Abstract：
:Two types of intranuclear inclusions were described in a brain biopsy from a patient with Creutzfeldt-Jakob disease. The first type of intranculear inclusion was papova virus-like and was observed within 20% of the nuclei of all astrocytes and neurons examined. The particles measured 32 nm in diameter and consisted of a dense core surrounded by a multi-layered shell. The second type of intranuclear inculsion was a granulo-fibrillar nuclear body found within the nuclei of astrocytes and neurons. The possible significance of these inculsions to the etiology of Creutzfeldt-Jakob disease is discussed.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Payne CM,Sibley WAdoi
10.1007/BF00687930subject
Has Abstractpub_date
1975-01-01 00:00:00pages
353-61issue
4eissn
0001-6322issn
1432-0533journal_volume
31pub_type
杂志文章abstract：:Primary cortical and hippocampal neuronal cultures submitted to brief histotoxic hypoxia suffer delayed neuronal death after 24 h [Uto et al. (1995) J Neurochem 64: 2185-2192]. In this study the ultrastructural changes were monitored during the first 6 h following 5-min histotoxic hypoxia induced by exposure to 100 mi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050559
更新日期：1996-12-01 00:00:00
abstract：:An autopsy case of Nasu-Hakola's disease (membranous lipodystrophy) was reported. A 29-year-old Japanese woman whose younger sister had been affected with typical Nasu-Hakola's disease with skeletal and neuropsychiatric syndromes and membrano-cystic lesions in the bones developed forgetfulness and lack of initiative. ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00689400
更新日期：1981-01-01 00:00:00
abstract：:The binding patterns of lectins to normal peripheral nerves were examined. Twelve biotinylated lectins were used in this study; Canavalia ensiformis (Con A), Pisum sativum (PSA), Lens culinaris (LCA), Ricinus communis 1 (RCA-1), Arachis hypogaea (PNA), Glycine max (SBA), Sophora japonica (SJA), Bandeiraea simplicifoli...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294292
更新日期：1993-01-01 00:00:00
abstract：:Severe hypoxic-ischemic cerebral damage was produced in 8-day-old rats following permanent bilateral carotid artery occlusion and 15 min of ischemia. Cellular damage consisted of early necrosis and appearance of cells with apoptotic-like morphology (karyorrhectic cells) and cells with granular chromatin degeneration i...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050753
更新日期：1997-12-01 00:00:00
abstract：:Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell proliferation and differentiation, as well as tissue remodeling, are mediated in part by infiltrating monocyte-derived macrophages. It is now clear that these infiltrating macrophages have distinct functions from resident microglia a...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-019-01992-3
更新日期：2019-05-01 00:00:00
abstract：:The mechanism of antibody-mediated central nervous system (CNS) demyelination in vivo was studied using rabbit eyes. Injection of anti-galactocerebroside (Gal C) antiserum alone into the normal rabbit vitreous body induced demyelination in the epiretinal myelinated fibers. This activity of the antiserum disappeared af...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687890
更新日期：1989-01-01 00:00:00
abstract：:A 50-year-old carpenter died in Western Pennsylvania of rabies on January 4, 1979. He had been hospitalized in an intensive care unit for 28 days. The diagnosis was made postmortem from light and electron microscopic examination of central nervous system tissue. Immunofluorescence studies confirmed the diagnosis later...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687393
更新日期：1980-01-01 00:00:00
abstract：:Fifteen cases of mitochondrial myopathy, three cases of hereditary motor and sensory neuropathy (HMSN) VI, and 280 cases of neuropathies of different etiologies were examined by electron microscopy for the presence of mitochondrial abnormalities in the sural nerve. Altered mitochondrial were found in most cases of mit...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/BF00293381
更新日期：1991-01-01 00:00:00
abstract：:A 9-year-old male patient developed a germ cell tumor in the right basal ganglia which secreted beta-human chorionic gonadotropin (beta-HCG) and caused precocious puberty. Histology and immunohistochemical staining for placental alkaline phosphatase (PLAP), alpha-fetoprotein (alpha-FP), and beta-HCG showed a mixed pop...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687797
更新日期：1988-01-01 00:00:00
