HTLV-III-like particles within a cell process surrounded by a myelin sheath in an AIDS brain.

abstract：:Lectin-binding sites located on the endothelial cell (EC) surfaces in unaltered, leaking and resorbing micro-blood vessels (MBVs) in cryo-injured cat brain were studied. Lectin or glycoprotein-gold complexes and brain samples embedded in hydrophilic resin Lowicryl K4M were used. The lectins tested recognize the follow...

journal_title：Acta neuropathologica

authors： Vorbrodt AW

更新日期：1986-01-01 00:00:00

abstract：:Seven patients with the typical clinical picture and muscle biopsy findings of classical Werdnig-Hoffmann disease showed Wallerian degeneration in their biopsied sural nerves. In dorsal root ganglia of one patient there were residual nodules and several chromatolytic neurons. By electron microscopy the changes of chro...

journal_title：Acta neuropathologica

authors： Carpenter S,Karpati G,Rothman S,Watters G,Andermann F

更新日期：1978-05-24 00:00:00

abstract：:We examined whether the Golgi apparatus (GA) is fragmented in nigral neurons in 18 cases with Parkinson's disease (PD) and in 8 control cases. The nigral neurons in cases with PD showed various degrees of Lewy pathology with alpha-synuclein immunohistochemistry, and we divided the neurons into three subtypes according...

journal_title：Acta neuropathologica

authors： Fujita Y,Ohama E,Takatama M,Al-Sarraj S,Okamoto K

更新日期：2006-09-01 00:00:00

abstract：:Three cases of spontaneous olfactory neuroblastoma (ONB) in domestic cats were morphologically and immunocytochemically characterized. Diagnostic light microscopic features included Flexner and Homer-Wright rosettes, while ultrastructurally the cells had neuritic processes, intracellular intermediate filaments, and in...

journal_title：Acta neuropathologica

authors： Schrenzel MD,Higgins RJ,Hinrichs SH,Smith MO,Torten M

更新日期：1990-01-01 00:00:00

abstract：:The authors present the case of a hypertensive patient with a thrombosis of a saccular microaneurysm (SMA) and underlying cerebral (pontine) lacunae. This SMA lay at the junction between the main vessel and two small feeding arteries penetrating into the necrotic territory. Microhemorrhages were observed in and outsid...

journal_title：Acta neuropathologica

authors： Benhaiem-Sigaux N,Gherardi R,Salama J,Gray F,Amouroux J,Poirier J

更新日期：1986-01-01 00:00:00

abstract：:Sera from guinea pigs with acute or chronic relapsing experimental allergic encephalomyelitis (EAE) were injected into lumbosacral subarachnoid space of normal recipient rats. Seventeen of 37 sera induced demyelination in the CNS, and 27 of 37 sera caused demyelinated peripheral nerve fibers in the roots. The highest ...

journal_title：Acta neuropathologica

authors： Lassmann H,Kitz K,Wisniewski HM

更新日期：1981-01-01 00:00:00

abstract：:To investigate the relationship between cerebral amyloid angiopathy and subcortical (lobar) hemorrhage, we examined the severity of amyloid deposition in the leptomeningeal, cortical and subcortical arteries in 28 autopsied elderly patients with cerebral amyloid angiopathy with subcortical hemorrhage, deep cerebral he...

journal_title：Acta neuropathologica

authors： Iwamoto N,Ishihara T,Ito H,Uchino F

更新日期：1993-01-01 00:00:00

abstract：:Medulloblastoma comprises four distinct molecular variants with distinct genetics, transcriptomes, and outcomes. Subgroup affiliation has been previously shown to remain stable at the time of recurrence, which likely reflects their distinct cells of origin. However, a therapeutically relevant question that remains una...

journal_title：Acta neuropathologica

authors： Wang X,Dubuc AM,Ramaswamy V,Mack S,Gendoo DM,Remke M,Wu X,Garzia L,Luu B,Cavalli F,Peacock J,López B,Skowron P,Zagzag D,Lyden D,Hoffman C,Cho YJ,Eberhart C,MacDonald T,Li XN,Van Meter T,Northcott PA,Haibe-Kain

更新日期：2015-03-01 00:00:00

abstract：:Charcot-Marie-Tooth disease type 1A (CMT1A) is a common hereditary demyelinating neuropathy caused by a duplication of the gene for the myelin protein PMP22, resulting in overexpression of PMP22 in young patients. Although genetically well defined, the pathogenesis of the hereditary demyelinating neuropathy CMT1A is s...

journal_title：Acta neuropathologica

authors： Hanemann CO,Gabreëls-Festen AA,Stoll G,Müller HW

更新日期：1997-10-01 00:00:00

abstract：:Muscle biopsy samples from five patients with cytoplasmic body myopathy (CBM) were investigated by immunohistochemical (antibodies to desmin, actin, dystrophin, spectrin, alpha actinin and utrophin), immunoelectron microscopic (antibodies to desmin, actin and dystrophin) and biochemical (desmin, dystrophin, actin and ...

