Abstract：
:We examined whether the Golgi apparatus (GA) is fragmented in nigral neurons in 18 cases with Parkinson's disease (PD) and in 8 control cases. The nigral neurons in cases with PD showed various degrees of Lewy pathology with alpha-synuclein immunohistochemistry, and we divided the neurons into three subtypes according to differences in alpha-synuclein immunoreactivity: (1) neurons without pale bodies or Lewy bodies, (2) neurons with pale bodies, and (3) neurons with Lewy bodies. In controls, we did not observe fragmented GA in nigral neurons by immunocytochemistry with an anti-TGN46 antibody. In PD, the GA was fragmented in 3% of the nigral neurons without inclusions, and in 5% of the neurons with Lewy bodies. In contrast, fragmented GA was noted in 19% of the neurons containing pale bodies. Since pale bodies represent early stages in the development of brainstem Lewy bodies, our results suggest that the cytotoxicity of alpha-synuclein-positive aggregates is reduced in the process of Lewy body formation.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Fujita Y,Ohama E,Takatama M,Al-Sarraj S,Okamoto Kdoi
10.1007/s00401-006-0114-4subject
Has Abstractpub_date
2006-09-01 00:00:00pages
261-5issue
3eissn
0001-6322issn
1432-0533journal_volume
112pub_type
杂志文章abstract：:Interleukin-6 (IL-6) immunoreactivity has previously been shown in plaques in Alzheimer's disease (AD) and elevated IL-6 concentrations have been measured biochemically in brains of AD patients. In this study, we investigated the appearance of IL-6 immunoreactivity in AD plaques according to the stage of plaque format...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00571510
更新日期：1995-01-01 00:00:00
abstract：:Healthy nodes of Ranvier are crucial for action potential propagation along myelinated axons, both in the central and in the peripheral nervous system. Surprisingly, the node of Ranvier has often been neglected when describing CNS disorders, with most pathologies classified simply as being due to neuronal defects in t...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-014-1305-z
更新日期：2014-08-01 00:00:00
abstract：:Respiratory chain dysfunction leads to reactive oxygen species (ROS) generation with following oxidative stress and cellular damage. A histochemical and immunohistochemical study was performed on muscle biopsies from 17 patients with mitochondrial disease [chronic progressive external ophthalmoplegia (CPEO), mitochond...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100455
更新日期：2002-03-01 00:00:00
abstract：:Structural proteins of cultured neurofibromatosis (NF) tumor and skin cells were studied with reference to control skin fibroblasts. In polyacrylamide gel electrophoresis (PAGE)/fluorography the banding patterns of the cell lysates were markedly similar. NF tumor cells, however, produced a 60 kD band with a stronger a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687332
更新日期：1984-01-01 00:00:00
abstract：:We report a sporadic tauopathy of 6-year duration in a 76-year-old woman. Her initial symptoms were asymmetrical parkinsonism and muscle weakness, with apraxia appearing 2 years later. The brain showed frontal and temporal cerebral atrophy; severe neuronal loss and gliosis were observed in the precentral cortex (loss ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-1086-5
更新日期：2005-12-01 00:00:00
abstract：:Cerebral β-amyloidosis can be exogenously induced by the intracerebral injection of brain extracts containing aggregated β-amyloid (Aβ) into young, pre-depositing Aβ precursor protein- (APP) transgenic mice. Previous work has shown that the induction involves a prion-like seeding mechanism in which the seeding agent i...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-014-1339-2
更新日期：2014-10-01 00:00:00
abstract：:Transient forebrain ischemia produces a spatially and temporally selective pattern of neuronal degeneration in the hippocampal formation of the Mongolian gerbil. Ischemic neuronal death has been suggested to depend on the activation of excitatory hippocampal pathways that project to the vulnerable neurons. This idea w...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687758
更新日期：1989-01-01 00:00:00
abstract：:A complex neuropathological study of two cases of Niemann-Pick disease (NPD) type C (NPDC) revealed some novel features in the chemical pathology of the neuronal storage. Lipid histochemistry showed the presence of a lipid which met the criteria of a neuronal glycosphingolipid. Sphingomyelin (SM) was not detected in t...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690966
