for alphaS and Ub, both amplified with catalyzed ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-1066-9
更新日期：2005-10-01 00:00:00
abstract：:Adult rabbits were subjected to 4.5 Gy of whole-blody or brain alone gamma-irradiation, and their hippocampus was examined with the light and electron microscope. Pycnotic cells were found at the base of the granular layer of the dentate gyrus in the so-called subgranular zone, as soon as 3 h after irradiation, and we...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690520
更新日期：1979-12-01 00:00:00
abstract：:The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of neuromuscular disorders subdivided into polymyositis (PM), sporadic inclusion body myositis (sIBM) and dermatomyositis (DM). Chemokines play an essential role in sustained inflammation associated with IIM. We studied the distribution of the alph...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-0989-5
更新日期：2005-06-01 00:00:00
abstract：:Among the various mechanisms proposed to explain the pathogenesis of cerebral lesions in human immunodeficiency virus (HIV)-induced encephalitis, a cytokine-mediated action has found most favour. Indeed, elevated expression of cytokines such as interleukin (IL)-1 and tumor necrosis factor-alpha (TNF-alpha), thought to...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050457
更新日期：1996-01-01 00:00:00
abstract：:Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3.3) subgroups were c...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-012-0998-0
更新日期：2012-09-01 00:00:00
abstract：:Immunohistochemical studies of monoamine neurons were performed to evaluate toxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on young adult mice and compare them with those of their offspring. Mice, 9-11 weeks old (C57BL/6J), injected subcutaneously with a large dose of MPTP (17 mg/kg per day) duri...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294662
更新日期：1989-01-01 00:00:00
abstract：:Histopathological, immunocytochemical, and electron microscopical investigations were carried out in a man with a protracted history of spastic paraparesis, adrenal insufficiency and hypogonadism. Pathological findings were identical with those of the few previously reported cases of adrenomyeloneuropathy (AMN) includ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690750
更新日期：1980-01-01 00:00:00
abstract：:Aluminum was observed in the nucleolus, interchromatin granules, rough endoplasmic reticulum, free ribosomes, euchromatin, and the heterochromatin of the neuron. The association of aluminum with the first four r-RNA-containing cellular components and with the last two DNA-containing chromatins suggests the association...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690191
更新日期：1985-01-01 00:00:00
abstract：:Impaired axonal transport of the fast or slow component has been reported in patients with sporadic amyotrophic lateral sclerosis (ALS), animal models for ALS, and familial ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) transgenic mice. However, little is known about the impairment of axonal transport in mutant S...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-1021-9
更新日期：2005-07-01 00:00:00
abstract：:Electrophysiological studies in subjects with HIV/AIDS demonstrate subtle changes in the visual pathway even in the absence of visual symptoms. But the pathological correlate of the electrophysiological abnormalities is largely unknown. This study attempts to correlate pathological changes in the retina and intraorbit...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0089-1
更新日期：2006-10-01 00:00:00
abstract：:Experimental neuropathy, characterized by endoneurial edema and demyelination, was induced by inoculating rabbits with a combination of Freund's complete adjuvant (FCA), gangliosides, lecithin and cholesterol. A less severe demyelinating neuropathy could be induced by treatment with FCA alone but no significant change...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00695496
更新日期：1987-01-01 00:00:00
abstract：:Glioblastomas, the most malignant human brain tumors, are characterized by marked aneuploidy, suggesting chromosomal instability which may be caused by a defective mitotic spindle checkpoint. We screened 22 glioblastomas for mutations in the mitotic spindle check-point genes hBUB1, hBUBR1 and hBUB3. DNA sequencing rev...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100366
更新日期：2001-04-01 00:00:00
abstract：:Marinesco-Sjögren syndrome (MSS) features cerebellar ataxia, mental retardation, cataracts, and progressive vacuolar myopathy with peculiar myonuclear alterations. Most MSS patients carry homozygous or compound heterozygous SIL1 mutations. SIL1 is a nucleotide exchange factor for the endoplasmic reticulum resident cha...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1224-4
更新日期：2014-05-01 00:00:00
