Colocalization of cholinesterases with beta amyloid protein in aged and Alzheimer's brains.

abstract：:Continuous intrathecal infusion of N-methyl-D-aspartate (NMDA) at the level of the lumbar enlargement of the spinal cord in middle-aged rats produced dose-dependent toxicity of spinal cord neuronal systems. Toxicity was enhanced by coadministration of glycine, but was significantly reduced when NMDA was co-administere...

journal_title：Acta neuropathologica

authors： Nag S,Riopelle RJ

更新日期：1990-01-01 00:00:00

abstract：:Mutations of isocitrate dehydrogenase 1 (IDH1) gene are most common in glioma, arguably preceding all known genetic alterations during tumor development. IDH1 mutations nearly invariably target the enzymatic active site Arg132, giving rise to the predominant IDH1R132H. Cells harboring IDH1 R132H -heterozygous mutation...

journal_title：Acta neuropathologica

authors： Tiburcio PDB,Xiao B,Berg S,Asper S,Lyne S,Zhang Y,Zhu X,Yan H,Huang LE

更新日期：2018-02-01 00:00:00

abstract：:Mutations in the gene coding for Sequestosome 1 (SQSTM1) have been genetically associated with amyotrophic lateral sclerosis (ALS) and Paget disease of bone. In the present study, we analyzed the SQSTM1 coding sequence for mutations in an extended cohort of 1,808 patients with frontotemporal lobar degeneration (FTLD),...

journal_title：Acta neuropathologica

authors： van der Zee J,Van Langenhove T,Kovacs GG,Dillen L,Deschamps W,Engelborghs S,Matěj R,Vandenbulcke M,Sieben A,Dermaut B,Smets K,Van Damme P,Merlin C,Laureys A,Van Den Broeck M,Mattheijssens M,Peeters K,Benussi L,Binetti

更新日期：2014-09-01 00:00:00

abstract：:The accumulation of misfolded α-synuclein (aSyn) and neuron loss define several neurodegenerative disorders including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). However, the precise relationship between pathology and neurotoxicity and why these processes disproportionately affect certain neuron subp...

journal_title：Acta neuropathologica

authors： Luna E,Decker SC,Riddle DM,Caputo A,Zhang B,Cole T,Caswell C,Xie SX,Lee VMY,Luk KC

更新日期：2018-06-01 00:00:00

abstract：:Gelatinase A is an enzyme capable of cleaving soluble beta-amyloid protein (beta AP), and may function as an alpha-secretase to produce secretory forms of amyloid precursor protein. We examined gelatinase A immunoreactivity in the brains and posterior roots of neurologically normal, lacunar stroke, Alzheimer disease (...

journal_title：Acta neuropathologica

authors： Yamada T,Miyazaki K,Koshikawa N,Takahashi M,Akatsu H,Yamamoto T

更新日期：1995-01-01 00:00:00

abstract：:Glucosylceramide lipidosis results from a defective lysosomal degradation of this glycolipid. Lipid degradation is controlled by two components, the enzyme beta-glucocerebrosidase and a sphingolipid activator protein. While most Gaucher cases are due to mutations within the gene that codes for the lysosomal enzyme, on...

journal_title：Acta neuropathologica

authors： Pàmpols T,Pineda M,Girós ML,Ferrer I,Cusi V,Chabás A,Sanmarti FX,Vanier MT,Christomanou H

更新日期：1999-01-01 00:00:00

abstract：:Skeins or skein-like inclusions, one of the two types of ubiquitinated intraneuronal inclusions in amyotrophic lateral sclerosis (ALS), in the neostriatum are not specific to the disease, but it has not yet been determined whether the other, spherical or crescent-shaped inclusions (SCI) are pathognomonic. To clarify t...

journal_title：Acta neuropathologica

authors： Kawashima T,Doh-ura K,Kikuchi H,Iwaki T

更新日期：2001-11-01 00:00:00

abstract：:In order to further evaluate the parameters whereby intracerebral administration of recombinant α-synuclein (αS) induces pathological phenotypes in mice, we conducted a series of studies where αS fibrils were injected into the brains of M83 (A53T) and M47 (E46K) αS transgenic (Tg) mice, and non-transgenic (nTg) mice. ...

journal_title：Acta neuropathologica

authors： Sacino AN,Brooks M,Thomas MA,McKinney AB,McGarvey NH,Rutherford NJ,Ceballos-Diaz C,Robertson J,Golde TE,Giasson BI

更新日期：2014-05-01 00:00:00

abstract：:Three cases of spinal tanycytic ependymoma are reported, a man aged 45 years and two women aged 36 and 55 years. Each patient developed gradual paraparesis over a few months prior to admission. Magnetic resonance imaging showed an enhancing, well-circumscribed tumor in the spinal cord in each case. Histologically, the...

