Abstract：
:The suprascapular nerve from 14 horses, which had no clinical evidence of spinatus muscle atrophy, were obtained to determine whether the nerve was sub-clinically compressed at the scapular edge. The nerves were divided into three portions, proximal and distal to the scapular edge and as it reflected around it. In nine horses there was evidence of a chronic neuropathy which varied in severity and which was most severe at the site of reflection, where the nerve appeared constricted by a tendinous band. At this site the predominant change was that of chronic demyelination and remyelination, with many scattered thinly myelinated fibres and occasionally profuse onion bulb formation. There were also occasional regenerating clusters, which were the only abnormalities seen in the distal nerve. Renaut bodies appeared to be more common and larger in nerves with chronic focal neuropathy. Teased fibres confirmed the chronic myelin sheath changes, and the presence of many paranodal swellings suggested a possible chronic compressive aetiology. This is the first reported spontaneous entrapment neuropathy in the domestic animals.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Duncan ID,Schneider RK,Hammang JPdoi
10.1007/BF00688338subject
Has Abstractpub_date
1987-01-01 00:00:00pages
53-61issue
1eissn
0001-6322issn
1432-0533journal_volume
74pub_type
杂志文章abstract：:In spite of several cases reported in the literature, the exact pathogenetic mechanism of neuropathic changes in porphyric neuropathy remains uncertain. Various authors have ascribed the neuropathologic findings to either a dying-back axonal degeneration or segmental demyelination. In recent years, the hypothesis of a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00697191
更新日期：1984-01-01 00:00:00
abstract：:Lysolecithin has been used in many studies to induce demyelination in peripheral nerves. In the present investigation lysolecithin (lysophosphatidyl choline) was injected into rat sciatic nerves at a dose of 2-3 microns of a 10 mg/ml solution in order to study the effects of this lipid on cellular elements other than ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690634
更新日期：1982-01-01 00:00:00
abstract：:Adult white rats were injected daily for 1 month with aluminum chloride and killed. Aluminum was identified, quantitated, and localized in the brains of these rats. The only detectable anomalies were crystals of aluminum and phosphorus in lysosomes and lipofuscin granules in the cytoplasm of neurons. ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00707114
更新日期：1980-01-01 00:00:00
abstract：:A significant reduction in the myelinated nerve fiber population was observed during quantitative electron-microscopic examination of peripheral nerves in chronic alloxan diabetic rats. Dystrophic axonal abnormalities and regenerating fibers were more numerous in diabetics than age-matched controls. Schwann cells show...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690466
更新日期：1984-01-01 00:00:00
abstract：:A description is given of three cases of ganglioneuromas, which originated from ganglia of the sympathetic chain of hamsters. Other reports of such tumors in this species are reviewed and the literature relative to hamster ganglioneuromas presented. In addition, the possible genesis of origin from adult ganglion cells...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00696794
更新日期：1975-10-01 00:00:00
abstract：:The transmissible spongiform encephalopathies (TSEs) or prion diseases of animals are characterised by CNS spongiform change, gliosis and the accumulation of disease-associated forms of prion protein (PrP(d)). Particularly in ruminant prion diseases, a wide range of morphological types of PrP(d) depositions are found ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-010-0700-3
更新日期：2011-01-01 00:00:00
abstract：:In order to elucidate the immunohistochemical features of hydrocephalic ependyma, immunohistochemical examination was undertaken in 11 normal, postmortem brains (age range, 11 weeks' postconception to 6 months after birth) and 12 hydrocephalic brains (three cases each of congenital aqueductal stenosis, Dandy-Walker ma...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050493
更新日期：1996-07-01 00:00:00
abstract：:The regional distribution of the postsynaptic microtubule-associated protein 2 (MAP2) and the presynaptic marker protein synaptophysin was investigated by immunohistochemistry in brains of rats submitted to 30-min forebrain ischemia by four-vessel occlusion. The following brain temperature profiles during ischemia wer...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00230493
