Idiopathic peripheral neuropathy in the horse with knuckling: muscle and nerve lesions in additional cases.

abstract：:A 1-year-old male chinchilla with a 2-week history of conjunctivitis suffered subsequently from neurological signs comprising seizures, disorientation, recumbency and apathy. After 3 weeks of progressive central nervous disease the animal was killed in view of the poor prognosis. A non-suppurative meningitis and polio...

journal_title：Acta neuropathologica

authors： Wohlsein P,Thiele A,Fehr M,Haas L,Henneicke K,Petzold DR,Baumgärtner W

更新日期：2002-12-01 00:00:00

abstract：:This study was designed to compare the degree of reactive astrogliosis occurring around a puncture wound in the brain of normal rats and at different intervals after a similar puncture wound in rats with a portocaval anastomosis. The gliosis was evaluated by the number of astrocytes, the thickness of their processes a...

journal_title：Acta neuropathologica

authors： Ma KC,Chang ZH,Shih H,Zhu JH,Wu JY

更新日期：1991-01-01 00:00:00

abstract：:New pericapillary inclusion bodies were found in 17 cases of sporadic amyotrophic lateral sclerosis (ALS). The inclusion bodies consisted of paracrystalline arrays with 5-7 nm electron-dense subunits, were discernible with the light microscope and had the staining properties of protein. They were surrounded by capilla...

journal_title：Acta neuropathologica

authors： Averback P

更新日期：1986-01-01 00:00:00

abstract：:Recent studies have shown that Cerebrolysin can enhance synaptic function and ameliorate synaptodendritic alterations in animal models of neurodegeneration, suggesting a synaptotrophic effect. We hypothesize that Cerebrolysin might exert this effect, in part, by regulating the expression of amyloid precursor protein (...

journal_title：Acta neuropathologica

authors： Mallory M,Honer W,Hsu L,Johnson R,Rockenstein E,Masliah E

更新日期：1999-05-01 00:00:00

abstract：:Intracranial solitary fibrous tumors (SFTs) are typically dural-based, CD34-positive neoplasms of uncertain histogenesis. We examined ten cases of meninges obtained at autopsy from patients with no history of neurological illness, head trauma, or neurosurgical intervention, and ten cases of typical meningiomas with at...

journal_title：Acta neuropathologica

authors： Cummings TJ,Burchette JL,McLendon RE

更新日期：2001-10-01 00:00:00

abstract：:To identify antigenic differences between gliomas and normal brain, we have immunohistochemically studied the expression of lymphocyte adhesion molecules (ICAM-1, ICAM-2, ICAM-3, VCAM-1, E-selectin and CD58), epidermal growth factor receptor (EGFR) and extracellular matrix proteins (collagen IV, fibronectin, laminin, ...

journal_title：Acta neuropathologica

authors： Mäenpää A,Kovanen PE,Paetau A,Jäáskeläinen J,Timonen T

更新日期：1997-09-01 00:00:00

abstract：:Focal cerebral ischemia was induced by occlusion of the right middle cerebral artery in hypoglycemic, normoglycemic, as well as in acute and chronic diabetic rats. The brain damage was studied after 4 days. The volume of infarction was decreased in hypoglycemia (29 +/- 19 mm3 (mean +/- SD) versus 58 +/- 35 mm3, P less...

journal_title：Acta neuropathologica

authors： Nedergaard M,Diemer NH

更新日期：1987-01-01 00:00:00

abstract：:Acute arterial hypertension was induced in male Wistar rats using two experimental techniques: (1) i.v. injection of Aramine and (2) infusion of physiological saline as a bolus via internal carotid artery. Horseradish peroxidase (HRP) was injected i.v. prior to both experimental procedures and subsequently localized i...

journal_title：Acta neuropathologica

authors： Nagy Z,Mathieson G,Hüttner I

更新日期：1979-10-01 00:00:00

abstract：:The unfolded protein response (UPR) is a stress response of the endoplasmic reticulum (ER) to a disturbance in protein folding. The so-called ER stress sensors PERK, IRE1 and ATF6 play a central role in the initiation and regulation of the UPR. The accumulation of misfolded and aggregated proteins is a common characte...

journal_title：Acta neuropathologica

authors： Scheper W,Hoozemans JJ

更新日期：2015-09-01 00:00:00

abstract：:The regional distribution of the postsynaptic microtubule-associated protein 2 (MAP2) and the presynaptic marker protein synaptophysin was investigated by immunohistochemistry in brains of rats submitted to 30-min forebrain ischemia by four-vessel occlusion. The following brain temperature profiles during ischemia wer...

journal_title：Acta neuropathologica

authors： Miyazawa T,Bonnekoh P,Hossmann KA

更新日期：1993-01-01 00:00:00

abstract：:Skeins or skein-like inclusions, one of the two types of ubiquitinated intraneuronal inclusions in amyotrophic lateral sclerosis (ALS), in the neostriatum are not specific to the disease, but it has not yet been determined whether the other, spherical or crescent-shaped inclusions (SCI) are pathognomonic. To clarify t...

