Transient axonal injury in the absence of demyelination: a correlate of clinical disease in acute experimental autoimmune encephalomyelitis.

abstract：:Transient forebrain ischemia produces a spatially and temporally selective pattern of neuronal degeneration in the hippocampal formation of the Mongolian gerbil. Ischemic neuronal death has been suggested to depend on the activation of excitatory hippocampal pathways that project to the vulnerable neurons. This idea w...

journal_title：Acta neuropathologica

authors： Kaplan TM,Lasner TM,Nadler JV,Crain BJ

更新日期：1989-01-01 00:00:00

abstract：:It was demonstrated that New Zealand Albino rabbits sensitized to galactocerebroside had high levels of anti-galactocerebroside antibody and of immune complexes. The rabbits was high titers of immune complexes developed demyelination in the peripheral nerves. Lesion were produced in the peripheral nerves of mice by th...

journal_title：Acta neuropathologica

authors： Tsukada N,Koh CS,Yanagisawa N,Taketomi T,Behan PO

更新日期：1985-01-01 00:00:00

abstract：:A case of multifocal axonopathy associated with intrathecal methotrexate (IT MTX) and radiation therapy is presented. A 33-year-old woman suffering from meningeal carcinomatosis of breast cancer origin had developed prominent multifocal axonal degeneration in the cerebral white matter after treatment with IT MTX thera...

journal_title：Acta neuropathologica

authors： Shibutani M,Okeda R,Hori A,Schipper H

更新日期：1989-01-01 00:00:00

abstract：:The selective toxicity of silica dust for macrophages has been used to assess the role of these cells in experimental allergic neuritis (EAN). Inbred Lewis rats were inoculated with bovine dorsal roots in Freund's complete adjuvant (day 0). In two experiments, animals received 200 mg of silica dust in 1 cm3 of saline ...

journal_title：Acta neuropathologica

authors： Craggs RI,King RH,Thomas PK

更新日期：1984-01-01 00:00:00

abstract：:The effects of ageing, cachexia and neoplasms on striated muscle were examined in histological sections of an autopsy material. Paraffin sections were examined from four separate muscles of 30 previously healthy subjects who died suddenly, from eight cases with cachexia and from 16 cases with cachexia and neoplasms. I...

journal_title：Acta neuropathologica

authors： Lindboe CF,Torvik A

更新日期：1982-01-01 00:00:00

abstract：:Abuse of the club drugs Methamphetamine (Meth) and Ecstasy (MDMA) is an international problem. The seriousness of this problem is the result of what appears to be programmed cell death (PCD) occurring within the brain following their use. This follow up study focused on determining which cell types, neurons and/or gli...

journal_title：Acta neuropathologica

authors： Warren MW,Larner SF,Kobeissy FH,Brezing CA,Jeung JA,Hayes RL,Gold MS,Wang KK

更新日期：2007-09-01 00:00:00

abstract：:A variety of age-related changes occur in the structure of neurons in the cerebral cortex of Wistar-Kyoto and spontaneously hypertensive rats. The most marked alteration associated with increasing age was the deposition of lipofuscin pigment, primarily at the bases of apical dendrites of pyramidal neurons. While no st...

journal_title：Acta neuropathologica

authors： Knox CA,Yates RD,Chen I

更新日期：1980-01-01 00:00:00

abstract：:The colocalization of beta amyloid protein with the enzymes acetyl- and butyrylcholinesterase was assessed using immunocytochemistry for beta amyloid protein and a sensitive histochemical technique for cholinesterases. In non-demented aged and Alzheimer's disease brains, double-stained sections for cholinesterases and...

journal_title：Acta neuropathologica

authors： Morán MA,Mufson EJ,Gómez-Ramos P

更新日期：1993-01-01 00:00:00

abstract：:Head and neck paragangliomas, rare neoplasms of the paraganglia composed of nests of neurosecretory and glial cells embedded in vascular stroma, provide a remarkable example of organoid tumor architecture. To identify genes and pathways commonly deregulated in head and neck paraganglioma, we integrated high-density ge...

journal_title：Acta neuropathologica

authors： Cama A,Verginelli F,Lotti LV,Napolitano F,Morgano A,D'Orazio A,Vacca M,Perconti S,Pepe F,Romani F,Vitullo F,di Lella F,Visone R,Mannelli M,Neumann HP,Raiconi G,Paties C,Moschetta A,Tagliaferri R,Veronese A,Sanna M

更新日期：2013-10-01 00:00:00

abstract：:An autopsy case of unclassifiable presenil dementia is reported. The outstanding pathological findings were as follows; 1. presence of senile plaques, neurofibrillary changes, Pick bodies, Hirano bodies, granulovacuolar degeneration of neurons, etc. 2. numerous Lewy bodies in the brain stem and diencephalon, 3. peculi...

