Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.

abstract：:Psammoma bodies at the perivascular area in five cases of meningioma were examined with the electron microscope. In general, meningocytic cells invest the outer aspect of blood vessels, which are constituted by multilayered basal laminae, collagen fibers, microfibrils, and pericytes. Remnants of degenerated cells are ...

journal_title：Acta neuropathologica

authors： Kubota T,Hirano A,Sato K,Yamamoto S

更新日期：1985-01-01 00:00:00

abstract：:An 18 month old cat had a 6 month history of abnormal high stepping gait, ataxia, muscle twitching and loss of sensory perception. The clinical course was interrupted by several episodes of temporary remission. The essential pathological features were those of a polyradiculoneuritis with segmental demyelination, focal...

journal_title：Acta neuropathologica

authors： Flecknell PA,Lucke VM

更新日期：1978-01-19 00:00:00

abstract：:The neurone-centred view of the past disregarded or downplayed the role of astroglia as a primary component in the pathogenesis of neurological diseases. As this concept is changing, so is also the perceived role of astrocytes in the healthy and diseased brain and spinal cord. We have started to unravel the different ...

journal_title：Acta neuropathologica

authors： Pekny M,Pekna M,Messing A,Steinhäuser C,Lee JM,Parpura V,Hol EM,Sofroniew MV,Verkhratsky A

更新日期：2016-03-01 00:00:00

abstract：:Two types of intranuclear inclusions were described in a brain biopsy from a patient with Creutzfeldt-Jakob disease. The first type of intranculear inclusion was papova virus-like and was observed within 20% of the nuclei of all astrocytes and neurons examined. The particles measured 32 nm in diameter and consisted of...

journal_title：Acta neuropathologica

authors： Payne CM,Sibley WA

更新日期：1975-01-01 00:00:00

abstract：:The amyloid cascade hypothesis of Alzheimer's disease (AD) is testable: it implies that interference with Abeta aggregation and plaque formation may be therapeutically useful. Abeta42 immunisation of amyloid precursor protein (APP) transgenic mice prevented plaque formation and caused removal of existing plaques. The ...

journal_title：Acta neuropathologica

authors： Boche D,Denham N,Holmes C,Nicoll JA

更新日期：2010-09-01 00:00:00

abstract：:The morphological effects of two chemically different neuroactive drugs (chlorpromazine and phenobarbital) on vasculogenesis in rat cerebellum were examined to determine the presence of vascular alterations. Therapeutic dosages of both drugs were chronically administered to separate groups of maternal rats beginning o...

journal_title：Acta neuropathologica

authors： Hannah RS,Roth SH,Spira AW

更新日期：1982-01-01 00:00:00

abstract：:We report two sporadic cases of tauopathy with unusual neuropathological features. The ages of the patients at death were 86 and 74 years, and the disease durations were 4 and 3 years, respectively. The former patient showed progressive dementia and amyotrophy (autopsy revealed that severe cervical spondylosis was res...

journal_title：Acta neuropathologica

authors： Sakai K,Piao YS,Kikugawa K,Ohara S,Hasegawa M,Takano H,Fukase M,Nishizawa M,Kakita A,Takahashi H

更新日期：2006-09-01 00:00:00

abstract：:Mineralization in the wall of central nervous system blood vessels is sporadically encountered in aged horses and cattle as in man, generally as an age-related change. This phenomenon has not to date been located in the meninges in dogs or cats. The present study reports a retrospective histological examination of 50 ...

journal_title：Acta neuropathologica

authors： Mandara MT

更新日期：2003-03-01 00:00:00

abstract：:Intermitochondrial septate structures were found in the dystrophic axons of two cases of infantile neuroaxonal dystrophy. Septate structures were previously seen in some tumors (glioblastomas and Schwannomas) and several organs of vertebrates and invertebrates, but never in human central nervous system (CNS). The stru...

journal_title：Acta neuropathologica

authors： Ramos PL,Wisniewski K,Jervis GA,Wisniewski HM

更新日期：1980-01-01 00:00:00

abstract：:Glycerol (an atoxic alcohol) and phenol (a toxic monohydroxybenzene) are currently used as neurolytic blocking agents to relieve pain or spasticity. In the present study we compared the endoneurial response of anhydrous glycerol and 7% phenol-aqua after intraneural injection into rat sciatic nerve, using electron micr...

journal_title：Acta neuropathologica

authors： Westerlund T,Vuorinen V,Röyttä M

更新日期：2001-07-01 00:00:00

abstract：:In this immunocytochemical study, the brains of nine squirrel monkeys (Saimiri sciureus), ranging from 8 to 27 years of age, were examined for the presence and distribution of beta/A4 amyloid, a 4-kilodalton peptide. In aged squirrel monkeys, amyloid is associated primarily with intracerebral and meningeal capillaries...

