Selective formation of certain advanced glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation.

abstract：:A variety of age-related changes occur in the structure of neurons in the cerebral cortex of Wistar-Kyoto and spontaneously hypertensive rats. The most marked alteration associated with increasing age was the deposition of lipofuscin pigment, primarily at the bases of apical dendrites of pyramidal neurons. While no st...

journal_title：Acta neuropathologica

authors： Knox CA,Yates RD,Chen I

更新日期：1980-01-01 00:00:00

abstract：:Laminin alpha2 (merosin)-deficient congenital muscular dystrophy (CMD) patients show progressive muscle fiber necrosis and ineffective muscle regeneration. This is probably due to decreased formation of multi nucleated myotubes resulting from a myoblast fusion defect. When receiving a mechanical signal from muscle mem...

journal_title：Acta neuropathologica

authors： Sakuma K,Nakao R,Inashima S,Hirata M,Kubo T,Yasuhara M

更新日期：2004-09-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus is a chronic metabolic disease that causes long-term secondary complications such as neuropathy. The occurrence of diabetic neuropathy has generally been thought of as being associated with hyperglycaemia. However, in a previous light microscopic examination of plantar nerves in dia...

journal_title：Acta neuropathologica

authors： Mohseni S,Hildebrand C

更新日期：1998-08-01 00:00:00

abstract：:The quadriceps femoris muscles of experimental allergic myositis, in strain 13 guinea pigs immunised with rabbit myosin B fraction, were subjected to histochemical, immunohistochemical and electron microscopic studies. They demonstrated a variety of degenerative changes of muscle fibres, infiltration of lymphocytes an...

journal_title：Acta neuropathologica

authors： Matsubara S,Takamori M

更新日期：1987-01-01 00:00:00

abstract：:Endoneurial cell response and type of nerve fibre damage were studied after perineural injections of 7% phenol-aqua and pure glycerol. Our previous studies have shown that phenol and glycerol induce different types of nerve fibre degeneration after intraneural injections: phenol dissolves axons and Schwann cells insid...

journal_title：Acta neuropathologica

authors： Westerlund T,Vuorinen V,Röyttä M

更新日期：2004-10-01 00:00:00

abstract：:This study was undertaken to elucidate, using the Golgi method, the neuropathological change in the brain of the macular mutant mouse, whose hemizygote (Ml/y) is considered to be a model of Menkes kinky hair disease (MKHD). The hemizygote mice gradually lost weight after 10 days of age and died with emaciation and sei...

journal_title：Acta neuropathologica

authors： Kawasaki H,Onaga A,Yamano T,Shimada M,Nishimura M

更新日期：1987-01-01 00:00:00

abstract：:A case of Creutzfeldt-Jakob disease (CJD) with a rare mutation of the prion protein (PrP) gene (PRNP) at codon 208 (R208H) is described. By comparison with two preceding reports, the case described here displayed two distinct biochemical and neuropathological features. Western blot analysis of brain homogenates showed...

journal_title：Acta neuropathologica

authors： Roeber S,Krebs B,Neumann M,Windl O,Zerr I,Grasbon-Frodl EM,Kretzschmar HA

更新日期：2005-04-01 00:00:00

abstract：:Bundles of paired helical filaments (PHF) accumulate in the pyramidal neurons that degenerate during Alzheimer's disease. This neurofibrillary degeneration is highly correlated with clinical signs of dementia. During the degenerating process, Tau proteins, which are the major antigenic components of PHF, are abnormall...

journal_title：Acta neuropathologica

authors： Delacourte A,Flament S,Dibe EM,Hublau P,Sablonnière B,Hémon B,Shérrer V,Défossez A

更新日期：1990-01-01 00:00:00

abstract：:A murine model of Tay-Sachs disease, the prototype of the GM2 gangliosidoses, was produced through the targeted disruption of the Hexa gene encoding the subunit of alpha-hexosaminidase A. The mice were completely devoid of beta-hexosaminidase A activity and accumulated GM2 ganglioside in the CNS in an age-dependent ma...

journal_title：Acta neuropathologica

authors： Taniike M,Yamanaka S,Proia RL,Langaman C,Bone-Turrentine T,Suzuki K

更新日期：1995-01-01 00:00:00

abstract：:Psammoma bodies in meningocytic whorls were investigated by electron microscopy. In some whorls, connective tissue fibers were seen and membrane-bound vesicles were contiguous to degenerated cells. Some small vesicles, 0.1 to 0.5 micron in diameter, were outlined by plasma membrane (matrix vesicles), other larger ones...

