Curly fibers are tau-positive strands in the pre- and post-synaptic neurites, consisting of paired helical filaments: observations by the freeze-etch and replica method.

abstract：:A 50-year-old carpenter died in Western Pennsylvania of rabies on January 4, 1979. He had been hospitalized in an intensive care unit for 28 days. The diagnosis was made postmortem from light and electron microscopic examination of central nervous system tissue. Immunofluorescence studies confirmed the diagnosis later...

journal_title：Acta neuropathologica

authors： Lamas CC,Martinez AJ,Baraff R,Bajwa J

更新日期：1980-01-01 00:00:00

abstract：:The choroid plexus is an epithelial-endothelial vascular convolute within the ventricular system of the vertebrate brain. It consists of epithelial cells, fenestrated blood vessels, and the stroma, dependent on various physiological or pathological conditions, which may contain fibroblasts, mast cells, macrophages, gr...

journal_title：Acta neuropathologica

authors： Wolburg H,Paulus W

更新日期：2010-01-01 00:00:00

abstract：:Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by the expansion of a polyglutamine tract in the androgen receptor (AR). The mechanism by which expansion of polyglutamine in AR causes muscle atrophy is unknown. Here, we investigated pathological pathways underlying muscle atrophy in SBMA kn...

journal_title：Acta neuropathologica

authors： Rocchi A,Milioto C,Parodi S,Armirotti A,Borgia D,Pellegrini M,Urciuolo A,Molon S,Morbidoni V,Marabita M,Romanello V,Gatto P,Blaauw B,Bonaldo P,Sambataro F,Robins DM,Lieberman AP,Sorarù G,Vergani L,Sandri M,Pennuto

更新日期：2016-07-01 00:00:00

abstract：:Data on the relationship between Parkinson's disease (PD) and stroke have been conflicting, some studies showing a reduced risk of stroke during life, and others indicating an increased risk of stroke-related death. Consecutive cases (n=617) of autopsy-proven idiopathic PD (Lewy body disease of the brain stem type) an...

journal_title：Acta neuropathologica

authors： Jellinger KA

更新日期：2003-05-01 00:00:00

abstract：:Four of seven patients with nemaline myopathy had severe, rapidly progressing symptoms. These four showed an increase in acid phosphatase activity in muscle fibers demonstrated by histochemistry and cathepsin B&L activity by biochemical measurement. On electron microscopy, nemaline bodies, occasionally disorganized my...

journal_title：Acta neuropathologica

authors： Nonaka I,Ishiura S,Arahata K,Ishibashi-Ueda H,Maruyama T,Ii K

更新日期：1989-01-01 00:00:00

abstract：:Leukocyte adhesion molecules to endothelium plays an important role in the pathogenesis of inflammatory diseases, including HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). To help define the role of adhesion molecules in HAM/TSP, we studied the expression of lymphocyte function-associated antige...

journal_title：Acta neuropathologica

authors： Umehara F,Izumo S,Takeya M,Takahashi K,Sato E,Osame M

更新日期：1996-01-01 00:00:00

abstract：:We examined the effect of lactic acid on cultured human glioma cell lines expressing glial fibrillary acidic protein (GFAP), vimentin and neuron-specific enolase (NSE). The growth of the cells was inhibited by the lactic acid in a dose-dependent manner. At 56 mM of lactic acid, the surviving cells of the KNS-42-c2 cel...

journal_title：Acta neuropathologica

authors： Takeshita I,Sawa H,Nakamura T,Kuramitsu M,Kitamura K,Fukui M

更新日期：1990-01-01 00:00:00

abstract：:A case of Creutzfeldt-Jakob disease (CJD) with a rare mutation of the prion protein (PrP) gene (PRNP) at codon 208 (R208H) is described. By comparison with two preceding reports, the case described here displayed two distinct biochemical and neuropathological features. Western blot analysis of brain homogenates showed...

journal_title：Acta neuropathologica

authors： Roeber S,Krebs B,Neumann M,Windl O,Zerr I,Grasbon-Frodl EM,Kretzschmar HA

更新日期：2005-04-01 00:00:00

abstract：:A woman of 36 was admitted to hospital because of griping abdominal pain which occurred especially during the night when turning in bed. She had a history of constipation and bloating since birth. Irrigoscopy revealed megacolon extending from the middle of the transverse colon to the rectum. A rectal biopsy excluded H...

journal_title：Acta neuropathologica

authors： Lassmann G

更新日期：1987-01-01 00:00:00

abstract：:A patient with mixed gonadal dysgenesis showed glove and stocking-type sensory impairment and slowing of motor and sensory nerve conduction. Sural nerve biopsy revealed minifascicular formation with decreased density of myelinated fibers. As far as we are aware, this is the first report of polyneuropathy with minifasc...

