Abstract：
:Histamine dihydrochloride (10 micrograms of 500 micrograms/ml) was infused during 1 min into the lateral cerebral ventricle of rats, which resulted in a significant stimulation of pinocytosis in the endothelial cells. Systemic injections of mepyramine or metiamide could not prevent this activation. In contrast, ranitidine, injected with histamine was able to inhibit the stimulation of pinocytosis. Albumin exudation from the blood was not found. There was also no change in water and electrolyte contents of the brain tissue. The results suggest that histamine reaching the abluminal membrane can activate the pinocytosis in the cerebral endothelial cells in the reverse direction, i.e., from brain to blood, without opening the blood-brain barrier.
journal_name
Acta Neuropatholjournal_title
Acta neuropathologicaauthors
Dux E,Dóczi T,Joó F,Szerdahelyi P,Siklós Ldoi
10.1007/BF00686387subject
Has Abstractpub_date
1988-01-01 00:00:00pages
484-8issue
5eissn
0001-6322issn
1432-0533journal_volume
76pub_type
杂志文章abstract：:This study was designed to compare the degree of reactive astrogliosis occurring around a puncture wound in the brain of normal rats and at different intervals after a similar puncture wound in rats with a portocaval anastomosis. The gliosis was evaluated by the number of astrocytes, the thickness of their processes a...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00310926
更新日期：1991-01-01 00:00:00
abstract：:Since we reported a case of acute relaxant-steroid myopathy (ARSM) in 1994, we continued histological studies and compared the findings with those in a case of corticosteroid myopathy (CM). It was revealed that (1) dystrophin, spectrin, beta dystroglycan, and sarcoglycans on the cell surface were decreased, (2) regula...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051022
更新日期：1999-05-01 00:00:00
abstract：:Considering the possibility of a paracellular route for edema resolution we studied the microvasculature of the subependymal and subcortical white matter in hydrocephalic rats. Normal adult rats were used as controls. After injection of kaolin suspension into the cisterna magna, the animals were killed at intervals of...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00695575
更新日期：1984-01-01 00:00:00
abstract：:Focal cortical dysplasias (FCDs) are increasingly recognized as one of the most common causes of pharmaco-resistant epilepsies. FCDs were recently divided into various clinico-pathological subtypes due to distinct imaging, electrophysiological, and outcome characteristics. In this review, we will overview the internat...
journal_title：Acta neuropathologica
pub_type： 杂志文章,评审
doi：10.1007/s00401-014-1304-0
更新日期：2014-07-01 00:00:00
abstract：:Ectopic neurons have been detected in the hippocampus of postnatal hooded rats aged 5-24 days. These rats were exposed to methylazoxymethanol acetate (MAMac) during foetal development by injecting the mother rats with this neurotoxin. At birth, the hippocampus of rats exposed to MAMac showed a normal cytoarchitecture;...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688698
更新日期：1977-10-10 00:00:00
abstract：:Cerebral cortical lesions of tuberous sclerosis (TSC) and focal cortical dysplasia (FCD) show disturbances in laminar architecture and cellular differentiation. We immunohistochemically studied the expression of doublecortin, a fetal neuronal protein that regulates neuronal migration, in the surgical specimens of five...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0575-z
更新日期：2002-10-01 00:00:00
abstract：:Aim of the present study was to establish different immunohistochemical staining patterns for a subsequent comparison with those of primitive neuroectodermal (PNET) subsets, i.e. PNET-NOS (not otherwise specified) or PNET with focal neuronal, astrocytic or ependymal differentiation, to relate neoplastic to embryonal d...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00293385
更新日期：1991-01-01 00:00:00
abstract：:Lectin-binding sites located on the endothelial cell (EC) surfaces in unaltered, leaking and resorbing micro-blood vessels (MBVs) in cryo-injured cat brain were studied. Lectin or glycoprotein-gold complexes and brain samples embedded in hydrophilic resin Lowicryl K4M were used. The lectins tested recognize the follow...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00691427
更新日期：1986-01-01 00:00:00
