Abstract：
:The hemizygote of the macular mutant mice, which is clinically and neuropathologically considered to be a model of Menkes kinky hair disease (MKHD), were injected intraperitoneally four times with 10, 20, 20 and 30 micrograms of cupric chloride on days 4, 6, 8 and 10 after birth, respectively. Their cerebral and cerebellar cortices were chronologically examined by electron microscopy. In the cerebral cortex, only a few abnormal mitochondria with electron-lucent matrix and short peripherally located cristae were scattered in the neurons on day 14, and these had almost entirely vanished after day 21. In the cerebellar cortex, abnormal mitochondria were frequently found on day 14 in the dendrites of the Purkinje cells, whereas they were only occasionally observed in their cytoplasm. Those in the dendrites had decreased in number on day 30, and only a few of them were seen in the cerebellum after day 45. These results show that the copper therapy reduced ultrastructural abnormalities in the hemizygote of this mutant mouse.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Yamano T,Shimada M,Onaga A,Kawasaki H,Iwane S,Ono K,Nishimura Mdoi
10.1007/BF00689595subject
Has Abstractpub_date
1988-01-01 00:00:00pages
574-80issue
6eissn
0001-6322issn
1432-0533journal_volume
76pub_type
杂志文章abstract：:Neuregulins belong to a family of multipotent growth-promoting proteins, and have been shown to have a crucial role in accumulating acetylcholine receptor at neuromuscular junctions. A functional role of neuregulins in muscle regeneration has not yet been identified. Using reverse transcription (RT)-PCR, Western blot ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0198-5
更新日期：2007-04-01 00:00:00
abstract：:Equine grass sickness (EGS) is an acquired disease of unknown aetiology affecting horses kept at grass. The disease is characterised by postganglionic sympathetic and parasympathetic neuronal pathology and is categorised as a dysautonomia. This study undertook a systematic examination of brain stem cranial nerve nucle...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010000289
更新日期：2001-08-01 00:00:00
abstract：:Spinal and bulbar muscular atrophy (SBMA) is an inherited neuromuscular disease caused by expansion of a polyglutamine (polyQ) tract in the androgen receptor (AR). SBMA is triggered by the interaction between polyQ-AR and its natural ligands, testosterone and dihydrotestosterone (DHT). SBMA is characterized by the los...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1122-9
更新日期：2013-07-01 00:00:00
abstract：:Focal cerebral ischemia was induced by occlusion of the right middle cerebral artery in hypoglycemic, normoglycemic, as well as in acute and chronic diabetic rats. The brain damage was studied after 4 days. The volume of infarction was decreased in hypoglycemia (29 +/- 19 mm3 (mean +/- SD) versus 58 +/- 35 mm3, P less...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00693778
更新日期：1987-01-01 00:00:00
abstract：:Tumours of the neuroglia, 172 in all (50 glioblastomas, 65 fibrillar and gemistocytic astrocytomas, 26 pilocytic astrocytomas and 31 oligodendrogliomas), were studied by automated microscopic picture analysis. Thirteen morphometric and densitometric parameters of the tumour cell nuclei as well as two mitotic parameter...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00692692
更新日期：1982-01-01 00:00:00
abstract：:In this study, we used immunohistochemistry to screen for alpha-synuclein pathology in the brains of 241 individuals without clinical evidence of neurologic disease, and discovered 36 cases (15%) with incidental Lewy bodies (LBs) and one case, a 96-year-old woman (0.4%), with inclusions similar to those seen in multip...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-008-0398-7
更新日期：2008-09-01 00:00:00
abstract：:A macrosomic male infant with multiple malformations survived for 4 days. His external dysplasias comprised macrocephalus, cheilopalatoschisis, auricular anomalies, and unilateral hexadactyl; his internal dysplasias included cysts of kidneys and pancreas, and a patent foramen ovale. The child had frequent generalized ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00690449
更新日期：1980-01-01 00:00:00
abstract：:An unusual case of cerebellar neurocytoma with rhabdomyomatous differentiation in a 6-year-old boy is reported. Immunocytochemical and ultrastructural features of the tumour were studied. Abortive synapse formation, the presence of clear vesicles and synaptophysin immunoreactivity of the tumour cells indicated its int...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050805
更新日期：1998-03-01 00:00:00
