Accelerated infarct development, cytogenesis and apoptosis following transient cerebral ischemia in aged rats.

abstract：:Psammoma bodies at the perivascular area in five cases of meningioma were examined with the electron microscope. In general, meningocytic cells invest the outer aspect of blood vessels, which are constituted by multilayered basal laminae, collagen fibers, microfibrils, and pericytes. Remnants of degenerated cells are ...

journal_title：Acta neuropathologica

authors： Kubota T,Hirano A,Sato K,Yamamoto S

更新日期：1985-01-01 00:00:00

abstract：:Four of seven patients with nemaline myopathy had severe, rapidly progressing symptoms. These four showed an increase in acid phosphatase activity in muscle fibers demonstrated by histochemistry and cathepsin B&L activity by biochemical measurement. On electron microscopy, nemaline bodies, occasionally disorganized my...

journal_title：Acta neuropathologica

authors： Nonaka I,Ishiura S,Arahata K,Ishibashi-Ueda H,Maruyama T,Ii K

更新日期：1989-01-01 00:00:00

abstract：:The effect of induced hypertension instituted after a 2-h delay following middle cerebral artery occlusion (MCAO) on brain edema formation and histochemical injury was studied. Under isoflurane anesthesia, the MCA of 14 spontaneously hypertensive rats was occluded. In the control group (n = 7), the mean arterial press...

journal_title：Acta neuropathologica

authors： Patel PM,Drummond JC,Cole DJ,Giamela R,Steinauer J

更新日期：1991-01-01 00:00:00

abstract：:A 64-year-old woman developed septicemia and a generalized peripheral neuropathy while being ventilated postoperatively. No cause for the neuropathy could be found during life. At autopsy she was found to have infective endocarditis and multifocal inflammatory lesions in the central and peripheral nervous systems, con...

journal_title：Acta neuropathologica

authors： Pamphlett R,Walsh J

更新日期：1989-01-01 00:00:00

abstract：:The pathological changes in the nucleus basalis of Meynert (nbM) in 10 autopsied cases with Pick's disease were studied in comparison with 15 age-matched controls. Both the number and density of nerve cells and the degree of fibrillary gliosis were examined at the anterior, intermediate, and posterior divisions of the...

journal_title：Acta neuropathologica

authors： Mizukami K,Kosaka K

更新日期：1989-01-01 00:00:00

abstract：:An unresolved issue in the study of demyelinating disease is whether blood-brain barrier damage is dependent upon the migration of inflammatory cells into the central nervous system (CNS). In a study of experimental autoimmune encephalomyelitis (EAE) in rabbits, a freeze-dried, paraffin-embedded tissue technique was e...

journal_title：Acta neuropathologica

authors： Simmons RD,Buzbee TM,Linthicum DS,Mandy WJ,Chen G,Wang C

更新日期：1987-01-01 00:00:00

abstract：:Using a fluorescent antibody technique, sections of the brains of patients with senile dementia or Alzheimer's disease containing senile plaques were treated with rabbit antihuman immunoglobulins labelled with FITC (fluorescein isothiocyanate, BBL). The senile plaques and the cerebral amyloid angiopathy (drusige Entar...

journal_title：Acta neuropathologica

authors： Ishii T,Haga S

更新日期：1975-08-11 00:00:00

abstract：:Muscle fiber abnormalities are described in three cases of neonatal maple syrup disease. There were important variations in fiber diameters. Lesions consisted in focal or diffuse destruction of myofibrils. In view of recent biochemical and clinical data, a direct relation between elevated branched-chain amino acid lev...

journal_title：Acta neuropathologica

authors： Ferrière G,de Castro M,Rodriguez J

更新日期：1984-01-01 00:00:00

abstract：:The close correlation between abnormally low pre-mortem cerebrospinal fluid (CSF) concentrations of amyloid-β1-42 (Aβ(1-42)) and plaque burden measured by amyloid imaging as well as between pathologically increased levels of CSF tau and the extent of neurodegeneration measured by MRI has led to growing interest in usi...

journal_title：Acta neuropathologica

authors： Shaw LM,Vanderstichele H,Knapik-Czajka M,Figurski M,Coart E,Blennow K,Soares H,Simon AJ,Lewczuk P,Dean RA,Siemers E,Potter W,Lee VM,Trojanowski JQ,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2011-05-01 00:00:00

abstract：:Electronmicroscope studies have been performed on the greater splanchnic nerve and the nerve to the medial head of gastrocnemius muscle of control and acrylamide poisoned cats. Degeneration of unmyelinated as well as of myelinated fibres was observed in both nerves. In cats severely poisoned with acrylamide, some very...