更新日期：1985-01-01 00:00:00
abstract：:To assess whether amyloid plaque accumulation in the monkey brain can account for age-related cognitive impairment that begins at about 20 years of age, we measured plaque content in the brains of 14 rhesus monkeys aged 5-30 years. We used immunohistochemistry employing the monoclonal antibody 6E10, which is specific ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050735
更新日期：1997-11-01 00:00:00
abstract：:The choroid plexus is an epithelial-endothelial vascular convolute within the ventricular system of the vertebrate brain. It consists of epithelial cells, fenestrated blood vessels, and the stroma, dependent on various physiological or pathological conditions, which may contain fibroblasts, mast cells, macrophages, gr...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-009-0627-8
更新日期：2010-01-01 00:00:00
abstract：:This ultrastructural study deals with the synapses of primary dendrites of the anterior horn neurons in the lower lumbar spinal cords of seven patients with amyotrophic lateral sclerosis (ALS) who had mild neuronal depletion. Specimens from seven age-matched, neurologically normal individuals served as controls. In ea...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050426
更新日期：1996-01-01 00:00:00
abstract：:When 22 members of the BrainNet Europe (BNE) consortium assessed 31 cases with alpha-synuclein (alphaS) immunoreactive (IR) pathology applying the consensus protocol described by McKeith and colleagues in 2005, the inter-observer agreement was 80%, being lowest in the limbic category (73%). When applying the staging p...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-009-0523-2
更新日期：2009-06-01 00:00:00
abstract：:Human immune deficiency virus (HIV) disease may be associated, neuropathologically, with significant neuronal loss and clinically with a severe dementia. However, the significance of neuronal loss in the development of dementia has not been established. In this study we have undertaken a stereological determination of...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00296490
更新日期：1994-01-01 00:00:00
abstract：:The effect of induced hypertension instituted after a 2-h delay following middle cerebral artery occlusion (MCAO) on brain edema formation and histochemical injury was studied. Under isoflurane anesthesia, the MCA of 14 spontaneously hypertensive rats was occluded. In the control group (n = 7), the mean arterial press...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00305878
更新日期：1991-01-01 00:00:00
abstract：:Lectin-binding sites located on the endothelial cell (EC) surfaces in unaltered, leaking and resorbing micro-blood vessels (MBVs) in cryo-injured cat brain were studied. Lectin or glycoprotein-gold complexes and brain samples embedded in hydrophilic resin Lowicryl K4M were used. The lectins tested recognize the follow...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691427
更新日期：1986-01-01 00:00:00
abstract：:Immunohistochemical techniques were employed to examine the changes in free ubiquitin within the hippocampus 1, 3, 7, 14, and 30 days after a unilateral perforant pathway lesion occurred in the rat brain. Immunoreactivity for ubiquitin was remarkably decreased in the cell body and proximal dendrites of neurons through...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-001-0489-1
更新日期：2002-05-01 00:00:00
abstract：:Amyloid-beta (Abeta) deposition in cerebral blood vessel walls is one of the key features of Alzheimer's disease (AD). Abeta(1-40) carrying the "Dutch" mutation (DAbeta(1-40)) induces rapid degeneration of cultured human brain pericytes (HBP). To study the mechanisms of this Abeta-induced toxicity, a comparative cDNA ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0585-x
更新日期：2002-11-01 00:00:00
abstract：:Aberrant peripheral nerve fiber bundles, i.e., masses of peripheral nerve fibers without perineural sheath cells, are found in the perivascular spaces of some spinal cords. The 514 spinal cords examined for these structures were separated into two groups; 507 spinal cords without definite necrotic lesions (group 1) an...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308951
更新日期：1989-01-01 00:00:00
abstract：:Human adenovirus type 12 (Ad 12) was inoculated intraperitoneally, intrapleurally, intramuscularly or subcutaneously into newborn rodents. Tumors developed preferentially in the peritoneal cavities in 93.9% of the hamsters and 82.6% of the mice, but none in rats; in contrast to the high incidence of brain tumors in ra...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687575