abstract：:Abuse of the club drugs Methamphetamine (Meth) and Ecstasy (MDMA) is an international problem. The seriousness of this problem is the result of what appears to be programmed cell death (PCD) occurring within the brain following their use. This follow up study focused on determining which cell types, neurons and/or gli...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0259-9
更新日期：2007-09-01 00:00:00
abstract：:The immunoreactivity to the free radical-related enzymes, nitric oxide synthase (NOS) and superoxide dismutase (SOD), was examined in brain tissue in progressive supranuclear palsy (PSP). To determine the relationship between the immunoexpression of these enzymes and tau-positive, argyrophilic cytoplasmic inclusions, ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010050808
更新日期：1998-04-01 00:00:00
abstract：:Gelatinase A is an enzyme capable of cleaving soluble beta-amyloid protein (beta AP), and may function as an alpha-secretase to produce secretory forms of amyloid precursor protein. We examined gelatinase A immunoreactivity in the brains and posterior roots of neurologically normal, lacunar stroke, Alzheimer disease (...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00309334
更新日期：1995-01-01 00:00:00
abstract：:A limited cortical resection including the rolandic fissure and the pre- and postcentral cortical regions was carried out in a patient suffering from epilepsia partialis continua resistant to antiepileptic drugs. The histological examination revealed several foci of very large neurons distributed with no laminar organ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00299415
更新日期：1992-01-01 00:00:00
abstract：:A description is given of three cases of ganglioneuromas, which originated from ganglia of the sympathetic chain of hamsters. Other reports of such tumors in this species are reviewed and the literature relative to hamster ganglioneuromas presented. In addition, the possible genesis of origin from adult ganglion cells...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00696794
更新日期：1975-10-01 00:00:00
abstract：:Damage to axons in acute multiple sclerosis (MS) lesions is now well established but the mechanisms of this damage remain obscure. Here we have applied a panel of antibodies that identify cell populations and proteins contained in them with a view to detecting those cells and proteins that are localised particularly c...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0045-0
更新日期：2006-04-01 00:00:00
abstract：:Cryostat sections of 12 gliomas and of 3 peritumoral brain tissue samples were investigated for mononuclear cell infiltration by immunohistochemistry, concentrating on cells expressing monocyte/macrophage markers. Only low numbers of T cells were detected in the tumors, whereas in average 20%-30% of all cells present ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294647
更新日期：1990-01-01 00:00:00
abstract：:A cerebral biopsy was performed in a 39-year-old male patient with subacute paraparesis who later developed severe dementia and moderate cerebellar involvement. The histological examination showed a marked neuronal loss, severe neurofibrillary degeneration, and a great number of senile plaques. No PAS-positive plaques...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00703200
更新日期：1983-01-01 00:00:00
abstract：:This study reports the histological, ultrastructural, and immunocytochemical characteristics of intracytoplasmic eosinophilic inclusion bodies occurring in various types of neurons of the human central nervous system. By light microscopy, the inclusions were brightly eosinophilic, slightly birefringent, and sharply de...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00308960
更新日期：1989-01-01 00:00:00
abstract：:Widespread damage to axons in the white matter of the brain is a well-recognised consequence of non-missile head injury. This diffuse axonal injury is characterised by a gradual swelling of the axon associated with an accumulation of cellular organelles and proteins. We have investigated the relationship between the s...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s004010051069
更新日期：1999-08-01 00:00:00
abstract：:Using a four-step immunoperoxidase (PAP) method and the monoclonal antibody MAbA9-C6 (MAbA9-C6), which defines an epitope of the retinal S-antigen (S-Ag), we investigated the S-Ag immunoreactivity in human fetal, newborn, infantile and adult pineal glands and in 13 human pineal parenchymal tumors. S-Ag immunoreactivit...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688043
更新日期：1986-01-01 00:00:00
