Intranuclear inclusions in a case of Creutzfeldt-Jakob disease: an ultrastructural study.


:Two types of intranuclear inclusions were described in a brain biopsy from a patient with Creutzfeldt-Jakob disease. The first type of intranculear inclusion was papova virus-like and was observed within 20% of the nuclei of all astrocytes and neurons examined. The particles measured 32 nm in diameter and consisted of a dense core surrounded by a multi-layered shell. The second type of intranuclear inculsion was a granulo-fibrillar nuclear body found within the nuclei of astrocytes and neurons. The possible significance of these inculsions to the etiology of Creutzfeldt-Jakob disease is discussed.


Acta Neuropathol


Acta neuropathologica


Payne CM,Sibley WA




Has Abstract


1975-01-01 00:00:00












  • Early ultrastructural changes after brief histotoxic hypoxia in cultured cortical and hippocampal CA1 neurons.

    abstract::Primary cortical and hippocampal neuronal cultures submitted to brief histotoxic hypoxia suffer delayed neuronal death after 24 h [Uto et al. (1995) J Neurochem 64: 2185-2192]. In this study the ultrastructural changes were monitored during the first 6 h following 5-min histotoxic hypoxia induced by exposure to 100 mi...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Dux E,Oschlies U,Uto A,Kusumoto M,Hossmann KA

    更新日期:1996-12-01 00:00:00

  • Nasu-Hakola's disease (membranous lipodystrophy). A case report.

    abstract::An autopsy case of Nasu-Hakola's disease (membranous lipodystrophy) was reported. A 29-year-old Japanese woman whose younger sister had been affected with typical Nasu-Hakola's disease with skeletal and neuropsychiatric syndromes and membrano-cystic lesions in the bones developed forgetfulness and lack of initiative. ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Matsushita M,Oyanagi S,Hanawa S,Shiraki H,Kosaka K

    更新日期:1981-01-01 00:00:00

  • Lectin histochemistry of normal and neoplastic peripheral nerve sheath. 1. Lectin binding pattern of normal peripheral nerve in man.

    abstract::The binding patterns of lectins to normal peripheral nerves were examined. Twelve biotinylated lectins were used in this study; Canavalia ensiformis (Con A), Pisum sativum (PSA), Lens culinaris (LCA), Ricinus communis 1 (RCA-1), Arachis hypogaea (PNA), Glycine max (SBA), Sophora japonica (SJA), Bandeiraea simplicifoli...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Matsumura K,Nakasu S,Nioka H,Handa J

    更新日期:1993-01-01 00:00:00

  • Bcl-2, Bax and Bcl-x expression following hypoxia-ischemia in the infant rat brain.

    abstract::Severe hypoxic-ischemic cerebral damage was produced in 8-day-old rats following permanent bilateral carotid artery occlusion and 15 min of ischemia. Cellular damage consisted of early necrosis and appearance of cells with apoptotic-like morphology (karyorrhectic cells) and cells with granular chromatin degeneration i...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Ferrer I,Pozas E,López E,Ballabriga J

    更新日期:1997-12-01 00:00:00

  • The origin, fate, and contribution of macrophages to spinal cord injury pathology.

    abstract::Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell proliferation and differentiation, as well as tissue remodeling, are mediated in part by infiltrating monocyte-derived macrophages. It is now clear that these infiltrating macrophages have distinct functions from resident microglia a...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章,评审


    authors: Milich LM,Ryan CB,Lee JK

    更新日期:2019-05-01 00:00:00

  • In vivo CNS demyelination mediated by anti-galactocerebroside antibody.

    abstract::The mechanism of antibody-mediated central nervous system (CNS) demyelination in vivo was studied using rabbit eyes. Injection of anti-galactocerebroside (Gal C) antiserum alone into the normal rabbit vitreous body induced demyelination in the epiretinal myelinated fibers. This activity of the antiserum disappeared af...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Ozawa K,Saida T,Saida K,Nishitani H,Kameyama M

    更新日期:1989-01-01 00:00:00

  • Rabies encephaloradiculomyelitis. Case report.

