In vivo effect of sera from animals with chronic relapsing experimental allergic encephalomyelitis on central and peripheral myelin.

abstract：:Astrocytic alpha-synuclein-immunoreactive inclusions have recently been noted to develop in sporadic Parkinson's disease (PD). Here, the presence of immunoreactive astrocytes is reported in 14 autopsy cases with clinically diagnosed PD and a neuropathological stage of 4 or higher. The labeled astrocytes occur preferen...

journal_title：Acta neuropathologica

authors： Braak H,Sastre M,Del Tredici K

更新日期：2007-09-01 00:00:00

abstract：:Skeins or skein-like inclusions, one of the two types of ubiquitinated intraneuronal inclusions in amyotrophic lateral sclerosis (ALS), in the neostriatum are not specific to the disease, but it has not yet been determined whether the other, spherical or crescent-shaped inclusions (SCI) are pathognomonic. To clarify t...

journal_title：Acta neuropathologica

authors： Kawashima T,Doh-ura K,Kikuchi H,Iwaki T

更新日期：2001-11-01 00:00:00

abstract：:Mineralization in the wall of central nervous system blood vessels is sporadically encountered in aged horses and cattle as in man, generally as an age-related change. This phenomenon has not to date been located in the meninges in dogs or cats. The present study reports a retrospective histological examination of 50 ...

journal_title：Acta neuropathologica

authors： Mandara MT

更新日期：2003-03-01 00:00:00

abstract：:This report concerns an immunocytochemical and ultrastructural study of the motor cortices of 11 patients with amyotrophic lateral sclerosis (ALS). Specimens from 12 normal individuals served as controls. Antibodies against phosphorylated neurofilament (PNF; 200 kDa), ubiquitin, glial fibrillary acidic protein (GFAP) ...

journal_title：Acta neuropathologica

authors： Sasaki S,Maruyama S

更新日期：1994-01-01 00:00:00

abstract：:Glioblastomas, the most malignant human brain tumors, are characterized by marked aneuploidy, suggesting chromosomal instability which may be caused by a defective mitotic spindle checkpoint. We screened 22 glioblastomas for mutations in the mitotic spindle check-point genes hBUB1, hBUBR1 and hBUB3. DNA sequencing rev...

journal_title：Acta neuropathologica

authors： Reis RM,Nakamura M,Masuoka J,Watanabe T,Colella S,Yonekawa Y,Kleihues P,Ohgaki H

更新日期：2001-04-01 00:00:00

abstract：:A human glioma cell line, SA146, was initiated on precoated extracellular matrix from a stereotactic biopsy of a glioblastoma. We report modulation in the expression of glial fibrillary acidic protein (GFAP) by SA146 passed in vitro before or after xenogenic transplantation into nude mice. Immunofluorescence data show...

journal_title：Acta neuropathologica

authors： Gomès D,de Néchaud B,Maunoury R,Moura Neto V,Brigaudeau C,Labrousse F,Dupouey P

更新日期：1997-10-01 00:00:00

abstract：:Morphometric observations have been made on the medial plantar division of the tibial nerve (MPD) and on the motor branches of the tibial nerve to the calf muscles (MBC) in rats ranging in age from weaning (3 weeks) to 12 months. Axon size, assessed by measurements of circumference and cross-sectional area, increased ...

journal_title：Acta neuropathologica

authors： Fraher JP,O'Leary D,Moran MA,Cole M,King RH,Thomas PK

更新日期：1990-01-01 00:00:00

abstract：:This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive con...

journal_title：Acta neuropathologica

authors： Kato S,Hirano A,Kato M,Herz F,Ohama E

更新日期：1992-01-01 00:00:00

abstract：:Marinesco-Sjögren syndrome (MSS) features cerebellar ataxia, mental retardation, cataracts, and progressive vacuolar myopathy with peculiar myonuclear alterations. Most MSS patients carry homozygous or compound heterozygous SIL1 mutations. SIL1 is a nucleotide exchange factor for the endoplasmic reticulum resident cha...

journal_title：Acta neuropathologica

authors： Roos A,Buchkremer S,Kollipara L,Labisch T,Gatz C,Zitzelsberger M,Brauers E,Nolte K,Schröder JM,Kirschner J,Jesse CM,Goebel HH,Goswami A,Zimmermann R,Zahedi RP,Senderek J,Weis J

更新日期：2014-05-01 00:00:00

abstract：:Recent studies have documented carbonyl stress involvement in the pathogenesis of sporadic amyotrophic lateral sclerosis (ALS). The aim of the present study was to assess a role for carbonyl stress in motor neuron degeneration associated with superoxide dismutase-1 (SOD1) mutant familial ALS and its transgenic mouse m...

journal_title：Acta neuropathologica

authors： Shibata N,Hirano A,Hedley-Whyte ET,Dal Canto MC,Nagai R,Uchida K,Horiuchi S,Kawaguchi M,Yamamoto T,Kobayashi M

更新日期：2002-08-01 00:00:00

abstract：:The colonic enteric nervous system was investigated in autopsy specimens from 12 patients with familial amyloidotic neuropathy (FAP) and 9 controls. The infiltration of amyloid deposits in the enteric nervous system was studied by double staining for amyloid and nerve elements. The myenteric plexus was immunostained f...

