In vivo and in vitro staining of acidophilic neurons as indicative of cell death following kainic acid-induced lesions in rat brain.

abstract：:Localization of organ-specific brain antigens in the central nervous system of the rat has been studied by means of indirect immunofluorescence. Rabbit antiserum against homogenate of rat brain, previously absorbed with normal serum and homogenates of rat organs (kidney, liver, spleen), reacted with the water-soluble ...

journal_title：Acta neuropathologica

authors： Weinrauder H,Lach B

更新日期：1977-08-16 00:00:00

abstract：:There is evidence that apoptotic cell death mechanisms contribute to muscle fibre loss in dystrophinopathies, but little knowledge about the activators of the final degrading caspase cascade in muscle fibre apoptosis. As mitochondria-related activation of this caspase cascade, through e.g. APAF-1, could not be proven ...

journal_title：Acta neuropathologica

authors： Tews DS

更新日期：2005-02-01 00:00:00

abstract：:Data on the relationship between Parkinson's disease (PD) and stroke have been conflicting, some studies showing a reduced risk of stroke during life, and others indicating an increased risk of stroke-related death. Consecutive cases (n=617) of autopsy-proven idiopathic PD (Lewy body disease of the brain stem type) an...

journal_title：Acta neuropathologica

authors： Jellinger KA

更新日期：2003-05-01 00:00:00

abstract：:Cerebellar torpedoes, unique fusiform swellings of Purkinje cell axons within the granular layer, have been known to occur sparsely associated with diffuse cerebellar changes. This report describes, in three human autopsy cases with focal necrotic lesions in the cerebellar white matter, torpedoes which were essentiall...

journal_title：Acta neuropathologica

authors： Takahashi N,Iwatsubo T,Nakano I,Machinami R

更新日期：1992-01-01 00:00:00

abstract：:Aberrant peripheral nerve fiber bundles, i.e., masses of peripheral nerve fibers without perineural sheath cells, are found in the perivascular spaces of some spinal cords. The 514 spinal cords examined for these structures were separated into two groups; 507 spinal cords without definite necrotic lesions (group 1) an...

journal_title：Acta neuropathologica

authors： Kamiya M,Hashizume Y

更新日期：1989-01-01 00:00:00

abstract：:Pelizaeus-Merzbacher disease (PMD) is an untreatable and fatal leukodystrophy. In a model of PMD with perturbed blood-brain barrier integrity, cholesterol supplementation promotes myelin membrane growth. Here, we show that in contrast to the mouse model, dietary cholesterol in two PMD patients did not lead to a major ...

journal_title：Acta neuropathologica

authors： Stumpf SK,Berghoff SA,Trevisiol A,Spieth L,Düking T,Schneider LV,Schlaphoff L,Dreha-Kulaczewski S,Bley A,Burfeind D,Kusch K,Mitkovski M,Ruhwedel T,Guder P,Röhse H,Denecke J,Gärtner J,Möbius W,Nave KA,Saher G

更新日期：2019-07-01 00:00:00

abstract：:Defects of major histocompatibility complex (MHC) class I antigen-processing machinery (APM) components have been shown to contribute to immune escape of malignant cells. We investigated the expression of APM components in astrocytomas without detectable defects in HLA class I antigen expression and correlated it with...

journal_title：Acta neuropathologica

authors： Mehling M,Simon P,Mittelbronn M,Meyermann R,Ferrone S,Weller M,Wiendl H

更新日期：2007-08-01 00:00:00

abstract：:A 56-day-old infant with alpha-neuraminidase deficiency, whose clinical features included severe edema of extremities and ascites which resembled those in severe infantile sialidosis, was autopsied. Perforation, whose pathogenesis was unclear, was found on the descending portion of the duodenum. Light and electron mic...

journal_title：Acta neuropathologica

authors： Yamano T,Shimada M,Matsuzaki K,Matsumoto Y,Yoshihara W,Okada S,Inui K,Yutaka T,Yabuuchi H

更新日期：1986-01-01 00:00:00

abstract：:Acute arterial hypertension was induced in male Wistar rats using two experimental techniques: (1) i.v. injection of Aramine and (2) infusion of physiological saline as a bolus via internal carotid artery. Horseradish peroxidase (HRP) was injected i.v. prior to both experimental procedures and subsequently localized i...

journal_title：Acta neuropathologica

authors： Nagy Z,Mathieson G,Hüttner I

更新日期：1979-10-01 00:00:00

abstract：:Pilocytic astrocytomas (PAs) are the most common brain tumors in pediatric patients and can cause significant morbidity, including chronic neurological deficiencies. They are characterized by activating alterations in the mitogen-activated protein kinase pathway, but little else is known about their development. To ma...

