Abstract：
:With an incidence of approximately 350 in 100,000, stroke is the third leading cause of death and a major cause of disability in industrialized countries. At present, although progress has been made in understanding the molecular pathways that lead to ischemic cell death, the current clinical treatments remain poorly effective. There is mounting evidence that inflammation plays an important role in cerebral ischemia. Experimentally and clinically, brain response to ischemic injury is associated with an acute and prolonged inflammatory process characterized by the activation of resident glial cells, production of inflammatory cytokines as well as leukocyte and monocyte infiltration in the brain, events that may contribute to ischemic brain injury and affect brain recovery and plasticity. However, whether the post-ischemic inflammatory response is deleterious or beneficial to brain recovery is presently a matter of debate and controversies. Here, we summarize the current knowledge on the molecular mechanisms underlying post-ischemic neuronal plasticity and the potential role of inflammation in regenerative processes and functional recovery after stroke. Furthermore, because of the dynamic nature of the brain inflammatory response, we highlight the importance of the development of novel experimental approaches such as real-time imaging. Finally, we discuss the novel transgenic reporter mice models that have allowed us to visualize and to analyze the processes such as neuroinflammation and neuronal repair from the ischemic brains of live animals.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Kriz J,Lalancette-Hébert Mdoi
10.1007/s00401-009-0496-1subject
Has Abstractpub_date
2009-05-01 00:00:00pages
497-509issue
5eissn
0001-6322issn
1432-0533journal_volume
117pub_type
杂志文章,评审abstract：:A simple and reproducible method for cryopreservation of brain tissue from patients with Alzheimer's disease is described. Fresh brain slices (1 cm thick) obtained less than 6 h postmortem are placed in sealed plastic bags, sandwiched between 0.3-cm-thick aluminium sheets, and frozen by placing the entire "sandwich" b...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294305
更新日期：1993-01-01 00:00:00
abstract：:Following maternal chicken pox in the 14th week of pregnancy, a male infant was born with low birth weight, muscle wasting and limb contractures, hypotonia and areflexia. A rising titre of varicella-zoster-specific IgM (by enzyme-linked immunoabsorbent assay) confirmed congenital infection, and electromyogram showed w...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687781
更新日期：1988-01-01 00:00:00
abstract：:Localization of organ-specific brain antigens in the central nervous system of the rat has been studied by means of indirect immunofluorescence. Rabbit antiserum against homogenate of rat brain, previously absorbed with normal serum and homogenates of rat organs (kidney, liver, spleen), reacted with the water-soluble ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00703316
更新日期：1977-08-16 00:00:00
abstract：:We report a sporadic tauopathy of 6-year duration in a 76-year-old woman. Her initial symptoms were asymmetrical parkinsonism and muscle weakness, with apraxia appearing 2 years later. The brain showed frontal and temporal cerebral atrophy; severe neuronal loss and gliosis were observed in the precentral cortex (loss ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-1086-5
更新日期：2005-12-01 00:00:00
abstract：:A massive expansion of a GGGGCC repeat upstream of the C9orf72 coding region is the most common known cause of amyotrophic lateral sclerosis and frontotemporal dementia. Despite its intronic localization and lack of a canonical start codon, both strands are translated into aggregating dipeptide repeat (DPR) proteins: ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-015-1450-z
更新日期：2015-10-01 00:00:00
abstract：:The growth potential of 65 pituitary adenomas was determined by histochemical analysis with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine (BrdUdR) labeling, and counts of argyrophilic nucleolar organizer regions (Ag-NORs). The mean proliferating cell indices (PCIs) determined by Ki-67 an...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00311392
更新日期：1992-01-01 00:00:00
abstract：:A 25-year-old homosexual AIDS patient presented with progressive cognitive, motor and behavioral disturbances consistent with HIV encephalopathy. CT scans demonstrated progressive diffuse brain atrophy. Neuropathology showed predominant cortical changes including severe neuronal loss corroborated by morphometry. Only ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294450
更新日期：1991-01-01 00:00:00