journal_title：Acta neuropathologica

authors： Caron A,Viader F,Lechevalier B,Chapon F

更新日期：1995-01-01 00:00:00

abstract：:Sporadic Creutzfeldt-Jakob disease (sCJD) is a transmissible brain proteinopathy. Five main clinicopathological subtypes (sCJD-MM(V)1, -MM(V)2C, -MV2K, -VV1, and -VV2) are currently distinguished. Histopathological evidence suggests that the localisation of prion aggregates and spongiform lesions varies among subtypes...

journal_title：Acta neuropathologica

authors： Pascuzzo R,Oxtoby NP,Young AL,Blevins J,Castelli G,Garbarino S,Cohen ML,Schonberger LB,Gambetti P,Appleby BS,Alexander DC,Bizzi A

更新日期：2020-08-01 00:00:00

abstract：:Cystic necrosis in the cerebellar white matter was found in three premature infants. The necrosis was characteristically localized in the center of the white matter of the superficial cerebellar folia, sparing the overlying cortex. The patients were aged between 28 and 34 gestational weeks, and had a clinical history ...

journal_title：Acta neuropathologica

authors： Tsuru A,Mizuguchi M,Takashima S

更新日期：1995-01-01 00:00:00

abstract：:We investigated whether the brainstem is affected by the pathologic process of sporadic Creutzfeldt-Jakob disease (sCJD), with particular attention to brainstem atrophy, neuronal loss, pyramidal tract degeneration, and prion protein (PrP) deposition, in 33 patients with sCJD. Brainstem atrophy, particularly in the pon...

journal_title：Acta neuropathologica

authors： Iwasaki Y,Hashizume Y,Yoshida M,Kitamoto T,Sobue G

更新日期：2005-06-01 00:00:00

abstract：:Thirty-three rectus superior extraocular muscles from 23 autopsy cases, all over 60 years, were examined. Eosinophilic inclusions (Hirano bodies) were observed in all the muscles; they were stained deep red by Masson's trichrome stain and were positive for protein stain. They consisted of a collection of filamentous s...

journal_title：Acta neuropathologica

authors： Tomonaga M

更新日期：1983-01-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus is a chronic metabolic disease that causes long-term secondary complications such as neuropathy. The occurrence of diabetic neuropathy has generally been thought of as being associated with hyperglycaemia. However, in a previous light microscopic examination of plantar nerves in dia...

journal_title：Acta neuropathologica

authors： Mohseni S,Hildebrand C

更新日期：1998-08-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the gradual appearance of α-synuclein (α-syn)-containing neuronal protein aggregates. Although the exact mechanism of...

journal_title：Acta neuropathologica

authors： Tan Y,Sgobio C,Arzberger T,Machleid F,Tang Q,Findeis E,Tost J,Chakroun T,Gao P,Höllerhage M,Bötzel K,Herms J,Höglinger G,Koeglsperger T

更新日期：2020-02-01 00:00:00

abstract：:Histomorphological and histochemical variability was studied in muscle specimens from 30 patients with congenital muscular dystrophy (CMD). We found involvement of the central nervous system in 8 patients (Fukuyama CMD, F-CMD), involvement of the brain and the eyes in 5 patients (muscle, eye and brain disease, MEB-D) ...

journal_title：Acta neuropathologica

authors： Leyten QH,ter Laak HJ,Gabreëls FJ,Renier WO,Renkawek K,Sengers RC

更新日期：1993-01-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by an expanded trinucleotide CAG repeat in the gene coding for huntingtin. Deregulation of chromatin remodeling is linked to the pathogenesis of HD but the mechanism remains elusive. To identify what genes are deregulated by trimethyla...

journal_title：Acta neuropathologica

authors： Lee J,Hwang YJ,Shin JY,Lee WC,Wie J,Kim KY,Lee MY,Hwang D,Ratan RR,Pae AN,Kowall NW,So I,Kim JI,Ryu H

更新日期：2013-05-01 00:00:00

abstract：:Fifteen cases of mitochondrial myopathy, three cases of hereditary motor and sensory neuropathy (HMSN) VI, and 280 cases of neuropathies of different etiologies were examined by electron microscopy for the presence of mitochondrial abnormalities in the sural nerve. Altered mitochondrial were found in most cases of mit...

journal_title：Acta neuropathologica

authors： Schröder JM,Sommer C

更新日期：1991-01-01 00:00:00

abstract：:We studied the muscle biopsy from an asymptomatic patient with high serum creatine kinase values. Subsarcolemmal and intermyofibrillar granular inclusions were seen at the light microscopy level. Ultrastructural observation showed clusters of cylindrical spirals (CS). CS are nonspecific, morphological finding, so far ...

journal_title：Acta neuropathologica

authors： Rapuzzi S,Prelle A,Moggio M,Rigoletto C,Ciscato P,Comi G,Francesca F,Scarlato G

更新日期：1995-01-01 00:00:00

abstract：:We report a sporadic tauopathy of 6-year duration in a 76-year-old woman. Her initial symptoms were asymmetrical parkinsonism and muscle weakness, with apraxia appearing 2 years later. The brain showed frontal and temporal cerebral atrophy; severe neuronal loss and gliosis were observed in the precentral cortex (loss ...

