Abstract：
:The brain tissue obtained from ninety-five cognitively unimpaired subjects, with ages ranging from 22 to 50 years upon death, were immunohistochemically assessed for neurodegenerative changes, i.e., hyperphosphorylated tau (HPτ) and β-amyloid (Aβ) pathology in predilection neuroanatomical areas. HPτ pathology was observed in the transentorhinal cortex and/or the locus coeruleus (LC) in 33% of the subjects, without any obvious risk factors known to alter the microtubule-associated protein. HPτ pathology was noted in the LC in 25 out of 83 subjects (30%), lacking concomitant cortical Aβ or transentorhinal HPτ pathology. This observation was present even when assessing only one routine section of 7 μm thickness. The recent suggestion of prion-like propagation of neurodegeneration and the finding of neurodegeneration being quite common in middle-aged persons is alarming. It is noteworthy, however, that a substantial number of neurologically unimpaired subjects even at a very old age display only sparse to modest extent of neurodegenerative pathology. Thus, only a subset of subjects with neurodegenerative changes early in life seem to progress to a symptomatic disease with ageing. This observation brings forth the notion that other, yet unknown modifying factors influence the progression of degeneration that leads to a symptomatic disorder. The known association between alterations in the LC and mood disorders, and the finding of the LC being frequently affected with HPτ pathology suggest that clinicopathological studies on young subjects both with or without mood disorders are warranted.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Elobeid A,Soininen H,Alafuzoff Idoi
10.1007/s00401-011-0906-zsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
97-104issue
1eissn
0001-6322issn
1432-0533journal_volume
123pub_type
杂志文章abstract：:Meningiomas are among the most frequent intracranial tumors. The secretory variant of meningioma is characterized by glandular differentiation, formation of intracellular lumina and pseudopsammoma bodies, expression of a distinct pattern of cytokeratins and clinically by pronounced perifocal brain edema. Here we descr...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1093-x
更新日期：2013-03-01 00:00:00
abstract：:The morphological effects of two chemically different neuroactive drugs (chlorpromazine and phenobarbital) on vasculogenesis in rat cerebellum were examined to determine the presence of vascular alterations. Therapeutic dosages of both drugs were chronically administered to separate groups of maternal rats beginning o...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00692188
更新日期：1982-01-01 00:00:00
abstract：:The quadriceps femoris muscles of experimental allergic myositis, in strain 13 guinea pigs immunised with rabbit myosin B fraction, were subjected to histochemical, immunohistochemical and electron microscopic studies. They demonstrated a variety of degenerative changes of muscle fibres, infiltration of lymphocytes an...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00692845
更新日期：1987-01-01 00:00:00
abstract：:Fifteen cases of mitochondrial myopathy, three cases of hereditary motor and sensory neuropathy (HMSN) VI, and 280 cases of neuropathies of different etiologies were examined by electron microscopy for the presence of mitochondrial abnormalities in the sural nerve. Altered mitochondrial were found in most cases of mit...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/BF00293381
更新日期：1991-01-01 00:00:00
abstract：:The thoracic sympathetic preganglionic outflow is important in the maintenance of postural normotension in man. Normative data on the intermediolateral column (ILC) neuron cell bodies is lacking. Counts and measurements on the right ILC cytons have been performed on the T6, T7 and T8 segments of 12 spinal cords of man...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688573
更新日期：1977-09-26 00:00:00
abstract：:Tumours of the neuroglia, 172 in all (50 glioblastomas, 65 fibrillar and gemistocytic astrocytomas, 26 pilocytic astrocytomas and 31 oligodendrogliomas), were studied by automated microscopic picture analysis. Thirteen morphometric and densitometric parameters of the tumour cell nuclei as well as two mitotic parameter...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00692692
更新日期：1982-01-01 00:00:00
abstract：:The nature and distribution of vascular changes in acute Wernicke's encephalopathy (WE) were analyzed in three autopsy cases. Lesions of the lateral vestibular nucleus of the medulla oblongata (three cases) and lateral ventricular wall (one case) were examined by reconstruction of 200 serial sections, and the capillar...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00307646
更新日期：1995-01-01 00:00:00