journal_title：Acta neuropathologica

authors： Kosaka K,Oyanagi S,Matsushita M,Hori A

更新日期：1976-11-15 00:00:00

abstract：:Cystic necrosis in the cerebellar white matter was found in three premature infants. The necrosis was characteristically localized in the center of the white matter of the superficial cerebellar folia, sparing the overlying cortex. The patients were aged between 28 and 34 gestational weeks, and had a clinical history ...

journal_title：Acta neuropathologica

authors： Tsuru A,Mizuguchi M,Takashima S

更新日期：1995-01-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed the question of whether or not sequential distribution patterns can be recognized for PS...

journal_title：Acta neuropathologica

authors： Kovacs GG,Lukic MJ,Irwin DJ,Arzberger T,Respondek G,Lee EB,Coughlin D,Giese A,Grossman M,Kurz C,McMillan CT,Gelpi E,Compta Y,van Swieten JC,Laat LD,Troakes C,Al-Sarraj S,Robinson JL,Roeber S,Xie SX,Lee VM,Trojan

更新日期：2020-08-01 00:00:00

abstract：:Following maternal chicken pox in the 14th week of pregnancy, a male infant was born with low birth weight, muscle wasting and limb contractures, hypotonia and areflexia. A rising titre of varicella-zoster-specific IgM (by enzyme-linked immunoabsorbent assay) confirmed congenital infection, and electromyogram showed w...

journal_title：Acta neuropathologica

authors： Harding B,Baumer JA

更新日期：1988-01-01 00:00:00

abstract：:Methylmercury (MeHg) poisoning (20 mg/kg body weight) in embryonic mice resulted in significant reductions of mitotic indices in the neuroepithelial germinal cells of the telencephalon at the ventricular surface 4 to 12 h following intoxication. After 24 h, no significant difference in the mitotic indices was observed...

journal_title：Acta neuropathologica

authors： Choi BH

更新日期：1991-01-01 00:00:00

abstract：:Rat sciatic nerve was assayed for total collagen and total protein both immediately post-mortem and at weekly intervals after death. No significant difference was found in collagen and protein content between corresponding nerve segments assayed fresh and up to 4 weeks post mortem. However, variation was found in peri...

journal_title：Acta neuropathologica

authors： McFarlane KR,Pollock M,Myers DB

更新日期：1980-01-01 00:00:00

abstract：:Pleomorphic xanthoastrocytoma (PXA), a tumor most often presenting superficially over the cerebral hemisphere of young subjects, has certain morphological similarities to fibrous histiocytoma (or fibrous xanthoma) of the meninges and brain, namely the occurrence of lipid-laden neoplastic cells and, frequently, a dense...

journal_title：Acta neuropathologica

authors： Kepes JJ,Rubinstein LJ,Ansbacher L,Schreiber DJ

更新日期：1989-01-01 00:00:00

abstract：:The Trembler mouse suffers from an hereditary demyelinating neuropathy. Schwann cell myelination of peripheral nerve fibres in the Trembler mouse is abnormal. Myelination of central nerve fibres in the deeper layers of white matter of the spinal cord is normal. At the junction between the peripheral nervous system and...

journal_title：Acta neuropathologica

authors： Harrison BM

更新日期：1977-04-29 00:00:00

abstract：:The kidney of a 7-month-old male Cairn terrier with globoid cell leukodystrophy (GLD) was investigated with light and electron microscopes. A few tubular epithelial cells in the inner medulla as well as some exfoliated cells in the lumina revealed PAS-positive cytoplasm in which needle-like structures were to be seen ...

journal_title：Acta neuropathologica

authors： Suzuki K

更新日期：1986-01-01 00:00:00

abstract：:Intracranial germ cell tumors (iGCTs) are the second most common brain tumors among children under 14 in Japan. The World Health Organization classification recognizes several subtypes of iGCTs, which are conventionally subclassified into pure germinoma or non-germinomatous GCTs. Recent exhaustive genomic studies show...

journal_title：Acta neuropathologica

authors： Fukushima S,Yamashita S,Kobayashi H,Takami H,Fukuoka K,Nakamura T,Yamasaki K,Matsushita Y,Nakamura H,Totoki Y,Kato M,Suzuki T,Mishima K,Yanagisawa T,Mukasa A,Saito N,Kanamori M,Kumabe T,Tominaga T,Nagane M,Iuchi T

更新日期：2017-03-01 00:00:00

abstract：:The deficiency of the cholinergic cortical projection system arising in the different basal forebrain structures collectively referred to as nucleus basalis of Meynert complex is a constant finding in Alzheimer's disease, a disorder which is neuro-pathologically characterised by the appearance of three intracerebral f...

journal_title：Acta neuropathologica

authors： Arendt T,Taubert G,Bigl V,Arendt A

更新日期：1988-01-01 00:00:00

abstract：:The ultrastructure of the nervous tissue in a benign ovarian teratoma is described. This tissue was organized into areas having both "meningeal" and "ependymal" surfaces, between which were found astrocytes, ependymal cells, neurones with synapses and microglia. These cells all had ultrastructural similarities to thei...

