Simultaneous visualization of vascular permeability change and leukocyte egress in the central nervous system during autoimmune encephalomyelitis.

Abstract:

:An unresolved issue in the study of demyelinating disease is whether blood-brain barrier damage is dependent upon the migration of inflammatory cells into the central nervous system (CNS). In a study of experimental autoimmune encephalomyelitis (EAE) in rabbits, a freeze-dried, paraffin-embedded tissue technique was exploited to enable (1) the immobilization of intravenously injected sodium fluorescein tracer, as an index of vascular permeability; and (2) an effective labeling by monoclonal antibodies of both T-lymphocytes and mononuclear phagocytes in "unfixed" neural tissue. Using these newly combined methods, evidence was found that increased vascular permeability in the CNS during EAE occurs concomitantly with, and not prior to, infiltration by mononuclear phagocytes.

journal_name

Acta Neuropathol

journal_title

Acta neuropathologica

authors

Simmons RD,Buzbee TM,Linthicum DS,Mandy WJ,Chen G,Wang C

doi

10.1007/BF00692851

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

191-3

issue

2

eissn

0001-6322

issn

1432-0533

journal_volume

74

pub_type

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