Immunohistochemical and electron microscopical studies of myocardial inclusions in hereditary myopathy of the diaphragmatic muscles in Holstein-Friesian cattle.

abstract：:Widespread damage to axons in the white matter of the brain is a well-recognised consequence of non-missile head injury. This diffuse axonal injury is characterised by a gradual swelling of the axon associated with an accumulation of cellular organelles and proteins. We have investigated the relationship between the s...

journal_title：Acta neuropathologica

authors： Wilkinson AE,Bridges LR,Sivaloganathan S

更新日期：1999-08-01 00:00:00

abstract：:Tumours of the neuroglia, 172 in all (50 glioblastomas, 65 fibrillar and gemistocytic astrocytomas, 26 pilocytic astrocytomas and 31 oligodendrogliomas), were studied by automated microscopic picture analysis. Thirteen morphometric and densitometric parameters of the tumour cell nuclei as well as two mitotic parameter...

journal_title：Acta neuropathologica

authors： Martin H,Voss K

更新日期：1982-01-01 00:00:00

abstract：:Intracranial cartilaginous tumors are rare lesions, usually arising from the skull base in older individuals. We report the case of a 12-year-old girl with a low-grade type chondrosarcoma arising from the falx cerebri. To our knowledge this is the first such case reported in a child. She was treated with gross total s...

journal_title：Acta neuropathologica

authors： Gerszten PC,Pollack IF,Hamilton RL

更新日期：1998-01-01 00:00:00

abstract：:Pelizaeus-Merzbacher disease (PMD) is an untreatable and fatal leukodystrophy. In a model of PMD with perturbed blood-brain barrier integrity, cholesterol supplementation promotes myelin membrane growth. Here, we show that in contrast to the mouse model, dietary cholesterol in two PMD patients did not lead to a major ...

journal_title：Acta neuropathologica

authors： Stumpf SK,Berghoff SA,Trevisiol A,Spieth L,Düking T,Schneider LV,Schlaphoff L,Dreha-Kulaczewski S,Bley A,Burfeind D,Kusch K,Mitkovski M,Ruhwedel T,Guder P,Röhse H,Denecke J,Gärtner J,Möbius W,Nave KA,Saher G

更新日期：2019-07-01 00:00:00

abstract：:Histological, ultrastructural and morphometrical observations on Clarke's column were carried out in 18 patients with sporadic amyotrophic lateral sclerosis (ALS) and 15 age-matched control subjects. Of the 18 ALS patients 6 had been on a respirator before death. Bunina bodies were found in the neuronal cytoplasm in 7...

journal_title：Acta neuropathologica

authors： Takahashi H,Oyanagi K,Ohama E,Ikuta F

更新日期：1992-01-01 00:00:00

abstract：:Defects of major histocompatibility complex (MHC) class I antigen-processing machinery (APM) components have been shown to contribute to immune escape of malignant cells. We investigated the expression of APM components in astrocytomas without detectable defects in HLA class I antigen expression and correlated it with...

journal_title：Acta neuropathologica

authors： Mehling M,Simon P,Mittelbronn M,Meyermann R,Ferrone S,Weller M,Wiendl H

更新日期：2007-08-01 00:00:00

abstract：:Histochemical and electron microscopic studies of the brains inclusive of the leptomeninges containing large blood vessels from 7 patients with mucopolysaccharidosis (MPS) I, II, IIIA and V showed marked increase in mesenchymal elements and the generalized presence of characteristic lesions around cerebral veins and a...

journal_title：Acta neuropathologica

authors： Dekaban AS,Constantopoulos G

更新日期：1977-07-15 00:00:00

abstract：:Large cell/anaplastic (LC/A) medulloblastoma (MB) is a recently recognized variant of medulloblastoma known to be associated with an advanced stage and a poor prognosis. Although Eberhart et al. suggested histopathologic grading of medulloblastoma in 2002, no consensus has been reached in terms of determining the crit...

journal_title：Acta neuropathologica

authors： Min HS,Lee YJ,Park K,Cho BK,Park SH

更新日期：2006-07-01 00:00:00

abstract：:The binding patterns of lectins to normal peripheral nerves were examined. Twelve biotinylated lectins were used in this study; Canavalia ensiformis (Con A), Pisum sativum (PSA), Lens culinaris (LCA), Ricinus communis 1 (RCA-1), Arachis hypogaea (PNA), Glycine max (SBA), Sophora japonica (SJA), Bandeiraea simplicifoli...

journal_title：Acta neuropathologica

authors： Matsumura K,Nakasu S,Nioka H,Handa J

更新日期：1993-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a major cause of dementia. Characteristic neuropathological features of AD include neurofibrillary tangles, senile plaques, amyloid angiopathy and microvascular atrophy. The ultra-structure of the microvascular atrophy in AD and its pathogenetic significance have not been defined. This repo...

