Transient axonal injury in the absence of demyelination: a correlate of clinical disease in acute experimental autoimmune encephalomyelitis.


:Axonal degeneration contributes to the transient and permanent neurological deficits seen in multiple sclerosis, an inflammatory disease of the central nervous system. To study the immunological mechanisms causing axonal degeneration, we induced experimental autoimmune encephalomyelitis (EAE) in wildtype Lewis rats and Lewis rats with a slowly progressive myelin degeneration due to proteolipid protein (PLP) overexpression. EAE was triggered either by the transfer of encephalitogenic T-cells alone or by the co-transfer of T-cells with demyelinating antibodies. Inducible nitric oxide synthase (iNOS) expression in perivascular macrophages was associated with a transient functional disturbance of axons, reflected by the focal and reversible accumulation of amyloid precursor protein. Clinical disease correlated with the numbers of APP positive axon spheroids. Demyelination was associated with a further increase of iNOS expression in macrophages and with a higher degree of axonal injury. Our studies suggest that nitric oxide and its metabolites contribute to axonal pathology and possibly also to subsequent neurological dysfunction in EAE.


Acta Neuropathol


Acta neuropathologica


Aboul-Enein F,Weiser P,Höftberger R,Lassmann H,Bradl M




Has Abstract


2006-06-01 00:00:00












  • Automated image analysis of glioblastomas and other gliomas.

    abstract::Tumours of the neuroglia, 172 in all (50 glioblastomas, 65 fibrillar and gemistocytic astrocytomas, 26 pilocytic astrocytomas and 31 oligodendrogliomas), were studied by automated microscopic picture analysis. Thirteen morphometric and densitometric parameters of the tumour cell nuclei as well as two mitotic parameter...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Martin H,Voss K

    更新日期:1982-01-01 00:00:00

  • Ultrastructure of non-myelinated neurons during energy deprivation.

    abstract::This paper examines the neuropathology of oxygen-glucose deprivation uncomplicated by stagnant conditions. Rabbit vagus nerves were pulled into a multi-compartment perfusion chamber, stimulated five times per second and deprived of energy by substituting nitrogen and deoxyglucose for oxygen and glucose in the Locke's ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Dahl NA,Looney GA,Black WH

    更新日期:1982-01-01 00:00:00

  • Laminar spongiosis of the dentate gyrus: a sign of disconnection, present in cases of severe Alzheimer's disease.

    abstract::An extensive laminar spongiosis was found in the outer part of the dentate gyrus in an 84-year-old patient. An old cavitary infarct in the parahippocampal gyrus disconnected the dentate gyrus from the entorhinal area. This finding prompted us to seek laminar spongiosis in Alzheimer's disease, where the neuronal loss i...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Duyckaerts C,Colle MA,Seilhean D,Hauw JJ

    更新日期:1998-04-01 00:00:00

  • Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas.

    abstract::Glioblastomas, the most malignant human brain tumors, are characterized by marked aneuploidy, suggesting chromosomal instability which may be caused by a defective mitotic spindle checkpoint. We screened 22 glioblastomas for mutations in the mitotic spindle check-point genes hBUB1, hBUBR1 and hBUB3. DNA sequencing rev...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Reis RM,Nakamura M,Masuoka J,Watanabe T,Colella S,Yonekawa Y,Kleihues P,Ohgaki H

    更新日期:2001-04-01 00:00:00

  • Expression of adhesion molecules and monocyte chemoattractant protein -1 (MCP-1) in the spinal cord lesions in HTLV-I-associated myelopathy.

    abstract::Leukocyte adhesion molecules to endothelium plays an important role in the pathogenesis of inflammatory diseases, including HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). To help define the role of adhesion molecules in HAM/TSP, we studied the expression of lymphocyte function-associated antige...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Umehara F,Izumo S,Takeya M,Takahashi K,Sato E,Osame M

    更新日期:1996-01-01 00:00:00

  • [The effect of piromen on the flial-mesenchymal scar in the cortex of hamsters].

    abstract::In the present work the effect of Piromen is studied on the formation of the glial-mesenchymal scar in the experimentally injuried cortex of hamsters. The uniform effect of the bacterial polysaccharide is suggested in a strong and lasting stimulation of proliferating reactive cells in the traumatic area. The excessive...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: von Cramon D

    更新日期:1975-01-01 00:00:00

  • Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA.

