Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas.

abstract：:A 56-day-old infant with alpha-neuraminidase deficiency, whose clinical features included severe edema of extremities and ascites which resembled those in severe infantile sialidosis, was autopsied. Perforation, whose pathogenesis was unclear, was found on the descending portion of the duodenum. Light and electron mic...

journal_title：Acta neuropathologica

authors： Yamano T,Shimada M,Matsuzaki K,Matsumoto Y,Yoshihara W,Okada S,Inui K,Yutaka T,Yabuuchi H

更新日期：1986-01-01 00:00:00

abstract：:CD44 antigen (CD44), the principle cell surface receptor for hyaluronate, is up-regulated in the human demyelinating disease multiple sclerosis on fibrous astrocytes. As astrocytes are the main target cell of canine distemper virus (CDV), the consequences of a CDV infection on the CD44 expression and distribution in b...

journal_title：Acta neuropathologica

authors： Alldinger S,Fonfara S,Kremmer E,Baumgärtner W

更新日期：2000-02-01 00:00:00

abstract：:Double immunofluorescence for paired helical filament (PHF)-tau (AT8) and ubiquitin, enhanced by catalyzed reporter deposition amplification, was combined with thiazin red (TR), a fluorochrome, which has an affinity to fibrillary structures such as neurofibrillary tangles (NFTs). After recording these triple-fluoresce...

journal_title：Acta neuropathologica

authors： Uchihara T,Nakamura A,Yamazaki M,Mori O

更新日期：2001-06-01 00:00:00

abstract：:Cornelia de Lange syndrome (CDLS) is a rare multisystemic malformative syndrome of uncertain etiology characterized by severe psychomotor and mental retardation. Here we report the neuropathological analysis of a 35-year-old patient who displayed the classical clinical symptomatology of CDLS. A congenital dysgenesis o...

journal_title：Acta neuropathologica

authors： Vuilleumier N,Kövari E,Michon A,Hof PR,Mentenopoulos G,Giannakopoulos P,Bouras C

更新日期：2002-09-01 00:00:00

abstract：:Alpha-synuclein is known to play an important role in several neurodegenerative diseases. Moreover, it is expressed in central nervous system neuronal tumors, and another member of the synuclein family, gamma-synuclein, is overexpressed in breast and ovarian carcinomas. However, the expression of alpha-synuclein has n...

journal_title：Acta neuropathologica

authors： Mori F,Inenaga C,Yoshimoto M,Umezu H,Tanaka R,Takahashi H,Wakabayashi K

更新日期：2002-02-01 00:00:00

abstract：:A study was undertaken to determine the pathological significance of previously unrecognized intracytoplasmic eosinophilic inclusions (IEIs) in ependymoma. The study group consisted of 58 ependymomas, all of which were pathologically characterized and graded according to the 1993 WHO classification. Electron microscop...

journal_title：Acta neuropathologica

authors： Kawano N,Ohba Y,Nagashima K

更新日期：2000-02-01 00:00:00

abstract：:Neurons of Area 11 in the fronto-orbital cortex of 18 unselected AIDS brains are analyzed by means of stereology. Neurological abnormalities including dementing symptoms were described in eight patients. Neuropathology diagnosed human immunodeficiency virus (HIV)-specific changes in four, and diffuse poliodystrophy in...

journal_title：Acta neuropathologica

authors： Ketzler S,Weis S,Haug H,Budka H

更新日期：1990-01-01 00:00:00

abstract：:Myotubular myopathy and centronuclear myopathies (CNM) are congenital myopathies characterized by generalized muscle weakness and mislocalization of muscle fiber nuclei. Genetically distinct forms exist, and mutations in BIN1 were recently identified in autosomal recessive cases (ARCNM). Amphiphysins have been implica...

journal_title：Acta neuropathologica

authors： Toussaint A,Cowling BS,Hnia K,Mohr M,Oldfors A,Schwab Y,Yis U,Maisonobe T,Stojkovic T,Wallgren-Pettersson C,Laugel V,Echaniz-Laguna A,Mandel JL,Nishino I,Laporte J

更新日期：2011-02-01 00:00:00

abstract：:We report a sporadic tauopathy of 6-year duration in a 76-year-old woman. Her initial symptoms were asymmetrical parkinsonism and muscle weakness, with apraxia appearing 2 years later. The brain showed frontal and temporal cerebral atrophy; severe neuronal loss and gliosis were observed in the precentral cortex (loss ...

journal_title：Acta neuropathologica

authors： Piao YS,Tan CF,Iwanaga K,Kakita A,Takano H,Nishizawa M,Lashley T,Revesz T,Lees A,de Silva R,Tsujihata M,Takahashi H

更新日期：2005-12-01 00:00:00

abstract：:Data on the relationship between Parkinson's disease (PD) and stroke have been conflicting, some studies showing a reduced risk of stroke during life, and others indicating an increased risk of stroke-related death. Consecutive cases (n=617) of autopsy-proven idiopathic PD (Lewy body disease of the brain stem type) an...