abstract：:Hyper- and hypothyroidism repercussions on soma, nucleus and cytoplasm increases were studied by electron microscopy on 7-, 14-, 21-, and 35-day-old rats. Adult normal animals were compared with adult ones made hypothyroid until they were 35 days old. Also heat value restriction of food intake effects were compared wi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：
更新日期：1978-09-15 00:00:00
abstract：:Newborn rats were exposed to daily intraperitoneal injections of 10 mg lead nitrate per kg body weight for the first 15 postnatal days. The growth and mortality of the lead-exposed animals did not differ from their control litter-mates, injected with vehicle only. In our previous studies, focal hemorrhages and spongy ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687071
更新日期：1987-01-01 00:00:00
abstract：:X-linked adrenoleukodystrophy (X-ALD) is a rare neurometabolic disease characterized by the accumulation of very long chain fatty acids (VLCFAs) due to a loss of function of the peroxisomal transporter ABCD1. Here, using in vivo and in vitro models, we demonstrate that autophagic flux was impaired due to elevated mamm...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-014-1378-8
更新日期：2015-03-01 00:00:00
abstract：:The nuclei for the nerves of a dorsal (m. splenius) and a ventral (m. longus capitis) neck muscle of the rat were retrogradely labeled by applying horseradish peroxidase (HRP) to the respective cut muscle nerves. Motoneurons of both muscles were analyzed for their localization, diameter of perikarya, and area of dendr...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690368
更新日期：1981-01-01 00:00:00
abstract：:Flow cytofluorometric analysis was used to determine the distribution of the DNA content in cells from selected areas of normal human brain and in benign and malignant brain tumors. Propidium iodide was employed as DNA fluorochrome and the analysis was carried out on a suspension of single cells. Normal, nonstimulated...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00684802
更新日期：1979-04-12 00:00:00
abstract：:Solanezumab and Crenezumab are two humanized antibodies targeting Amyloid-β (Aβ) which are currently tested in multiple clinical trials for the prevention of Alzheimer's disease. However, there is a scientific discussion ongoing about the target engagement of these antibodies. Here, we report the immunohistochemical s...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-015-1489-x
更新日期：2015-11-01 00:00:00
abstract：:The conventional concept of Pick's disease does not distinguish Pick's disease with Pick bodies (Pick body disease, PBD) from Pick's disease without Pick bodies [lobar atrophy without Pick bodies, LA-PB(-)]. Recently, intraneuronal ubiquitin-positive inclusions (ub-inclusions), which are thought to be a hallmark of am...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-001-0513-5
更新日期：2002-07-01 00:00:00
abstract：:We have obtained a cDNA fragment to human glial fibrillary acidic protein (GFAP) by immunoscreening a lambda gt11 human brain cDNA library with antibody to bovine GFAP. The highly homologous nucleotide sequence of this clone with that of the mouse GFAP enabled the identification of this cDNA as one encoding GFAP. As t...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687396
更新日期：1989-01-01 00:00:00
abstract：:In the present work the effect of Piromen is studied on the formation of the glial-mesenchymal scar in the experimentally injuried cortex of hamsters. The uniform effect of the bacterial polysaccharide is suggested in a strong and lasting stimulation of proliferating reactive cells in the traumatic area. The excessive...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00684561
更新日期：1975-01-01 00:00:00
abstract：:Using a fluorescent antibody technique, sections of the brains of patients with senile dementia or Alzheimer's disease containing senile plaques were treated with rabbit antihuman immunoglobulins labelled with FITC (fluorescein isothiocyanate, BBL). The senile plaques and the cerebral amyloid angiopathy (drusige Entar...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00689569
更新日期：1975-08-11 00:00:00
abstract：:Muscle fiber abnormalities are described in three cases of neonatal maple syrup disease. There were important variations in fiber diameters. Lesions consisted in focal or diffuse destruction of myofibrils. In view of recent biochemical and clinical data, a direct relation between elevated branched-chain amino acid lev...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685251
更新日期：1984-01-01 00:00:00
abstract：:Brain slices are used extensively for biochemical, electrophysiological and molecular investigations. However, only the time frame for electrophysiological and biochemical investigations has as yet been defined. The goal of the present study was to investigate the time course of nuclear structure in live brain slices....
