Abstract：
:The conventional concept of Pick's disease does not distinguish Pick's disease with Pick bodies (Pick body disease, PBD) from Pick's disease without Pick bodies [lobar atrophy without Pick bodies, LA-PB(-)]. Recently, intraneuronal ubiquitin-positive inclusions (ub-inclusions), which are thought to be a hallmark of amyotrophic lateral sclerosis with dementia (ALS-D), have been found also in LA-PB(-). We reconfirmed that ub-inclusions are consistently detected in LA-PB(-) as well as ALS-D. Subsequently, morphometric evaluation for involvement of the upper and lower motor neuron systems were performed in seven cases each of PBD, LA-PB(-), ALS-D and controls. As an indicator of upper motor neuron involvement, the total number of axons through the pyramis of the medulla oblongata was employed and for lower motor neuron involvement, the number of hypoglossal neurons per unit area was calculated. In LA-PB(-), axons of the pyramidal tract were significantly reduced in comparison to PBD and controls, while the lower motor neurons were preserved. Contrary to LA-PB(-), ALS-D revealed significant reduction of hypoglossal neurons but its pyramidal tract tends to be relatively preserved. These results seem to indicate that LA-PB(-) and ALS-D belong to the same spectrum and consist of subgroups with ub-inclusions and involvement of motor neuron system in common. The involvement of the upper motor neuron system is emphasized in LA-PB(-), while ALS-D accentuates the lower motor neuron system. However, the border between the two group is not always clear and there are patients who can not be definitively classified.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Ikeda K,Akiyama H,Arai T,Ueno H,Tsuchiya K,Kosaka Kdoi
10.1007/s00401-001-0513-5subject
Has Abstractpub_date
2002-07-01 00:00:00pages
21-8issue
1eissn
0001-6322issn
1432-0533journal_volume
104pub_type
杂志文章abstract：:It is conventionally accepted that during the early stages of Wallerian degeneration of myelinated peripheral nerve fibres Schmidt-Lanterman incisures represent the sites at which the myelin sheath, together with enclosed axoplasm, is segmented into myelin ovoids. This mechanism is considered by some authors to be fac...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：
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abstract：:We examined whether the Golgi apparatus (GA) is fragmented in nigral neurons in 18 cases with Parkinson's disease (PD) and in 8 control cases. The nigral neurons in cases with PD showed various degrees of Lewy pathology with alpha-synuclein immunohistochemistry, and we divided the neurons into three subtypes according...
journal_title：Acta neuropathologica
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doi：10.1007/s00401-006-0114-4
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journal_title：Acta neuropathologica
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051075
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1124-7
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journal_title：Acta neuropathologica
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687041
更新日期：1986-01-01 00:00:00
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更新日期：2020-12-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-013-1189-3
更新日期：2013-12-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050594
更新日期：1997-02-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00318572
更新日期：1995-01-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050519
更新日期：1996-09-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00304464
更新日期：1992-01-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00685374
更新日期：1982-01-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0032-5
更新日期：2006-03-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00304627
更新日期：1992-01-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00684545
更新日期：1977-01-31 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00369442
更新日期：1993-01-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0093-5
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journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
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journal_title：Acta neuropathologica
pub_type： 杂志文章
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294314
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687890
更新日期：1989-01-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-003-0764-4
更新日期：2003-12-01 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688698
更新日期：1977-10-10 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00293469
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00389504
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journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：
更新日期：1978-09-15 00:00:00
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journal_title：Acta neuropathologica
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
