Selective localization of gelatinase A, an enzyme degrading beta-amyloid protein, in white matter microglia and in Schwann cells.

abstract：:The cholinergic basal forebrain is divided into four subregions (Ch1-4), and cholinergic neuronal loss in the nucleus basalis of Meynert (Ch4) has been correlated with cognitive impairments in both Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). However, the Ch1-2 regions, which provide the major choline...

journal_title：Acta neuropathologica

authors： Fujishiro H,Umegaki H,Isojima D,Akatsu H,Iguchi A,Kosaka K

更新日期：2006-02-01 00:00:00

abstract：:A case of 14-year-old girl is reported in whom an alveolar rhabdomyosarcoma occurred in the soft tissues of the left forearm 4 years prior to death. Despite extensive surgery as well as chemotherapy and radiotherapy the tumor recurred locally and produced extensive metastases including a metastasis to the brain. Cereb...

journal_title：Acta neuropathologica

authors： Kleinert R,Beham A,Rosanelli G

更新日期：1985-01-01 00:00:00

abstract：:The accumulation of calcium in the hippocampal and thalamic vascular endothelium and the perivascular space was detected histochemically by means of the pyroantimonate technique 30, 60 and 120 min after systemic kainic acid administration. An increased number of calcium pyroantimonate deposits was found in the endothe...

journal_title：Acta neuropathologica

authors： Sztriha L,Joo F

更新日期：1986-01-01 00:00:00

abstract：:Electronmicroscope studies have been performed on the greater splanchnic nerve and the nerve to the medial head of gastrocnemius muscle of control and acrylamide poisoned cats. Degeneration of unmyelinated as well as of myelinated fibres was observed in both nerves. In cats severely poisoned with acrylamide, some very...

journal_title：Acta neuropathologica

authors： Post EJ

更新日期：1978-04-26 00:00:00

abstract：:Myotubular myopathy and centronuclear myopathies (CNM) are congenital myopathies characterized by generalized muscle weakness and mislocalization of muscle fiber nuclei. Genetically distinct forms exist, and mutations in BIN1 were recently identified in autosomal recessive cases (ARCNM). Amphiphysins have been implica...

journal_title：Acta neuropathologica

authors： Toussaint A,Cowling BS,Hnia K,Mohr M,Oldfors A,Schwab Y,Yis U,Maisonobe T,Stojkovic T,Wallgren-Pettersson C,Laugel V,Echaniz-Laguna A,Mandel JL,Nishino I,Laporte J

更新日期：2011-02-01 00:00:00

abstract：:Basal ganglionic lesions in three young infants were found in a prospective search for early stages of status marmoratus. The lesions had formed and had passed into glial scars well before myelination of the basal ganglia commenced. The myelinating fibers crossing the scarred tissue were disoriented; however, fiber st...

journal_title：Acta neuropathologica

authors： Friede RL,Schachenmayr W

更新日期：1977-05-16 00:00:00

abstract：:In our recent ultrastructural studies on synapses of the nucleus dorsalis, central cervical nucleus, and anterior horn of the spinal cord of the normal cat we happened to find spheroids and several types of axonal alterations. These spheroids were up to 39 micrometer in diameter. They were found in myelinated and unmy...

journal_title：Acta neuropathologica

authors： Saito K

更新日期：1980-01-01 00:00:00

abstract：:Neuropeptides have turned out to be promising new parameters, in addition to the routinely performed histochemical diagnosis, of Hirschsprung's disease (HD). Studies of the peptidergic innervation of the affected intestinal segment of patients with HD have demonstrated a marked reduction in the density of several neur...

journal_title：Acta neuropathologica

authors： Berger A,Kofler B,Santic R,Zipperer E,Sperl W,Hauser-Kronberger C

更新日期：2003-01-01 00:00:00

abstract：:Observations have been made on the structure of the paranodal region at nodes of Ranvier in the sural nerve of patients with diabetic sensory polyneuropathy. The structure of the paranodes was examined with particular attention to the definition and assessment of axoglial dysjunction, which has been claimed to be a ch...

journal_title：Acta neuropathologica

authors： Thomas PK,Beamish NG,Small JR,King RH,Tesfaye S,Ward JD,Tsigos C,Young RJ,Boulton AJ

更新日期：1996-12-01 00:00:00

abstract：:Six medulloblastomas were studied by electron microscopy. Two features were found which seem to be constant and essential characteristics of medulloblastoma. First, cell junctions are abundant between tumor cells. These are mostly desmosome-like but other, closer junctions, were also seen. Second, the capillary endoth...