journal_title：Acta neuropathologica

authors： Anan I,El-Salhy M,Ando Y,Forsgren S,Nyhlin N,Terazaki H,Sakashita N,Suhr OB

更新日期：1999-07-01 00:00:00

abstract：:A patient with mixed gonadal dysgenesis showed glove and stocking-type sensory impairment and slowing of motor and sensory nerve conduction. Sural nerve biopsy revealed minifascicular formation with decreased density of myelinated fibers. As far as we are aware, this is the first report of polyneuropathy with minifasc...

journal_title：Acta neuropathologica

authors： Umehara F,Yamaguchi N,Kodama D,Takenaga S,Kiwaki T,Sonoda Y,Arimura Y,Yamada H,Arimura K,Osame M

更新日期：1999-09-01 00:00:00

abstract：:Abundant proliferation of cells having the histologic and tinctorial features of microglia, were seen in the brain of 34-year old man who suffered cardiac arrest 10 days before death and whose bone marrow was nearly totally depleted of white-blood-cell precursors. It is suggested, that in adult human brains there are ...

journal_title：Acta neuropathologica

authors： Neuwelt EA,Garcia JH,Mena H

更新日期：1978-09-15 00:00:00

abstract：:Two distinct species of amyloid beta protein (A beta) with different carboxyl termini, A beta 40 and A beta 42(43), are deposited in plaques in the brains of patients with Alzheimer's disease and Down's syndrome. The relationship between these two forms of A beta and microglial cells was investigated in 16 subjects wi...

journal_title：Acta neuropathologica

authors： Mann DM,Iwatsubo T,Fukumoto H,Ihara Y,Odaka A,Suzuki N

更新日期：1995-01-01 00:00:00

abstract：:Neuronal and glial cytoplasmic inclusions (NCIs and GCIs), which contain alpha-synuclein as a major component, are characteristic cytopathological features of multiple system atrophy (MSA). We report MSA of 19 years' duration in a 73-year-old woman. Her initial symptom was parkinsonism, with dementia appearing about 8...

journal_title：Acta neuropathologica

authors： Piao YS,Hayashi S,Hasegawa M,Wakabayashi K,Yamada M,Yoshimoto M,Ishikawa A,Iwatsubo T,Takahashi H

更新日期：2001-03-01 00:00:00

abstract：:MicroRNA (miRNA) expression was assessed in human cerebral cortical gray matter (GM) and white matter (WM) in order to provide the first insights into the difference between GM and WM miRNA repertoires across a range of Alzheimer's disease (AD) pathology. RNA was isolated separately from GM and WM portions of superior...

journal_title：Acta neuropathologica

authors： Wang WX,Huang Q,Hu Y,Stromberg AJ,Nelson PT

更新日期：2011-02-01 00:00:00

abstract：:Primary brain tumours (gliomas) initiate a strong host response and can contain large amounts of immune cells (myeloid cells) such as microglia and tumour-infiltrating macrophages. In gliomas the course of pathology is not only controlled by the genetic make-up of the tumour cells, but also depends on the interplay wi...

journal_title：Acta neuropathologica

authors： Glass R,Synowitz M

更新日期：2014-09-01 00:00:00

abstract：:The neuropathological staging model of Alzheimer's disease proposed by Braak and Braak [Acta Neuropathol (1991) 82:259] requires that the evolution of neurofibrillary pathology follows a predictable pattern that can be ordered in a regular regional hierarchy. We have operationalized the neuropathological staging syste...

journal_title：Acta neuropathologica

authors： Gertz HJ,Xuereb J,Huppert F,Brayne C,McGee MA,Paykel E,Harrington C,Mukaetova-Ladinska E,Arendt T,Wischik CM

更新日期：1998-02-01 00:00:00

abstract：:We described a new type of cytoplasmic inclusion in the choroidal epithelial cells of humans. The inclusions usually appeared as brown, round or elongated bodies with or without an inner core, ranging in size from 1.3 to 7.0 micron. Histochemically, they contained polysaccharides, proteins and compound lipids. Ultrast...

journal_title：Acta neuropathologica

authors： Ohama E,Takeda S,Ikuta F

更新日期：1988-01-01 00:00:00

abstract：:The central distal axonopathy induced in dogs by the administration of high doses of clioquinol is contrasted with the central-peripheral distal axonopathy precipitated by intoxication with 2,5-hexanedione. Mature, pure-bred Beagle dogs received a daily oral dose of 400 mg/kg of clioquinol for up to 7 months, or 1 ml ...

journal_title：Acta neuropathologica

authors： Krinke G,Schaumburg HH,Spencer PS,Thomann P,Hess R

更新日期：1979-08-01 00:00:00

abstract：:Alpha-synuclein (αSyn) preformed fibrils (PFF) induce endogenous αSyn aggregation leading to reduced synaptic transmission. Neuronal activity modulates release of αSyn; however, whether neuronal activity regulates the spreading of αSyn pathology remains elusive. Here, we established a hippocampal slice culture system ...