journal_title：Acta neuropathologica

authors： Kawano N,Yagishita S,Oka H,Utsuki S,Kobayashi I,Suzuki S,Tachibana S,Fujii K

更新日期：2001-01-01 00:00:00

abstract：:The evolvement of amyloid beta (Abeta) deposition in the frontal cerebral cortex of 24 patients of increasing age with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D) was studied using end-specific monoclonal antibodies to Abetax-42 (Abeta42) or Abetax-40 (Abeta40) and markers for degenerating neu...

journal_title：Acta neuropathologica

authors： Maat-Schieman ML,Yamaguchi H,van Duinen SG,Natté R,Roos RA

更新日期：2000-04-01 00:00:00

abstract：:Experimental allergic neuritis was induced in Lewis rats by inoculation with autoreactive T cell lines sensitized to residue 57-81 of P2 myelin protein. Control rats received cells derived from immunization to complete Freund's adjuvant alone. Endoneurial fluid pressure (EFP) was measured in both sciatic nerves at 0, ...

journal_title：Acta neuropathologica

authors： Powell HC,Myers RR,Mizisin AP,Olee T,Brostoff SW

更新日期：1991-01-01 00:00:00

abstract：:This study reports the histological, ultrastructural, and immunocytochemical characteristics of intracytoplasmic eosinophilic inclusion bodies occurring in various types of neurons of the human central nervous system. By light microscopy, the inclusions were brightly eosinophilic, slightly birefringent, and sharply de...

journal_title：Acta neuropathologica

authors： Peña CE,Katoh A

更新日期：1989-01-01 00:00:00

abstract：:In a study designed to identify the neuropathological features typical of chronic inflammatory demyelinating polyneuropathy (CIDP), we reviewed the sural nerve biopsy findings in 105 patients with this disorder. The patients' mean age at biopsy was 49 years. In 65% of patients the disease had a progressive and in 35% ...

journal_title：Acta neuropathologica

authors： Rizzuto N,Morbin M,Cavallaro T,Ferrari S,Fallahi M,Galiazzo Rizzuto S

更新日期：1998-12-01 00:00:00

abstract：:Cryostat sections of 12 gliomas and of 3 peritumoral brain tissue samples were investigated for mononuclear cell infiltration by immunohistochemistry, concentrating on cells expressing monocyte/macrophage markers. Only low numbers of T cells were detected in the tumors, whereas in average 20%-30% of all cells present ...

journal_title：Acta neuropathologica

authors： Morimura T,Neuchrist C,Kitz K,Budka H,Scheiner O,Kraft D,Lassmann H

更新日期：1990-01-01 00:00:00

abstract：:Neuropathological studies have revealed that the brains of HIV-1-infected AIDS patients show the typical encephalitis and, in addition, neuronal loss. More recently, this neuronal cell loss has been thought to take place via programmed cell death (apoptosis) which has been demonstrated by an in situ end labelling (ISE...

journal_title：Acta neuropathologica

authors： An SF,Giometto B,Scaravilli T,Tavolato B,Gray F,Scaravilli F

更新日期：1996-01-01 00:00:00

abstract：:It is conventionally accepted that during the early stages of Wallerian degeneration of myelinated peripheral nerve fibres Schmidt-Lanterman incisures represent the sites at which the myelin sheath, together with enclosed axoplasm, is segmented into myelin ovoids. This mechanism is considered by some authors to be fac...

journal_title：Acta neuropathologica

authors： Ghabriel MN,Allt G

更新日期：1979-11-01 00:00:00

abstract：:We report a case of embryonal tumor with novel inclusion bodies occurring in the cerebellum of a 12-year-old girl. The tumor was histopathologically composed of small undifferentiated cells intermingled with a small number of rhabdoid cells, which had an ultrastructural feature of intermediate filament whorls. Immunoh...

journal_title：Acta neuropathologica

authors： Sasaki A,Kurihara H,Ishiuchi S,Hirato J,Saito N,Nakazato Y

更新日期：2005-07-01 00:00:00

abstract：:The neurone-centred view of the past disregarded or downplayed the role of astroglia as a primary component in the pathogenesis of neurological diseases. As this concept is changing, so is also the perceived role of astrocytes in the healthy and diseased brain and spinal cord. We have started to unravel the different ...

journal_title：Acta neuropathologica

authors： Pekny M,Pekna M,Messing A,Steinhäuser C,Lee JM,Parpura V,Hol EM,Sofroniew MV,Verkhratsky A

更新日期：2016-03-01 00:00:00

abstract：:We have developed a functional vegetative model by an 18-min clamping of the ascending aorta combined with a bypass formation between the aorta to right atrium and the aorta to femoral vein. Complete global brain ischemia (CGBI) induced for 18 min with this model provided the following distinct advantages: cardiopulmo...