    abstract::Abuse of the club drugs Methamphetamine (Meth) and Ecstasy (MDMA) is an international problem. The seriousness of this problem is the result of what appears to be programmed cell death (PCD) occurring within the brain following their use. This follow up study focused on determining which cell types, neurons and/or gli...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Warren MW,Larner SF,Kobeissy FH,Brezing CA,Jeung JA,Hayes RL,Gold MS,Wang KK

    更新日期:2007-09-01 00:00:00

  • Effects of methylmercury on neuroepithelial germinal cells in the developing telencephalic vesicles of mice.

    abstract::Methylmercury (MeHg) poisoning (20 mg/kg body weight) in embryonic mice resulted in significant reductions of mitotic indices in the neuroepithelial germinal cells of the telencephalon at the ventricular surface 4 to 12 h following intoxication. After 24 h, no significant difference in the mitotic indices was observed...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Choi BH

    更新日期:1991-01-01 00:00:00

  • Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.

    abstract::Aging and neurodegeneration are often accompanied by a functionally impaired ubiquitin-proteasome system (UPS). In tauopathies and polyglutamine diseases, a mutant form of ubiquitin B (UBB(+1)) accumulates in disease-specific aggregates. UBB(+1) mRNA is generated at low levels in vivo during transcription from the ubi...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Irmler M,Gentier RJ,Dennissen FJ,Schulz H,Bolle I,Hölter SM,Kallnik M,Cheng JJ,Klingenspor M,Rozman J,Ehrhardt N,Hermes DJ,Gailus-Durner V,Fuchs H,Hrabě de Angelis M,Meyer HE,Hopkins DA,Van Leeuwen FW,Beckers J

    更新日期:2012-08-01 00:00:00

  • Secondary changes of the motor endplate in Lambert-Eaton myasthenic syndrome: a quantitative study.

    abstract::Underlying the Lambert-Eaton myasthenic syndrome (LEMS) is a decrease in the release of the neurotransmitter acetylcholine. Only few reports on light and transmission electron microscopical observations of motor endplates in LEMS are available and changes reported so far differ from those found in experimental blockin...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Hesselmans LF,Jennekens FG,Kartman J,Wokke JH,de Visser M,Klaver-Krol EG,DeBaets M,Spaans F,Veldman H

    更新日期:1992-01-01 00:00:00

  • Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease.

    abstract::Astrocytic alpha-synuclein-immunoreactive inclusions have recently been noted to develop in sporadic Parkinson's disease (PD). Here, the presence of immunoreactive astrocytes is reported in 14 autopsy cases with clinically diagnosed PD and a neuropathological stage of 4 or higher. The labeled astrocytes occur preferen...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Braak H,Sastre M,Del Tredici K

    更新日期:2007-09-01 00:00:00

  • Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition.

    abstract::Brain tumors are the most common solid tumors of childhood, and the genetic drivers and optimal therapeutic strategies for many of the different subtypes remain unknown. Here, we identify that bithalamic gliomas harbor frequent mutations in the EGFR oncogene, only rare histone H3 mutation (in contrast to their unilate...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Mondal G,Lee JC,Ravindranathan A,Villanueva-Meyer JE,Tran QT,Allen SJ,Barreto J,Gupta R,Doo P,Van Ziffle J,Onodera C,Devine P,Grenert JP,Samuel D,Li R,Metrock LK,Jin LW,Antony R,Alashari M,Cheshier S,Whipple NS,

    更新日期:2020-06-01 00:00:00

  • Differential expression of tenascin-C and tenascin-X in human astrocytomas.

    abstract::Tenascins (TNs) are a family of extracellular matrix glycoproteins. The first member of this family to be recognized, tenascin-C (TN-C), is known to be expressed in various tumors including human astrocytomas. Tenascin-X (TN-X) is the latest member of the TN family to be reported, and its expression in tumor tissues h...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Hasegawa K,Yoshida T,Matsumoto K,Katsuta K,Waga S,Sakakura T

    更新日期:1997-05-01 00:00:00

  • Apolipoprotein E epsilon4 allele and progression of cortical Lewy body pathology in Parkinson's disease.

