Electrolyte-induced demyelination in rats. 1. Role of the blood-brain barrier and edema.

abstract：:We evaluated by in situ nick end labeling the presence of apoptotic glial cells in the spinal cord of rats which have sustained a moderate and severe compression injury at the level of T8-9, resulting in a severe but reversible paraparesis and irreversible paraplegia, respectively. In a previous investigation we found...

journal_title：Acta neuropathologica

authors： Li GL,Farooque M,Holtz A,Olsson Y

更新日期：1999-11-01 00:00:00

abstract：:Granule-containing vacuoles in the cytoplasm of hippocampal neurons are a neuropathological feature of Alzheimer's disease. Granulovacuolar degeneration (GVD) is not disease-specific and can be observed in other neurodegenerative disorders and even in the brains of non-demented elderly people. However, several studies...

journal_title：Acta neuropathologica

authors： Köhler C

更新日期：2016-09-01 00:00:00

abstract：:The expression of glial fibrillary acidic protein (GFAP) in continuous glioma and non-glioma cell lines was evaluated by molecular hybridization and immunocytochemistry. RNA transcripts from the GFAP gene were detected in two of six cell lines by Northern blot analysis of cellular RNAs using a cloned mouse GFAP cDNA p...

journal_title：Acta neuropathologica

authors： Dewhurst S,Stevenson M,McComb RD,Volsky DJ

更新日期：1987-01-01 00:00:00

abstract：:The neuropathologic findings in the brain of a National Aeronautics and Space Administration (NASA) engineer, who died subsequent to nitrogen inhalation, are reported. Findings which are unusual in other forms of anoxia included relative preservation of neurons in the Sommer sector of the hippocampus and a pattern of ...

journal_title：Acta neuropathologica

authors： Hunter S,Ballinger WE Jr,Greer M

更新日期：1985-01-01 00:00:00

abstract：:PICALM, a clathrin adaptor protein, plays important roles in clathrin-mediated endocytosis in all cell types. Recently, genome-wide association studies identified single nucleotide polymorphisms in PICALM gene as genetic risk factors for late-onset Alzheimer disease (LOAD). We analysed by western blotting with several...

journal_title：Acta neuropathologica

authors： Ando K,Brion JP,Stygelbout V,Suain V,Authelet M,Dedecker R,Chanut A,Lacor P,Lavaur J,Sazdovitch V,Rogaeva E,Potier MC,Duyckaerts C

更新日期：2013-06-01 00:00:00

abstract：:Inflammatory myopathy with abundant macrophages (IMAM) and dermatomyositis (DM) are considered to represent related disorders, since they share inflammatory infiltrates and skin alterations. In order to get more insight into these disorders, we addressed the cellular composition of the inflammatory infiltrates in musc...

journal_title：Acta neuropathologica

authors： Brunn A,Hans VJ,Vogelgesang S,Deckert M

更新日期：2009-12-01 00:00:00

abstract：:Electron microscopy revealed the presence of cytoplasmic tubular aggregates in the capillary endothelium of a sparsely granulated growth hormone cell adenoma removed surgically from a 25-year-old female patient with acromegaly. To our knowledge, this is the second publication describing these structures in hypophysial...

journal_title：Acta neuropathologica

authors： Kovacs K,Horvath E,Pritzker KP,Schwartz ML

更新日期：1977-01-31 00:00:00

abstract：:Impaired axonal transport of the fast or slow component has been reported in patients with sporadic amyotrophic lateral sclerosis (ALS), animal models for ALS, and familial ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) transgenic mice. However, little is known about the impairment of axonal transport in mutant S...

journal_title：Acta neuropathologica

authors： Sasaki S,Warita H,Abe K,Iwata M

更新日期：2005-07-01 00:00:00

abstract：:Vasa vasorum are adventitial vessels that play a role in pathogenesis of atherosclerosis, aneurysm, vasculitides, and graft vascular disease. The existence of vasa vasorum in human intracranial arteries is not yet well defined. The specific aims of this study are to determine whether the human intracranial arteries ha...

journal_title：Acta neuropathologica

authors： Aydin F

更新日期：1998-07-01 00:00:00

abstract：:The long-term survival of oligodendrocytes in the absence of axons in adult animals was studied following Wallerian degeneration of the optic nerves of adult rats for periods up to 22 months. In contrast to the findings in development and in young animals, large numbers of oligodendrocytes survived during this time pe...

journal_title：Acta neuropathologica

authors： Ludwin SK

更新日期：1990-01-01 00:00:00

abstract：:Uniform neuropathological changes are described in eight cases of the progressive encephalopathy syndrome with edema, hypsarrhythmia and optic atrophy (PEHO syndrome). Two of the autopsied patients were sisters and two other cases were familial. Macroscopically, cerebral and pronounced cerebellar atrophy was seen, the...