    abstract::A 50-year-old carpenter died in Western Pennsylvania of rabies on January 4, 1979. He had been hospitalized in an intensive care unit for 28 days. The diagnosis was made postmortem from light and electron microscopic examination of central nervous system tissue. Immunofluorescence studies confirmed the diagnosis later...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Lamas CC,Martinez AJ,Baraff R,Bajwa J

    更新日期:1980-01-01 00:00:00

  • Mitochondrial abnormalities in human sural nerves: fine structural evaluation of cases with mitochondrial myopathy, hereditary and non-hereditary neuropathies, and review of the literature.

    abstract::Fifteen cases of mitochondrial myopathy, three cases of hereditary motor and sensory neuropathy (HMSN) VI, and 280 cases of neuropathies of different etiologies were examined by electron microscopy for the presence of mitochondrial abnormalities in the sural nerve. Altered mitochondrial were found in most cases of mit...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章,评审


    authors: Schröder JM,Sommer C

    更新日期:1991-01-01 00:00:00

  • Intracranial mixed germ cell tumor with syncytiotrophoblastic giant cells and precocious puberty.

    abstract::A 9-year-old male patient developed a germ cell tumor in the right basal ganglia which secreted beta-human chorionic gonadotropin (beta-HCG) and caused precocious puberty. Histology and immunohistochemical staining for placental alkaline phosphatase (PLAP), alpha-fetoprotein (alpha-FP), and beta-HCG showed a mixed pop...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Aguzzi A,Hedinger CE,Kleihues P,Yaşargil MG

    更新日期:1988-01-01 00:00:00

  • [Effects of thyroid hormones and heat value restriction of food intake on the glial surrounding and soma development of Purkinje cell (author's transl)].

    abstract::Hyper- and hypothyroidism repercussions on soma, nucleus and cytoplasm increases were studied by electron microscopy on 7-, 14-, 21-, and 35-day-old rats. Adult normal animals were compared with adult ones made hypothyroid until they were 35 days old. Also heat value restriction of food intake effects were compared wi...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Rebière A,Dainat J

    更新日期:1978-09-15 00:00:00

  • Extracellular edema and glial response to it in the cerebellum of suckling rats with low-dose lead encephalopathy. An electron microscopic and immunohistochemical study.

    abstract::Newborn rats were exposed to daily intraperitoneal injections of 10 mg lead nitrate per kg body weight for the first 15 postnatal days. The growth and mortality of the lead-exposed animals did not differ from their control litter-mates, injected with vehicle only. In our previous studies, focal hemorrhages and spongy ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Sundström R,Kalimo H

    更新日期:1987-01-01 00:00:00

  • Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy.

    abstract::X-linked adrenoleukodystrophy (X-ALD) is a rare neurometabolic disease characterized by the accumulation of very long chain fatty acids (VLCFAs) due to a loss of function of the peroxisomal transporter ABCD1. Here, using in vivo and in vitro models, we demonstrate that autophagic flux was impaired due to elevated mamm...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Launay N,Aguado C,Fourcade S,Ruiz M,Grau L,Riera J,Guilera C,Giròs M,Ferrer I,Knecht E,Pujol A

    更新日期:2015-03-01 00:00:00

  • [Musculi longus capitis et splenius of the rat and innervating motoneurons (author's transl)].

    abstract::The nuclei for the nerves of a dorsal (m. splenius) and a ventral (m. longus capitis) neck muscle of the rat were retrogradely labeled by applying horseradish peroxidase (HRP) to the respective cut muscle nerves. Motoneurons of both muscles were analyzed for their localization, diameter of perikarya, and area of dendr...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Stillhard G

    更新日期:1981-01-01 00:00:00

  • Flow cytometric analysis of the DNA distribution in human brain tumors.

    abstract::Flow cytofluorometric analysis was used to determine the distribution of the DNA content in cells from selected areas of normal human brain and in benign and malignant brain tumors. Propidium iodide was employed as DNA fluorochrome and the analysis was carried out on a suspension of single cells. Normal, nonstimulated...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Kawamoto K,Herz F,Wolley RC,Hirano A,Kajikawa H,Koss LG

    更新日期:1979-04-12 00:00:00

  • Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N‑truncated Abeta in sporadic Alzheimer disease cases and mouse models.