journal_title：Acta neuropathologica

authors： Kubota T,Yamashima T,Hasegawa M,Kida S,Hayashi M,Yamamoto S

更新日期：1986-01-01 00:00:00

abstract：:The colonic enteric nervous system was investigated in autopsy specimens from 12 patients with familial amyloidotic neuropathy (FAP) and 9 controls. The infiltration of amyloid deposits in the enteric nervous system was studied by double staining for amyloid and nerve elements. The myenteric plexus was immunostained f...

journal_title：Acta neuropathologica

authors： Anan I,El-Salhy M,Ando Y,Forsgren S,Nyhlin N,Terazaki H,Sakashita N,Suhr OB

更新日期：1999-07-01 00:00:00

abstract：:A monoclonal antibody, raised against extracts from Alzheimer brain, that recognizes a phosphorylated epitope in high molecular weight neurofilament proteins and tau proteins also immunostains Alzheimer neurofibrillary tangles, neurites in senile plaques and granulovacuolar degeneration. This result suggest that granu...

journal_title：Acta neuropathologica

authors： Dickson DW,Ksiezak-Reding H,Davies P,Yen SH

更新日期：1987-01-01 00:00:00

abstract：:The transmissible spongiform encephalopathies (TSEs) or prion diseases of animals are characterised by CNS spongiform change, gliosis and the accumulation of disease-associated forms of prion protein (PrP(d)). Particularly in ruminant prion diseases, a wide range of morphological types of PrP(d) depositions are found ...

journal_title：Acta neuropathologica

authors： Jeffrey M,McGovern G,Sisó S,González L

更新日期：2011-01-01 00:00:00

abstract：:Muscle fiber abnormalities are described in three cases of neonatal maple syrup disease. There were important variations in fiber diameters. Lesions consisted in focal or diffuse destruction of myofibrils. In view of recent biochemical and clinical data, a direct relation between elevated branched-chain amino acid lev...

journal_title：Acta neuropathologica

authors： Ferrière G,de Castro M,Rodriguez J

更新日期：1984-01-01 00:00:00

abstract：:In the present study we assessed the neuroprotective effects of the pan-caspase inhibitor z-VAD.fmk [N-benzyloxycarbony-valine-alanine-aspartate-(OMe)-fluoromethylketone], and the caspase-3 inhibitor Ac-DEVD.CHO (acetyl-aspartate-chloromethylketone) in the double-lesion rat model of striatonigral degeneration (SND), t...

journal_title：Acta neuropathologica

authors： Mantoan L,Stefanova N,Egger KE,Jellinger KA,Poewe W,Wenning GK

更新日期：2005-02-01 00:00:00

abstract：:An immunoperoxidase technique was used to locate synaptophysin (protein p38), a major integral membrane glycoprotein of synaptic vesicles, in the rat brain. In addition to a diffuse distribution of nerve terminal stainings for synaptophysin appearing as numerous small puncta, the large-sized cells with spindled or pol...

journal_title：Acta neuropathologica

authors： Goto S,Korematsu K,Nagahiro S,Ushio Y

更新日期：1993-01-01 00:00:00

abstract：:Focal cortical dysplasias (FCDs) are increasingly recognized as one of the most common causes of pharmaco-resistant epilepsies. FCDs were recently divided into various clinico-pathological subtypes due to distinct imaging, electrophysiological, and outcome characteristics. In this review, we will overview the internat...

journal_title：Acta neuropathologica

authors： Najm IM,Tassi L,Sarnat HB,Holthausen H,Russo GL

更新日期：2014-07-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and adult onset X-linked recessive bulbospinal muscular atrophy (SPMA), constituting the category of adult onset form of motor neuron disease, were analyzed on motor nerve roots. The results of morphometric analysis on ventral spinal roots (VSR) of all spinal segments from ALS and S...

journal_title：Acta neuropathologica

authors： Sobue G,Matsuoka Y,Mukai E,Takayanagi T,Sobue I,Hashizume Y

更新日期：1981-01-01 00:00:00

abstract：:Chronic traumatic encephalopathy (CTE) is a progressive degenerative disorder associated with repetitive traumatic brain injury. One of the primary defining neuropathological lesions in CTE, based on the first consensus conference, is the accumulation of hyperphosphorylated tau in gray matter sulcal depths. Post-morte...

journal_title：Acta neuropathologica

authors： Holleran L,Kim JH,Gangolli M,Stein T,Alvarez V,McKee A,Brody DL

更新日期：2017-03-01 00:00:00

abstract：:A quantitative study was performed on spinal cord lesions in seven patients with X-linked recessive spinal and bulbar muscular atrophy. The myelinated fiber density of the lateral corticospinal tracts at the T7 cord level was well preserved for both large and small myelinated fibers. On the other hand, neurons in the ...

