Abstract：
:"Diffuse neurofibrillary tangles with calcification" (DNTC) is a rare form of slowly progressive dementia characterized by temporal or fronto-temporal atrophy with neuronal loss and astrocytosis, neurofibrillary tangles and Fahr-type calcification, but no senile plaques in the cerebral cortex. In patients with DNTC, we detected a novel histopathological abnormality that we termed "plaque-like structures" (PLS). PLS appeared as oval, slightly eosinophilic masses of up to 100 microns in diameter. With methenamine silver stain, the PLS were argyrophilic, and thread-like structures were observed in and around them. Most PLS were observed in deep layers of the cortex and subcortical white matter, and were accompanied by small vessels. They were intimately associated with the small-vessel walls and astrocytes. They were composed of two types of fibers. The first type comprised straight and loosely interwoven fibers about 25-30 nm in diameter, while the other type evoked tangles. These structures have not been found in other neurodegenerative diseases, including Alzheimer's disease. In addition, to evaluate hyaline arteriosclerosis in DNTC, we examined sclerotic changes of the medullary arteries and assessed white matter lesions in affected patients. In three of four patients with DNTC, sclerosis of the medullary arteries was significantly more extensive than in age-matched controls. In all four patients, the severity of white matter lesions was graded as moderate or severe in the temporal lobe and as mild or moderate in the frontal lobe. Arteriosclerotic changes and white matter lesions can occur without hypertension and beta amyloid deposits in DNTC.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Terada S,Ishizu H,Tanabe Y,Takehisa Y,Haraguchi T,Hamaya K,Nose S,Sudo K,Kuroda Sdoi
10.1007/s004010100411subject
Has Abstractpub_date
2001-12-01 00:00:00pages
597-603issue
6eissn
0001-6322issn
1432-0533journal_volume
102pub_type
杂志文章abstract：:Wistar rats were given intravenous (i.v.) horseradish peroxidase (HRP) in saline in doses commonly used to study vascular permeability and the blood-brain barrier. Samples of blood were taken from conscious animals via indwelling catheters at intervals up to 6 h after the HRP injection. Plasma concentrations of adreno...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687945
更新日期：1986-01-01 00:00:00
abstract：:We studied the densities of utrophin and dystrophin at the motor end-plates of patients with myasthenia gravis (MG) using immunohistochemical analysis. The densities were compared with those found in patients with amyotrophic lateral sclerosis, Lambert-Eaton myasthenic syndrome and normal controls. Utrophin was reduce...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050483
更新日期：1996-07-01 00:00:00
abstract：:Electron microscopy and computerized morphometric techniques were employed to examine pericyte ultrastructure and to assess quantitatively their relationship to endothelial cells in five cases of cerebellar capillary hemangioblastoma. A total of 97 cross-sectioned capillary profiles were studied. Pericyte coverage of ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687810
更新日期：1985-01-01 00:00:00
abstract：:A case of progressive polyneuropathy associated with Waldenström's macroglobulinaemia is reported. A monoclonal IgM-lambda gradient was detected in the serum and cerebro-spinal fluid. By electro-immunoblot analysis antibodies against myelin-associated glycoprotein were found in the serum and cerebro-spinal fluid. The ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690395
更新日期：1984-01-01 00:00:00
abstract：:Disturbance of intracellular trafficking plays a major role in several neurodegenerative disorders including Alzheimer or Parkinson's disease. The Chediak-Higashi syndrome (CHS), a life-threatening autosomal recessive disease with frequent mutations in the LYST gene, and its animal model, the beige mouse, are both cha...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0092-6
更新日期：2006-09-01 00:00:00
abstract：:There is evidence that apoptotic cell death mechanisms contribute to muscle fibre loss in dystrophinopathies, but little knowledge about the activators of the final degrading caspase cascade in muscle fibre apoptosis. As mitochondria-related activation of this caspase cascade, through e.g. APAF-1, could not be proven ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0934-z
更新日期：2005-02-01 00:00:00
abstract：:The Norrbottnian type of Gaucher disease is characterized by infantile or juvenile onset and variable degrees of neurological symptoms, some of which develop only after splenectomy. A full neuropathological description of this type of Gaucher disease has not been reported previously. The brains of five patients were e...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690463