    abstract::To elucidate whether the apolipoprotein E epsilon4 allele (APOE4) affects cortical neuropathology in Parkinson's disease (PD), we determined APOE genotypes and quantified the densities of cortical Lewy bodies (LBs), amyloid plaques and neurofibrillary tangles in 22 autopsy-proven PD cases (12 with dementia; 10 without...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Wakabayashi K,Kakita A,Hayashi S,Okuizumi K,Onodera O,Tanaka H,Ishikawa A,Tsuji S,Takahashi H

    更新日期:1998-05-01 00:00:00

  • Microtubule-associated protein 5 is a component of Lewy bodies and Lewy neurites in the brainstem and forebrain regions affected in Parkinson's disease.

    abstract::Ubiquitin-positive Lewy neurites and Lewy bodies are found in idiopathic Parkinson's disease (PD) and diffuse Lewy body disease (DLBD). We found that, in three patients with PD and one with DLBD, microtubule-associated protein 5 (MAP5) immunostaining was consistently present in both Lewy neurites and Lewy bodies throu...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Gai WP,Blumbergs PC,Blessing WW

    更新日期:1996-01-01 00:00:00

  • Effect of dexamethasone on glial fibrillary acidic protein in peritumorous edema of cats: a morphometric study.

    abstract::In 54 cats experimental brain tumors were produced by xenotransplantation of the blastomatous glial cell clone RG2 into the internal capsule of the left hemisphere. Fifteen of these animals were treated with dexamethasone for 1 week and four animals for 2 h. The occurrence of glial fibrillary acidic (GFA) protein in t...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Szymas J,Hossmann KA

    更新日期:1984-01-01 00:00:00

  • Differential expression of intercellular adhesion molecule-1 (ICAM-1) in the A beta-containing lesions in brains of patients with dementia of the Alzheimer type.

    abstract::Inflammatory processes have been implicated in the formation of senile plaques in the cerebral cortex of patients with dementia of the Alzheimer type (DAT), since several inflammation-induced proteins are present within these plaques. The relation between inflammatory components and other amyloid beta protein (A beta)...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Verbeek MM,Otte-Höller I,Wesseling P,Ruiter DJ,de Waal RM

    更新日期:1996-01-01 00:00:00

  • Electrolyte-induced demyelination in rats. 1. Role of the blood-brain barrier and edema.

    abstract::The blood-brain barrier (BBB) was studied in rats with electrolyte-induced demyelination (EID), an experimental model for central pontine myelinolysis. Intravenously injected peroxidase was extravasated at 3 h post hypertonic saline injection (PHS) into regions frequently involved in EID. Increased pinocytotic activit...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Rojiani AM,Prineas JW,Cho ES

    更新日期:1994-01-01 00:00:00

  • Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes.

    abstract::Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Dickson DW,Yen SH,Suzuki KI,Davies P,Garcia JH,Hirano A

    更新日期:1986-01-01 00:00:00

  • Progressive accumulation of ubiquitin and disappearance of alpha-synuclein epitope in multiple system atrophy-associated glial cytoplasmic inclusions: triple fluorescence study combined with Gallyas-Braak method.

    abstract::Alpha-synuclein (alphaS) and ubiquitin (Ub) are shared constituents of glial cytoplasmic inclusions (GCIs) and Lewy bodies (LBs), both composed of fibrillary structures. Staining profiles of GCIs were investigated with triple immunofluorescence involving immunostaining for alphaS and Ub, both amplified with catalyzed ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Sakamoto M,Uchihara T,Nakamura A,Mizutani T,Mizusawa H

    更新日期:2005-10-01 00:00:00

  • Biphasic NF-kappaB activation in the excitotoxic hippocampus.

    abstract::Excitotoxic stimulation of NMDA receptors results in the activation of a variety of cellular responses. The inducible transcription factor NF-kappaB is known to be involved in excitotoxic responses by neurons. Here, we show that NF-kappaB activation occurs in a biphasic manner in hippocampal slices following a 20-min ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Caba E,Bahr BA

    更新日期:2004-09-01 00:00:00

  • Granulovacuolar degeneration in the hippocampal cortex of aging and demented patients--a quantitative study.

    abstract::The occurrence and topographic analysis of granulovacuolar degeneration (GVD) in the hippocampal cortex of mentally normal controls (75 cases) and patients with Alzheimer's dementia (AD; 17 cases which included Alzheimer's disease and senile dementia of Alzheimer type), multi-infarct dementia (MID; 16 cases), Pick's d...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Xu M,Shibayama H,Kobayashi H,Yamada K,Ishihara R,Zhao P,Takeuchi T,Yoshida K,Inagaki T,Nokura K