journal_title：Acta neuropathologica

authors： Post EJ

更新日期：1978-04-26 00:00:00

abstract：:In a study designed to identify the neuropathological features typical of chronic inflammatory demyelinating polyneuropathy (CIDP), we reviewed the sural nerve biopsy findings in 105 patients with this disorder. The patients' mean age at biopsy was 49 years. In 65% of patients the disease had a progressive and in 35% ...

journal_title：Acta neuropathologica

authors： Rizzuto N,Morbin M,Cavallaro T,Ferrari S,Fallahi M,Galiazzo Rizzuto S

更新日期：1998-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have identified several new molecular constituents of ALS-linked cellular aggregates, including FUS, TDP-43, OPTN, UBQLN2 and the translational product...

journal_title：Acta neuropathologica

authors： Blokhuis AM,Groen EJ,Koppers M,van den Berg LH,Pasterkamp RJ

更新日期：2013-06-01 00:00:00

abstract：:An 18 month old cat had a 6 month history of abnormal high stepping gait, ataxia, muscle twitching and loss of sensory perception. The clinical course was interrupted by several episodes of temporary remission. The essential pathological features were those of a polyradiculoneuritis with segmental demyelination, focal...

journal_title：Acta neuropathologica

authors： Flecknell PA,Lucke VM

更新日期：1978-01-19 00:00:00

abstract：:Numerous families exhibiting both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have been described, and although many of these have been shown to harbour a repeat expansion in C9ORF72, several C9ORF72-negative FTD-ALS families remain. We performed neuropathological and genetic analysis of a la...

journal_title：Acta neuropathologica

authors： Dobson-Stone C,Luty AA,Thompson EM,Blumbergs P,Brooks WS,Short CL,Field CD,Panegyres PK,Hecker J,Solski JA,Blair IP,Fullerton JM,Halliday GM,Schofield PR,Kwok JB

更新日期：2013-04-01 00:00:00

abstract：:Primary cortical and hippocampal neuronal cultures submitted to brief histotoxic hypoxia suffer delayed neuronal death after 24 h [Uto et al. (1995) J Neurochem 64: 2185-2192]. In this study the ultrastructural changes were monitored during the first 6 h following 5-min histotoxic hypoxia induced by exposure to 100 mi...

journal_title：Acta neuropathologica

authors： Dux E,Oschlies U,Uto A,Kusumoto M,Hossmann KA

更新日期：1996-12-01 00:00:00

abstract：:A mixed lymphoblastic T cell lymphoma and gonadotroph cell pituitary adenoma occurred 25 years after first resection of the adenoma. Within 1 year the lymphoma overgrew the adenoma, but was still restricted to the sellar region. Histologically, lymphoma and adenoma components were tightly admixed. Possible pathogeneti...

journal_title：Acta neuropathologica

authors： Kuhn D,Buchfelder M,Brabletz T,Paulus W

更新日期：1999-03-01 00:00:00

abstract：:Alpha-synuclein is known to play an important role in several neurodegenerative diseases. Moreover, it is expressed in central nervous system neuronal tumors, and another member of the synuclein family, gamma-synuclein, is overexpressed in breast and ovarian carcinomas. However, the expression of alpha-synuclein has n...

journal_title：Acta neuropathologica

authors： Mori F,Inenaga C,Yoshimoto M,Umezu H,Tanaka R,Takahashi H,Wakabayashi K

更新日期：2002-02-01 00:00:00

abstract：:The expression of glial fibrillary acidic protein (GFAP), vimentin, S-100 protein (S-100), HNK-1, myelin basic protein (MBP) and fibronectin was investigated immunohistochemically in 51 ethylnitrosourea (ENU)-induced neurinomas of the rat. Additionally, 90 transplantation tumors derived from ENU-induced neurinomas and...

journal_title：Acta neuropathologica

authors： Vogeley KT,Bilzer T,Reifenberger G,Wechsler W

更新日期：1991-01-01 00:00:00

abstract：:Clinical and morphological findings in an 8-year-old Jewish girl with spongy leukodystrophy are presented. Ultrastructural changes indicated that this may be a form of Canavan's disease with some atypical features. Biochemical measurements indicated that synaptosomal membranes prepared from the striatum but not from t...

journal_title：Acta neuropathologica

authors： Boehme DH,Marks N

更新日期：1981-01-01 00:00:00

abstract：:Pregnant rats were administered a liquid diet containing 5% (w/v) ethanol between gestational days 10 and 21, and the brains of nine offspring were examined at 8 weeks of age. Two ethanol-treated offspring showed obvious hydrocephalus characterized by markedly enlarged lateral ventricles. Most of the other ethanol-tre...

journal_title：Acta neuropathologica

authors： Sakata-Haga H,Sawada K,Ohnishi T,Fukui Y

更新日期：2004-11-01 00:00:00

abstract：:Multiple system atrophy (MSA) is characterized by the presence of distinctive glial cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein alpha-synuclein (aSyn) and the oligodendroglia-specific phosphoprotein TPPP/p25α. However, the role of oligodendroglial aSyn and p25α in the format...