abstract：:Inappropriate apoptosis has been implicated in the mechanism of neuronal death in Huntington's disease (HD). In this study, we report the expression of apoptotic markers in HD caudate nucleus (grades 1-4) and compare this with controls without neurological disease. Terminal transferase-mediated biotinylated-UTP nick e...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-004-0957-5
更新日期：2005-03-01 00:00:00
abstract：:Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild impact traumatic brain injury from contact sports. Recently, a consensus panel defined the pathognomonic lesion for CTE as accumulations of abnormally hyperphosphorylated tau (p-tau) in neurons (neurofibrillary tangle...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-016-1649-7
更新日期：2017-03-01 00:00:00
abstract：:The deficiency of the cholinergic cortical projection system arising in the different basal forebrain structures collectively referred to as nucleus basalis of Meynert complex is a constant finding in Alzheimer's disease, a disorder which is neuro-pathologically characterised by the appearance of three intracerebral f...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690530
更新日期：1988-01-01 00:00:00
abstract：:Adult white rats were injected daily for 1 month with aluminum chloride and killed. Aluminum was identified, quantitated, and localized in the brains of these rats. The only detectable anomalies were crystals of aluminum and phosphorus in lysosomes and lipofuscin granules in the cytoplasm of neurons. ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00707114
更新日期：1980-01-01 00:00:00
abstract：:The neurone-centred view of the past disregarded or downplayed the role of astroglia as a primary component in the pathogenesis of neurological diseases. As this concept is changing, so is also the perceived role of astrocytes in the healthy and diseased brain and spinal cord. We have started to unravel the different ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-015-1513-1
更新日期：2016-03-01 00:00:00
abstract：:APO2 ligand (APO2L)/TRAIL is a novel member of the tumor necrosis factor cytokine family and a potent inducer of apoptosis in tumor cell lines. We recently reported that APO2L is consistently expressed in low-grade astrocytomas, anaplastic astrocytomas, glioblastomas, and cell lines derived thereof, and that malignant...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/pl00007399
更新日期：2000-01-01 00:00:00
abstract：:Since we reported a case of acute relaxant-steroid myopathy (ARSM) in 1994, we continued histological studies and compared the findings with those in a case of corticosteroid myopathy (CM). It was revealed that (1) dystrophin, spectrin, beta dystroglycan, and sarcoglycans on the cell surface were decreased, (2) regula...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051022
更新日期：1999-05-01 00:00:00
abstract：:We report the case of an elderly woman with a history of headache, vomiting and dizziness while walking. On CT scans a mass was identified in the right cerebellar hemisphere exhibiting radiological characteristics of lipomatous tissue. Surgery revealed a compact lesion consisting of whitish-yellow tissue with a fatty ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00389504
更新日期：1994-01-01 00:00:00
abstract：:The effect of the cytokine, colony stimulating factor-1 (CSF-1), on neuronal survival in cerebral cortex ischemic lesion was determined. Ischemic lesions were made in C3H/HeJ mice by disrupting blood vessels that penetrate the cerebral cortex from the pial-vascular plexus. Recombinant human colony stimulating factor 1...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050550
更新日期：1996-11-01 00:00:00
abstract：:Cyclooxygenases (COX, prostaglandin endoperoxide synthases, PGG/H synthases) are potent mediators of inflammation. While COX-1 is constitutively expressed in a wide range of tissues, COX-2 is cytokine inducible. Although COX-1 expression is observed in normal tissue, enhanced COX-2 expression has been attributed a key...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051075
更新日期：1999-09-01 00:00:00
abstract：:Conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer's disease (LOAD). Mutations and/or differential expression of microglial specific receptors such as TREM2, CD33, and CR3 have been associated wi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1737-3
更新日期：2017-11-01 00:00:00
abstract：:Amebic Meningoencephalitis (AM) and Primary Amebic Meningoencephalitis (PAM) are infectious diseases essentially confined to the Central Nervous System (CNS) and caused by free-living amebas of the genus Acanthamoeba (A.) and Naegleria (N.) respectively. AM due to A. sp. (Acanthamoeba castellanii and Acanthamoeba culb...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686877