abstract：:Flurothyl-induced status epilepticus was studied by light and electron microscopy (LM, EM) to determine the time course and structural features of neuronal necrosis in the vulnerable brain regions in epilepsy. The cerebral cortex, hippocampus and thalamus were examined after closely spaced recovery periods of up to 1 ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687789
更新日期：1988-01-01 00:00:00
abstract：:We studied the distribution pattern of pathology and cholinergic deficits in the subnuclei of the amygdaloid complex (AC) in five patients with Alzheimer's disease (AD), eight with dementia with Lewy bodies (DLB) and five normal controls. In controls, the basal nucleus contained the highest choline acetyltransferase a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-005-0003-2
更新日期：2006-02-01 00:00:00
abstract：:A quantitative study was performed on spinal cord lesions in seven patients with X-linked recessive spinal and bulbar muscular atrophy. The myelinated fiber density of the lateral corticospinal tracts at the T7 cord level was well preserved for both large and small myelinated fibers. On the other hand, neurons in the ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050575
更新日期：1997-01-01 00:00:00
abstract：:Electron microscopy revealed the presence of cytoplasmic tubular aggregates in the capillary endothelium of a sparsely granulated growth hormone cell adenoma removed surgically from a 25-year-old female patient with acromegaly. To our knowledge, this is the second publication describing these structures in hypophysial...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00684545
更新日期：1977-01-31 00:00:00
abstract：:Chronic traumatic encephalopathy (CTE) is a progressive degenerative disorder associated with repetitive traumatic brain injury. One of the primary defining neuropathological lesions in CTE, based on the first consensus conference, is the accumulation of hyperphosphorylated tau in gray matter sulcal depths. Post-morte...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-017-1686-x
更新日期：2017-03-01 00:00:00
abstract：:Spinal cord-notochord relationship was analyzed histologically and immunohistochemically in normal human conceptuses between the 4-8 developmental weeks and in a 8-week embryo with double spinal cord. In the early 4-week embryo, the gradual closure of the neural tube along the cranio-caudal body axis was paralleled by...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00228587
更新日期：1993-01-01 00:00:00
abstract：:Foetal rat brain reaggregate cultures have been employed to investigate the morphological changes associated with the neurotoxic action of ethylcholine mustard aziridinium (ECMA). In a companion study we provided evidence for apparent selective cholinergic neurotoxicity. Exposure of 9-day-old cultures to 12.5 microM E...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00334882
更新日期：1993-01-01 00:00:00
abstract：:We report a patient who showed pathological features of both multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) at autopsy. The clinical features included severe cerebellar ataxia, autonomic failure, and rigid-akinetic parkinsonism. The clinical diagnosis was MSA. Pathological examination showed se...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010100433
更新日期：2002-01-01 00:00:00
abstract：:Frontotemporal lobar degeneration is the term used to describe the non-Alzheimer clinical syndromes of frontotemporal dementia, semantic dementia and progressive non-fluent aphasia, regardless of the underlying neuropathological features. Considerable progress has been made in recent years in our understanding of the ...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-007-0241-6
更新日期：2007-07-01 00:00:00
abstract：:Multiple different pathological protein aggregates are frequently seen in human postmortem brains and hence mixed pathology is common. Mixed dementia on the other hand is less frequent and neuropathologically should only be diagnosed if criteria for more than one full blown disease are met. We quantitatively measured ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-015-1406-3
更新日期：2015-05-01 00:00:00
abstract：:In the nerve tissue with proliferating macroglia cells were observed a lowered oxygen consumption, an increased aerobic glycolysis and alanine formation and a higher alanine aminotransferase and glutamate dehydrogenase activity than in the control tissue in the homogenates and in the cell sap fraction. The substrate s...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00684665
更新日期：1976-03-15 00:00:00
abstract：:The pathogenesis of HIV-associated cognitive changes is poorly understood. Cytokines such as tumor necrosis factor-alpha (TNF-alpha) have been postulated to contribute to the mechanism of the neurological complications of HIV infection. One of the effects of TNF-alpha is to induce astrocyte proliferation in vitro. The...