更新日期：1993-01-01 00:00:00
abstract：:There is evidence that apoptotic cell death mechanisms contribute to muscle fibre loss in dystrophinopathies, but little knowledge about the activators of the final degrading caspase cascade in muscle fibre apoptosis. As mitochondria-related activation of this caspase cascade, through e.g. APAF-1, could not be proven ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0934-z
更新日期：2005-02-01 00:00:00
abstract：:The post-mortem diagnosis of lysosomal storage diseases can be confounded by the unavailability of suitable material. Here we report the diagnosis of GM1-gangliosidosis in a cross-bred dog, from which only formalin-fixed brain was available, by a combination of electron microscopy and the detection of elevated levels ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000187
更新日期：2000-10-01 00:00:00
abstract：:Numbers of synapses were counted in columns of neuropil orientated at right angles to the pia in frontal and temporal regions from postmortem brains. In the frontal region of 28 patients aged 26-90 years there were 1.2 X 10(8) mm3 (SD 0.03 X 10(8], and in the temporal of 18 patients aged 16-90 years there were 1.4 X 1...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00684929
更新日期：1983-01-01 00:00:00
abstract：:Sporadic Creutzfeldt-Jakob disease (sCJD) is a transmissible brain proteinopathy. Five main clinicopathological subtypes (sCJD-MM(V)1, -MM(V)2C, -MV2K, -VV1, and -VV2) are currently distinguished. Histopathological evidence suggests that the localisation of prion aggregates and spongiform lesions varies among subtypes...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-020-02168-0
更新日期：2020-08-01 00:00:00
abstract：:Neuropathological studies have revealed that the brains of HIV-1-infected AIDS patients show the typical encephalitis and, in addition, neuronal loss. More recently, this neuronal cell loss has been thought to take place via programmed cell death (apoptosis) which has been demonstrated by an in situ end labelling (ISE...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050409
更新日期：1996-01-01 00:00:00
abstract：:A 1-year-old male chinchilla with a 2-week history of conjunctivitis suffered subsequently from neurological signs comprising seizures, disorientation, recumbency and apathy. After 3 weeks of progressive central nervous disease the animal was killed in view of the poor prognosis. A non-suppurative meningitis and polio...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0597-6
更新日期：2002-12-01 00:00:00
abstract：:Mutations in the gene coding for Sequestosome 1 (SQSTM1) have been genetically associated with amyotrophic lateral sclerosis (ALS) and Paget disease of bone. In the present study, we analyzed the SQSTM1 coding sequence for mutations in an extended cohort of 1,808 patients with frontotemporal lobar degeneration (FTLD),...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-014-1298-7
更新日期：2014-09-01 00:00:00
abstract：:The Trembler mouse suffers from an hereditary demyelinating neuropathy. Schwann cell myelination of peripheral nerve fibres in the Trembler mouse is abnormal. Myelination of central nerve fibres in the deeper layers of white matter of the spinal cord is normal. At the junction between the peripheral nervous system and...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691273
更新日期：1977-04-29 00:00:00
abstract：:Severe hypoxic-ischemic cerebral damage was produced in 8-day-old rats following permanent bilateral carotid artery occlusion and 15 min of ischemia. Cellular damage consisted of early necrosis and appearance of cells with apoptotic-like morphology (karyorrhectic cells) and cells with granular chromatin degeneration i...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050753
更新日期：1997-12-01 00:00:00
abstract：:An unusual tumor of the pituitary gland is reported. The most characteristic finding of the present tumor was the presence of numerous "colloid" and mucoid secretions. The cells were stellate in shape and there were intra- or intercellular lumina which were lined by many microvilli and occasional cilia. There were als...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687617
更新日期：1984-01-01 00:00:00
abstract：:A unique pathological finding of astrocytes was observed in the brain of a 20-year-old man who had severe physical and mental retardation. The brain was malformed showing micropolygyria in several cortical areas. A large number of hypertrophic astrocytes with eosinophilic granular substances in their cytoplasm were fo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00427225
