Abstract:
:A macrosomic male infant with multiple malformations survived for 4 days. His external dysplasias comprised macrocephalus, cheilopalatoschisis, auricular anomalies, and unilateral hexadactyl; his internal dysplasias included cysts of kidneys and pancreas, and a patent foramen ovale. The child had frequent generalized convulsions and died of bronchopneumonia. Chromosomal analysis was normal. The main neuropathological findings were a cleft foramen magnum, micropolygria and heterotopia of the neocerebrum, hypoplasia of the vermis and central white matter of the cerebellum, diffuse heterotopia of Purkinje cells, and unique heterotopic gray matter in the central cervical cord. The infant's disorder was classified as Gruber's syndrome, and this report may be the first detailed description of CNS malformations in this syndrome which, however, are probably not specific for this syndrome. The neuropathological findings were compatible with a heterochronic pathogenesis. this and the familial occurrence of malformations suggest a genetic nature of the syndrome.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Hori A,Orthner H,Kohlschütter A,Schott KM,Hirabayashi K,Shimokawa Kdoi
10.1007/BF00690449subject
Has Abstractpub_date
1980-01-01 00:00:00pages
93-7issue
2eissn
0001-6322issn
1432-0533journal_volume
51pub_type
杂志文章abstract::This study concerns an autopsy case of motor neuron disease with dementia (MND-D) that exhibited unusual clinical and neuropathological findings. The patient was a Japanese man without any relevant family history who was 60 years old at the time of death. His clinical manifestation included character change at the age...
journal_title:Acta neuropathologica
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pub_type: 已发布勘误
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
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更新日期:1991-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00334445
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00690383
更新日期:1977-07-15 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Acta neuropathologica
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journal_title:Acta neuropathologica
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更新日期:1995-01-01 00:00:00
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journal_title:Acta neuropathologica
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更新日期:1991-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00688264
更新日期:1987-01-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章
doi:10.1007/BF00690634
更新日期:1982-01-01 00:00:00
abstract::With an incidence of approximately 350 in 100,000, stroke is the third leading cause of death and a major cause of disability in industrialized countries. At present, although progress has been made in understanding the molecular pathways that lead to ischemic cell death, the current clinical treatments remain poorly ...
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pub_type: 杂志文章,评审
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abstract::We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identifie...
journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Acta neuropathologica
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更新日期:2011-02-01 00:00:00
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journal_title:Acta neuropathologica
pub_type: 杂志文章,评审
doi:10.1007/s004010050604
更新日期:1997-02-01 00:00:00
abstract::Alpha-synuclein is known to play an important role in several neurodegenerative diseases. Moreover, it is expressed in central nervous system neuronal tumors, and another member of the synuclein family, gamma-synuclein, is overexpressed in breast and ovarian carcinomas. However, the expression of alpha-synuclein has n...
journal_title:Acta neuropathologica
pub_type: 杂志文章
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更新日期:2002-02-01 00:00:00