journal_title：Acta neuropathologica

authors： Lambert SR,Witt H,Hovestadt V,Zucknick M,Kool M,Pearson DM,Korshunov A,Ryzhova M,Ichimura K,Jabado N,Fontebasso AM,Lichter P,Pfister SM,Collins VP,Jones DT

更新日期：2013-08-01 00:00:00

abstract：:The present investigation examined the morphological characteristics of epiplexus macrophages following a single intracisternal injection of the antigen, bacillus Calmette-Guerin (BCG). Three days following injection of BCG (0.5 - 4.0 X 10(8) viable microorganisms), mongrel dogs were perfused with buffered aldehydes. ...

journal_title：Acta neuropathologica

authors： Merchant RE

更新日期：1979-08-01 00:00:00

abstract：:A 40-year-old man suffering from amyotrophic lateral sclerosis with symmetrical degeneration of the thalamus and the substantia nigra is reported. The distribution pattern of the thalamic degeneration in the present case was characteristic in that the Nucleus centralis was the severest affected of the thalamic nuclei...

journal_title：Acta neuropathologica

authors： Kosaka K,Mehraein P

更新日期：1978-12-15 00:00:00

abstract：:The dynamics of cerebrospinal fluid (CSF) tau and Aβ biomarkers over time in Alzheimer's disease (AD) patients from prodromal pre-symptomatic to severe stages of dementia have not been clearly defined and recent studies, most of which are cross-sectional, present conflicting findings. To clarify this issue, we analyze...

journal_title：Acta neuropathologica

authors： Toledo JB,Xie SX,Trojanowski JQ,Shaw LM

更新日期：2013-11-01 00:00:00

abstract：:Nodding syndrome is an epidemic neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa. We report the neuropathologic findings in five fatal cases (13-18 years of age at death) of nodding syndrome from the Acholi people in northern Uganda. Neuropathologic exami...

journal_title：Acta neuropathologica

authors： Pollanen MS,Onzivua S,Robertson J,McKeever PM,Olawa F,Kitara DL,Fong A

更新日期：2018-11-01 00:00:00

abstract：:The blood-brain barrier (BBB) was studied in rats with electrolyte-induced demyelination (EID), an experimental model for central pontine myelinolysis. Intravenously injected peroxidase was extravasated at 3 h post hypertonic saline injection (PHS) into regions frequently involved in EID. Increased pinocytotic activit...

journal_title：Acta neuropathologica

authors： Rojiani AM,Prineas JW,Cho ES

更新日期：1994-01-01 00:00:00

abstract：:Mineralization in the wall of central nervous system blood vessels is sporadically encountered in aged horses and cattle as in man, generally as an age-related change. This phenomenon has not to date been located in the meninges in dogs or cats. The present study reports a retrospective histological examination of 50 ...

journal_title：Acta neuropathologica

authors： Mandara MT

更新日期：2003-03-01 00:00:00

abstract：:Old age is associated with a deficient recovery from stroke, but the cellular mechanisms underlying such phenomena are poorly understood. To address this issue, focal cerebral ischemia was produced by reversible occlusion of the right middle cerebral artery in 3- and 20-month-old male Sprague-Dawley rats. Aged rats sh...

journal_title：Acta neuropathologica

authors： Popa-Wagner A,Badan I,Walker L,Groppa S,Patrana N,Kessler C

更新日期：2007-03-01 00:00:00

abstract：:Several cases of progressive multifocal leukoencephalopathy (PML) have been associated with simian virus 40 (SV40), rather than with JC virus (JCV), the polyomavirus originally isolated from PML tissue. PML has, therefore, been defined as a demyelinating syndrome with possible multiple viral etiologies. Tissues from t...

journal_title：Acta neuropathologica

authors： Stoner GL,Ryschkewitsch CF

更新日期：1998-09-01 00:00:00

abstract：:Primary extradural ependymomas are rare neoplasms usually of the myxopapillary type. Reports on malignant primary extradural ependymal tumors are exceptionally rare. We here report on a 3-year-old boy with Schinzel-Giedion syndrome (SGS), who presented with lumbar spina bifida occulta and a progressive extraspinal les...

journal_title：Acta neuropathologica

authors： Beschorner R,Wehrmann M,Ernemann U,Bonin M,Horber V,Oehl-Jaschkowitz B,Meyermann R,Dufke A

更新日期：2007-03-01 00:00:00

abstract：:Multiple system atrophy (MSA) is characterized by the presence of distinctive glial cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein alpha-synuclein (aSyn) and the oligodendroglia-specific phosphoprotein TPPP/p25α. However, the role of oligodendroglial aSyn and p25α in the format...

journal_title：Acta neuropathologica

authors： Mavroeidi P,Arvanitaki F,Karakitsou AK,Vetsi M,Kloukina I,Zweckstetter M,Giller K,Becker S,Sorrentino ZA,Giasson BI,Jensen PH,Stefanis L,Xilouri M

