Meningoencephalitis due to Acanthamoeba SP. Pathogenesis and clinico-pathological study.

abstract：:This study was undertaken to elucidate morphological changes in the synaptic area of the Purkinje cell dendritic spines when granule cells were decreased in number. The mice were injected s.c. with 30 mg/kg b.w. of cytosine arabinoside on days 2, 3, and 4, and on days 7, 8 and 9, and were designated as group I and gro...

journal_title：Acta neuropathologica

authors： Yamano T,Shimada M,Ohno M,Utsunomiya T,Oya N

更新日期：1983-01-01 00:00:00

abstract：:The brain of a 69-year-old man exhibited extensive granulomatous inflammation in the walls of arteries in the leptomeninges, associated with amyloid deposition in the media of the involved arteries. The extracranial arteries exhibited neither granulomatous inflammation nor amyloid deposition in their walls. ...

journal_title：Acta neuropathologica

authors： Shintaku M,Osawa K,Toki J,Maeda R,Nishiyama T

更新日期：1986-01-01 00:00:00

abstract：:The effect of induced hypertension instituted after a 2-h delay following middle cerebral artery occlusion (MCAO) on brain edema formation and histochemical injury was studied. Under isoflurane anesthesia, the MCA of 14 spontaneously hypertensive rats was occluded. In the control group (n = 7), the mean arterial press...

journal_title：Acta neuropathologica

authors： Patel PM,Drummond JC,Cole DJ,Giamela R,Steinauer J

更新日期：1991-01-01 00:00:00

abstract：:To identify antigenic differences between gliomas and normal brain, we have immunohistochemically studied the expression of lymphocyte adhesion molecules (ICAM-1, ICAM-2, ICAM-3, VCAM-1, E-selectin and CD58), epidermal growth factor receptor (EGFR) and extracellular matrix proteins (collagen IV, fibronectin, laminin, ...

journal_title：Acta neuropathologica

authors： Mäenpää A,Kovanen PE,Paetau A,Jäáskeläinen J,Timonen T

更新日期：1997-09-01 00:00:00

abstract：:In an autopsy case of the sporadic juvenile ALS (a 17-year-old girl) intracytoplasmic inclusions are found in the upper and lower motor neurons and in nerve cells of the dentate nucleus, pontine nucleus, brain stem reticular formation, substantia nigra, thalamus, globus pallidus and others. Histochemically they contai...

journal_title：Acta neuropathologica

authors： Oda M,Akagawa N,Tabuchi Y,Tanabe H

更新日期：1978-12-15 00:00:00

abstract：:A unique pathological finding of astrocytes was observed in the brain of a 20-year-old man who had severe physical and mental retardation. The brain was malformed showing micropolygyria in several cortical areas. A large number of hypertrophic astrocytes with eosinophilic granular substances in their cytoplasm were fo...

journal_title：Acta neuropathologica

authors： Minagawa M,Shioda K,Shimizu Y,Isshiki T

更新日期：1992-01-01 00:00:00

abstract：:This study concerns an autopsy case of motor neuron disease with dementia (MND-D) that exhibited unusual clinical and neuropathological findings. The patient was a Japanese man without any relevant family history who was 60 years old at the time of death. His clinical manifestation included character change at the age...

journal_title：Acta neuropathologica

authors： Sudo S,Fukutani Y,Matsubara R,Sasaki K,Shiozawa M,Wada Y,Naiki H,Isaki K

更新日期：2002-05-01 00:00:00

abstract：:Abuse of the club drugs Methamphetamine (Meth) and Ecstasy (MDMA) is an international problem. The seriousness of this problem is the result of what appears to be programmed cell death (PCD) occurring within the brain following their use. This follow up study focused on determining which cell types, neurons and/or gli...

journal_title：Acta neuropathologica

authors： Warren MW,Larner SF,Kobeissy FH,Brezing CA,Jeung JA,Hayes RL,Gold MS,Wang KK

更新日期：2007-09-01 00:00:00

abstract：:A macrosomic male infant with multiple malformations survived for 4 days. His external dysplasias comprised macrocephalus, cheilopalatoschisis, auricular anomalies, and unilateral hexadactyl; his internal dysplasias included cysts of kidneys and pancreas, and a patent foramen ovale. The child had frequent generalized ...

journal_title：Acta neuropathologica

authors： Hori A,Orthner H,Kohlschütter A,Schott KM,Hirabayashi K,Shimokawa K

更新日期：1980-01-01 00:00:00

abstract：:To elucidate whether the apolipoprotein E epsilon4 allele (APOE4) affects cortical neuropathology in Parkinson's disease (PD), we determined APOE genotypes and quantified the densities of cortical Lewy bodies (LBs), amyloid plaques and neurofibrillary tangles in 22 autopsy-proven PD cases (12 with dementia; 10 without...

