Abstract：
:Surgical specimens of 4 intracranial saccular aneurysms were studied by scanning electron microscopy. The internal surface of the aneurysms showed crater-like defects and cytoplasmic bridges. In some areas the endothelium was preserved, but its longitudinal convolutions were higher and thicker than those found in unchanged areas. On the damaged endothelial surface there was an increased number of blood cells. The adventitia resembled that of a normal cerebral artery. In conclusion the alterations observed are similar to those found in atherosclerosis and are most likely due to the high wear and tear provoked by the blood streaming into the aneurysm. The results of this study are in agreement with the findings of a companion transmission electron microscopy study and emphasize the importance of degenerative changes on the development and rupture of intracranial saccular aneurysms.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Scanarini M,Mingrino S,Zuccarello M,Trincia Gdoi
10.1007/BF00691478subject
Has Abstractpub_date
1978-11-15 00:00:00pages
131-4issue
2eissn
0001-6322issn
1432-0533journal_volume
44pub_type
杂志文章abstract：:An immunoperoxidase technique was used to locate synaptophysin (protein p38), a major integral membrane glycoprotein of synaptic vesicles, in the rat brain. In addition to a diffuse distribution of nerve terminal stainings for synaptophysin appearing as numerous small puncta, the large-sized cells with spindled or pol...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00304146
更新日期：1993-01-01 00:00:00
abstract：:We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identifie...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294437
更新日期：1991-01-01 00:00:00
abstract：:The nuclei for the nerves of a dorsal (m. splenius) and a ventral (m. longus capitis) neck muscle of the rat were retrogradely labeled by applying horseradish peroxidase (HRP) to the respective cut muscle nerves. Motoneurons of both muscles were analyzed for their localization, diameter of perikarya, and area of dendr...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690368
更新日期：1981-01-01 00:00:00
abstract：:We examined whether the Golgi apparatus (GA) is fragmented in nigral neurons in 18 cases with Parkinson's disease (PD) and in 8 control cases. The nigral neurons in cases with PD showed various degrees of Lewy pathology with alpha-synuclein immunohistochemistry, and we divided the neurons into three subtypes according...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0114-4
更新日期：2006-09-01 00:00:00
abstract：:APO2 ligand (APO2L)/TRAIL is a novel member of the tumor necrosis factor cytokine family and a potent inducer of apoptosis in tumor cell lines. We recently reported that APO2L is consistently expressed in low-grade astrocytomas, anaplastic astrocytomas, glioblastomas, and cell lines derived thereof, and that malignant...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/pl00007399
更新日期：2000-01-01 00:00:00
abstract：:CD44 antigen (CD44), the principle cell surface receptor for hyaluronate, is up-regulated in the human demyelinating disease multiple sclerosis on fibrous astrocytes. As astrocytes are the main target cell of canine distemper virus (CDV), the consequences of a CDV infection on the CD44 expression and distribution in b...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/pl00007417
更新日期：2000-02-01 00:00:00
abstract：:This study tests the effects of chronic electrostimulation on denervated/reinnervated skeletal muscle in producing an optimal restoration of size and mechanical and histochemical properties. We compared tibialis anterior muscles in four groups of rats: in unoperated control (C) and 10 weeks following nerve lesion with...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0035-2
更新日期：2006-06-01 00:00:00
abstract：:We recently examined the brain from an 8-month-old infant with Down's syndrome and found argyrophilic plaque-like deposits throughout the neocortex and cerebellum. To ascertain the specificity of this observation, we examined 27 additional brains from the pediatric autopsy service, including 1 from another patient wit...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294258
更新日期：1995-01-01 00:00:00
abstract：:Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by the expansion of a polyglutamine tract in the androgen receptor (AR). The mechanism by which expansion of polyglutamine in AR causes muscle atrophy is unknown. Here, we investigated pathological pathways underlying muscle atrophy in SBMA kn...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-016-1550-4
更新日期：2016-07-01 00:00:00
abstract：:Long-term epidemiological studies indicate that environmental factors play a causative role in high-incidence amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) in the western Pacific. An increased risk for disease is acquired in youth and remains for life. The low concentrations of calcium and magnesi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688211
更新日期：1989-01-01 00:00:00
abstract：:Two cases of Central neurocytoma arising in the lateral ventricles are presented. Both patients had well-circumscribed masses in the right lateral ventricle causing hydrocephalus. The tumors were composed of small round cells forming Homer Wright rosettes against a fine fibrillary background. In one patient surgical r...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687981
更新日期：1986-01-01 00:00:00
abstract：:This study was undertaken to elucidate morphological changes in the synaptic area of the Purkinje cell dendritic spines when granule cells were decreased in number. The mice were injected s.c. with 30 mg/kg b.w. of cytosine arabinoside on days 2, 3, and 4, and on days 7, 8 and 9, and were designated as group I and gro...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685343
更新日期：1983-01-01 00:00:00
abstract：:A retrospective study of 450 consecutive AIDS autopsy cases (397 males, 53 females; mean age at death 38.4 years) in Vienna, Austria, between 1984 and 1999 compares the central nervous system (CNS) findings in three cohorts: 1984-1992 (190 cases), 1993-1995 (162 cases) and 1996-1999 (98 cases, after introduction of tr...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000245
更新日期：2000-08-01 00:00:00
abstract：:Conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer's disease (LOAD). Mutations and/or differential expression of microglial specific receptors such as TREM2, CD33, and CR3 have been associated wi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1737-3