journal_title：Acta neuropathologica

authors： Walker LC,Masters C,Beyreuther K,Price DL

更新日期：1990-01-01 00:00:00

abstract：:The presence and distribution of human immunodeficiency virus (HIV) were examined in the CNS of two children with severe HIV encephalitis and myelitis. Using polymerase chain reaction-mediated DNA amplification and subsequent Southern analysis, proviral HIV gag sequences were identified in brain tissue of both patient...

journal_title：Acta neuropathologica

authors： Brüstle O,Spiegel H,Leib SL,Finn T,Stein H,Kleihues P,Wiestler OD

更新日期：1992-01-01 00:00:00

abstract：:A case of classic medulloblastoma that metastasized, despite the absence of local recurrence, to extraneural sites 7 years after treatment is reported. The metastases were, in contrast to the primary tumor, of large cell type and displayed abortive myogenic and, in one site, also rhabdoid differentiation. The primary ...

journal_title：Acta neuropathologica

authors： Donner LR

更新日期：2005-05-01 00:00:00

abstract：:Stereological estimates of mean volumes, surface areas, and cortical thicknesses were obtained on formalin-fixed brains from 19 men with AIDS and 19 controls. Volumes of neocortex, white matter, central brain nuclei, ventricles and archicortex were estimated using point counting and Cavalieri's unbiased principle for ...

journal_title：Acta neuropathologica

authors： Oster S,Christoffersen P,Gundersen HJ,Nielsen JO,Pakkenberg B,Pedersen C

更新日期：1993-01-01 00:00:00

abstract：:In chronic granulomatous disease (CGD) enzyme-deficient neutrophils and mononuclear cells lack the respiratory burst required for biocidal activity. Recurrent infections lead to granulomas in various organs but brain lesions are rare. In the present case, a 23-year-old male with numerous infections since early childho...

journal_title：Acta neuropathologica

authors： Hadfield MG,Ghatak NR,Laine FJ,Myer EC,Massie FS,Kramer WM

更新日期：1991-01-01 00:00:00

abstract：:The present study investigated the expression of c-erbB-2 in 59 meningiomas, including different histological subtypes and anaplastic variants, by immunocytochemistry and molecular biological techniques. Immunohistochemistry using the monoclonal antibody FWP-51 directed against c-erbB-2-encoded oncoprotein gp185 demon...

journal_title：Acta neuropathologica

authors： Schlegel J,Ullrich B,Stumm G,Gass P,Harwerth IM,Hynes NE,Kiessling M

更新日期：1993-01-01 00:00:00

abstract：:We examined the immunohistochemical localization of p35nck5a, the regulatory subunit of cyclin-dependent kinase 5 (cdk5), in brains obtained postmortem from patients with Parkinson's disease (PD) and controls. We found p35nck5a immunoreactivity in Lewy bodies (LB) in the substantia nigra, locus ceruleus, and neocortex...

journal_title：Acta neuropathologica

authors： Nakamura S,Kawamoto Y,Nakano S,Akiguchi I,Kimura J

更新日期：1997-08-01 00:00:00

abstract：:The suprascapular nerve from 14 horses, which had no clinical evidence of spinatus muscle atrophy, were obtained to determine whether the nerve was sub-clinically compressed at the scapular edge. The nerves were divided into three portions, proximal and distal to the scapular edge and as it reflected around it. In nin...

journal_title：Acta neuropathologica

authors： Duncan ID,Schneider RK,Hammang JP

更新日期：1987-01-01 00:00:00

abstract：:Medulloblastoma (MB) represents approximately 4% of adult brain tumours, and as such is a poorly studied disease. Although many adult MB are treated using paediatric MB protocols, the reported outcomes are inferior to those observed in children. It remains unclear whether biologic differences underlie these clinical o...

journal_title：Acta neuropathologica

authors： Al-Halabi H,Nantel A,Klekner A,Guiot MC,Albrecht S,Hauser P,Garami M,Bognar L,Kavan P,Gerges N,Shirinian M,Roberge D,Muanza T,Jabado N

更新日期：2011-02-01 00:00:00

abstract：:Long-term epidemiological studies indicate that environmental factors play a causative role in high-incidence amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) in the western Pacific. An increased risk for disease is acquired in youth and remains for life. The low concentrations of calcium and magnesi...

journal_title：Acta neuropathologica

authors： Garruto RM,Shankar SK,Yanagihara R,Salazar AM,Amyx HL,Gajdusek DC

更新日期：1989-01-01 00:00:00

abstract：:A 24-year-old woman was found comatose after 2 days of cephalalgia and vomiting. An immediate diagnosis of carbon monoxyde poisoning was disclaimed when blood carbon monoxyde was found to be 1.75 ml/100. A diagnosis of acute intracranial hypertension led to trephination with ventricular punction and brain biopsy on th...