journal_title：Acta neuropathologica

authors： Jellinger KA

更新日期：2003-05-01 00:00:00

abstract：:Various parts of the central and peripheral nervous system of the mutant hamster with hind leg paralysis were studied in the electron microscope. A number of alterations involving the myelin sheath, the axon and certain neuronal perikarya were observed. Anterior horn cells were apparently well preserved. This conditio...

journal_title：Acta neuropathologica

authors： Hirano A

更新日期：1977-08-31 00:00:00

abstract：:Axonal degeneration contributes to the transient and permanent neurological deficits seen in multiple sclerosis, an inflammatory disease of the central nervous system. To study the immunological mechanisms causing axonal degeneration, we induced experimental autoimmune encephalomyelitis (EAE) in wildtype Lewis rats an...

journal_title：Acta neuropathologica

authors： Aboul-Enein F,Weiser P,Höftberger R,Lassmann H,Bradl M

更新日期：2006-06-01 00:00:00

abstract：:Glucosylceramide lipidosis results from a defective lysosomal degradation of this glycolipid. Lipid degradation is controlled by two components, the enzyme beta-glucocerebrosidase and a sphingolipid activator protein. While most Gaucher cases are due to mutations within the gene that codes for the lysosomal enzyme, on...

journal_title：Acta neuropathologica

authors： Pàmpols T,Pineda M,Girós ML,Ferrer I,Cusi V,Chabás A,Sanmarti FX,Vanier MT,Christomanou H

更新日期：1999-01-01 00:00:00

abstract：:Peroxiredoxin-ll (Prxll) and glutathione peroxidase-l (GPxl) are regulators of the redox system that is one of the most crucial supporting systems in neurons. This system is an antioxidant enzyme defense system and is synchronously linked to other important cell supporting systems. To clarify the common self-survival ...

journal_title：Acta neuropathologica

authors： Kato S,Kato M,Abe Y,Matsumura T,Nishino T,Aoki M,Itoyama Y,Asayama K,Awaya A,Hirano A,Ohama E

更新日期：2005-08-01 00:00:00

abstract：:The topographic distribution of brain atrophy was quantified by image analysis of fixed coronal brain slices from four patients dying with cortical Lewy body disease (CLBD) all with Alzheimer-type pathology and compared to that in four other patients of similar age and gender dying with Alzheimer's disease (AD) alone....

journal_title：Acta neuropathologica

authors： Mann DM,Snowden JS

更新日期：1995-01-01 00:00:00

abstract：:Immunohistochemical studies of monoamine neurons were performed to evaluate toxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on young adult mice and compare them with those of their offspring. Mice, 9-11 weeks old (C57BL/6J), injected subcutaneously with a large dose of MPTP (17 mg/kg per day) duri...

journal_title：Acta neuropathologica

authors： Furune S,Miura K,Watanabe K,Nagao S,Takahashi H,Sakai M,Spatz M,Nagatsu I

更新日期：1989-01-01 00:00:00

abstract：:Based on the Kellie-Munro doctrine according to which the intracranial compartments--blood, brain, and CSF--are in a state of pressure and volume equilibrium, we examined if traumatic lesions of the liquor absorption passages could change the intracranial pressure (ICP). Therefore, we reviewed the arachnoid villi and ...

journal_title：Acta neuropathologica

authors： Dirnhofer R,Sigrist T

更新日期：1979-02-15 00:00:00

abstract：:This study was undertaken to elucidate, using the Golgi method, the neuropathological change in the brain of the macular mutant mouse, whose hemizygote (Ml/y) is considered to be a model of Menkes kinky hair disease (MKHD). The hemizygote mice gradually lost weight after 10 days of age and died with emaciation and sei...

journal_title：Acta neuropathologica

authors： Kawasaki H,Onaga A,Yamano T,Shimada M,Nishimura M

更新日期：1987-01-01 00:00:00

abstract：:We have previously reported a pathological investigation of peripheral neuropathy in a horse with knuckling. This report describes details of the muscle and peripheral nerve lesions in two additional cases of light horse yearlings with knuckling. The skeletal muscles showed neurogenic atrophy characterized by scattere...

journal_title：Acta neuropathologica

authors： Furuoka H,Okamoto R,Kitayama S,Asou S,Matsui T,Miyahara K

更新日期：1998-10-01 00:00:00

abstract：:Oxidative stress has been implicated in the pathogenesis of a number of diseases including Alzheimer's disease (AD). The oxidative stress hypothesis of AD pathogenesis, in part, is based on beta-amyloid peptide (Abeta)-induced oxidative stress in both in vitro and in vivo studies. Oxidative modification of the protein...

journal_title：Acta neuropathologica

authors： Sultana R,Perluigi M,Butterfield DA

更新日期：2009-07-01 00:00:00

abstract：:A giant-cell glioblastoma was examined by electron microscopy and by the freeze-fracture technique. The cell membranes bordering the extensive extracellular space often showed complicated undulations and peripheral vacuoles as well as occasional microvilli or filopodia. The undulations were mainly composed of plasmale...