更新日期：2017-11-01 00:00:00
abstract：:The identification of the alpha-synuclein gene on chromosome 4q as a locus for familial Lewy-body parkinsonism and of alpha-synuclein as a component of Lewy bodies has heralded a new era in the study of Parkinson's disease. We have identified a large family with Lewy body parkinsonism linked to a novel locus on chromo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051177
更新日期：2000-06-01 00:00:00
abstract：:In hereditary myopathy of the diaphragmatic muscles in Holstein-Friesian cattle, the largest number of acidophilic intracytoplasmic inclusions was found in the myocardium. These inclusions, which were oval and measured 12-15 microm in the transverse sections, were characterized by a dense, amorphous zone, and a relati...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050972
更新日期：1999-02-01 00:00:00
abstract：:We studied a case of primary leptomeningeal glioma (PLG) on the left parietal lobe of a 74-year-old woman and compared the tissue with heterotopic glial tissue from another case. The PLG tumor consisted of spindle-shaped cells with marked nuclear atypism, which tended to be arranged in a fascicular pattern, and the ma...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00310033
更新日期：1992-01-01 00:00:00
abstract：:Observations have been made on the structure of the paranodal region at nodes of Ranvier in the sural nerve of patients with diabetic sensory polyneuropathy. The structure of the paranodes was examined with particular attention to the definition and assessment of axoglial dysjunction, which has been claimed to be a ch...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050569
更新日期：1996-12-01 00:00:00
abstract：:Pilocytic astrocytomas are the most common astrocytic tumors of childhood and differ clinically and histopathologically from those astrocytomas that affect adults. Studies of adult astrocytic tumors have revealed allelic losses on chromosomes 10, 17p, 19q and alterations in the epidermal growth factor receptor (EGFR) ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00454903
更新日期：1993-01-01 00:00:00
abstract：:Uniform neuropathological changes are described in eight cases of the progressive encephalopathy syndrome with edema, hypsarrhythmia and optic atrophy (PEHO syndrome). Two of the autopsied patients were sisters and two other cases were familial. Macroscopically, cerebral and pronounced cerebellar atrophy was seen, the...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00227717
更新日期：1993-01-01 00:00:00
abstract：:Unusual inclusions with some of the features of "reducing bodies" were encountered in the skeletal muscle biopsy of a 2.5-year-old boy with childhood-onset acid maltase deficiency. The biopsy revealed a vacuolar myopathy with lysosomal storage of glycogen and eosinophilic refractile inclusions in myofibers, which appe...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00304641
更新日期：1992-01-01 00:00:00
abstract：:This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive con...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00227818
更新日期：1992-01-01 00:00:00
abstract：:The mechanism of inflammatory demyelination in canine distemper encephalitis (CDE) is uncertain but macrophages are thought to play an important effector role in this lesion. Serum and cerebrospinal fluid (CSF), containing anti-canine distemper virus and anti-myelin antibodies from dogs with CDE were tested for their ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688176
更新日期：1989-01-01 00:00:00
abstract：:An 18 month old cat had a 6 month history of abnormal high stepping gait, ataxia, muscle twitching and loss of sensory perception. The clinical course was interrupted by several episodes of temporary remission. The essential pathological features were those of a polyradiculoneuritis with segmental demyelination, focal...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00689561
更新日期：1978-01-19 00:00:00
abstract：:Most cases of frontotemporal lobar degeneration (FTLD) are characterized by abnormal intracellular accumulation of either tau or TDP-43 protein. However, in ~10% of cases, composed of a heterogenous collection of uncommon disorders, the molecular basis remains to be uncertain. We recently discovered that the pathologi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-010-0764-0
更新日期：2011-02-01 00:00:00
abstract：:The peripheral immune system plays a critical role in aging and in the response to brain injury. Emerging data suggest inflammatory responses are exacerbated in older animals following ischemic stroke; however, our understanding of these age-related changes is poor. In this work, we demonstrate marked differences in t...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-018-1859-2
更新日期：2018-07-01 00:00:00
abstract：:We report the case of an 11-year-old male who developed subacute diffuse polyradiculoneuropathy, associated with digestive symptoms and Epstein-Barr virus infection. Parental consanguinity was present. The laboratory findings including bone marrow smear were consistent with hemophagocytic lymphohistiocytosis (HLH). El...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0897-0
更新日期：2004-10-01 00:00:00
abstract：:In search of novel genes associated with glioma pathogenesis, we have previously shown frequent deletions of the KIAA1797/FOCAD gene in malignant gliomas, and a tumor suppressor function of the encoded focadhesin impacting proliferation and migration of glioma cells in vitro and in vivo. Here, we examined an associati...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-019-02067-z
更新日期：2020-01-01 00:00:00
abstract：:Eleven atypical teratoid/rhabdoid tumors (AT/RT) and 121 primitive neuroectodermal tumors/medulloblastomas (PNET/MB) were included in this study for evaluation of the histopathological features of AT/RT and comparison between AT/RT and PNET/MB. Histopathological studies of AT/RT showed that in addition to the commonly...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051149
更新日期：2000-05-01 00:00:00
abstract：:The colocalization of beta amyloid protein with the enzymes acetyl- and butyrylcholinesterase was assessed using immunocytochemistry for beta amyloid protein and a sensitive histochemical technique for cholinesterases. In non-demented aged and Alzheimer's disease brains, double-stained sections for cholinesterases and...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00334445
更新日期：1993-01-01 00:00:00