journal_title：Acta neuropathologica

authors： Haltia M,Somer M

更新日期：1993-01-01 00:00:00

abstract：:α-Synuclein (αSyn) histopathology defines several neurodegenerative disorders, including Parkinson's disease, Lewy body dementia, and Alzheimer's disease (AD). However, the functional link between soluble αSyn and disease etiology remains elusive, especially in AD. We, therefore, genetically targeted αSyn in APP trans...

journal_title：Acta neuropathologica

authors： Khan SS,LaCroix M,Boyle G,Sherman MA,Brown JL,Amar F,Aldaco J,Lee MK,Bloom GS,Lesné SE

更新日期：2018-10-01 00:00:00

abstract：:Striped skunks were inoculated intracerebrally with the scrapie agent (suspension of brain from a naturally infected Suffolk sheep) or intramuscularly with street rabies virus (suspension of salivary glands from naturally infected skunks). Those given the scrapie agent developed clinical signs of weakness, posterior a...

journal_title：Acta neuropathologica

authors： Bundza A,Charlton KM

更新日期：1988-01-01 00:00:00

abstract：:In adult mice, administration of the anticonvulsive drug phenytoin caused focal swellings along the Purkinje cell axon correlated with ataxia and incoordination of movements. In our model, we used murine cerebellar slice cultures to study the influence of phenytoin on postnatal Purkinje cell axon differentiation. Almo...

journal_title：Acta neuropathologica

authors： Tauer U,Knoth R,Volk B

更新日期：1998-06-01 00:00:00

abstract：:A case of secretory meningioma with numerous meningothelial rosettes is reported. A 66-year-old man with moyamoya disease gradually developed skull deformity, and underwent surgery for the skull tumor overlying the hemisphere. Histological examination disclosed numerous meningothelial rosettes quite similar to those i...

journal_title：Acta neuropathologica

authors： Tada T,Ishii K,Oshima S,Hara H,Kobayashi S

更新日期：1992-01-01 00:00:00

abstract：:Aim of the present study was to establish different immunohistochemical staining patterns for a subsequent comparison with those of primitive neuroectodermal (PNET) subsets, i.e. PNET-NOS (not otherwise specified) or PNET with focal neuronal, astrocytic or ependymal differentiation, to relate neoplastic to embryonal d...

journal_title：Acta neuropathologica

authors： Kleinert R

更新日期：1991-01-01 00:00:00

abstract：:In the present work the effect of Piromen is studied on the formation of the glial-mesenchymal scar in the experimentally injuried cortex of hamsters. The uniform effect of the bacterial polysaccharide is suggested in a strong and lasting stimulation of proliferating reactive cells in the traumatic area. The excessive...

journal_title：Acta neuropathologica

authors： von Cramon D

更新日期：1975-01-01 00:00:00

abstract：:The expression of glial fibrillary acidic protein (GFAP), vimentin, S-100 protein (S-100), HNK-1, myelin basic protein (MBP) and fibronectin was investigated immunohistochemically in 51 ethylnitrosourea (ENU)-induced neurinomas of the rat. Additionally, 90 transplantation tumors derived from ENU-induced neurinomas and...

journal_title：Acta neuropathologica

authors： Vogeley KT,Bilzer T,Reifenberger G,Wechsler W

更新日期：1991-01-01 00:00:00

abstract：:The presence of many neurofibrillary tangles (NFTs) in the central nervous system is a hallmark of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) in people living in the Kii peninsula of Japan and in the island of Guam. To determine whether or not ALS and PDC are on a spectrum of a single ...

journal_title：Acta neuropathologica

authors： Mimuro M,Kokubo Y,Kuzuhara S

更新日期：2007-06-01 00:00:00

abstract：:During corticogenesis, neurons adopt different migration pathways to reach their final position. The precursors of pyramidal neurons migrate radially, whereas most of the GABA-containing interneurons are generated in the ventral telencephalon and migrate tangentially into the neocortex. Then, they use a radial migrati...

journal_title：Acta neuropathologica

authors： Marcorelles P,Laquerrière A,Adde-Michel C,Marret S,Saugier-Veber P,Beldjord C,Friocourt G

更新日期：2010-10-01 00:00:00

abstract：:An unusual case of cerebellar neurocytoma with rhabdomyomatous differentiation in a 6-year-old boy is reported. Immunocytochemical and ultrastructural features of the tumour were studied. Abortive synapse formation, the presence of clear vesicles and synaptophysin immunoreactivity of the tumour cells indicated its int...