journal_title：Acta neuropathologica

authors： Claudio L

更新日期：1996-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have identified several new molecular constituents of ALS-linked cellular aggregates, including FUS, TDP-43, OPTN, UBQLN2 and the translational product...

journal_title：Acta neuropathologica

authors： Blokhuis AM,Groen EJ,Koppers M,van den Berg LH,Pasterkamp RJ

更新日期：2013-06-01 00:00:00

abstract：:Experimental allergic neuritis (EAN) was induced in normal and irradiated Lewis rats by passively transferring T cells sensitized to SP-26, a peptide fragment of P2 myelin protein. The recipients became sick 4-8 days post transfer and the degree of disability correlated directly with the dose of T cells. Smaller doses...

journal_title：Acta neuropathologica

authors： Hahn AF,Feasby TE,Lovgren D,Wilkie L

更新日期：1993-01-01 00:00:00

abstract：:Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis and neurodegeneration. However, the mechanisms through which the brain's immune system recognizes and controls viral infections propagating across synaptically linked neuronal circuits have rem...

journal_title：Acta neuropathologica

authors： Fekete R,Cserép C,Lénárt N,Tóth K,Orsolits B,Martinecz B,Méhes E,Szabó B,Németh V,Gönci B,Sperlágh B,Boldogkői Z,Kittel Á,Baranyi M,Ferenczi S,Kovács K,Szalay G,Rózsa B,Webb C,Kovacs GG,Hortobágyi T,West BL,Kö

更新日期：2018-09-01 00:00:00

abstract：:MicroRNA (miRNA) expression was assessed in human cerebral cortical gray matter (GM) and white matter (WM) in order to provide the first insights into the difference between GM and WM miRNA repertoires across a range of Alzheimer's disease (AD) pathology. RNA was isolated separately from GM and WM portions of superior...

journal_title：Acta neuropathologica

authors： Wang WX,Huang Q,Hu Y,Stromberg AJ,Nelson PT

更新日期：2011-02-01 00:00:00

abstract：:Mice develop a fatal encephalomyelitis after infection with the Trinidad donkey strain of Venezuelan equine encephalitis (VEE) virus. Adult mice were inoculated intraperitoneally with VEE virus and the brains were examined at different time points. Morphological changes were assessed by histological staining. VEE viru...

journal_title：Acta neuropathologica

authors： Jackson AC,Rossiter JP

更新日期：1997-04-01 00:00:00

abstract：:The alterations in oligodendrocytes in myelin basic protein-induced acute experimental autoimmune encephalomyelitis (EAE) in the Lewis rat were studied using the technique of pre-embedding immunolabelling with the Rip monoclonal antibody, which specifically labels the cytoplasm of the cell bodies and processes of olig...

journal_title：Acta neuropathologica

authors： Nguyen KB,Pender MP

更新日期：1998-01-01 00:00:00

abstract：:Neurotrophins regulate the proliferation and differentiation of neurons in the central nervous system via a family of specialized receptors, including TrkA, TrkB, and TrkC. As little is known about their expression or potential role in human glial tissues and glial tumors, we undertook an immunohistochemical analysis ...

journal_title：Acta neuropathologica

authors： Wang Y,Hagel C,Hamel W,Müller S,Kluwe L,Westphal M

更新日期：1998-10-01 00:00:00

abstract：:We have previously characterized three human leucine-rich repeats and immunoglobulin-like domains (LRIG) genes and proteins, named LRIG1-3 and proposed that they may act as suppressors of tumor growth. The LRIG1 transmembrane protein antagonizes the activity of epidermal growth factor receptor family receptor tyrosine...

journal_title：Acta neuropathologica

authors： Guo D,Nilsson J,Haapasalo H,Raheem O,Bergenheim T,Hedman H,Henriksson R

更新日期：2006-03-01 00:00:00

abstract：:A 50-year-old carpenter died in Western Pennsylvania of rabies on January 4, 1979. He had been hospitalized in an intensive care unit for 28 days. The diagnosis was made postmortem from light and electron microscopic examination of central nervous system tissue. Immunofluorescence studies confirmed the diagnosis later...

journal_title：Acta neuropathologica

authors： Lamas CC,Martinez AJ,Baraff R,Bajwa J

更新日期：1980-01-01 00:00:00

abstract：:This study was designed to compare the degree of reactive astrogliosis occurring around a puncture wound in the brain of normal rats and at different intervals after a similar puncture wound in rats with a portocaval anastomosis. The gliosis was evaluated by the number of astrocytes, the thickness of their processes a...