journal_title：Acta neuropathologica

authors： Scott T,Pesce C

更新日期：1987-01-01 00:00:00

abstract：:Medulloblastoma comprises four distinct molecular variants with distinct genetics, transcriptomes, and outcomes. Subgroup affiliation has been previously shown to remain stable at the time of recurrence, which likely reflects their distinct cells of origin. However, a therapeutically relevant question that remains una...

journal_title：Acta neuropathologica

authors： Wang X,Dubuc AM,Ramaswamy V,Mack S,Gendoo DM,Remke M,Wu X,Garzia L,Luu B,Cavalli F,Peacock J,López B,Skowron P,Zagzag D,Lyden D,Hoffman C,Cho YJ,Eberhart C,MacDonald T,Li XN,Van Meter T,Northcott PA,Haibe-Kain

更新日期：2015-03-01 00:00:00

abstract：:A histochemical study is reported of regional differences of the lipid storage in a case of Niemann-Pick disease (NPD) type C. Besides tissues known to be affected (reticulo-endothelium, hepatocytes, nervous system), storage was demonstrated in adrenal cortical spongiocytes, sweat glands, renal glomerular and tubular ...

journal_title：Acta neuropathologica

authors： Elleder M,Jirásek A,Smíd F

更新日期：1975-12-19 00:00:00

abstract：:Extracellular deposition of amyloid β-protein (Aβ) in amyloid plaques and intracellular accumulation of abnormally phosphorylated τ-protein (p-τ) in neurofibrillary tangles (NFTs) represent pathological hallmark lesions of Alzheimer's disease (AD). Both lesions develop in parallel in the human brain throughout the pre...

journal_title：Acta neuropathologica

authors： Gomes LA,Hipp SA,Rijal Upadhaya A,Balakrishnan K,Ospitalieri S,Koper MJ,Largo-Barrientos P,Uytterhoeven V,Reichwald J,Rabe S,Vandenberghe R,von Arnim CAF,Tousseyn T,Feederle R,Giudici C,Willem M,Staufenbiel M,Thal DR

更新日期：2019-12-01 00:00:00

abstract：:To assess whether amyloid plaque accumulation in the monkey brain can account for age-related cognitive impairment that begins at about 20 years of age, we measured plaque content in the brains of 14 rhesus monkeys aged 5-30 years. We used immunohistochemistry employing the monoclonal antibody 6E10, which is specific ...

journal_title：Acta neuropathologica

authors： Sloane JA,Pietropaolo MF,Rosene DL,Moss MB,Peters A,Kemper T,Abraham CR

更新日期：1997-11-01 00:00:00

abstract：:Considering the possibility of a paracellular route for edema resolution we studied the microvasculature of the subependymal and subcortical white matter in hydrocephalic rats. Normal adult rats were used as controls. After injection of kaolin suspension into the cisterna magna, the animals were killed at intervals of...

journal_title：Acta neuropathologica

authors： Nakagawa Y,Cervós-Navarro J,Artigas J

更新日期：1984-01-01 00:00:00

abstract：:Excitotoxic stimulation of NMDA receptors results in the activation of a variety of cellular responses. The inducible transcription factor NF-kappaB is known to be involved in excitotoxic responses by neurons. Here, we show that NF-kappaB activation occurs in a biphasic manner in hippocampal slices following a 20-min ...

journal_title：Acta neuropathologica

authors： Caba E,Bahr BA

更新日期：2004-09-01 00:00:00

abstract：:Circumscribed pink areas 0.3-1.0 cm in diameter seen in deeper parts of otherwise well-fixed brains are usually ascribed to inadequate fixation. Twenty-three patients with pink areas in their fixed brains had evidence of inflammation in at least one organ. Blood vessels in the pink areas contained bacteria. Postmortem...

journal_title：Acta neuropathologica

authors： Hedley-Whyte ET

更新日期：1985-01-01 00:00:00

abstract：:There is evidence that apoptotic cell death mechanisms contribute to muscle fibre loss in dystrophinopathies, but little knowledge about the activators of the final degrading caspase cascade in muscle fibre apoptosis. As mitochondria-related activation of this caspase cascade, through e.g. APAF-1, could not be proven ...

journal_title：Acta neuropathologica

authors： Tews DS

更新日期：2005-02-01 00:00:00

abstract：:The brain tissue obtained from ninety-five cognitively unimpaired subjects, with ages ranging from 22 to 50 years upon death, were immunohistochemically assessed for neurodegenerative changes, i.e., hyperphosphorylated tau (HPτ) and β-amyloid (Aβ) pathology in predilection neuroanatomical areas. HPτ pathology was obse...

journal_title：Acta neuropathologica

authors： Elobeid A,Soininen H,Alafuzoff I

更新日期：2012-01-01 00:00:00