journal_title：Acta neuropathologica

authors： Pal L,Santosh V,Gayathri N,Das S,Das BS,Jayakumar PN,Shankar SK

更新日期：1998-03-01 00:00:00

abstract：:A 1-year-old male chinchilla with a 2-week history of conjunctivitis suffered subsequently from neurological signs comprising seizures, disorientation, recumbency and apathy. After 3 weeks of progressive central nervous disease the animal was killed in view of the poor prognosis. A non-suppurative meningitis and polio...

journal_title：Acta neuropathologica

authors： Wohlsein P,Thiele A,Fehr M,Haas L,Henneicke K,Petzold DR,Baumgärtner W

更新日期：2002-12-01 00:00:00

abstract：:Histomorphological and histochemical variability was studied in muscle specimens from 30 patients with congenital muscular dystrophy (CMD). We found involvement of the central nervous system in 8 patients (Fukuyama CMD, F-CMD), involvement of the brain and the eyes in 5 patients (muscle, eye and brain disease, MEB-D) ...

journal_title：Acta neuropathologica

authors： Leyten QH,ter Laak HJ,Gabreëls FJ,Renier WO,Renkawek K,Sengers RC

更新日期：1993-01-01 00:00:00

abstract：:Mice develop a fatal encephalomyelitis after infection with the Trinidad donkey strain of Venezuelan equine encephalitis (VEE) virus. Adult mice were inoculated intraperitoneally with VEE virus and the brains were examined at different time points. Morphological changes were assessed by histological staining. VEE viru...

journal_title：Acta neuropathologica

authors： Jackson AC,Rossiter JP

更新日期：1997-04-01 00:00:00

abstract：:Presence and distribution of S-100 protein (S-100), neuron-specific enolase (NSE), cytokeratin polypeptides, glial fibrillary acidic protein (GFAP), vimentin, actin, lysozyme and pituitary hormones (prolactin, hGH, ACTH, beta-FSH, beta-LH, beta-TSH, alpha subunit) in folliculo-stellate cells (FSC) were studied in seve...

journal_title：Acta neuropathologica

authors： Höfler H,Walter GF,Denk H

更新日期：1984-01-01 00:00:00

abstract：:The recently identified GGGGCC repeat expansion in the noncoding region of C9ORF72 is the most common pathogenic mutation in patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). We generated a human neuronal model and investigated the pathological phenotypes of human neurons containing G...

journal_title：Acta neuropathologica

authors： Almeida S,Gascon E,Tran H,Chou HJ,Gendron TF,Degroot S,Tapper AR,Sellier C,Charlet-Berguerand N,Karydas A,Seeley WW,Boxer AL,Petrucelli L,Miller BL,Gao FB

更新日期：2013-09-01 00:00:00

abstract：:The thoracic sympathetic preganglionic outflow is important in the maintenance of postural normotension in man. Normative data on the intermediolateral column (ILC) neuron cell bodies is lacking. Counts and measurements on the right ILC cytons have been performed on the T6, T7 and T8 segments of 12 spinal cords of man...

journal_title：Acta neuropathologica

authors： Low PA,Okazaki H,Dyck PJ

更新日期：1977-09-26 00:00:00

abstract：:The close correlation between abnormally low pre-mortem cerebrospinal fluid (CSF) concentrations of amyloid-β1-42 (Aβ(1-42)) and plaque burden measured by amyloid imaging as well as between pathologically increased levels of CSF tau and the extent of neurodegeneration measured by MRI has led to growing interest in usi...

journal_title：Acta neuropathologica

authors： Shaw LM,Vanderstichele H,Knapik-Czajka M,Figurski M,Coart E,Blennow K,Soares H,Simon AJ,Lewczuk P,Dean RA,Siemers E,Potter W,Lee VM,Trojanowski JQ,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2011-05-01 00:00:00

abstract：:Glioblastomas, the most malignant human brain tumors, are characterized by marked aneuploidy, suggesting chromosomal instability which may be caused by a defective mitotic spindle checkpoint. We screened 22 glioblastomas for mutations in the mitotic spindle check-point genes hBUB1, hBUBR1 and hBUB3. DNA sequencing rev...

journal_title：Acta neuropathologica

authors： Reis RM,Nakamura M,Masuoka J,Watanabe T,Colella S,Yonekawa Y,Kleihues P,Ohgaki H

更新日期：2001-04-01 00:00:00

abstract：:The paper describes the clinical and morphological features of a congenital neurological disease affecting two in-bred litter-mate kittens. The principal neurological features were ataxia and dysmetria. In one of the kittens light microscopy revealed widespread vacuolation of white and grey matter of the brain and spi...

journal_title：Acta neuropathologica

authors： Kelly DF,Gaskell CJ

更新日期：1976-06-15 00:00:00