更新日期：1984-01-01 00:00:00
abstract：:The formation of oedema in peripheral nerves was studied in rats at intervals varying from 6 h to 14 days after transection of the right sciatic nerve. Samples were removed proximal and distal to the injury, and the degree of oedema was determined by a microgravimetric method and by measurements of the water content a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686069
更新日期：1986-01-01 00:00:00
abstract：:The blood-brain barrier (BBB) was studied in rats with electrolyte-induced demyelination (EID), an experimental model for central pontine myelinolysis. Intravenously injected peroxidase was extravasated at 3 h post hypertonic saline injection (PHS) into regions frequently involved in EID. Increased pinocytotic activit...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00310371
更新日期：1994-01-01 00:00:00
abstract：:Using both tumor specimen and cultured tumor cells, we have studied the differentiation of a pineocytoma by light and electron microscopy (EM) and immunohistochemical demonstration of glial, neuronal and neuroendocrine markers. Only interstitial cells were labeled with anti-glial fibrillary acidic protein and anti-S10...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050834
更新日期：1998-05-01 00:00:00
abstract：:The effect of the cytokine, colony stimulating factor-1 (CSF-1), on neuronal survival in cerebral cortex ischemic lesion was determined. Ischemic lesions were made in C3H/HeJ mice by disrupting blood vessels that penetrate the cerebral cortex from the pial-vascular plexus. Recombinant human colony stimulating factor 1...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050550
更新日期：1996-11-01 00:00:00
abstract：:We estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington's disease (HD; four males, three females, mean age 52.4 +/- 13.6 years) and age- and sex-matched controls (four males, three females, mea...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051037
更新日期：1999-06-01 00:00:00
abstract：:A unique pathological finding of astrocytes was observed in the brain of a 20-year-old man who had severe physical and mental retardation. The brain was malformed showing micropolygyria in several cortical areas. A large number of hypertrophic astrocytes with eosinophilic granular substances in their cytoplasm were fo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00427225
更新日期：1992-01-01 00:00:00
abstract：:When 22 members of the BrainNet Europe (BNE) consortium assessed 31 cases with alpha-synuclein (alphaS) immunoreactive (IR) pathology applying the consensus protocol described by McKeith and colleagues in 2005, the inter-observer agreement was 80%, being lowest in the limbic category (73%). When applying the staging p...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-009-0523-2
更新日期：2009-06-01 00:00:00
abstract：:We have investigated relationships between hippocampal/temporal lobe neuropathology and psychosis in subjects with temporal lobe epilepsy, paying particular attention to possible differences in density of hippocampal neurons immunoreactive for calcium-binding proteins. There was a trend for a greater prevalence of lef...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051159
更新日期：2000-05-01 00:00:00
abstract：:The microtubule-associated protein tau accumulates as cytoplasmic inclusions in Alzheimer's disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). We investigated the immunoreactivity of tau-positive structures using a panel of antibodies to epitopes spanning the ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0671-8
更新日期：2003-05-01 00:00:00
abstract：:Mutations of isocitrate dehydrogenase 1 (IDH1) gene are most common in glioma, arguably preceding all known genetic alterations during tumor development. IDH1 mutations nearly invariably target the enzymatic active site Arg132, giving rise to the predominant IDH1R132H. Cells harboring IDH1 R132H -heterozygous mutation...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1800-0
更新日期：2018-02-01 00:00:00
abstract：:Immunofluorescence and immunogold labelling were used to localise the 43-kDa dystrophin-associated glycoprotein (43DAG) of the dystrophin-glycoprotein complex in control and Duchenne muscular dystrophy (DMD) biopsies. In control muscle 43DAG was localised by immunofluorescence to the periphery of the fibre and, by imm...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00313603
更新日期：1994-01-01 00:00:00
abstract：:Mice develop a fatal encephalomyelitis after infection with the Trinidad donkey strain of Venezuelan equine encephalitis (VEE) virus. Adult mice were inoculated intraperitoneally with VEE virus and the brains were examined at different time points. Morphological changes were assessed by histological staining. VEE viru...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050626
