Abstract:
:To identify antigenic differences between gliomas and normal brain, we have immunohistochemically studied the expression of lymphocyte adhesion molecules (ICAM-1, ICAM-2, ICAM-3, VCAM-1, E-selectin and CD58), epidermal growth factor receptor (EGFR) and extracellular matrix proteins (collagen IV, fibronectin, laminin, merosin, tenascin and vitronectin) in these tissues. Gliomas expressed high levels of ICAM-1, CD58 (LFA-3), EGFR, tenascin and vitronectin, whereas only very low levels were detected in normal brain. VCAM-1 expression was detected in 15 out of 25 gliomas but not in normal brain. The presence of VCAM-1 in gliomas was verified by immunoblotting and RNase protection assay, and in glioma cell lines by Northern blotting. Expression of VCAM-1 in gliomas may partially explain lymphocytic infiltration, and anti-VCAM-1 antibodies may be of potential in antibody mixtures for targeted therapy of gliomas.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Mäenpää A,Kovanen PE,Paetau A,Jäáskeläinen J,Timonen Tdoi
10.1007/s004010050696subject
Has Abstractpub_date
1997-09-01 00:00:00pages
216-25issue
3eissn
0001-6322issn
1432-0533journal_volume
94pub_type
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