    abstract::Solanezumab and Crenezumab are two humanized antibodies targeting Amyloid-β (Aβ) which are currently tested in multiple clinical trials for the prevention of Alzheimer's disease. However, there is a scientific discussion ongoing about the target engagement of these antibodies. Here, we report the immunohistochemical s...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Bouter Y,Lopez Noguerola JS,Tucholla P,Crespi GA,Parker MW,Wiltfang J,Miles LA,Bayer TA

    更新日期:2015-11-01 00:00:00

  • Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia.

    abstract::The conventional concept of Pick's disease does not distinguish Pick's disease with Pick bodies (Pick body disease, PBD) from Pick's disease without Pick bodies [lobar atrophy without Pick bodies, LA-PB(-)]. Recently, intraneuronal ubiquitin-positive inclusions (ub-inclusions), which are thought to be a hallmark of am...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Ikeda K,Akiyama H,Arai T,Ueno H,Tsuchiya K,Kosaka K

    更新日期:2002-07-01 00:00:00

  • Differential expression of glial fibrillary acidic protein in human glioma cell lines.

    abstract::We have obtained a cDNA fragment to human glial fibrillary acidic protein (GFAP) by immunoscreening a lambda gt11 human brain cDNA library with antibody to bovine GFAP. The highly homologous nucleotide sequence of this clone with that of the mouse GFAP enabled the identification of this cDNA as one encoding GFAP. As t...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Nishiyama A,Onda K,Washiyama K,Kumanishi T,Kuwano R,Sakimura K,Takahashi Y

    更新日期:1989-01-01 00:00:00

  • [The effect of piromen on the flial-mesenchymal scar in the cortex of hamsters].

    abstract::In the present work the effect of Piromen is studied on the formation of the glial-mesenchymal scar in the experimentally injuried cortex of hamsters. The uniform effect of the bacterial polysaccharide is suggested in a strong and lasting stimulation of proliferating reactive cells in the traumatic area. The excessive...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: von Cramon D

    更新日期:1975-01-01 00:00:00

  • Identification of components of immunoglobulins in senile plaques by means of fluorescent antibody technique.

    abstract::Using a fluorescent antibody technique, sections of the brains of patients with senile dementia or Alzheimer's disease containing senile plaques were treated with rabbit antihuman immunoglobulins labelled with FITC (fluorescein isothiocyanate, BBL). The senile plaques and the cerebral amyloid angiopathy (drusige Entar...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Ishii T,Haga S

    更新日期:1975-08-11 00:00:00

  • Abnormalities of muscle fibers in maple syrup urine disease.

    abstract::Muscle fiber abnormalities are described in three cases of neonatal maple syrup disease. There were important variations in fiber diameters. Lesions consisted in focal or diffuse destruction of myofibrils. In view of recent biochemical and clinical data, a direct relation between elevated branched-chain amino acid lev...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Ferrière G,de Castro M,Rodriguez J

    更新日期:1984-01-01 00:00:00

  • Nuclear shrinkage in live mouse hippocampal slices.

    abstract::Brain slices are used extensively for biochemical, electrophysiological and molecular investigations. However, only the time frame for electrophysiological and biochemical investigations has as yet been defined. The goal of the present study was to investigate the time course of nuclear structure in live brain slices....

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Kasischke K,Büchner M,Ludolph AC,Riepe MW

    更新日期:2001-05-01 00:00:00

  • Plaque-like structures and arteriosclerotic changes in "diffuse neurofibrillary tangles with calcification" (DNTC).

    abstract::"Diffuse neurofibrillary tangles with calcification" (DNTC) is a rare form of slowly progressive dementia characterized by temporal or fronto-temporal atrophy with neuronal loss and astrocytosis, neurofibrillary tangles and Fahr-type calcification, but no senile plaques in the cerebral cortex. In patients with DNTC, w...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Terada S,Ishizu H,Tanabe Y,Takehisa Y,Haraguchi T,Hamaya K,Nose S,Sudo K,Kuroda S

    更新日期:2001-12-01 00:00:00

  • Pericapillary rosettes in the human spinal cord.

    abstract::We have found large eosinophilic bodies in the pericapillary regions of the gray and white matter in the human spinal cord. These are entirely different from the previously reported pericapillary inclusion bodies (PIB). We have designated them pericapillary rosettes (PR), since they consist of clusters of round or ovo...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Sasaki S,Maruyama S