journal_title：Acta neuropathologica
pub_type： 临床试验,杂志文章
doi：10.1007/s004010050646
更新日期：1997-05-01 00:00:00
abstract：:Three cases of spontaneous olfactory neuroblastoma (ONB) in domestic cats were morphologically and immunocytochemically characterized. Diagnostic light microscopic features included Flexner and Homer-Wright rosettes, while ultrastructurally the cells had neuritic processes, intracellular intermediate filaments, and in...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294617
更新日期：1990-01-01 00:00:00
abstract：:Various parts of the central and peripheral nervous system of the mutant hamster with hind leg paralysis were studied in the electron microscope. A number of alterations involving the myelin sheath, the axon and certain neuronal perikarya were observed. Anterior horn cells were apparently well preserved. This conditio...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691701
更新日期：1977-08-31 00:00:00
abstract：:Motor neuron disease (MND) may be complicated by frontotemporal dementia and/or an extrapyramidal movement disorder. Several studies have identified the pathological substrate for dementia in MND as being ubiquitin-immunoreactive inclusions and dystrophic neurites in the extramotor neocortex and hippocampus. Although ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0814-y
更新日期：2004-04-01 00:00:00
abstract：:Six subtypes of sporadic Creutzfeldt-Jakob disease with distinctive clinico-pathological features have been identified largely based on two types of the abnormal prion protein, PrP(Sc), and the methionine (M)/valine (V) polymorphic codon 129 of the prion protein. The existence of affected subjects showing mixed phenot...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-009-0585-1
更新日期：2009-11-01 00:00:00
abstract：:Presence and distribution of S-100 protein (S-100), neuron-specific enolase (NSE), cytokeratin polypeptides, glial fibrillary acidic protein (GFAP), vimentin, actin, lysozyme and pituitary hormones (prolactin, hGH, ACTH, beta-FSH, beta-LH, beta-TSH, alpha subunit) in folliculo-stellate cells (FSC) were studied in seve...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00689825
更新日期：1984-01-01 00:00:00
abstract：:The ultrastructure of the curly fibers was examined by the transmission and immunoelectron microscopy as well as by the rapid-freeze, deep-etch and replica method. The curly fibers consisted mainly of paired helical filaments (PHF) in the neuropils, both pre- and post-synaptic. On the deep-etch replicas, PHF in the ne...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00334498
更新日期：1990-01-01 00:00:00
abstract：:A monoclonal antibody, raised against extracts from Alzheimer brain, that recognizes a phosphorylated epitope in high molecular weight neurofilament proteins and tau proteins also immunostains Alzheimer neurofibrillary tangles, neurites in senile plaques and granulovacuolar degeneration. This result suggest that granu...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00686619
更新日期：1987-01-01 00:00:00
abstract：:Focal cortical dysplasias (FCDs) are increasingly recognized as one of the most common causes of pharmaco-resistant epilepsies. FCDs were recently divided into various clinico-pathological subtypes due to distinct imaging, electrophysiological, and outcome characteristics. In this review, we will overview the internat...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-014-1304-0
更新日期：2014-07-01 00:00:00
abstract：:The pattern of recovery of myelinated axons in the posterior tibial nerve after crushing was studied in rats chronically intoxicated with 2,5-hexanedione. It was given for 2 weeks before crushing (200 mg/kg i.p. 5 times a week) or additionally for two further weeks after the nerve crush. Two animals were examined from...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00703206
更新日期：1983-01-01 00:00:00
abstract：:Neuropathological changes were studied in a consecutive autopsy series of 135 cases, comprising 73% of all patients who died of AIDS in Switzerland between April 1981 and December 1987. Central nervous system involvement was found in 119 patients (88%), 19 of which had multiple concomitant intracerebral lesions. Among...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687372
更新日期：1989-01-01 00:00:00