更新日期：1989-01-01 00:00:00
abstract：:Axonal degeneration contributes to the transient and permanent neurological deficits seen in multiple sclerosis, an inflammatory disease of the central nervous system. To study the immunological mechanisms causing axonal degeneration, we induced experimental autoimmune encephalomyelitis (EAE) in wildtype Lewis rats an...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0047-y
更新日期：2006-06-01 00:00:00
abstract：:We studied a 27-year-old woman who died after a 6-year history of progressive dementia, dystonia, ataxia, apraxia, spasticity, choreoathetosis, visual and auditory hallucinations, and optic atrophy. Magnetic resonance imaging showed decreased intensity in the globus pallidus, substantia nigra, and dentate nuclei in T2...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000224
更新日期：2000-11-01 00:00:00
abstract：:Progression of neuritic dystrophy is a histological hallmark of Alzheimer's disease (AD) in addition to amyloid deposition and neurofibrillary tangle formation. Dystrophic neurites (DNs) are abnormal neurites, and are closely associated with amyloid deposits. To clarify the process of DN formation, we immunohistochemi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0907-2
更新日期：2004-11-01 00:00:00
abstract：:MicroRNA (miRNA) expression was assessed in human cerebral cortical gray matter (GM) and white matter (WM) in order to provide the first insights into the difference between GM and WM miRNA repertoires across a range of Alzheimer's disease (AD) pathology. RNA was isolated separately from GM and WM portions of superior...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-010-0756-0
更新日期：2011-02-01 00:00:00
abstract：:The alterations in oligodendrocytes in myelin basic protein-induced acute experimental autoimmune encephalomyelitis (EAE) in the Lewis rat were studied using the technique of pre-embedding immunolabelling with the Rip monoclonal antibody, which specifically labels the cytoplasm of the cell bodies and processes of olig...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050763
更新日期：1998-01-01 00:00:00
abstract：:Observations have been made on the structure of the paranodal region at nodes of Ranvier in the sural nerve of patients with diabetic sensory polyneuropathy. The structure of the paranodes was examined with particular attention to the definition and assessment of axoglial dysjunction, which has been claimed to be a ch...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050569
更新日期：1996-12-01 00:00:00
abstract：:In a large series of 116 cortical resections for treatment of medically intractable epilepsy, 10 glial hamartomas and 11 neuronoglial malformative lesions were found. Glial hamartomas were astrocytic in 3 cases, oligodendrocytic in 6 and mixed oligoastrocytic in 1. Neuronoglial lesions corresponded to "focal cortical ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00296190
更新日期：1994-01-01 00:00:00
abstract：:We recently examined the brain from an 8-month-old infant with Down's syndrome and found argyrophilic plaque-like deposits throughout the neocortex and cerebellum. To ascertain the specificity of this observation, we examined 27 additional brains from the pediatric autopsy service, including 1 from another patient wit...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294258
更新日期：1995-01-01 00:00:00
abstract：:Remyelination in multiple sclerosis (MS) lesions often remains incomplete despite the presence of oligodendrocyte progenitor cells (OPCs). Amongst other factors, successful remyelination depends on the phagocytic clearance of myelin debris. However, the proteins in myelin debris that act as potent and selective inhibi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-015-1521-1
更新日期：2016-02-01 00:00:00
abstract：:A case of progressive polyneuropathy associated with Waldenström's macroglobulinaemia is reported. A monoclonal IgM-lambda gradient was detected in the serum and cerebro-spinal fluid. By electro-immunoblot analysis antibodies against myelin-associated glycoprotein were found in the serum and cerebro-spinal fluid. The ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690395
更新日期：1984-01-01 00:00:00
abstract：:The neuropathologic findings in the brain of a National Aeronautics and Space Administration (NASA) engineer, who died subsequent to nitrogen inhalation, are reported. Findings which are unusual in other forms of anoxia included relative preservation of neurons in the Sommer sector of the hippocampus and a pattern of ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688632
更新日期：1985-01-01 00:00:00