journal_title：Acta neuropathologica

authors： Mavroeidi P,Arvanitaki F,Karakitsou AK,Vetsi M,Kloukina I,Zweckstetter M,Giller K,Becker S,Sorrentino ZA,Giasson BI,Jensen PH,Stefanis L,Xilouri M

更新日期：2019-09-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the gradual appearance of α-synuclein (α-syn)-containing neuronal protein aggregates. Although the exact mechanism of...

journal_title：Acta neuropathologica

authors： Tan Y,Sgobio C,Arzberger T,Machleid F,Tang Q,Findeis E,Tost J,Chakroun T,Gao P,Höllerhage M,Bötzel K,Herms J,Höglinger G,Koeglsperger T

更新日期：2020-02-01 00:00:00

abstract：:Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3.3) subgroups were c...

journal_title：Acta neuropathologica

authors： Khuong-Quang DA,Buczkowicz P,Rakopoulos P,Liu XY,Fontebasso AM,Bouffet E,Bartels U,Albrecht S,Schwartzentruber J,Letourneau L,Bourgey M,Bourque G,Montpetit A,Bourret G,Lepage P,Fleming A,Lichter P,Kool M,von Deimling

更新日期：2012-09-01 00:00:00

abstract：:The most common cause of familial frontotemporal lobar degeneration with TAR DNA-binding protein-43 pathology (FTLD-TDP) has been found to be an expansion of a hexanucleotide repeat (GGGGCC) in a noncoding region of the gene C9ORF72. Hippocampal sclerosis (HpScl) is a common finding in FTLD-TDP. Our objective was to s...

journal_title：Acta neuropathologica

authors： Murray ME,Bieniek KF,Banks Greenberg M,DeJesus-Hernandez M,Rutherford NJ,van Blitterswijk M,Niemantsverdriet E,Ash PE,Gendron TF,Kouri N,Baker M,Goodman IJ,Petrucelli L,Rademakers R,Dickson DW

更新日期：2013-10-01 00:00:00

abstract：:A series of 50 human primary intracranial tumors were cultivated in vitro in an attempt to establish cell lines with the trypsinization technique. During the in vitro adaptation period, cultures were maintained at high cell density to avoid rapid over-growth by connective tissue. Five lines were established from 5 tum...

journal_title：Acta neuropathologica

authors： Maunoury R

更新日期：1977-07-15 00:00:00

abstract：:Intracranial cartilaginous tumors are rare lesions, usually arising from the skull base in older individuals. We report the case of a 12-year-old girl with a low-grade type chondrosarcoma arising from the falx cerebri. To our knowledge this is the first such case reported in a child. She was treated with gross total s...

journal_title：Acta neuropathologica

authors： Gerszten PC,Pollack IF,Hamilton RL

更新日期：1998-01-01 00:00:00

abstract：:We have found large eosinophilic bodies in the pericapillary regions of the gray and white matter in the human spinal cord. These are entirely different from the previously reported pericapillary inclusion bodies (PIB). We have designated them pericapillary rosettes (PR), since they consist of clusters of round or ovo...

journal_title：Acta neuropathologica

authors： Sasaki S,Maruyama S

更新日期：1992-01-01 00:00:00

abstract：:Mice develop a fatal encephalomyelitis after infection with the Trinidad donkey strain of Venezuelan equine encephalitis (VEE) virus. Adult mice were inoculated intraperitoneally with VEE virus and the brains were examined at different time points. Morphological changes were assessed by histological staining. VEE viru...

journal_title：Acta neuropathologica

authors： Jackson AC,Rossiter JP

更新日期：1997-04-01 00:00:00

abstract：:The pathogenesis of HIV-associated cognitive changes is poorly understood. Cytokines such as tumor necrosis factor-alpha (TNF-alpha) have been postulated to contribute to the mechanism of the neurological complications of HIV infection. One of the effects of TNF-alpha is to induce astrocyte proliferation in vitro. The...

journal_title：Acta neuropathologica

authors： Seilhean D,Kobayashi K,He Y,Uchihara T,Rosenblum O,Katlama C,Bricaire F,Duyckaerts C,Hauw JJ

更新日期：1997-05-01 00:00:00

abstract：:The extent of DNA fragmentation analysed using the TUNEL technique was evaluated in post-mortem human brain tissue. Twenty-four patients with clinical and histopathological diagnosis of Alzheimer's disease (AD) and a short post-mortem delay were analysed. We report an increase in the count of TUNEL-labelled cells as t...

journal_title：Acta neuropathologica

authors： Overmyer M,Kraszpulski M,Helisalmi S,Soininen H,Alafuzoff I

更新日期：2000-12-01 00:00:00