abstract：:Cornelia de Lange syndrome (CDLS) is a rare multisystemic malformative syndrome of uncertain etiology characterized by severe psychomotor and mental retardation. Here we report the neuropathological analysis of a 35-year-old patient who displayed the classical clinical symptomatology of CDLS. A congenital dysgenesis o...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-002-0562-4
更新日期：2002-09-01 00:00:00
abstract：:Defects of major histocompatibility complex (MHC) class I antigen-processing machinery (APM) components have been shown to contribute to immune escape of malignant cells. We investigated the expression of APM components in astrocytomas without detectable defects in HLA class I antigen expression and correlated it with...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-007-0231-8
更新日期：2007-08-01 00:00:00
abstract：:Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by the expansion of a polyglutamine tract in the androgen receptor (AR). The mechanism by which expansion of polyglutamine in AR causes muscle atrophy is unknown. Here, we investigated pathological pathways underlying muscle atrophy in SBMA kn...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-016-1550-4
更新日期：2016-07-01 00:00:00
abstract：:The binding patterns of lectins to normal peripheral nerves were examined. Twelve biotinylated lectins were used in this study; Canavalia ensiformis (Con A), Pisum sativum (PSA), Lens culinaris (LCA), Ricinus communis 1 (RCA-1), Arachis hypogaea (PNA), Glycine max (SBA), Sophora japonica (SJA), Bandeiraea simplicifoli...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00294292
更新日期：1993-01-01 00:00:00
abstract：:Histochemical and electron microscopic studies were performed in an attempt to clarify the muscle pathology in an 18-year-old man with Fabry disease, showing proximal limb muscle atrophy, and his 52-year-old mother, who is a Fabry carrier with hypertrophic cardiomyopathy. Despite the relatively mild myopathic changes ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00296520
更新日期：1995-01-01 00:00:00
abstract：:Although much work has been directed recently towards unravelling the protein chemistry of neurofibrillary tangle (NFT) and senile plaque (SP) components in Alzheimer's disease, the pathogeneses of these lesions remains largely unknown and the problem of their relationship is unresolved. In particular, although paired...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687379
更新日期：1989-01-01 00:00:00
abstract：:The pro-inflammatory and blood-brain barrier (BBB) effects of intratumoral (IT) injection of human recombinant tumor necrosis factor-alpha (rTNF-alpha) were studied in the Fischer rat RT-2 glioma model. Animals received a single stereotaxic injection of either 6 x 10(4) U rTNF-alpha or excipient (vehicle) into the cen...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/pl00007398
更新日期：1997-01-01 00:00:00
abstract：:Flurothyl-induced status epilepticus was studied by light and electron microscopy (LM, EM) to determine the time course and structural features of neuronal necrosis in the vulnerable brain regions in epilepsy. The cerebral cortex, hippocampus and thalamus were examined after closely spaced recovery periods of up to 1 ...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687789
更新日期：1988-01-01 00:00:00
abstract：:The pathological changes in the nucleus basalis of Meynert (nbM) in 10 autopsied cases with Pick's disease were studied in comparison with 15 age-matched controls. Both the number and density of nerve cells and the degree of fibrillary gliosis were examined at the anterior, intermediate, and posterior divisions of the...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00687402
更新日期：1989-01-01 00:00:00
abstract：:We report an experimental model of Creutzfeldt-Jakob's disease (CJD) in mice leading to the formation of giant autophagic vacuoles (AV) in neurons of the cerebral cortex. These AV appear at the end of the incubation period (4-6 months postinoculation), together with spongy changes and clinical symptoms. Autophagy, a p...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/BF00688178
更新日期：1989-01-01 00:00:00
abstract：:The aim of the present work was to investigate whether nestin, a member of the intermediate filament family, is immunohistochemically expressed in the non-tumoral human hypophysis and pituitary neoplasms. Twenty-three normal pituitaries and 125 pituitary neoplasms were included. The tissues were formalin-fixed and par...
journal_title：Acta neuropathologica
pub_type： 杂志文章
doi：10.1007/s00401-006-0031-6
更新日期：2006-03-01 00:00:00