journal_title：Acta neuropathologica

authors： Hassoun J,Hirano A,Zimmerman HM

更新日期：1975-10-27 00:00:00

abstract：:Defects of major histocompatibility complex (MHC) class I antigen-processing machinery (APM) components have been shown to contribute to immune escape of malignant cells. We investigated the expression of APM components in astrocytomas without detectable defects in HLA class I antigen expression and correlated it with...

journal_title：Acta neuropathologica

authors： Mehling M,Simon P,Mittelbronn M,Meyermann R,Ferrone S,Weller M,Wiendl H

更新日期：2007-08-01 00:00:00

abstract：:Upon brain reperfusion following ischemia, there is widespread inhibition of neuronal protein synthesis that is due to phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha), which persists in selectively vulnerable neurons (SVNs) destined to die. Other investigators have shown that expression of mutant eI...

journal_title：Acta neuropathologica

authors： Page AB,Owen CR,Kumar R,Miller JM,Rafols JA,White BC,DeGracia DJ,Krause GS

更新日期：2003-07-01 00:00:00

abstract：:Using immunohistochemical methods optimized to detect herpes simplex virus type 2 (HSV-2) antigen, paraffin sections from human central nervous system tissues from 31 cases pathologically diagnosed as multiple sclerosis (MS), 34 cases of other neurological diseases, 4 adult cases of HSV encephalitis, and mouse brains ...

journal_title：Acta neuropathologica

authors： Martin JR,Holt RK,Webster HD

更新日期：1988-01-01 00:00:00

abstract：:APO2 ligand (APO2L)/TRAIL is a novel member of the tumor necrosis factor cytokine family and a potent inducer of apoptosis in tumor cell lines. We recently reported that APO2L is consistently expressed in low-grade astrocytomas, anaplastic astrocytomas, glioblastomas, and cell lines derived thereof, and that malignant...

journal_title：Acta neuropathologica

authors： Nakamura M,Rieger J,Weller M,Kim J,Kleihues P,Ohgaki H

更新日期：2000-01-01 00:00:00

abstract：:The conventional concept of Pick's disease does not distinguish Pick's disease with Pick bodies (Pick body disease, PBD) from Pick's disease without Pick bodies [lobar atrophy without Pick bodies, LA-PB(-)]. Recently, intraneuronal ubiquitin-positive inclusions (ub-inclusions), which are thought to be a hallmark of am...

journal_title：Acta neuropathologica

authors： Ikeda K,Akiyama H,Arai T,Ueno H,Tsuchiya K,Kosaka K

更新日期：2002-07-01 00:00:00

abstract：:Cornelia de Lange syndrome (CDLS) is a rare multisystemic malformative syndrome of uncertain etiology characterized by severe psychomotor and mental retardation. Here we report the neuropathological analysis of a 35-year-old patient who displayed the classical clinical symptomatology of CDLS. A congenital dysgenesis o...

journal_title：Acta neuropathologica

authors： Vuilleumier N,Kövari E,Michon A,Hof PR,Mentenopoulos G,Giannakopoulos P,Bouras C

更新日期：2002-09-01 00:00:00

abstract：:Two young zebra siblings from consecutive pregnancies suffered from neurological disease, characterized by ventral deviation of the neck and tetraparesis which progressed to tetraplegia within a few weeks. On histological examination widespread neuronal degeneration was observed in the ventral horns of the spinal cord...

journal_title：Acta neuropathologica

authors： Higgins RJ,Vandevelde M,Hoff EJ,Jagar JE,Cork LC,Silberman MS

更新日期：1977-01-31 00:00:00

abstract：:The nature and distribution of vascular changes in acute Wernicke's encephalopathy (WE) were analyzed in three autopsy cases. Lesions of the lateral vestibular nucleus of the medulla oblongata (three cases) and lateral ventricular wall (one case) were examined by reconstruction of 200 serial sections, and the capillar...

journal_title：Acta neuropathologica

authors： Okeda R,Taki K,Ikari R,Funata N

更新日期：1995-01-01 00:00:00

abstract：:A quantitative study was performed on spinal cord lesions in seven patients with X-linked recessive spinal and bulbar muscular atrophy. The myelinated fiber density of the lateral corticospinal tracts at the T7 cord level was well preserved for both large and small myelinated fibers. On the other hand, neurons in the ...

journal_title：Acta neuropathologica

authors： Terao S,Sobue G,Li M,Hashizume Y,Tanaka F,Mitsuma T

更新日期：1997-01-01 00:00:00

abstract：:The extent of DNA fragmentation analysed using the TUNEL technique was evaluated in post-mortem human brain tissue. Twenty-four patients with clinical and histopathological diagnosis of Alzheimer's disease (AD) and a short post-mortem delay were analysed. We report an increase in the count of TUNEL-labelled cells as t...