journal_title：Acta neuropathologica

authors： Foncin JF,Le Beau J

更新日期：1978-08-07 00:00:00

abstract：:We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identifie...

journal_title：Acta neuropathologica

authors： Powers JM,Liu Y,Hair LS,Kascsack RJ,Lewis LD,Levy LA

更新日期：1991-01-01 00:00:00

abstract：:The authors describe in biopsies from 6 cases of Werdnig-Hoffmann disease, including 2 of the more benign type, the ultrastructural typical aspects of denervation. They compare their findings with those of other workers. The striking points are the great variation in the diameter of the muscle fibres and the myofibril...

journal_title：Acta neuropathologica

authors： Szliwowski HB,Drochmans P

更新日期：1975-01-01 00:00:00

abstract：:A case of secretory meningioma with numerous meningothelial rosettes is reported. A 66-year-old man with moyamoya disease gradually developed skull deformity, and underwent surgery for the skull tumor overlying the hemisphere. Histological examination disclosed numerous meningothelial rosettes quite similar to those i...

journal_title：Acta neuropathologica

authors： Tada T,Ishii K,Oshima S,Hara H,Kobayashi S

更新日期：1992-01-01 00:00:00

abstract：:Ubiquitin-positive Lewy neurites and Lewy bodies are found in idiopathic Parkinson's disease (PD) and diffuse Lewy body disease (DLBD). We found that, in three patients with PD and one with DLBD, microtubule-associated protein 5 (MAP5) immunostaining was consistently present in both Lewy neurites and Lewy bodies throu...

journal_title：Acta neuropathologica

authors： Gai WP,Blumbergs PC,Blessing WW

更新日期：1996-01-01 00:00:00

abstract：:A murine model of Tay-Sachs disease, the prototype of the GM2 gangliosidoses, was produced through the targeted disruption of the Hexa gene encoding the subunit of alpha-hexosaminidase A. The mice were completely devoid of beta-hexosaminidase A activity and accumulated GM2 ganglioside in the CNS in an age-dependent ma...

journal_title：Acta neuropathologica

authors： Taniike M,Yamanaka S,Proia RL,Langaman C,Bone-Turrentine T,Suzuki K

更新日期：1995-01-01 00:00:00

abstract：:Oral administration of N-[4-(3-ethoxy-2-hydropropoxy)phenyl] acrylamide (EHA) induced selective granule cell destruction in the granular layer of the cerebellar cortex together with neurological signs, such as delayed righting reflex, gait or truncal ataxia, and convulsion. Neuropathologically, it caused multifocal gr...

journal_title：Acta neuropathologica

authors： Tanaka G,Okeda R

更新日期：2000-04-01 00:00:00

abstract：:Pathways for transfer of horseradish peroxidase (HRP) across the cerebral microvasculature were studied in Mongolian gerbils after inducing either unilateral carotid-artery ligation or intracarotid air embolism. Electron microscopy on samples from both ipsilateral and contralateral brain hemispheres showed the reactio...

journal_title：Acta neuropathologica

authors： Lossinsky AS,Garcia JH,Iwanowski L,Lightfoote WE Jr

更新日期：1979-07-13 00:00:00

abstract：:The effect of induced hypertension instituted after a 2-h delay following middle cerebral artery occlusion (MCAO) on brain edema formation and histochemical injury was studied. Under isoflurane anesthesia, the MCA of 14 spontaneously hypertensive rats was occluded. In the control group (n = 7), the mean arterial press...

journal_title：Acta neuropathologica

authors： Patel PM,Drummond JC,Cole DJ,Giamela R,Steinauer J

更新日期：1991-01-01 00:00:00

abstract：:Frontotemporal lobar degeneration with TAR DNA-binding protein 43 inclusions (FTLD-TDP) is the most common pathology associated with frontotemporal dementia (FTD). Repeat expansions in chromosome 9 open reading frame 72 (C9ORF72) and mutations in progranulin (GRN) are the major known genetic causes of FTLD-TDP; howeve...

journal_title：Acta neuropathologica

authors： Pottier C,Bieniek KF,Finch N,van de Vorst M,Baker M,Perkersen R,Brown P,Ravenscroft T,van Blitterswijk M,Nicholson AM,DeTure M,Knopman DS,Josephs KA,Parisi JE,Petersen RC,Boylan KB,Boeve BF,Graff-Radford NR,Veltman JA

更新日期：2015-07-01 00:00:00