journal_title：Acta neuropathologica

authors： Wakabayashi K,Kakita A,Hayashi S,Okuizumi K,Onodera O,Tanaka H,Ishikawa A,Tsuji S,Takahashi H

更新日期：1998-05-01 00:00:00

abstract：:A quantitative study was performed on spinal cord lesions in seven patients with X-linked recessive spinal and bulbar muscular atrophy. The myelinated fiber density of the lateral corticospinal tracts at the T7 cord level was well preserved for both large and small myelinated fibers. On the other hand, neurons in the ...

journal_title：Acta neuropathologica

authors： Terao S,Sobue G,Li M,Hashizume Y,Tanaka F,Mitsuma T

更新日期：1997-01-01 00:00:00

abstract：:The ultrastructure of the nervous tissue in a benign ovarian teratoma is described. This tissue was organized into areas having both "meningeal" and "ependymal" surfaces, between which were found astrocytes, ependymal cells, neurones with synapses and microglia. These cells all had ultrastructural similarities to thei...

journal_title：Acta neuropathologica

authors： Scott T,Pesce C

更新日期：1987-01-01 00:00:00

abstract：:Uniform neuropathological changes are described in eight cases of the progressive encephalopathy syndrome with edema, hypsarrhythmia and optic atrophy (PEHO syndrome). Two of the autopsied patients were sisters and two other cases were familial. Macroscopically, cerebral and pronounced cerebellar atrophy was seen, the...

journal_title：Acta neuropathologica

authors： Haltia M,Somer M

更新日期：1993-01-01 00:00:00

abstract：:The aim of the present work was to investigate whether nestin, a member of the intermediate filament family, is immunohistochemically expressed in the non-tumoral human hypophysis and pituitary neoplasms. Twenty-three normal pituitaries and 125 pituitary neoplasms were included. The tissues were formalin-fixed and par...

journal_title：Acta neuropathologica

authors： Rotondo F,Kovacs K,Horvath E,Bell CD,Lloyd RV,Scheithauer BW

更新日期：2006-03-01 00:00:00

abstract：:The presence of many neurofibrillary tangles (NFTs) in the central nervous system is a hallmark of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) in people living in the Kii peninsula of Japan and in the island of Guam. To determine whether or not ALS and PDC are on a spectrum of a single ...

journal_title：Acta neuropathologica

authors： Mimuro M,Kokubo Y,Kuzuhara S

更新日期：2007-06-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX), a rare autosomal-recessive lipid storage disease, has been well characterized clinically and biochemically, and recently also from the molecular biological aspect. However, only a very few publications deal with its neuropathology, and views on its pathogenesis vary. Based on a re...

journal_title：Acta neuropathologica

authors： Soffer D,Benharroch D,Berginer V

更新日期：1995-01-01 00:00:00

abstract：:We report the case of an 11-year-old male who developed subacute diffuse polyradiculoneuropathy, associated with digestive symptoms and Epstein-Barr virus infection. Parental consanguinity was present. The laboratory findings including bone marrow smear were consistent with hemophagocytic lymphohistiocytosis (HLH). El...

journal_title：Acta neuropathologica

authors： De Armas R,Sindou P,Gelot A,Routon MC,Ponsot G,Vallat JM

更新日期：2004-10-01 00:00:00

abstract：:The fine structure of an intracerebellar "fibroma" has been examined. The tumor consists of irregularly-shaped cells connected by well developed junctional complexes. Unusual, fenestrated capillaries with extremely narrow and irregular lumens are frequent. Collagen fibers are not common but the wide extracellular spac...

journal_title：Acta neuropathologica

authors： Hirano A,Llena JF,Chung HD

更新日期：1975-08-27 00:00:00

abstract：:The present investigation examined the morphological characteristics of epiplexus macrophages following a single intracisternal injection of the antigen, bacillus Calmette-Guerin (BCG). Three days following injection of BCG (0.5 - 4.0 X 10(8) viable microorganisms), mongrel dogs were perfused with buffered aldehydes. ...

journal_title：Acta neuropathologica

authors： Merchant RE

更新日期：1979-08-01 00:00:00

abstract：:The cholinergic basal forebrain is divided into four subregions (Ch1-4), and cholinergic neuronal loss in the nucleus basalis of Meynert (Ch4) has been correlated with cognitive impairments in both Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). However, the Ch1-2 regions, which provide the major choline...