journal_title：Acta neuropathologica

authors： Overmyer M,Kraszpulski M,Helisalmi S,Soininen H,Alafuzoff I

更新日期：2000-12-01 00:00:00

abstract：:The present investigation examined the morphological characteristics of epiplexus macrophages following a single intracisternal injection of the antigen, bacillus Calmette-Guerin (BCG). Three days following injection of BCG (0.5 - 4.0 X 10(8) viable microorganisms), mongrel dogs were perfused with buffered aldehydes. ...

journal_title：Acta neuropathologica

authors： Merchant RE

更新日期：1979-08-01 00:00:00

abstract：:In the cytoplasm of Schwann cells of a sural nerve biopsy from a 21-year-old female patient with chronic neuropathy we noted numerous unique, usually double membrane-bound, osmiophilic, granular or globular inclusions, approximately 30-600 microm in diameter. Some of these membrane-bound vesicular or tubular structure...

journal_title：Acta neuropathologica

authors： Schröder JM,Wang JF,Sindern E,Malin JP

更新日期：1999-10-01 00:00:00

abstract：:Histamine dihydrochloride (10 micrograms of 500 micrograms/ml) was infused during 1 min into the lateral cerebral ventricle of rats, which resulted in a significant stimulation of pinocytosis in the endothelial cells. Systemic injections of mepyramine or metiamide could not prevent this activation. In contrast, raniti...

journal_title：Acta neuropathologica

authors： Dux E,Dóczi T,Joó F,Szerdahelyi P,Siklós L

更新日期：1988-01-01 00:00:00

abstract：:In chronic granulomatous disease (CGD) enzyme-deficient neutrophils and mononuclear cells lack the respiratory burst required for biocidal activity. Recurrent infections lead to granulomas in various organs but brain lesions are rare. In the present case, a 23-year-old male with numerous infections since early childho...

journal_title：Acta neuropathologica

authors： Hadfield MG,Ghatak NR,Laine FJ,Myer EC,Massie FS,Kramer WM

更新日期：1991-01-01 00:00:00

abstract：:The kidney of a 7-month-old male Cairn terrier with globoid cell leukodystrophy (GLD) was investigated with light and electron microscopes. A few tubular epithelial cells in the inner medulla as well as some exfoliated cells in the lumina revealed PAS-positive cytoplasm in which needle-like structures were to be seen ...

journal_title：Acta neuropathologica

authors： Suzuki K

更新日期：1986-01-01 00:00:00

abstract：:A histopathological study was carried out on the brains of eight ex-boxers (ages 56 to 83) using conventional histological staining methods and immunocytochemistry with antibodies to amyloid beta-protein and the PHF-related tau protein. All cases showed a large number of tau-immunoreactive neurofibrillary tangles and ...

journal_title：Acta neuropathologica

authors： Tokuda T,Ikeda S,Yanagisawa N,Ihara Y,Glenner GG

更新日期：1991-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have identified several new molecular constituents of ALS-linked cellular aggregates, including FUS, TDP-43, OPTN, UBQLN2 and the translational product...

journal_title：Acta neuropathologica

authors： Blokhuis AM,Groen EJ,Koppers M,van den Berg LH,Pasterkamp RJ

更新日期：2013-06-01 00:00:00

abstract：:Acute arterial hypertension was induced in male Wistar rats using two experimental techniques: (1) i.v. injection of Aramine and (2) infusion of physiological saline as a bolus via internal carotid artery. Horseradish peroxidase (HRP) was injected i.v. prior to both experimental procedures and subsequently localized i...

journal_title：Acta neuropathologica

authors： Nagy Z,Mathieson G,Hüttner I

更新日期：1979-10-01 00:00:00

abstract：:Hydrocephalic neonates were observed in a small breeding colony of rats. Normal rats from this colony were obtained and brother-sister mated for seven generations. The overall prevalence of hydrocephalics was approximately 23%; however, in one subline, the prevalence approached 50%. Breeding data suggested the trait t...

journal_title：Acta neuropathologica

authors： Kohn DF,Chinookoswong N,Chou SM

更新日期：1981-01-01 00:00:00

abstract：:It is conventionally accepted that during the early stages of Wallerian degeneration of myelinated peripheral nerve fibres Schmidt-Lanterman incisures represent the sites at which the myelin sheath, together with enclosed axoplasm, is segmented into myelin ovoids. This mechanism is considered by some authors to be fac...

journal_title：Acta neuropathologica

authors： Ghabriel MN,Allt G

更新日期：1979-11-01 00:00:00