abstract：:With increasing longevity, the number of older schizophrenic patients is growing. Previous criteria used the age of symptom onset to differentiate between the late manifestations of early-onset schizophrenia and late-onset schizophreniform disorders. Current DSM-IV or ICD 10 nomenclatures do not differentiate between ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-001-0468-6
更新日期：2002-04-01 00:00:00
abstract：:Histochemical and electron microscopic studies of the brains inclusive of the leptomeninges containing large blood vessels from 7 patients with mucopolysaccharidosis (MPS) I, II, IIIA and V showed marked increase in mesenchymal elements and the generalized presence of characteristic lesions around cerebral veins and a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690379
更新日期：1977-07-15 00:00:00
abstract：:To assess whether amyloid plaque accumulation in the monkey brain can account for age-related cognitive impairment that begins at about 20 years of age, we measured plaque content in the brains of 14 rhesus monkeys aged 5-30 years. We used immunohistochemistry employing the monoclonal antibody 6E10, which is specific ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050735
更新日期：1997-11-01 00:00:00
abstract：:Primary cortical and hippocampal neuronal cultures submitted to brief histotoxic hypoxia suffer delayed neuronal death after 24 h [Uto et al. (1995) J Neurochem 64: 2185-2192]. In this study the ultrastructural changes were monitored during the first 6 h following 5-min histotoxic hypoxia induced by exposure to 100 mi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050559
更新日期：1996-12-01 00:00:00
abstract：:Specific pathological hallmarks have been described in amyotrophic lateral sclerosis (ALS), which include motor neuronal loss, Bunina bodies (BBs) and skein like inclusions (SLIs). We investigated the relation between these three lesions in the cervical and lumbar anterior horns and the hypoglossal nuclei of 20 ALS pa...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-001-0507-3
更新日期：2002-06-01 00:00:00
abstract：:Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed the question of whether or not sequential distribution patterns can be recognized for PS...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-020-02158-2
更新日期：2020-08-01 00:00:00
abstract：:Macroautophagy is a dynamic process whereby cytoplasmic components are initially sequestered within autophagosomes. Recent studies have shown that the autophagosome membrane can selectively recognize ubiquitinated proteins and organelles through interaction with adapter proteins such as p62 and NBR1. Both proteins are...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-012-0975-7
更新日期：2012-08-01 00:00:00
abstract：:Although clinical and electrophysiological evidence indicates that the amygdaloid body plays an important role in the pathogenesis of temporal lobe epilepsy, there are very few detailed data on histopathological changes in this nucleus in epilepsy patients. In the present study we have examined the lateral nucleus of ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050658
更新日期：1997-06-01 00:00:00
abstract：:A complex neuropathological study of two cases of Niemann-Pick disease (NPD) type C (NPDC) revealed some novel features in the chemical pathology of the neuronal storage. Lipid histochemistry showed the presence of a lipid which met the criteria of a neuronal glycosphingolipid. Sphingomyelin (SM) was not detected in t...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690966
更新日期：1985-01-01 00:00:00
abstract：:Severe hypoxic-ischemic cerebral damage was produced in 8-day-old rats following permanent bilateral carotid artery occlusion and 15 min of ischemia. Cellular damage consisted of early necrosis and appearance of cells with apoptotic-like morphology (karyorrhectic cells) and cells with granular chromatin degeneration i...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050753
更新日期：1997-12-01 00:00:00
abstract：:Damage to axons in acute multiple sclerosis (MS) lesions is now well established but the mechanisms of this damage remain obscure. Here we have applied a panel of antibodies that identify cell populations and proteins contained in them with a view to detecting those cells and proteins that are localised particularly c...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0045-0
更新日期：2006-04-01 00:00:00
abstract：:The case of a child is described who at the age of 2 years showed the first evidence of a developing neurological disease. Within a couple of years, profound mental retardation and severe motor deficit with spastic tetraplegia became established. No seizures and no pigmentation of the retina were observed. The conditi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688145
更新日期：1975-01-01 00:00:00
abstract：:Brain slices are used extensively for biochemical, electrophysiological and molecular investigations. However, only the time frame for electrophysiological and biochemical investigations has as yet been defined. The goal of the present study was to investigate the time course of nuclear structure in live brain slices....