journal_title：Acta neuropathologica

authors： Fujishiro H,Umegaki H,Isojima D,Akatsu H,Iguchi A,Kosaka K

更新日期：2006-02-01 00:00:00

abstract：:Basal ganglionic lesions in three young infants were found in a prospective search for early stages of status marmoratus. The lesions had formed and had passed into glial scars well before myelination of the basal ganglia commenced. The myelinating fibers crossing the scarred tissue were disoriented; however, fiber st...

journal_title：Acta neuropathologica

authors： Friede RL,Schachenmayr W

更新日期：1977-05-16 00:00:00

abstract：:The evolvement of amyloid beta (Abeta) deposition in the frontal cerebral cortex of 24 patients of increasing age with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D) was studied using end-specific monoclonal antibodies to Abetax-42 (Abeta42) or Abetax-40 (Abeta40) and markers for degenerating neu...

journal_title：Acta neuropathologica

authors： Maat-Schieman ML,Yamaguchi H,van Duinen SG,Natté R,Roos RA

更新日期：2000-04-01 00:00:00

abstract：:Histological, ultrastructural and morphometrical observations on Clarke's column were carried out in 18 patients with sporadic amyotrophic lateral sclerosis (ALS) and 15 age-matched control subjects. Of the 18 ALS patients 6 had been on a respirator before death. Bunina bodies were found in the neuronal cytoplasm in 7...

journal_title：Acta neuropathologica

authors： Takahashi H,Oyanagi K,Ohama E,Ikuta F

更新日期：1992-01-01 00:00:00

abstract：:Vascular smooth muscle cells are involved in deposition of amyloid in brain blood vessels. Accumulation of amyloid-beta peptide (Abeta) in cultured brain vascular smooth muscle cells that overexpress human amyloid-beta precursor protein (APP) Swedish, is strongly enhanced by exposure to iron ions. We studied cellular ...

journal_title：Acta neuropathologica

authors： Frackowiak J,Potempska A,Mazur-Kolecka B

更新日期：2009-05-01 00:00:00

abstract：:Considering the possibility of a paracellular route for edema resolution we studied the microvasculature of the subependymal and subcortical white matter in hydrocephalic rats. Normal adult rats were used as controls. After injection of kaolin suspension into the cisterna magna, the animals were killed at intervals of...

journal_title：Acta neuropathologica

authors： Nakagawa Y,Cervós-Navarro J,Artigas J

更新日期：1984-01-01 00:00:00

abstract：:Continuous intrathecal infusion of N-methyl-D-aspartate (NMDA) at the level of the lumbar enlargement of the spinal cord in middle-aged rats produced dose-dependent toxicity of spinal cord neuronal systems. Toxicity was enhanced by coadministration of glycine, but was significantly reduced when NMDA was co-administere...

journal_title：Acta neuropathologica

authors： Nag S,Riopelle RJ

更新日期：1990-01-01 00:00:00

abstract：:We have obtained a cDNA fragment to human glial fibrillary acidic protein (GFAP) by immunoscreening a lambda gt11 human brain cDNA library with antibody to bovine GFAP. The highly homologous nucleotide sequence of this clone with that of the mouse GFAP enabled the identification of this cDNA as one encoding GFAP. As t...

journal_title：Acta neuropathologica

authors： Nishiyama A,Onda K,Washiyama K,Kumanishi T,Kuwano R,Sakimura K,Takahashi Y

更新日期：1989-01-01 00:00:00

abstract：:Interphase cytogenetics, i.e., in situ hybridization using probes to chromosome-specific DNA, enables histological identification of cells bearing numerical chromosome aberrations and cytogenetic analysis of composite tumors. We studied routinely processed tissues from seven glioblastomas and three gliosarcomas using ...

journal_title：Acta neuropathologica

authors： Paulus W,Bayas A,Ott G,Roggendorf W

更新日期：1994-01-01 00:00:00

abstract：:In spite of several cases reported in the literature, the exact pathogenetic mechanism of neuropathic changes in porphyric neuropathy remains uncertain. Various authors have ascribed the neuropathologic findings to either a dying-back axonal degeneration or segmental demyelination. In recent years, the hypothesis of a...

journal_title：Acta neuropathologica

authors： Di Trapani G,Casali C,Tonali P,Topi GC

更新日期：1984-01-01 00:00:00

abstract：:In recent years, we have used a variety of tau immunological markers combined with the dye thiazin red (TR), an accurate marker to differentiate the fibrillar from the nonfibrillar state of both amyloid-beta and tau in Alzheimer's disease (AD). In this study, we used TR as a potential diagnostic marker of AD in frozen...

journal_title：Acta neuropathologica

authors： Luna-Muñoz J,Peralta-Ramirez J,Chávez-Macías L,Harrington CR,Wischik CM,Mena R

更新日期：2008-11-01 00:00:00