Abstract:
:Cerebellar torpedoes, unique fusiform swellings of Purkinje cell axons within the granular layer, have been known to occur sparsely associated with diffuse cerebellar changes. This report describes, in three human autopsy cases with focal necrotic lesions in the cerebellar white matter, torpedoes which were essentially confined to the cerebellar cortex overlying the lesions. Purkinje cells in the same region showed no recognizable change, but were obviously decreased in number. The location of the necrotic lesions was such that they may well have severed Purkinje cell axons projecting into the deeply located cerebellar nuclei from the torpedo-carrying cortex. These findings indicate that damage to Purkinje cell axons, even if it occurs far away from the cell bodies, may have a critical influence upon the metabolism of Purkinje cells and play an important role in the formation of torpedoes.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Takahashi N,Iwatsubo T,Nakano I,Machinami Rdoi
10.1007/BF00311388subject
Has Abstractpub_date
1992-01-01 00:00:00pages
153-6issue
2eissn
0001-6322issn
1432-0533journal_volume
84pub_type
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