journal_title：Acta neuropathologica

authors： Ma KC,Chang ZH,Shih H,Zhu JH,Wu JY

更新日期：1991-01-01 00:00:00

abstract：:Synemin is a member of the intermediate protein superfamily. Previous studies in avian and rodent skeletal and cardiac muscles have demonstrated that synemin localises at the Z-band, where it associates with desmin and alpha-actinin. In the present study, the distribution of synemin was examined using immunohistochemi...

journal_title：Acta neuropathologica

authors： Olivé M,Goldfarb L,Dagvadorj A,Sambuughin N,Paulin D,Li Z,Goudeau B,Vicart P,Ferrer I

更新日期：2003-07-01 00:00:00

abstract：:We report the case of an 11-year-old male who developed subacute diffuse polyradiculoneuropathy, associated with digestive symptoms and Epstein-Barr virus infection. Parental consanguinity was present. The laboratory findings including bone marrow smear were consistent with hemophagocytic lymphohistiocytosis (HLH). El...

journal_title：Acta neuropathologica

authors： De Armas R,Sindou P,Gelot A,Routon MC,Ponsot G,Vallat JM

更新日期：2004-10-01 00:00:00

abstract：:An in vivo method for positively staining dead neurons was developed and compared with an in vitro staining method using acid fuchsin. Neurons previously killed by intracerebral injections of kainic acid were selectively stained by trypan blue within 15 min of its injection in vivo into the central nervous system of r...

journal_title：Acta neuropathologica

authors： Lees GJ

更新日期：1989-01-01 00:00:00

abstract：:A neuropathological study is presented of a case showing the association of tuberous sclerosis of the brain and dysplasia of the corpus callosum as well as omphalocele and malrotated colon. No signs of tuberous sclerosis were found in the internal organs. From a review of the literature this appears to be the fourth c...

journal_title：Acta neuropathologica

authors： Barth PG,Stam FC,von der Harten JJ

更新日期：1978-04-26 00:00:00

abstract：:The colonic enteric nervous system was investigated in autopsy specimens from 12 patients with familial amyloidotic neuropathy (FAP) and 9 controls. The infiltration of amyloid deposits in the enteric nervous system was studied by double staining for amyloid and nerve elements. The myenteric plexus was immunostained f...

journal_title：Acta neuropathologica

authors： Anan I,El-Salhy M,Ando Y,Forsgren S,Nyhlin N,Terazaki H,Sakashita N,Suhr OB

更新日期：1999-07-01 00:00:00

abstract：:The quadriceps femoris muscles of experimental allergic myositis, in strain 13 guinea pigs immunised with rabbit myosin B fraction, were subjected to histochemical, immunohistochemical and electron microscopic studies. They demonstrated a variety of degenerative changes of muscle fibres, infiltration of lymphocytes an...

journal_title：Acta neuropathologica

authors： Matsubara S,Takamori M

更新日期：1987-01-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is a rare neurometabolic disease characterized by the accumulation of very long chain fatty acids (VLCFAs) due to a loss of function of the peroxisomal transporter ABCD1. Here, using in vivo and in vitro models, we demonstrate that autophagic flux was impaired due to elevated mamm...

journal_title：Acta neuropathologica

authors： Launay N,Aguado C,Fourcade S,Ruiz M,Grau L,Riera J,Guilera C,Giròs M,Ferrer I,Knecht E,Pujol A

更新日期：2015-03-01 00:00:00

abstract：:We evaluated by in situ nick end labeling the presence of apoptotic glial cells in the spinal cord of rats which have sustained a moderate and severe compression injury at the level of T8-9, resulting in a severe but reversible paraparesis and irreversible paraplegia, respectively. In a previous investigation we found...

journal_title：Acta neuropathologica

authors： Li GL,Farooque M,Holtz A,Olsson Y

更新日期：1999-11-01 00:00:00

abstract：:Amplification of the epidermal growth factor receptor (EGFR) gene is found in about 40% of glioblastomas (GBMs) but is rarely detected in GBM cell lines. We confirmed that the exceptional SKMG-3 GBM cell line retained amplified EGFR genes in vitro, and found that these sequences were concentrated on extra-chromosomal ...

journal_title：Acta neuropathologica

authors： Thomas C,Ely G,James CD,Jenkins R,Kastan M,Jedlicka A,Burger P,Wharen R

更新日期：2001-06-01 00:00:00

abstract：:A massive expansion of a GGGGCC repeat upstream of the C9orf72 coding region is the most common known cause of amyotrophic lateral sclerosis and frontotemporal dementia. Despite its intronic localization and lack of a canonical start codon, both strands are translated into aggregating dipeptide repeat (DPR) proteins: ...

journal_title：Acta neuropathologica

authors： Schludi MH,May S,Grässer FA,Rentzsch K,Kremmer E,Küpper C,Klopstock T,German Consortium for Frontotemporal Lobar Degeneration.,Bavarian Brain Banking Alliance.,Arzberger T,Edbauer D

更新日期：2015-10-01 00:00:00