Protracted form of Canavan's disease: case history and protein kinase activity of membrane fractions.

Abstract:

:Clinical and morphological findings in an 8-year-old Jewish girl with spongy leukodystrophy are presented. Ultrastructural changes indicated that this may be a form of Canavan's disease with some atypical features. Biochemical measurements indicated that synaptosomal membranes prepared from the striatum but not from the cerebral cortex were deficient in protein kinase activity based on incorporation of 32P into proteins. Both areas contained the same spectrum of proteins. Cyclic AMP (cAMP) measurements indicated no significant differences between brain areas, or when compared to tissue obtained from a stillborn and a 5-year-old child.

journal_name

Acta Neuropathol

journal_title

Acta neuropathologica

authors

Boehme DH,Marks N

doi

10.1007/BF00691321

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

221-5

issue

3

eissn

0001-6322

issn

1432-0533

journal_volume

55

pub_type

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