journal_title：Acta neuropathologica

authors： Sato M,Hashimoto H,Kosaka F

更新日期：1990-01-01 00:00:00

abstract：:Surgical specimens of 4 intracranial saccular aneurysms were studied by scanning electron microscopy. The internal surface of the aneurysms showed crater-like defects and cytoplasmic bridges. In some areas the endothelium was preserved, but its longitudinal convolutions were higher and thicker than those found in unch...

journal_title：Acta neuropathologica

authors： Scanarini M,Mingrino S,Zuccarello M,Trincia G

更新日期：1978-11-15 00:00:00

abstract：:A 50-year-old carpenter died in Western Pennsylvania of rabies on January 4, 1979. He had been hospitalized in an intensive care unit for 28 days. The diagnosis was made postmortem from light and electron microscopic examination of central nervous system tissue. Immunofluorescence studies confirmed the diagnosis later...

journal_title：Acta neuropathologica

authors： Lamas CC,Martinez AJ,Baraff R,Bajwa J

更新日期：1980-01-01 00:00:00

abstract：:The gastrocnemius muscles of 3 groups of 10 rats, sacrified 5, 7, and 12 days respectively, following tenotomy, were submitted to different types of fixation, fixative and embedding. The occurrence of target fibres is shown not to be an artefact due to the histological procedures. Further examination demonstrates that...

journal_title：Acta neuropathologica

authors： De Reuck J,De Coster W,vander Eecken H

更新日期：1978-05-24 00:00:00

abstract：:Long-term epidemiological studies indicate that environmental factors play a causative role in high-incidence amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) in the western Pacific. An increased risk for disease is acquired in youth and remains for life. The low concentrations of calcium and magnesi...

journal_title：Acta neuropathologica

authors： Garruto RM,Shankar SK,Yanagihara R,Salazar AM,Amyx HL,Gajdusek DC

更新日期：1989-01-01 00:00:00

abstract：:Various parts of the central and peripheral nervous system of the mutant hamster with hind leg paralysis were studied in the electron microscope. A number of alterations involving the myelin sheath, the axon and certain neuronal perikarya were observed. Anterior horn cells were apparently well preserved. This conditio...

journal_title：Acta neuropathologica

authors： Hirano A

更新日期：1977-08-31 00:00:00

abstract：:A man of 75 years of age had had lightning pains in the legs for 8 years. Clinical examination demonstrated mild pyramidal signs and involvement of the posterior columns. A morphine pump was placed in the epidural space in the lumbar region to treat the pain. He died two weeks later from a massive pulmonary embolism. ...

journal_title：Acta neuropathologica

authors： Martin JJ,Cras P,De Schutter E

更新日期：1987-01-01 00:00:00

abstract：:An unusual case of concurrent MS and anaplastic astrocytoma is presented. MS was diagnosed in a female patient at the age of 22 years. A left side thalamotomy was performed for relief of severe intention tremor at age 28 and at age 32 she received immunosuppressive therapy for 1 year. At the age of 36 after a severe e...

journal_title：Acta neuropathologica

authors： Kalimo H,Frey H,Raine CS,Törmä T,Röyttä M

更新日期：1979-05-15 00:00:00

abstract：:We describe the clinical and neuropathological findings of three unrelated autopsy cases of MELAS harboring the A3243G transition in the mitochondrial DNA (mtDNA). Using immunohistochemical techniques, we studied the expression of several subunits of the respiratory chain in various brain regions from the same cases. ...

journal_title：Acta neuropathologica

authors： Sparaco M,Simonati A,Cavallaro T,Bartolomei L,Grauso M,Piscioli F,Morelli L,Rizzuto N

更新日期：2003-09-01 00:00:00

abstract：:Relatively little work has been done on the structural effects of organic lead in the central nervous system (CNS), although this form of lead may be a significant fraction of total brain lead. We tested a number of easily measured light-histological parameters of neuronal development in rats for sensitivity to (a) no...

journal_title：Acta neuropathologica

authors： Ferris NJ,Cragg BG

更新日期：1984-01-01 00:00:00

abstract：:A case of 14-year-old girl is reported in whom an alveolar rhabdomyosarcoma occurred in the soft tissues of the left forearm 4 years prior to death. Despite extensive surgery as well as chemotherapy and radiotherapy the tumor recurred locally and produced extensive metastases including a metastasis to the brain. Cereb...

journal_title：Acta neuropathologica

authors： Kleinert R,Beham A,Rosanelli G

更新日期：1985-01-01 00:00:00

abstract：:Two spontaneous neurodegenerative diseases of the horse, equine motor neuron disease (EMND) and equine degenerative myeloencephalopathy (EDM), have been associated with alpha-tocopherol deficiency, and both were characterized by prominent accumulations of endothelial lipopigment in the small vessels of the spinal cord...

journal_title：Acta neuropathologica

authors： Cummings JF,de Lahunta A,Mohammed HO,Divers TJ,Summers BA,Valentine BA,Jackson CA

更新日期：1995-01-01 00:00:00