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000317
更新日期：2001-05-01 00:00:00
abstract：:"Diffuse neurofibrillary tangles with calcification" (DNTC) is a rare form of slowly progressive dementia characterized by temporal or fronto-temporal atrophy with neuronal loss and astrocytosis, neurofibrillary tangles and Fahr-type calcification, but no senile plaques in the cerebral cortex. In patients with DNTC, w...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100411
更新日期：2001-12-01 00:00:00
abstract：:We have found large eosinophilic bodies in the pericapillary regions of the gray and white matter in the human spinal cord. These are entirely different from the previously reported pericapillary inclusion bodies (PIB). We have designated them pericapillary rosettes (PR), since they consist of clusters of round or ovo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00299408
更新日期：1992-01-01 00:00:00
abstract：:Focal cerebral ischemia was induced by occlusion of the right middle cerebral artery in hypoglycemic, normoglycemic, as well as in acute and chronic diabetic rats. The brain damage was studied after 4 days. The volume of infarction was decreased in hypoglycemia (29 +/- 19 mm3 (mean +/- SD) versus 58 +/- 35 mm3, P less...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00693778
更新日期：1987-01-01 00:00:00
abstract：:Alterations in sphingolipid metabolism are described to contribute to various neurological disorders. We here determined the expression of enzymes involved in the sphingomyelin cycle and their products in postmortem brain tissue of multiple sclerosis (MS) patients. In parallel, we investigated the effect of the sphing...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-012-1014-4
更新日期：2012-09-01 00:00:00
abstract：:A retrospective study of 450 consecutive AIDS autopsy cases (397 males, 53 females; mean age at death 38.4 years) in Vienna, Austria, between 1984 and 1999 compares the central nervous system (CNS) findings in three cohorts: 1984-1992 (190 cases), 1993-1995 (162 cases) and 1996-1999 (98 cases, after introduction of tr...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000245
更新日期：2000-08-01 00:00:00
abstract：:Four melanin pigment-containing intracranial tumors were found in three Long-Evans rats in the course of experimental oncogenesis by transplacental ethylnitrosourea (ENU). One of them was a leptomeningeal melanoma. Aside from the presence of scattered melanin-pigmented cells, the other three had the typical histologic...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688941
更新日期：1976-05-18 00:00:00
abstract：:We examined the immunohistochemical localization of the proinflammatory cytokines tumor necrosis factor-alpha, lymphotoxin and interferon-gamma in 22 autopsy brains of patients with either cerebrovascular disease (CVD) or other neurological diseases as well as 2 non-neurological control brains. These cytokines were co...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050519
更新日期：1996-09-01 00:00:00
abstract：:Apoptosis of neurons and glial cells has been shown to occur in the brain of patients with the acquired immune deficiency syndrome (AIDS) and was postulated as contributing to brain atrophy and white matter damage in these patients. Since apoptotic events may be induced by the Fas-Fas ligand (FasL) system, we analyzed...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051094
更新日期：1999-10-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by motor neuron degeneration and associated with aggregation of nuclear RNA-binding proteins (RBPs), including FUS. How FUS aggregation and neurodegeneration are prevented in healthy motor neurons remain critically unanswered questions. Here, we use...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-019-01998-x
更新日期：2019-07-01 00:00:00