journal_title：Acta neuropathologica

authors： Tani E,Nakano M,Itagaki T,Fukumori T

更新日期：1978-01-19 00:00:00

abstract：:Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here, we report on DNA methylation-based central nervous system (CNS) tumor diagnostics conducted in our institution between the years 2015 and 2018....

journal_title：Acta neuropathologica

authors： Capper D,Stichel D,Sahm F,Jones DTW,Schrimpf D,Sill M,Schmid S,Hovestadt V,Reuss DE,Koelsche C,Reinhardt A,Wefers AK,Huang K,Sievers P,Ebrahimi A,Schöler A,Teichmann D,Koch A,Hänggi D,Unterberg A,Platten M,Wick

更新日期：2018-08-01 00:00:00

abstract：:The ultrastructural features of SOD1-positive aggregates were determined to clarify whether these aggregates are associated with the pathogenesis of SOD1 mutant mice. We examined the spinal cord of transgenic mice expressing a G93A mutant human SOD1 gene with fewer copies (gene copy 10). At the early presymptomatic st...

journal_title：Acta neuropathologica

authors： Sasaki S,Warita H,Murakami T,Shibata N,Komori T,Abe K,Kobayashi M,Iwata M

更新日期：2005-03-01 00:00:00

abstract：:We report a case of embryonal tumor with novel inclusion bodies occurring in the cerebellum of a 12-year-old girl. The tumor was histopathologically composed of small undifferentiated cells intermingled with a small number of rhabdoid cells, which had an ultrastructural feature of intermediate filament whorls. Immunoh...

journal_title：Acta neuropathologica

authors： Sasaki A,Kurihara H,Ishiuchi S,Hirato J,Saito N,Nakazato Y

更新日期：2005-07-01 00:00:00

abstract：:By unknown mechanisms, the symptoms of amyotrophic lateral sclerosis (ALS) seem to spread along neuroanatomical pathways to engulf the motor nervous system. The rate at which symptoms spread is one of the primary drivers of disease progression. One mechanism by which ALS symptoms could spread is by a prion-like propag...

journal_title：Acta neuropathologica

authors： Ayers JI,Fromholt S,Koch M,DeBosier A,McMahon B,Xu G,Borchelt DR

更新日期：2014-12-01 00:00:00

abstract：:The character of the silver positive reticulin network was analyzed with immunofluorescence and immunoperoxidase methods in an intra vitam diagnosed case of primary brain lymphoma. The network was shown to contain connective tissue proteins rich in hexose-sugars, such as type III collagen (classical "reticulin"), basa...

journal_title：Acta neuropathologica

authors： Kalimo H,Lehto M,Näntö-Salonen K,Jalkanen M,Risteli L,Risteli J,Narva EV

更新日期：1985-01-01 00:00:00

abstract：:Low-grade neuroepithelial tumors (LGNTs) are diverse CNS tumors presenting in children and young adults, often with a history of epilepsy. While the genetic profiles of common LGNTs, such as the pilocytic astrocytoma and 'adult-type' diffuse gliomas, are largely established, those of uncommon LGNTs remain to be define...

journal_title：Acta neuropathologica

authors： Qaddoumi I,Orisme W,Wen J,Santiago T,Gupta K,Dalton JD,Tang B,Haupfear K,Punchihewa C,Easton J,Mulder H,Boggs K,Shao Y,Rusch M,Becksfort J,Gupta P,Wang S,Lee RP,Brat D,Peter Collins V,Dahiya S,George D,Konomos

更新日期：2016-06-01 00:00:00

abstract：:Immunofluorescence and immunogold labelling were used to localise the 43-kDa dystrophin-associated glycoprotein (43DAG) of the dystrophin-glycoprotein complex in control and Duchenne muscular dystrophy (DMD) biopsies. In control muscle 43DAG was localised by immunofluorescence to the periphery of the fibre and, by imm...

journal_title：Acta neuropathologica

authors： Cullen MJ,Walsh J,Nicholson LV

更新日期：1994-01-01 00:00:00

abstract：:Transient forebrain ischemia produces a spatially and temporally selective pattern of neuronal degeneration in the hippocampal formation of the Mongolian gerbil. Ischemic neuronal death has been suggested to depend on the activation of excitatory hippocampal pathways that project to the vulnerable neurons. This idea w...

journal_title：Acta neuropathologica

authors： Kaplan TM,Lasner TM,Nadler JV,Crain BJ

更新日期：1989-01-01 00:00:00

abstract：:Lectin-binding sites located on the endothelial cell (EC) surfaces in unaltered, leaking and resorbing micro-blood vessels (MBVs) in cryo-injured cat brain were studied. Lectin or glycoprotein-gold complexes and brain samples embedded in hydrophilic resin Lowicryl K4M were used. The lectins tested recognize the follow...

journal_title：Acta neuropathologica

authors： Vorbrodt AW

更新日期：1986-01-01 00:00:00