Abstract:
:Mice develop a fatal encephalomyelitis after infection with the Trinidad donkey strain of Venezuelan equine encephalitis (VEE) virus. Adult mice were inoculated intraperitoneally with VEE virus and the brains were examined at different time points. Morphological changes were assessed by histological staining. VEE virus antigen was detected with immunoperoxidase staining, and DNA fragmentation was evaluated in situ using the terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) method. VEE antigen was found in many areas of the brain and it was prominent in neurons. There were mild associated inflammatory changes. DNA fragmentation was demonstrated in many of these areas using TUNEL. In areas with TUNEL staining, morphological neuronal changes ranged from nuclear chromatin condensations to nuclear and cellular fragmentation, which are characteristic of apoptosis. There is strong morphological and biochemical evidence of apoptotic cell death in this experimental model of VEE virus infection.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Jackson AC,Rossiter JPdoi
10.1007/s004010050626subject
Has Abstractpub_date
1997-04-01 00:00:00pages
349-53issue
4eissn
0001-6322issn
1432-0533journal_volume
93pub_type
杂志文章abstract::The cerebrovascular lesions of severe chronic hypertension were studied by light microscopy in perfusion-fixed, subserially sectioned brains from stroke-prone spontaneously hypertensive rats (SHRSP). The leakage and spread of plasma proteins were visualized by immunohistochemical detection of extravasated fibrinogen a...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00690831
更新日期:1985-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010050559
更新日期:1996-12-01 00:00:00
abstract::The dynamics of cell-associated Concanavalin A (Con A) in astrocytes of the newborn rat (RNA), the rat glioma (AC), and the human glioblastoma (GB) were studied in vitro by fluorescence and electron microscopy. Con A receptors on the cell surface were seen usually as a continuous thin layer, and Con A accumulations in...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00690804
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688573
更新日期:1977-09-26 00:00:00
abstract::To determine the origin of the large myelinated fibers in the anterolateral funiculus (ALF) in the spinal cord of humans, myelinated fibers in the ALF of the mid-cervical spinal cord were examined quantitatively. Five groups of subjects were examined, consisting of control subjects, patients with cerebral lesions and ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010051129
更新日期:1999-12-01 00:00:00
abstract::Behaviour of biogenic amines was studied in the brains of Mongolian gerbils subjected to unilateral occlusion of the common carotid artery. Assays on the hemispheres ipsilateral to occlusion revealed in symptom-positive animals a progressive decrease in norepinephrine and dopamine, and an increase in serotonin through...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00685142
更新日期:1976-09-15 00:00:00
abstract::The close correlation between abnormally low pre-mortem cerebrospinal fluid (CSF) concentrations of amyloid-β1-42 (Aβ(1-42)) and plaque burden measured by amyloid imaging as well as between pathologically increased levels of CSF tau and the extent of neurodegeneration measured by MRI has led to growing interest in usi...
journal_title:Acta neuropathologica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00401-011-0808-0
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-017-1683-0
更新日期:2017-04-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688193
更新日期:1987-01-01 00:00:00
abstract::Structural proteins of cultured neurofibromatosis (NF) tumor and skin cells were studied with reference to control skin fibroblasts. In polyacrylamide gel electrophoresis (PAGE)/fluorography the banding patterns of the cell lysates were markedly similar. NF tumor cells, however, produced a 60 kD band with a stronger a...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00687332
更新日期:1984-01-01 00:00:00
abstract::The occurrence of oligodendrocytes within astrocytes ("emperipolesis") has been described in demyelinating lesions in cases of multiple sclerosis and also in other non-demyelinating disorders. We found that this finding was common in the cerebral white matter of patients with Creutzfeldt-Jakob disease (CJD). Eight con...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-004-0880-9
更新日期:2004-09-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
abstract::An unusual case of cerebellar neurocytoma with rhabdomyomatous differentiation in a 6-year-old boy is reported. Immunocytochemical and ultrastructural features of the tumour were studied. Abortive synapse formation, the presence of clear vesicles and synaptophysin immunoreactivity of the tumour cells indicated its int...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010050805
更新日期:1998-03-01 00:00:00
abstract::Data on the dural invasiveness of pituitary adenomas have been correlated to the expression of matrix metalloproteinases (e.g. MMP-9). Serine proteases have not yet been investigated in human pituitary adenomas. In this study, paraffin-embedded material from 84 human pituitary adenomas (acromegaly n=18, Cushing's dise...
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更新日期:2003-11-01 00:00:00
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doi:10.1007/s00401-016-1546-0
更新日期:2016-04-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-009-0550-z
更新日期:2009-09-01 00:00:00
abstract::The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of neuromuscular disorders subdivided into polymyositis (PM), sporadic inclusion body myositis (sIBM) and dermatomyositis (DM). Chemokines play an essential role in sustained inflammation associated with IIM. We studied the distribution of the alph...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s00401-005-0989-5
更新日期:2005-06-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
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abstract::CD44 antigen (CD44), the principle cell surface receptor for hyaluronate, is up-regulated in the human demyelinating disease multiple sclerosis on fibrous astrocytes. As astrocytes are the main target cell of canine distemper virus (CDV), the consequences of a CDV infection on the CD44 expression and distribution in b...
journal_title:Acta neuropathologica
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更新日期:2000-02-01 00:00:00
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doi:10.1007/BF00688249
更新日期:1988-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00699239
更新日期:1981-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00294357
更新日期:1994-01-01 00:00:00
abstract::α-Synuclein (αSyn) histopathology defines several neurodegenerative disorders, including Parkinson's disease, Lewy body dementia, and Alzheimer's disease (AD). However, the functional link between soluble αSyn and disease etiology remains elusive, especially in AD. We, therefore, genetically targeted αSyn in APP trans...
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pub_type: 杂志文章
doi:10.1007/s00401-018-1886-z
更新日期:2018-10-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00695496
更新日期:1987-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688686
更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
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abstract::Amplification of the epidermal growth factor receptor (EGFR) gene is found in about 40% of glioblastomas (GBMs) but is rarely detected in GBM cell lines. We confirmed that the exceptional SKMG-3 GBM cell line retained amplified EGFR genes in vitro, and found that these sequences were concentrated on extra-chromosomal ...
journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/s004010000332
更新日期:2001-06-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00