journal_title：Acta neuropathologica

authors： Kawashima T,Doh-ura K,Kikuchi H,Iwaki T

更新日期：2001-11-01 00:00:00

abstract：:Paediatric high grade glioma (pHGG) (World Health Organisation astrocytoma grades III and IV) remains poor prognosis tumours, with a median survival of only 15 months following diagnosis. Current investigation of anti-angiogenic strategies has focused on adult glioblastoma multiforme (GBM) with phase III trials target...

journal_title：Acta neuropathologica

authors： Smith SJ,Tilly H,Ward JH,Macarthur DC,Lowe J,Coyle B,Grundy RG

更新日期：2012-07-01 00:00:00

abstract：:Glioblastoma (GBM), the most common malignant brain tumor, is among the most lethal neoplasms, with a median survival of approximately 1 year. Prognosis is poor since GBMs possess a strong migratory and highly invasive potential, making complete surgical resection impossible. Reduced expression of carboxypeptidase E (...

journal_title：Acta neuropathologica

authors： Höring E,Harter PN,Seznec J,Schittenhelm J,Bühring HJ,Bhattacharyya S,von Hattingen E,Zachskorn C,Mittelbronn M,Naumann U

更新日期：2012-07-01 00:00:00

abstract：:A 56-day-old infant with alpha-neuraminidase deficiency, whose clinical features included severe edema of extremities and ascites which resembled those in severe infantile sialidosis, was autopsied. Perforation, whose pathogenesis was unclear, was found on the descending portion of the duodenum. Light and electron mic...

journal_title：Acta neuropathologica

authors： Yamano T,Shimada M,Matsuzaki K,Matsumoto Y,Yoshihara W,Okada S,Inui K,Yutaka T,Yabuuchi H

更新日期：1986-01-01 00:00:00

abstract：:We studied the microscopic features of 137 cases of human cerebral infarct. In each case, the age of the lesion was determined by measuring the time elapsed between initial clinical presentation and date of surgery or death. Multiple microscopic variables were analyzed on hematoxylin and eosin-stained sections. There ...

journal_title：Acta neuropathologica

authors： Mena H,Cadavid D,Rushing EJ

更新日期：2004-12-01 00:00:00

abstract：:The binding patterns of lectins to normal peripheral nerves were examined. Twelve biotinylated lectins were used in this study; Canavalia ensiformis (Con A), Pisum sativum (PSA), Lens culinaris (LCA), Ricinus communis 1 (RCA-1), Arachis hypogaea (PNA), Glycine max (SBA), Sophora japonica (SJA), Bandeiraea simplicifoli...

journal_title：Acta neuropathologica

authors： Matsumura K,Nakasu S,Nioka H,Handa J

更新日期：1993-01-01 00:00:00

abstract：:A critical appraisal is presented of nearly two decades of research publications and review articles advocating the bidirectional transcytosis of fluid-phase molecules, most notably native horseradish peroxidase (HRP), through the normal and experimentally modified blood-brain barrier (BBB). Extracellular routes circu...

journal_title：Acta neuropathologica

authors： Broadwell RD

更新日期：1989-01-01 00:00:00

abstract：:Two young zebra siblings from consecutive pregnancies suffered from neurological disease, characterized by ventral deviation of the neck and tetraparesis which progressed to tetraplegia within a few weeks. On histological examination widespread neuronal degeneration was observed in the ventral horns of the spinal cord...

journal_title：Acta neuropathologica

authors： Higgins RJ,Vandevelde M,Hoff EJ,Jagar JE,Cork LC,Silberman MS

更新日期：1977-01-31 00:00:00

abstract：:During corticogenesis, neurons adopt different migration pathways to reach their final position. The precursors of pyramidal neurons migrate radially, whereas most of the GABA-containing interneurons are generated in the ventral telencephalon and migrate tangentially into the neocortex. Then, they use a radial migrati...

journal_title：Acta neuropathologica

authors： Marcorelles P,Laquerrière A,Adde-Michel C,Marret S,Saugier-Veber P,Beldjord C,Friocourt G

更新日期：2010-10-01 00:00:00

abstract：:In this immunocytochemical study, the brains of nine squirrel monkeys (Saimiri sciureus), ranging from 8 to 27 years of age, were examined for the presence and distribution of beta/A4 amyloid, a 4-kilodalton peptide. In aged squirrel monkeys, amyloid is associated primarily with intracerebral and meningeal capillaries...

journal_title：Acta neuropathologica

authors： Walker LC,Masters C,Beyreuther K,Price DL

更新日期：1990-01-01 00:00:00

abstract：:Spinal cord-notochord relationship was analyzed histologically and immunohistochemically in normal human conceptuses between the 4-8 developmental weeks and in a 8-week embryo with double spinal cord. In the early 4-week embryo, the gradual closure of the neural tube along the cranio-caudal body axis was paralleled by...