journal_title：Acta neuropathologica

authors： Umehara F,Yamaguchi N,Kodama D,Takenaga S,Kiwaki T,Sonoda Y,Arimura Y,Yamada H,Arimura K,Osame M

更新日期：1999-09-01 00:00:00

abstract：:Three cases of spontaneous olfactory neuroblastoma (ONB) in domestic cats were morphologically and immunocytochemically characterized. Diagnostic light microscopic features included Flexner and Homer-Wright rosettes, while ultrastructurally the cells had neuritic processes, intracellular intermediate filaments, and in...

journal_title：Acta neuropathologica

authors： Schrenzel MD,Higgins RJ,Hinrichs SH,Smith MO,Torten M

更新日期：1990-01-01 00:00:00

abstract：:Amyloid-beta (Abeta) peptide pathology in Alzheimer's disease (AD) comprises extracellular plaques and cerebral amyloid angiopathy (CAA). In Parkinson's disease (PD), alpha-synuclein forms intraneuronal Lewy bodies (LBs), and cortical LBs are thought to play a major role in cognitive decline designated as PD with deme...

journal_title：Acta neuropathologica

authors： Lashley T,Holton JL,Gray E,Kirkham K,O'Sullivan SS,Hilbig A,Wood NW,Lees AJ,Revesz T

更新日期：2008-04-01 00:00:00

abstract：:This ultrastructural study deals with the synapses of primary dendrites of the anterior horn neurons in the lower lumbar spinal cords of seven patients with amyotrophic lateral sclerosis (ALS) who had mild neuronal depletion. Specimens from seven age-matched, neurologically normal individuals served as controls. In ea...

journal_title：Acta neuropathologica

authors： Sasaki S,Iwata M

更新日期：1996-01-01 00:00:00

abstract：:Electron microscopy and computerized morphometric techniques were employed to examine pericyte ultrastructure and to assess quantitatively their relationship to endothelial cells in five cases of cerebellar capillary hemangioblastoma. A total of 97 cross-sectioned capillary profiles were studied. Pericyte coverage of ...

journal_title：Acta neuropathologica

authors： Ho KL

更新日期：1985-01-01 00:00:00

abstract：:In this report, we describe the clinical, topographical and immunohistochemical characteristics of neurofilament (NF) inclusion formation induced by the intracisternal inoculation of young adult New Zealand white rabbits at 28-day intervals with 100 micrograms AlCl3 over the course of 267 days. The ability to recover ...

journal_title：Acta neuropathologica

authors： Strong MJ,Gaytan-Garcia S,Jakowec DM

更新日期：1995-01-01 00:00:00

abstract：:Canine distemper virus (CDV) causes severe immunosuppression and neurological disease in dogs, associated with demyelination, and is a model for multiple sclerosis in man. In the early stage of the infection, demyelination is associated with viral replication in the white matter. In acute demyelinating lesions there i...

journal_title：Acta neuropathologica

authors： Vandevelde M,Zurbriggen A

更新日期：2005-01-01 00:00:00

abstract：:The cholinergic basal forebrain is divided into four subregions (Ch1-4), and cholinergic neuronal loss in the nucleus basalis of Meynert (Ch4) has been correlated with cognitive impairments in both Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). However, the Ch1-2 regions, which provide the major choline...

journal_title：Acta neuropathologica

authors： Fujishiro H,Umegaki H,Isojima D,Akatsu H,Iguchi A,Kosaka K

更新日期：2006-02-01 00:00:00

abstract：:Induction of differentiation is an attractive approach to the management of infiltrative tumors such as malignant glioma. Here, we report that lovastatin and phenylacetate induce apoptosis, but fail to induce differentiation, in malignant glioma cell lines and untransformed rat astrocytes. Lovastatin and phenylacetate...

journal_title：Acta neuropathologica

authors： Schmidt F,Groscurth P,Kermer M,Dichgans J,Weller M

更新日期：2001-03-01 00:00:00

abstract：:Two distinct species of amyloid beta protein (A beta) with different carboxyl termini, A beta 40 and A beta 42(43), are deposited in plaques in the brains of patients with Alzheimer's disease and Down's syndrome. The relationship between these two forms of A beta and microglial cells was investigated in 16 subjects wi...

journal_title：Acta neuropathologica

authors： Mann DM,Iwatsubo T,Fukumoto H,Ihara Y,Odaka A,Suzuki N

更新日期：1995-01-01 00:00:00

abstract：:A 9-year-old male patient developed a germ cell tumor in the right basal ganglia which secreted beta-human chorionic gonadotropin (beta-HCG) and caused precocious puberty. Histology and immunohistochemical staining for placental alkaline phosphatase (PLAP), alpha-fetoprotein (alpha-FP), and beta-HCG showed a mixed pop...