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000317
更新日期：2001-05-01 00:00:00
abstract：:Bundles of paired helical filaments (PHF) accumulate in the pyramidal neurons that degenerate during Alzheimer's disease. This neurofibrillary degeneration is highly correlated with clinical signs of dementia. During the degenerating process, Tau proteins, which are the major antigenic components of PHF, are abnormall...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308912
更新日期：1990-01-01 00:00:00
abstract：:Onion bulbs are concentric lamellar structures formed by Schwann or perineurial cells, which may be seen in several generalized or localized diseases of the peripheral nerve. There is debate regarding the pathogenesis of localized tumefactions displaying these microscopic structures. We report the fifth case, to our k...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/pl00007408
更新日期：2000-01-01 00:00:00
abstract：:We have previously shown that in the hippocampal formation of patients with acquired immunodeficiency syndrome (AIDS) there is neuronal atrophy, without cell loss. Because reductions in neuronal size are suggestive of associated neuritic alterations, we decided to study the dendritic trees of the main neuronal populat...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0781-3
更新日期：2004-02-01 00:00:00
abstract：:Collections of human postmortem brains gathered in brain banks have underpinned many significant developments in the understanding of central nervous system (CNS) disorders and continue to support current research. Unfortunately, the worldwide decline in postmortem examinations has had an adverse effect on research ti...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-008-0360-8
更新日期：2008-05-01 00:00:00
abstract：:In order to elucidate the role of humoral antibodies in the pathogenesis of myelin lesions in experimental allergic encephalomyelitis (EAE) a combined in vivo and in vitro study was done using rabbits immunized with the purified A1 basic protein. Rabbits injected with whole white matter were used for comparison. Demye...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00699636
更新日期：1976-12-21 00:00:00
abstract：:The aim of the present work was to investigate whether nestin, a member of the intermediate filament family, is immunohistochemically expressed in the non-tumoral human hypophysis and pituitary neoplasms. Twenty-three normal pituitaries and 125 pituitary neoplasms were included. The tissues were formalin-fixed and par...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0031-6
更新日期：2006-03-01 00:00:00
abstract：:Cavernous malformations (CVMs) and arteriovenous malformations (AVMs) were immunostained for three smooth muscle cell (SMC)-specific protein markers (smooth muscle alpha-actin, SM1 and SM2). Smooth muscle alpha-actin, a widely used marker of SMCs, is reportedly one of the earliest proteins expressed during differentia...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100362
更新日期：2001-09-01 00:00:00
abstract：:Focal cortical dysplasias (FCD) which represent a composite group of cortical malformations are increasingly recognized as morphological substrate for severe therapy-refractory epilepsy in children and young adults. However, presurgical evaluation remains challenging as not all FCD variants can be reliably detected by...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-011-0920-1
更新日期：2012-02-01 00:00:00
abstract：:Massive GGGGCC repeat expansion in the first intron of the gene C9orf72 is the most common known cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Despite its intronic localization and lack of an ATG start codon, the repeat region is translated in all three reading fra...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1189-3
更新日期：2013-12-01 00:00:00
abstract：:The distribution of the calcium-binding protein calretinin was investigated by immunohistochemistry in the hippocampus, the subicular areas, and the entorhinal cortex in patients with Alzheimer's disease and in control subjects. By double immunolabelling, the calretinin immunoreactivity was compared to the immunoreact...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294357
更新日期：1994-01-01 00:00:00