journal_title：Acta neuropathologica

authors： Saraga-Babić M,Stefanović V,Wartiovaara J,Lehtonen E

更新日期：1993-01-01 00:00:00

abstract：:A simple and reproducible method for cryopreservation of brain tissue from patients with Alzheimer's disease is described. Fresh brain slices (1 cm thick) obtained less than 6 h postmortem are placed in sealed plastic bags, sandwiched between 0.3-cm-thick aluminium sheets, and frozen by placing the entire "sandwich" b...

journal_title：Acta neuropathologica

authors： Nochlin D,Mackenzie AP,Bryant EM,Norwood TH,Sumi SM

更新日期：1993-01-01 00:00:00

abstract：:Experimental allergic neuritis (EAN) was induced in normal and irradiated Lewis rats by passively transferring T cells sensitized to SP-26, a peptide fragment of P2 myelin protein. The recipients became sick 4-8 days post transfer and the degree of disability correlated directly with the dose of T cells. Smaller doses...

journal_title：Acta neuropathologica

authors： Hahn AF,Feasby TE,Lovgren D,Wilkie L

更新日期：1993-01-01 00:00:00

abstract：:It was demonstrated that New Zealand Albino rabbits sensitized to galactocerebroside had high levels of anti-galactocerebroside antibody and of immune complexes. The rabbits was high titers of immune complexes developed demyelination in the peripheral nerves. Lesion were produced in the peripheral nerves of mice by th...

journal_title：Acta neuropathologica

authors： Tsukada N,Koh CS,Yanagisawa N,Taketomi T,Behan PO

更新日期：1985-01-01 00:00:00

abstract：:Old age is associated with a deficient recovery from stroke, but the cellular mechanisms underlying such phenomena are poorly understood. To address this issue, focal cerebral ischemia was produced by reversible occlusion of the right middle cerebral artery in 3- and 20-month-old male Sprague-Dawley rats. Aged rats sh...

journal_title：Acta neuropathologica

authors： Popa-Wagner A,Badan I,Walker L,Groppa S,Patrana N,Kessler C

更新日期：2007-03-01 00:00:00

abstract：:Muscle biopsy samples from five patients with cytoplasmic body myopathy (CBM) were investigated by immunohistochemical (antibodies to desmin, actin, dystrophin, spectrin, alpha actinin and utrophin), immunoelectron microscopic (antibodies to desmin, actin and dystrophin) and biochemical (desmin, dystrophin, actin and ...

journal_title：Acta neuropathologica

authors： Caron A,Viader F,Lechevalier B,Chapon F

更新日期：1995-01-01 00:00:00

abstract：:Pyroglutamylated amyloid-β (pE(3)-Aβ) has been suggested to play a major role in Alzheimer's disease (AD) pathogenesis as amyloid-β (Aβ) oligomers containing pE(3)-Aβ might initiate tau-dependent cytotoxicity. We aimed to further elucidate the associations among pE(3)-Aβ, full-length Aβ and hyperphosphorylated tau (HP...

journal_title：Acta neuropathologica

authors： Mandler M,Walker L,Santic R,Hanson P,Upadhaya AR,Colloby SJ,Morris CM,Thal DR,Thomas AJ,Schneeberger A,Attems J

更新日期：2014-07-01 00:00:00

abstract：:Experimental neuropathy, characterized by endoneurial edema and demyelination, was induced by inoculating rabbits with a combination of Freund's complete adjuvant (FCA), gangliosides, lecithin and cholesterol. A less severe demyelinating neuropathy could be induced by treatment with FCA alone but no significant change...

journal_title：Acta neuropathologica

authors： Powell HC,Mizisin AP,Wiley CA,Morey MK,Hughes RA

更新日期：1987-01-01 00:00:00

abstract：:Electronmicroscope studies have been performed on the greater splanchnic nerve and the nerve to the medial head of gastrocnemius muscle of control and acrylamide poisoned cats. Degeneration of unmyelinated as well as of myelinated fibres was observed in both nerves. In cats severely poisoned with acrylamide, some very...

journal_title：Acta neuropathologica

authors： Post EJ

更新日期：1978-04-26 00:00:00

abstract：:Laquinimod (LAQ) is a new oral immunomodulatory compound that reduces relapse rate, brain atrophy and disability progression in multiple sclerosis (MS). LAQ has well-documented effects on inflammation in the periphery, but little is known about its direct activity within the central nervous system (CNS). To elucidate ...

journal_title：Acta neuropathologica

authors： Brück W,Pförtner R,Pham T,Zhang J,Hayardeny L,Piryatinsky V,Hanisch UK,Regen T,van Rossum D,Brakelmann L,Hagemeier K,Kuhlmann T,Stadelmann C,John GR,Kramann N,Wegner C

更新日期：2012-09-01 00:00:00