    更新日期:1992-01-01 00:00:00

  • Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration.

    abstract::Focal cerebral ischemia was induced by occlusion of the right middle cerebral artery in hypoglycemic, normoglycemic, as well as in acute and chronic diabetic rats. The brain damage was studied after 4 days. The volume of infarction was decreased in hypoglycemia (29 +/- 19 mm3 (mean +/- SD) versus 58 +/- 35 mm3, P less...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Nedergaard M,Diemer NH

    更新日期:1987-01-01 00:00:00

  • Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes.

    abstract::Alterations in sphingolipid metabolism are described to contribute to various neurological disorders. We here determined the expression of enzymes involved in the sphingomyelin cycle and their products in postmortem brain tissue of multiple sclerosis (MS) patients. In parallel, we investigated the effect of the sphing...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: van Doorn R,Nijland PG,Dekker N,Witte ME,Lopes-Pinheiro MA,van het Hof B,Kooij G,Reijerkerk A,Dijkstra C,van van der Valk P,van Horssen J,de Vries HE

    更新日期:2012-09-01 00:00:00

  • Neuropathology and general autopsy findings in AIDS during the last 15 years.

    abstract::A retrospective study of 450 consecutive AIDS autopsy cases (397 males, 53 females; mean age at death 38.4 years) in Vienna, Austria, between 1984 and 1999 compares the central nervous system (CNS) findings in three cohorts: 1984-1992 (190 cases), 1993-1995 (162 cases) and 1996-1999 (98 cases, after introduction of tr...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Jellinger KA,Setinek U,Drlicek M,Böhm G,Steurer A,Lintner F

    更新日期:2000-08-01 00:00:00

  • Studies on experimental malignant nerve sheath tumors maintained in tissue and organ culture systems. III. Melanin pigment and melanogenesis in experimental neurogenic tumors: a reappraisal of the histogenesis of pigmented nerve sheath tumors.

    abstract::Four melanin pigment-containing intracranial tumors were found in three Long-Evans rats in the course of experimental oncogenesis by transplacental ethylnitrosourea (ENU). One of them was a leptomeningeal melanoma. Aside from the presence of scattered melanin-pigmented cells, the other three had the typical histologic...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Spence AM,Rubinstein LJ,Conley FK,Herman MM

    更新日期:1976-05-18 00:00:00

  • Glial expression of cytokines in the brains of cerebrovascular disease patients.

    abstract::We examined the immunohistochemical localization of the proinflammatory cytokines tumor necrosis factor-alpha, lymphotoxin and interferon-gamma in 22 autopsy brains of patients with either cerebrovascular disease (CVD) or other neurological diseases as well as 2 non-neurological control brains. These cytokines were co...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Tomimoto H,Akiguchi I,Wakita H,Kinoshita A,Ikemoto A,Nakamura S,Kimura J

    更新日期:1996-09-01 00:00:00

  • Upregulated expression of Fas and Fas ligand in brain through the spectrum of HIV-1 infection.

    abstract::Apoptosis of neurons and glial cells has been shown to occur in the brain of patients with the acquired immune deficiency syndrome (AIDS) and was postulated as contributing to brain atrophy and white matter damage in these patients. Since apoptotic events may be induced by the Fas-Fas ligand (FasL) system, we analyzed...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Elovaara I,Sabri F,Gray F,Alafuzoff I,Chiodi F

    更新日期:1999-10-01 00:00:00

  • FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy.

    abstract::Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by motor neuron degeneration and associated with aggregation of nuclear RNA-binding proteins (RBPs), including FUS. How FUS aggregation and neurodegeneration are prevented in healthy motor neurons remain critically unanswered questions. Here, we use...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Marrone L,Drexler HCA,Wang J,Tripathi P,Distler T,Heisterkamp P,Anderson EN,Kour S,Moraiti A,Maharana S,Bhatnagar R,Belgard TG,Tripathy V,Kalmbach N,Hosseinzadeh Z,Crippa V,Abo-Rady M,Wegner F,Poletti A,Troost D,A

    更新日期:2019-07-01 00:00:00