journal_title：Acta neuropathologica

authors： Piao YS,Tan CF,Iwanaga K,Kakita A,Takano H,Nishizawa M,Lashley T,Revesz T,Lees A,de Silva R,Tsujihata M,Takahashi H

更新日期：2005-12-01 00:00:00

abstract：:The intracellular localization of myoglobin(Mb) mRNA in the skeletal muscles of normal subjects and patients with Duchenne muscular dystrophy(DMD) or amyotrophic lateral sclerosis(ALS) was examined by in situ hybridization using a biotin-labeled cDNA probe. In cross sections of normal muscles, Mb mRNA signals were dem...

journal_title：Acta neuropathologica

authors： Mitsui T,Kawai H,Naruo T,Nishino H,Saito S

更新日期：1993-01-01 00:00:00

abstract：:A mixed lymphoblastic T cell lymphoma and gonadotroph cell pituitary adenoma occurred 25 years after first resection of the adenoma. Within 1 year the lymphoma overgrew the adenoma, but was still restricted to the sellar region. Histologically, lymphoma and adenoma components were tightly admixed. Possible pathogeneti...

journal_title：Acta neuropathologica

authors： Kuhn D,Buchfelder M,Brabletz T,Paulus W

更新日期：1999-03-01 00:00:00

abstract：:Observations have been made on the structure of the paranodal region at nodes of Ranvier in the sural nerve of patients with diabetic sensory polyneuropathy. The structure of the paranodes was examined with particular attention to the definition and assessment of axoglial dysjunction, which has been claimed to be a ch...

journal_title：Acta neuropathologica

authors： Thomas PK,Beamish NG,Small JR,King RH,Tesfaye S,Ward JD,Tsigos C,Young RJ,Boulton AJ

更新日期：1996-12-01 00:00:00

abstract：:The conventional concept of Pick's disease does not distinguish Pick's disease with Pick bodies (Pick body disease, PBD) from Pick's disease without Pick bodies [lobar atrophy without Pick bodies, LA-PB(-)]. Recently, intraneuronal ubiquitin-positive inclusions (ub-inclusions), which are thought to be a hallmark of am...

journal_title：Acta neuropathologica

authors： Ikeda K,Akiyama H,Arai T,Ueno H,Tsuchiya K,Kosaka K

更新日期：2002-07-01 00:00:00

abstract：:A giant-cell glioblastoma was examined by electron microscopy and by the freeze-fracture technique. The cell membranes bordering the extensive extracellular space often showed complicated undulations and peripheral vacuoles as well as occasional microvilli or filopodia. The undulations were mainly composed of plasmale...

journal_title：Acta neuropathologica

authors： Tani E,Nakano M,Itagaki T,Fukumori T

更新日期：1978-01-19 00:00:00

abstract：:The morphological effects of two chemically different neuroactive drugs (chlorpromazine and phenobarbital) on vasculogenesis in rat cerebellum were examined to determine the presence of vascular alterations. Therapeutic dosages of both drugs were chronically administered to separate groups of maternal rats beginning o...

journal_title：Acta neuropathologica

authors： Hannah RS,Roth SH,Spira AW

更新日期：1982-01-01 00:00:00

abstract：:Ubiquitin-immunoreactive (ub-ir) neuronal cytoplasmic inclusions are characteristically found in the extramotor cortex in patients with motor neuron disease and dementia (MND-dementia) and a subset of patients with frontotemporal dementia without motor symptoms (FTD-MND type). Recently, ub-ir neuronal intranuclear inc...

journal_title：Acta neuropathologica

authors： Mackenzie IR,Feldman H

更新日期：2003-06-01 00:00:00

abstract：:Alterations in sphingolipid metabolism are described to contribute to various neurological disorders. We here determined the expression of enzymes involved in the sphingomyelin cycle and their products in postmortem brain tissue of multiple sclerosis (MS) patients. In parallel, we investigated the effect of the sphing...

journal_title：Acta neuropathologica

authors： van Doorn R,Nijland PG,Dekker N,Witte ME,Lopes-Pinheiro MA,van het Hof B,Kooij G,Reijerkerk A,Dijkstra C,van van der Valk P,van Horssen J,de Vries HE

更新日期：2012-09-01 00:00:00

abstract：:Aging and neurodegeneration are often accompanied by a functionally impaired ubiquitin-proteasome system (UPS). In tauopathies and polyglutamine diseases, a mutant form of ubiquitin B (UBB(+1)) accumulates in disease-specific aggregates. UBB(+1) mRNA is generated at low levels in vivo during transcription from the ubi...

journal_title：Acta neuropathologica

authors： Irmler M,Gentier RJ,Dennissen FJ,Schulz H,Bolle I,Hölter SM,Kallnik M,Cheng JJ,Klingenspor M,Rozman J,Ehrhardt N,Hermes DJ,Gailus-Durner V,Fuchs H,Hrabě de Angelis M,Meyer HE,Hopkins DA,Van Leeuwen FW,Beckers J

更新日期：2012-08-01 00:00:00