更新日期：1997-04-01 00:00:00
abstract：:The transmissible spongiform encephalopathies (TSEs) or prion diseases of animals are characterised by CNS spongiform change, gliosis and the accumulation of disease-associated forms of prion protein (PrP(d)). Particularly in ruminant prion diseases, a wide range of morphological types of PrP(d) depositions are found ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-010-0700-3
更新日期：2011-01-01 00:00:00
abstract：:Progressive myopathy developed in two women who consumed ipecac syrup containing emetine hydrochloride to induce vomiting as part of their anorexia nervosa. Muscle biopsy specimens were characterized by severe disruption of the sarcomeres. The ultrastructural spectrum extended from "Z-band streaming" to the formation ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686202
更新日期：1988-01-01 00:00:00
abstract：:Using immunohistochemical methods optimized to detect herpes simplex virus type 2 (HSV-2) antigen, paraffin sections from human central nervous system tissues from 31 cases pathologically diagnosed as multiple sclerosis (MS), 34 cases of other neurological diseases, 4 adult cases of HSV encephalitis, and mouse brains ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686969
更新日期：1988-01-01 00:00:00
abstract：:The occurrence is reported of acute myositis in a man with meningoencephalitis due to toxoplasmosis. The ultrastructure and immunohistochemistry of a muscle biopsy of the patient were investigated. Toxoplasma organisms were not found in the muscle biopsy. The perivascular inflammatory cells in the muscle were mainly C...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00334513
更新日期：1990-01-01 00:00:00
abstract：:Interstitial cells are isolated neurons located in the infracortical white matter that are known to express neuropeptides. Twenty-four cases selected for the absence, slight (Braak stages I-II), moderate (Braak stages III-IV), or serious degree (Braak stages V-VI) of cortical neurofibrillary pathology were studied for...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0551-7
更新日期：2002-10-01 00:00:00
abstract：:Cerebellar torpedoes, unique fusiform swellings of Purkinje cell axons within the granular layer, have been known to occur sparsely associated with diffuse cerebellar changes. This report describes, in three human autopsy cases with focal necrotic lesions in the cerebellar white matter, torpedoes which were essentiall...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00311388
更新日期：1992-01-01 00:00:00
abstract：:Multiple different pathological protein aggregates are frequently seen in human postmortem brains and hence mixed pathology is common. Mixed dementia on the other hand is less frequent and neuropathologically should only be diagnosed if criteria for more than one full blown disease are met. We quantitatively measured ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-015-1406-3
更新日期：2015-05-01 00:00:00
abstract：:A desmoplastic primary cerebral neuroblastoma originating in the frontal lobe of a boy who died at the age of 6 years contained dense core vesicles within the cytoplasm of neoplastic cells as evidence of neuronal differentiation. Sarcomatous transformation had occurred at the time of recurrence. At autopsy, he also ha...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688540
更新日期：1980-01-01 00:00:00
abstract：:The ultrastructural features of SOD1-positive aggregates were determined to clarify whether these aggregates are associated with the pathogenesis of SOD1 mutant mice. We examined the spinal cord of transgenic mice expressing a G93A mutant human SOD1 gene with fewer copies (gene copy 10). At the early presymptomatic st...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0939-7
更新日期：2005-03-01 00:00:00
abstract：:Mouse embryos were infected with murine cytomegalovirus (MCMV) by injecting the virus into the cerebral ventricles at the late gestation. After deliveries, offspring were fed by the mothers until 4 weeks. Cystic brain lesions, regarded as porencephaly or paraventricular cysts, were observed in about 20% of the MCMV-in...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00293377
更新日期：1991-01-01 00:00:00
abstract：:We have found large eosinophilic bodies in the pericapillary regions of the gray and white matter in the human spinal cord. These are entirely different from the previously reported pericapillary inclusion bodies (PIB). We have designated them pericapillary rosettes (PR), since they consist of clusters of round or ovo...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00299408
更新日期：1992-01-01 00:00:00