journal_title：Acta neuropathologica

authors： Wu Q,Shaikh MA,Meymand ES,Zhang B,Luk KC,Trojanowski JQ,Lee VM

更新日期：2020-12-01 00:00:00

abstract：:A unique pathological finding of astrocytes was observed in the brain of a 20-year-old man who had severe physical and mental retardation. The brain was malformed showing micropolygyria in several cortical areas. A large number of hypertrophic astrocytes with eosinophilic granular substances in their cytoplasm were fo...

journal_title：Acta neuropathologica

authors： Minagawa M,Shioda K,Shimizu Y,Isshiki T

更新日期：1992-01-01 00:00:00

abstract：:Head and neck paragangliomas, rare neoplasms of the paraganglia composed of nests of neurosecretory and glial cells embedded in vascular stroma, provide a remarkable example of organoid tumor architecture. To identify genes and pathways commonly deregulated in head and neck paraganglioma, we integrated high-density ge...

journal_title：Acta neuropathologica

authors： Cama A,Verginelli F,Lotti LV,Napolitano F,Morgano A,D'Orazio A,Vacca M,Perconti S,Pepe F,Romani F,Vitullo F,di Lella F,Visone R,Mannelli M,Neumann HP,Raiconi G,Paties C,Moschetta A,Tagliaferri R,Veronese A,Sanna M

更新日期：2013-10-01 00:00:00

abstract：:Psammoma bodies in meningocytic whorls were investigated by electron microscopy. In some whorls, connective tissue fibers were seen and membrane-bound vesicles were contiguous to degenerated cells. Some small vesicles, 0.1 to 0.5 micron in diameter, were outlined by plasma membrane (matrix vesicles), other larger ones...

journal_title：Acta neuropathologica

authors： Kubota T,Yamashima T,Hasegawa M,Kida S,Hayashi M,Yamamoto S

更新日期：1986-01-01 00:00:00

abstract：:Recent studies have shown that Cerebrolysin can enhance synaptic function and ameliorate synaptodendritic alterations in animal models of neurodegeneration, suggesting a synaptotrophic effect. We hypothesize that Cerebrolysin might exert this effect, in part, by regulating the expression of amyloid precursor protein (...

journal_title：Acta neuropathologica

authors： Mallory M,Honer W,Hsu L,Johnson R,Rockenstein E,Masliah E

更新日期：1999-05-01 00:00:00

abstract：:Histamine dihydrochloride (10 micrograms of 500 micrograms/ml) was infused during 1 min into the lateral cerebral ventricle of rats, which resulted in a significant stimulation of pinocytosis in the endothelial cells. Systemic injections of mepyramine or metiamide could not prevent this activation. In contrast, raniti...

journal_title：Acta neuropathologica

authors： Dux E,Dóczi T,Joó F,Szerdahelyi P,Siklós L

更新日期：1988-01-01 00:00:00

abstract：:The present investigation examined the morphological characteristics of epiplexus macrophages following a single intracisternal injection of the antigen, bacillus Calmette-Guerin (BCG). Three days following injection of BCG (0.5 - 4.0 X 10(8) viable microorganisms), mongrel dogs were perfused with buffered aldehydes. ...

journal_title：Acta neuropathologica

authors： Merchant RE

更新日期：1979-08-01 00:00:00

abstract：:The current classification of human sporadic prion diseases recognizes six major phenotypic subtypes with distinctive clinicopathological features, which largely correlate at the molecular level with the genotype at the polymorphic codon 129 (methionine, M, or valine, V) in the prion protein gene and with the size of ...

journal_title：Acta neuropathologica

authors： Parchi P,de Boni L,Saverioni D,Cohen ML,Ferrer I,Gambetti P,Gelpi E,Giaccone G,Hauw JJ,Höftberger R,Ironside JW,Jansen C,Kovacs GG,Rozemuller A,Seilhean D,Tagliavini F,Giese A,Kretzschmar HA

更新日期：2012-10-01 00:00:00

abstract：:Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by the expansion of a polyglutamine tract in the androgen receptor (AR). The mechanism by which expansion of polyglutamine in AR causes muscle atrophy is unknown. Here, we investigated pathological pathways underlying muscle atrophy in SBMA kn...

journal_title：Acta neuropathologica

authors： Rocchi A,Milioto C,Parodi S,Armirotti A,Borgia D,Pellegrini M,Urciuolo A,Molon S,Morbidoni V,Marabita M,Romanello V,Gatto P,Blaauw B,Bonaldo P,Sambataro F,Robins DM,Lieberman AP,Sorarù G,Vergani L,Sandri M,Pennuto

更新日期：2016-07-01 00:00:00

abstract：:SNAP-25 (a synaptosomal-associated protein of 25 kDa) has been shown to be involved both in synaptic vesicle exocytosis and in axonal outgrowth. In the present study, we investigated the changes in SNAP-25 immunoreactivity in the hippocampus of the Mongolian gerbil (Meriones unguiculatus) at different time points afte...

journal_title：Acta neuropathologica

authors： Martí E,Ferrer I,Ballabriga J,Blasi J

更新日期：1998-03-01 00:00:00