    更新日期:1992-01-01 00:00:00

  • Neuronal accumulation of silver in brains of progeny from argyric rats.

    abstract::Using a photochemical method silver was demonstrated in the brains of 1-, 14-, and 45-day-old rats which had been exposed to silver on gestational days 18 and 19. In the brain tissue of new-born rats, silver was found in the lysosomes of neurons and astroglia. Minor changes in the anatomic distribution of silver were ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Rungby J,Danscher G

    更新日期:1983-01-01 00:00:00

  • Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease.

    abstract::Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by an expanded trinucleotide CAG repeat in the gene coding for huntingtin. Deregulation of chromatin remodeling is linked to the pathogenesis of HD but the mechanism remains elusive. To identify what genes are deregulated by trimethyla...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Lee J,Hwang YJ,Shin JY,Lee WC,Wie J,Kim KY,Lee MY,Hwang D,Ratan RR,Pae AN,Kowall NW,So I,Kim JI,Ryu H

    更新日期:2013-05-01 00:00:00

  • Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence.

    abstract::Double immunofluorescence for paired helical filament (PHF)-tau (AT8) and ubiquitin, enhanced by catalyzed reporter deposition amplification, was combined with thiazin red (TR), a fluorochrome, which has an affinity to fibrillary structures such as neurofibrillary tangles (NFTs). After recording these triple-fluoresce...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Uchihara T,Nakamura A,Yamazaki M,Mori O

    更新日期:2001-06-01 00:00:00

  • Early ultrastructural changes after brief histotoxic hypoxia in cultured cortical and hippocampal CA1 neurons.

    abstract::Primary cortical and hippocampal neuronal cultures submitted to brief histotoxic hypoxia suffer delayed neuronal death after 24 h [Uto et al. (1995) J Neurochem 64: 2185-2192]. In this study the ultrastructural changes were monitored during the first 6 h following 5-min histotoxic hypoxia induced by exposure to 100 mi...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Dux E,Oschlies U,Uto A,Kusumoto M,Hossmann KA

    更新日期:1996-12-01 00:00:00

  • The node of Ranvier in CNS pathology.

    abstract::Healthy nodes of Ranvier are crucial for action potential propagation along myelinated axons, both in the central and in the peripheral nervous system. Surprisingly, the node of Ranvier has often been neglected when describing CNS disorders, with most pathologies classified simply as being due to neuronal defects in t...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章,评审


    authors: Arancibia-Carcamo IL,Attwell D

    更新日期:2014-08-01 00:00:00

  • p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease.

    abstract::We examined the immunohistochemical localization of p35nck5a, the regulatory subunit of cyclin-dependent kinase 5 (cdk5), in brains obtained postmortem from patients with Parkinson's disease (PD) and controls. We found p35nck5a immunoreactivity in Lewy bodies (LB) in the substantia nigra, locus ceruleus, and neocortex...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Nakamura S,Kawamoto Y,Nakano S,Akiguchi I,Kimura J

    更新日期:1997-08-01 00:00:00

  • Schwann cell-onion bulb tumor of the trigeminal nerve: hyperplasia, dysplasia or neoplasia?

    abstract::Onion bulbs are concentric lamellar structures formed by Schwann or perineurial cells, which may be seen in several generalized or localized diseases of the peripheral nerve. There is debate regarding the pathogenesis of localized tumefactions displaying these microscopic structures. We report the fifth case, to our k...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: LaPoint SF,Powers JM,Woodruff JM,MacCollin M,Jacoby LB,Vortmeyer AO,Zhuang Z,Fong CT,Ifthikharuddin SF,Teot L,Coniglio JU,Sullivan RP

    更新日期:2000-01-01 00:00:00

  • Ultrastructure of pineal parenchymal neoplasms.

    abstract::The fine structures of two pineal parenchymal neoplasms has been described. The tumors contained a predominance of small, poorly differentiated cells with prominent nuclei and scanty cytoplasm. These cells were similar to those found in medulloblastomas, primitive cerebral neuroectodermal tumors, and fetal cerebellum ...

    journal_title:Acta neuropathologica

    pub_type: 杂志文章


    authors: Markesbery WR,Haugh RM,Young AB

    更新日期:1981-01-01 00:00:00