Abstract:
:Human adenovirus type 12 (Ad 12) was inoculated intraperitoneally, intrapleurally, intramuscularly or subcutaneously into newborn rodents. Tumors developed preferentially in the peritoneal cavities in 93.9% of the hamsters and 82.6% of the mice, but none in rats; in contrast to the high incidence of brain tumors in rats when the virus is injected intracranially. Serial section of peritoneal tissues and muscle of hamsters revealed multicentric microtumors with a close relation to peripheral nerve fibers 10 to 35 days after virus inoculation. Histologically, most tumors consisted of closely packed, irregularly arranged, small spindle or tadpole-shaped cells. However, divergent morphological differentiation showing palisade arrangement of spongioblastic tumor cells forming trabeculae, pseudorosettes with or without central blood vessel, and true rosettes of immature ependymal (ependymoblastic) or medulloepithelial type were observed. No further differentiation was detected on immunohistochemical or electron microscopical examination of the tumor cells. The immature neuroepithelial phenotypes and the early stages of tumor development indicated that Ad 12 had a definite affinity for embryonic neuroepithelial elements that have migrated along the peripheral nerve fibers of newborn hamsters and mice, perhaps with cells of neural crest origin, and had induced primitive neuroectodermal tumors as observed in human peripheral neuroepithelioma and medulloepithelioma.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Ogawa Kdoi
10.1007/BF00687575subject
Has Abstractpub_date
1989-01-01 00:00:00pages
244-53issue
3eissn
0001-6322issn
1432-0533journal_volume
77pub_type
杂志文章abstract::Knockout of genes encoding metabotropic glutamate receptor 5 (mGluR5) or its endogenous regulators, such as Norbin, induce a schizophrenia-like phenotype in rodents, suggesting dysregulation of mGluR5 in schizophrenia. Human genetic and pharmacological animal studies support this hypothesis, but no studies have explor...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-015-1411-6
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journal_title:Acta neuropathologica
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doi:
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journal_title:Acta neuropathologica
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pub_type: 杂志文章,评审
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journal_title:Acta neuropathologica
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pub_type: 杂志文章,评审
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journal_title:Acta neuropathologica
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doi:10.1007/BF00686202
更新日期:1988-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00686387
更新日期:1988-01-01 00:00:00
abstract::Numbers of synapses were counted in columns of neuropil orientated at right angles to the pia in frontal and temporal regions from postmortem brains. In the frontal region of 28 patients aged 26-90 years there were 1.2 X 10(8) mm3 (SD 0.03 X 10(8], and in the temporal of 18 patients aged 16-90 years there were 1.4 X 1...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00684929
更新日期:1983-01-01 00:00:00
abstract::Amyloid-beta (Abeta) peptide pathology in Alzheimer's disease (AD) comprises extracellular plaques and cerebral amyloid angiopathy (CAA). In Parkinson's disease (PD), alpha-synuclein forms intraneuronal Lewy bodies (LBs), and cortical LBs are thought to play a major role in cognitive decline designated as PD with deme...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-007-0336-0
更新日期:2008-04-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688007
更新日期:1980-01-01 00:00:00
abstract::Recent studies of genetic abnormalities in pediatric low-grade gliomas (LGGs) have focused on activation of the ERK/MAPK pathway by KIAA1549-BRAF gene fusions in the majority of pilocytic astrocytomas (PAs) and by rare mutations in elements of the pathway across histopathologically diverse LGGs. This study reports tha...
journal_title:Acta neuropathologica
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更新日期:2010-12-01 00:00:00
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journal_title:Acta neuropathologica
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doi:10.1007/pl00007398
更新日期:1997-01-01 00:00:00
abstract::A system is presented for the classification of chronic herniations of the cerebellar tonsils in the absence of space-occupying intracranial lesions, based on a survey of the literature and 13 own cases. The Arnold-Chiari malformation in adults typically involves herniation of the cerebellar tonsils instead of herniat...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688677
更新日期:1976-03-30 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00692692
更新日期:1982-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章,评审
doi:10.1007/s00401-011-0930-z
更新日期:2012-02-01 00:00:00
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00699636
更新日期:1976-12-21 00:00:00
abstract::The glial cytoplasmic inclusion (GCI) is a histological hallmark for multiple system atrophy (MSA): these inclusions are found in oligodendrocytes and consist of abnormal granule-coated fibrils of approximately 24- to 40-nm diameter. To clarify the significance of the presence of midkine (MK) in these GCIs, we carried...
journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:2000-11-01 00:00:00
abstract::Numbers of dystrophic neurites, seen with the electron microscope, in CA1 of the hippocampus of either C3H mice infected with 22C or 79A strains of scrapie, or LM mice infected with strain ME7 were greater than in age-matched control mice. Vacuolation, seen by light microscopy in CA1 of the hippocampus of mice infecte...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688263
更新日期:1987-01-01 00:00:00
abstract::Polyclonal antibodies directed towards synaptophysin were raised against a synthesised peptide corresponding to amino acids 246 to 260 of the human synaptophysin sequence. The antibodies, when applied for immunocytochemical staining, showed a staining pattern identical to that of the commercially available monoclonal ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00293325
更新日期:1994-01-01 00:00:00
abstract::Two distinct species of amyloid beta protein (A beta) with different carboxyl termini, A beta 40 and A beta 42(43), are deposited in plaques in the brains of patients with Alzheimer's disease and Down's syndrome. The relationship between these two forms of A beta and microglial cells was investigated in 16 subjects wi...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00294808
更新日期:1995-01-01 00:00:00
abstract::Granulovacuolar degeneration (GVD) is a common feature in Alzheimer's disease (AD). The occurrence of GVD is closely associated with that of neurofibrillary tangles (NFTs) and GVD is even considered to be a pre-NFT stage in the disease process of AD. Currently, the composition of GVD bodies, the mechanisms associated ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:2021-01-25 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
abstract::The calcium-activated protease calpain cleaves a variety of biologically important proteins and serves, therefore, as a key regulator of many cellular functions. Activation of both main isoforms, calpain 1 and calpain 2, was demonstrated previously in Alzheimer's disease. In this report, antibodies specifically recogn...
journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:2002-07-01 00:00:00