更新日期：1992-01-01 00:00:00
abstract：:Cerebellar torpedoes, unique fusiform swellings of Purkinje cell axons within the granular layer, have been known to occur sparsely associated with diffuse cerebellar changes. This report describes, in three human autopsy cases with focal necrotic lesions in the cerebellar white matter, torpedoes which were essentiall...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00311388
更新日期：1992-01-01 00:00:00
abstract：:Inappropriate apoptosis has been implicated in the mechanism of neuronal death in Huntington's disease (HD). In this study, we report the expression of apoptotic markers in HD caudate nucleus (grades 1-4) and compare this with controls without neurological disease. Terminal transferase-mediated biotinylated-UTP nick e...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0957-5
更新日期：2005-03-01 00:00:00
abstract：:Microglia are long-living resident immune cells of the brain, which secure a stable chemical and physical microenvironment necessary for the proper functioning of the central nervous system (CNS). These highly dynamic cells continuously scan their environment for pathogens and possess the ability to react to damage-in...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-015-1524-y
更新日期：2016-03-01 00:00:00
abstract：:Intracellular filamentous tau pathology is the defining feature of tauopathies, which form a subset of neurodegenerative diseases. We have analyzed pathological tau in Alzheimer's disease, and in frontotemporal lobar degeneration associated with tauopathy to include cases with Pick bodies, corticobasal degeneration, p...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-015-1503-3
更新日期：2016-02-01 00:00:00
abstract：:Progression of neuritic dystrophy is a histological hallmark of Alzheimer's disease (AD) in addition to amyloid deposition and neurofibrillary tangle formation. Dystrophic neurites (DNs) are abnormal neurites, and are closely associated with amyloid deposits. To clarify the process of DN formation, we immunohistochemi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0907-2
更新日期：2004-11-01 00:00:00
abstract：:The binding patterns of lectins to normal peripheral nerves were examined. Twelve biotinylated lectins were used in this study; Canavalia ensiformis (Con A), Pisum sativum (PSA), Lens culinaris (LCA), Ricinus communis 1 (RCA-1), Arachis hypogaea (PNA), Glycine max (SBA), Sophora japonica (SJA), Bandeiraea simplicifoli...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294292
更新日期：1993-01-01 00:00:00
abstract：:Flurothyl-induced status epilepticus was studied by light and electron microscopy (LM, EM) to determine the time course and structural features of neuronal necrosis in the vulnerable brain regions in epilepsy. The cerebral cortex, hippocampus and thalamus were examined after closely spaced recovery periods of up to 1 ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687789
更新日期：1988-01-01 00:00:00
abstract：:Intermitochondrial septate structures were found in the dystrophic axons of two cases of infantile neuroaxonal dystrophy. Septate structures were previously seen in some tumors (glioblastomas and Schwannomas) and several organs of vertebrates and invertebrates, but never in human central nervous system (CNS). The stru...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688007
更新日期：1980-01-01 00:00:00
abstract：:Stereological estimates of mean volumes, surface areas, and cortical thicknesses were obtained on formalin-fixed brains from 19 men with AIDS and 19 controls. Volumes of neocortex, white matter, central brain nuclei, ventricles and archicortex were estimated using point counting and Cavalieri's unbiased principle for ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00334671
更新日期：1993-01-01 00:00:00
abstract：:Intracranial germ cell tumors (iGCTs) are the second most common brain tumors among children under 14 in Japan. The World Health Organization classification recognizes several subtypes of iGCTs, which are conventionally subclassified into pure germinoma or non-germinomatous GCTs. Recent exhaustive genomic studies show...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1673-2
更新日期：2017-03-01 00:00:00
abstract：:Underlying the Lambert-Eaton myasthenic syndrome (LEMS) is a decrease in the release of the neurotransmitter acetylcholine. Only few reports on light and transmission electron microscopical observations of motor endplates in LEMS are available and changes reported so far differ from those found in experimental blockin...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308480
更新日期：1992-01-01 00:00:00