abstract：:A morphometric study of the basal nucleus of Meynert (bnM) has been performed in a 70-year-old man with a 4-year history of pathologically confirmed progressive supranuclear palsy (PSP). An important neuronal loss (52%) was demonstrated in the bnM. This finding has not been previously documented with morphometric meth...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00697397
更新日期：1983-01-01 00:00:00
abstract：:Axons of the peripheral nervous system (PNS) are reduced in caliber in response to the experimental diabetic state. The cause of this reduced axonal size is disputed. Various theories include (a) axonal dwindling, (b) inhibition of growth, and (c) shrinkage due to serum hyperosmolarity. This study was designed to dire...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688637
更新日期：1985-01-01 00:00:00
abstract：:Frontotemporal lobar degeneration with TAR DNA-binding protein 43 inclusions (FTLD-TDP) is the most common pathology associated with frontotemporal dementia (FTD). Repeat expansions in chromosome 9 open reading frame 72 (C9ORF72) and mutations in progranulin (GRN) are the major known genetic causes of FTLD-TDP; howeve...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-015-1436-x
更新日期：2015-07-01 00:00:00
abstract：:Bundles of paired helical filaments (PHF) accumulate in the pyramidal neurons that degenerate during Alzheimer's disease. This neurofibrillary degeneration is highly correlated with clinical signs of dementia. During the degenerating process, Tau proteins, which are the major antigenic components of PHF, are abnormall...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308912
更新日期：1990-01-01 00:00:00
abstract：:Silver-staining methods are helpful for histological identification of pathological deposits. In spite of some ambiguities regarding their mechanism and interpretation, they are widely used for histopathological diagnosis. In this review, four major silver-staining methods, modified Bielschowsky, Bodian, Gallyas (GAL)...
journal_title：Acta neuropathologica
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00401-007-0200-2
更新日期：2007-05-01 00:00:00
abstract：:Seizures commonly occur in glioma patients, but their pathogenesis is poorly understood, in part due to a lack of valid and versatile experimental models. We have established a new model that enables comprehensive neuropathological and neurophysiological analysis on identical tissue preparations. Rat C6 glioma cells s...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0771-5
更新日期：2004-01-01 00:00:00
abstract：:Methylmercury (MeHg) poisoning (20 mg/kg body weight) in embryonic mice resulted in significant reductions of mitotic indices in the neuroepithelial germinal cells of the telencephalon at the ventricular surface 4 to 12 h following intoxication. After 24 h, no significant difference in the mitotic indices was observed...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00293454
更新日期：1991-01-01 00:00:00
abstract：:A 24-year-old woman was found comatose after 2 days of cephalalgia and vomiting. An immediate diagnosis of carbon monoxyde poisoning was disclaimed when blood carbon monoxyde was found to be 1.75 ml/100. A diagnosis of acute intracranial hypertension led to trephination with ventricular punction and brain biopsy on th...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685010
更新日期：1978-08-07 00:00:00
abstract：:An unusual tumor of the pituitary gland is reported. The most characteristic finding of the present tumor was the presence of numerous "colloid" and mucoid secretions. The cells were stellate in shape and there were intra- or intercellular lumina which were lined by many microvilli and occasional cilia. There were als...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687617
更新日期：1984-01-01 00:00:00
abstract：:The pro-inflammatory and blood-brain barrier (BBB) effects of intratumoral (IT) injection of human recombinant tumor necrosis factor-alpha (rTNF-alpha) were studied in the Fischer rat RT-2 glioma model. Animals received a single stereotaxic injection of either 6 x 10(4) U rTNF-alpha or excipient (vehicle) into the cen...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/pl00007398
更新日期：1997-01-01 00:00:00
abstract：:Clinical and morphological findings in an 8-year-old Jewish girl with spongy leukodystrophy are presented. Ultrastructural changes indicated that this may be a form of Canavan's disease with some atypical features. Biochemical measurements indicated that synaptosomal membranes prepared from the striatum but not from t...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691321
更新日期：1981-01-01 00:00:00
abstract：:Polyclonal antibodies directed towards synaptophysin were raised against a synthesised peptide corresponding to amino acids 246 to 260 of the human synaptophysin sequence. The antibodies, when applied for immunocytochemical staining, showed a staining pattern identical to that of the commercially available monoclonal ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00293325
更新日期：1994-01-01 00:00:00