更新日期：1977-03-31 00:00:00
abstract：:Two distinct species of amyloid beta protein (A beta) with different carboxyl termini, A beta 40 and A beta 42(43), are deposited in plaques in the brains of patients with Alzheimer's disease and Down's syndrome. The relationship between these two forms of A beta and microglial cells was investigated in 16 subjects wi...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294808
更新日期：1995-01-01 00:00:00
abstract：:The authors describe in biopsies from 6 cases of Werdnig-Hoffmann disease, including 2 of the more benign type, the ultrastructural typical aspects of denervation. They compare their findings with those of other workers. The striking points are the great variation in the diameter of the muscle fibres and the myofibril...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687923
更新日期：1975-01-01 00:00:00
abstract：:In a large series of 116 cortical resections for treatment of medically intractable epilepsy, 10 glial hamartomas and 11 neuronoglial malformative lesions were found. Glial hamartomas were astrocytic in 3 cases, oligodendrocytic in 6 and mixed oligoastrocytic in 1. Neuronoglial lesions corresponded to "focal cortical ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00296190
更新日期：1994-01-01 00:00:00
abstract：:Recent evidence suggests that brain-derived neurotrophic factor (BDNF) and its tyrosine kinase B (TrkB) receptor, in addition to promoting neuronal survival and differentiation, modulates synaptic transmission by increasing N-methyl-D-aspartic acid receptor (NMDAR) activity. Overexpression of BDNF may, then, interfere...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000296
更新日期：2001-04-01 00:00:00
abstract：:Frontotemporal lobar degeneration is the term used to describe the non-Alzheimer clinical syndromes of frontotemporal dementia, semantic dementia and progressive non-fluent aphasia, regardless of the underlying neuropathological features. Considerable progress has been made in recent years in our understanding of the ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-007-0241-6
更新日期：2007-07-01 00:00:00
abstract：:This study was designed to compare the degree of reactive astrogliosis occurring around a puncture wound in the brain of normal rats and at different intervals after a similar puncture wound in rats with a portocaval anastomosis. The gliosis was evaluated by the number of astrocytes, the thickness of their processes a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00310926
更新日期：1991-01-01 00:00:00
abstract：:Neurotrophins regulate the proliferation and differentiation of neurons in the central nervous system via a family of specialized receptors, including TrkA, TrkB, and TrkC. As little is known about their expression or potential role in human glial tissues and glial tumors, we undertook an immunohistochemical analysis ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050906
更新日期：1998-10-01 00:00:00
abstract：:We describe the clinical and neuropathological findings of three unrelated autopsy cases of MELAS harboring the A3243G transition in the mitochondrial DNA (mtDNA). Using immunohistochemical techniques, we studied the expression of several subunits of the respiratory chain in various brain regions from the same cases. ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0716-z
更新日期：2003-09-01 00:00:00
abstract：:Respiratory chain dysfunction leads to reactive oxygen species (ROS) generation with following oxidative stress and cellular damage. A histochemical and immunohistochemical study was performed on muscle biopsies from 17 patients with mitochondrial disease [chronic progressive external ophthalmoplegia (CPEO), mitochond...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100455
更新日期：2002-03-01 00:00:00
abstract：:Immunofluorescence and immunogold labelling were used to localise the 43-kDa dystrophin-associated glycoprotein (43DAG) of the dystrophin-glycoprotein complex in control and Duchenne muscular dystrophy (DMD) biopsies. In control muscle 43DAG was localised by immunofluorescence to the periphery of the fibre and, by imm...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00313603
更新日期：1994-01-01 00:00:00
abstract：:The Trembler mouse suffers from an hereditary demyelinating neuropathy. Schwann cell myelination of peripheral nerve fibres in the Trembler mouse is abnormal. Myelination of central nerve fibres in the deeper layers of white matter of the spinal cord is normal. At the junction between the peripheral nervous system and...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691273
更新日期：1977-04-29 00:00:00