journal_title：Acta neuropathologica

authors： Aguzzi A,Hedinger CE,Kleihues P,Yaşargil MG

更新日期：1988-01-01 00:00:00

abstract：:Double immunofluorescence for paired helical filament (PHF)-tau (AT8) and ubiquitin, enhanced by catalyzed reporter deposition amplification, was combined with thiazin red (TR), a fluorochrome, which has an affinity to fibrillary structures such as neurofibrillary tangles (NFTs). After recording these triple-fluoresce...

journal_title：Acta neuropathologica

authors： Uchihara T,Nakamura A,Yamazaki M,Mori O

更新日期：2001-06-01 00:00:00

abstract：:Chronic traumatic encephalopathy (CTE) is a progressive degenerative disorder associated with repetitive traumatic brain injury. One of the primary defining neuropathological lesions in CTE, based on the first consensus conference, is the accumulation of hyperphosphorylated tau in gray matter sulcal depths. Post-morte...

journal_title：Acta neuropathologica

authors： Holleran L,Kim JH,Gangolli M,Stein T,Alvarez V,McKee A,Brody DL

更新日期：2017-03-01 00:00:00

abstract：:We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identifie...

journal_title：Acta neuropathologica

authors： Powers JM,Liu Y,Hair LS,Kascsack RJ,Lewis LD,Levy LA

更新日期：1991-01-01 00:00:00

abstract：:Involvement of the choroid plexus by lymphoma (Hodgkin) is a hitherto undescribed complication. We report herein the case of a 49-year-old man who developed, shortly before death, neurologic symptoms seemingly related to extensive involvement of choroid plexus and surrounding ventricular structures by lymphoma (Hodgki...

journal_title：Acta neuropathologica

authors： Sanchez JE,Garcia JH,Kwee H

更新日期：1977-02-28 00:00:00

abstract：:HTLV-III-like particles were observed within a cell process surrounded by a myelin sheath, in the brain of a 4-year-old boy with AIDS encephalopathy. Similar particles were also observed in the mononuclear macrophage-like cells. ...

journal_title：Acta neuropathologica

authors： Kato T,Dembitzer HM,Hirano A,Llena JF

更新日期：1987-01-01 00:00:00

abstract：:A neuropathological study is presented of a case showing the association of tuberous sclerosis of the brain and dysplasia of the corpus callosum as well as omphalocele and malrotated colon. No signs of tuberous sclerosis were found in the internal organs. From a review of the literature this appears to be the fourth c...

journal_title：Acta neuropathologica

authors： Barth PG,Stam FC,von der Harten JJ

更新日期：1978-04-26 00:00:00

abstract：:Disturbance of intracellular trafficking plays a major role in several neurodegenerative disorders including Alzheimer or Parkinson's disease. The Chediak-Higashi syndrome (CHS), a life-threatening autosomal recessive disease with frequent mutations in the LYST gene, and its animal model, the beige mouse, are both cha...

journal_title：Acta neuropathologica

authors： Rudelius M,Osanger A,Kohlmann S,Augustin M,Piontek G,Heinzmann U,Jennen G,Russ A,Matiasek K,Stumm G,Schlegel J

更新日期：2006-09-01 00:00:00

abstract：:In the nerve tissue with proliferating macroglia cells were observed a lowered oxygen consumption, an increased aerobic glycolysis and alanine formation and a higher alanine aminotransferase and glutamate dehydrogenase activity than in the control tissue in the homogenates and in the cell sap fraction. The substrate s...

journal_title：Acta neuropathologica

authors： Ruscák M,Hager H,Orlický J

更新日期：1976-03-15 00:00:00

abstract：:Accumulation of amyloid-β (Aβ) and neurofibrillary tangles in the brain, inflammation and synaptic and neuronal loss are some of the major neuropathological hallmarks of Alzheimer's disease (AD). While genetic mutations in amyloid precursor protein and presenilin-1 and -2 (PS1 and PS2) genes cause early-onset familial...

journal_title：Acta neuropathologica

authors： Wahlster L,Arimon M,Nasser-Ghodsi N,Post KL,Serrano-Pozo A,Uemura K,Berezovska O

更新日期：2013-02-01 00:00:00

abstract：:Autopsy findings of a patient, with sialidosis type I phenotype carrying V217M/G243R mutations in the lysosomal sialidase gene and biochemically defined isolated sialidase deficiency, who died of intractable lymphoma at the age of 32 years, are described. Perikaryal expansion of cytoplasm was evident, mostly in motor ...

journal_title：Acta neuropathologica

authors： Uchihara T,Ohashi K,Kitagawa M,Kurata M,Nakamura A,Hirokawa K,Kasuga T,Kobayashi T

更新日期：2010-01-01 00:00:00