更新日期：2019-09-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the gradual appearance of α-synuclein (α-syn)-containing neuronal protein aggregates. Although the exact mechanism of...

journal_title：Acta neuropathologica

authors： Tan Y,Sgobio C,Arzberger T,Machleid F,Tang Q,Findeis E,Tost J,Chakroun T,Gao P,Höllerhage M,Bötzel K,Herms J,Höglinger G,Koeglsperger T

更新日期：2020-02-01 00:00:00

abstract：:Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell proliferation and differentiation, as well as tissue remodeling, are mediated in part by infiltrating monocyte-derived macrophages. It is now clear that these infiltrating macrophages have distinct functions from resident microglia a...

journal_title：Acta neuropathologica

authors： Milich LM,Ryan CB,Lee JK

更新日期：2019-05-01 00:00:00

abstract：:The mechanisms underlying neurodegenerative diseases are the outcome of pathological alterations of evolutionary conserved molecular and cellular cascades. For this reason, Drosophila and C. elegans serve as useful model systems to study various aspects of neurodegenerative diseases. Here, we introduce the advantageou...

journal_title：Acta neuropathologica

authors： Shemesh OA,Spira ME

更新日期：2010-08-01 00:00:00

abstract：:Disturbance of intracellular trafficking plays a major role in several neurodegenerative disorders including Alzheimer or Parkinson's disease. The Chediak-Higashi syndrome (CHS), a life-threatening autosomal recessive disease with frequent mutations in the LYST gene, and its animal model, the beige mouse, are both cha...

journal_title：Acta neuropathologica

authors： Rudelius M,Osanger A,Kohlmann S,Augustin M,Piontek G,Heinzmann U,Jennen G,Russ A,Matiasek K,Stumm G,Schlegel J

更新日期：2006-09-01 00:00:00

abstract：:"Diffuse neurofibrillary tangles with calcification" (DNTC) is a rare form of slowly progressive dementia characterized by temporal or fronto-temporal atrophy with neuronal loss and astrocytosis, neurofibrillary tangles and Fahr-type calcification, but no senile plaques in the cerebral cortex. In patients with DNTC, w...

journal_title：Acta neuropathologica

authors： Terada S,Ishizu H,Tanabe Y,Takehisa Y,Haraguchi T,Hamaya K,Nose S,Sudo K,Kuroda S

更新日期：2001-12-01 00:00:00

abstract：:We examined the effect of lactic acid on cultured human glioma cell lines expressing glial fibrillary acidic protein (GFAP), vimentin and neuron-specific enolase (NSE). The growth of the cells was inhibited by the lactic acid in a dose-dependent manner. At 56 mM of lactic acid, the surviving cells of the KNS-42-c2 cel...

journal_title：Acta neuropathologica

authors： Takeshita I,Sawa H,Nakamura T,Kuramitsu M,Kitamura K,Fukui M

更新日期：1990-01-01 00:00:00

abstract：:A case of secretory meningioma with numerous meningothelial rosettes is reported. A 66-year-old man with moyamoya disease gradually developed skull deformity, and underwent surgery for the skull tumor overlying the hemisphere. Histological examination disclosed numerous meningothelial rosettes quite similar to those i...

journal_title：Acta neuropathologica

authors： Tada T,Ishii K,Oshima S,Hara H,Kobayashi S

更新日期：1992-01-01 00:00:00

abstract：:An autopsy case of Nasu-Hakola's disease (membranous lipodystrophy) was reported. A 29-year-old Japanese woman whose younger sister had been affected with typical Nasu-Hakola's disease with skeletal and neuropsychiatric syndromes and membrano-cystic lesions in the bones developed forgetfulness and lack of initiative. ...

journal_title：Acta neuropathologica

authors： Matsushita M,Oyanagi S,Hanawa S,Shiraki H,Kosaka K

更新日期：1981-01-01 00:00:00

abstract：:Oral administration of N-[4-(3-ethoxy-2-hydropropoxy)phenyl] acrylamide (EHA) induced selective granule cell destruction in the granular layer of the cerebellar cortex together with neurological signs, such as delayed righting reflex, gait or truncal ataxia, and convulsion. Neuropathologically, it caused multifocal gr...

journal_title：Acta neuropathologica

authors： Tanaka G,Okeda R

更新日期：2000-04-01 00:00:00

abstract：:The gastrocnemius muscles of 3 groups of 10 rats, sacrified 5, 7, and 12 days respectively, following tenotomy, were submitted to different types of fixation, fixative and embedding. The occurrence of target fibres is shown not to be an artefact due to the histological procedures. Further examination demonstrates that...

journal_title：Acta neuropathologica

authors： De Reuck J,De Coster W,vander Eecken H

更新日期：1978-05-24 00:00:00