journal_title：Acta neuropathologica

authors： Terao S,Sobue G,Li M,Hashizume Y,Tanaka F,Mitsuma T

更新日期：1997-01-01 00:00:00

abstract：:We have obtained a cDNA fragment to human glial fibrillary acidic protein (GFAP) by immunoscreening a lambda gt11 human brain cDNA library with antibody to bovine GFAP. The highly homologous nucleotide sequence of this clone with that of the mouse GFAP enabled the identification of this cDNA as one encoding GFAP. As t...

journal_title：Acta neuropathologica

authors： Nishiyama A,Onda K,Washiyama K,Kumanishi T,Kuwano R,Sakimura K,Takahashi Y

更新日期：1989-01-01 00:00:00

abstract：:Gliomatosis cerebri (GC), a rare and deadly CNS neoplasm characterized by involvement of at least three cerebral lobes, predominantly affects adults. While a few small series have reported its occurrence in children, little is known about the molecular characteristics of pediatric GC. We reviewed clinical, radiologica...

journal_title：Acta neuropathologica

authors： Broniscer A,Chamdine O,Hwang S,Lin T,Pounds S,Onar-Thomas A,Shurtleff S,Allen S,Gajjar A,Northcott P,Orr BA

更新日期：2016-02-01 00:00:00

abstract：:Defects of major histocompatibility complex (MHC) class I antigen-processing machinery (APM) components have been shown to contribute to immune escape of malignant cells. We investigated the expression of APM components in astrocytomas without detectable defects in HLA class I antigen expression and correlated it with...

journal_title：Acta neuropathologica

authors： Mehling M,Simon P,Mittelbronn M,Meyermann R,Ferrone S,Weller M,Wiendl H

更新日期：2007-08-01 00:00:00

abstract：:Focal cortical dysplasias (FCD) which represent a composite group of cortical malformations are increasingly recognized as morphological substrate for severe therapy-refractory epilepsy in children and young adults. However, presurgical evaluation remains challenging as not all FCD variants can be reliably detected by...

journal_title：Acta neuropathologica

authors： Mühlebner A,Coras R,Kobow K,Feucht M,Czech T,Stefan H,Weigel D,Buchfelder M,Holthausen H,Pieper T,Kudernatsch M,Blümcke I

更新日期：2012-02-01 00:00:00

abstract：:Transient forebrain ischemia produces a spatially and temporally selective pattern of neuronal degeneration in the hippocampal formation of the Mongolian gerbil. Ischemic neuronal death has been suggested to depend on the activation of excitatory hippocampal pathways that project to the vulnerable neurons. This idea w...

journal_title：Acta neuropathologica

authors： Kaplan TM,Lasner TM,Nadler JV,Crain BJ

更新日期：1989-01-01 00:00:00

abstract：:An ultrastructural study was performed on normal and Benzo(a)-pyrene(B(a)P)-transformed fetal mouse brain cells. Early subcultures of a strain initiated from whole brain presented three cell types in vitro: astroglial, poorly differentiated glial, and spongioblastic types. After B(a)P-treatment, there was an exclusive...

journal_title：Acta neuropathologica

authors： Tripier MF,Markovits P,Papadopoulo D,Toga M

更新日期：1979-08-01 00:00:00

abstract：:Large cell/anaplastic (LC/A) medulloblastoma (MB) is a recently recognized variant of medulloblastoma known to be associated with an advanced stage and a poor prognosis. Although Eberhart et al. suggested histopathologic grading of medulloblastoma in 2002, no consensus has been reached in terms of determining the crit...

journal_title：Acta neuropathologica

authors： Min HS,Lee YJ,Park K,Cho BK,Park SH

更新日期：2006-07-01 00:00:00

abstract：:The mechanisms underlying neurodegenerative diseases are the outcome of pathological alterations of evolutionary conserved molecular and cellular cascades. For this reason, Drosophila and C. elegans serve as useful model systems to study various aspects of neurodegenerative diseases. Here, we introduce the advantageou...

journal_title：Acta neuropathologica

authors： Shemesh OA,Spira ME

更新日期：2010-08-01 00:00:00

abstract：:The occurrence and topographic analysis of granulovacuolar degeneration (GVD) in the hippocampal cortex of mentally normal controls (75 cases) and patients with Alzheimer's dementia (AD; 17 cases which included Alzheimer's disease and senile dementia of Alzheimer type), multi-infarct dementia (MID; 16 cases), Pick's d...

journal_title：Acta neuropathologica

authors： Xu M,Shibayama H,Kobayashi H,Yamada K,Ishihara R,Zhao P,Takeuchi T,Yoshida K,Inagaki T,Nokura K

更新日期：1992-01-01 00:00:00

abstract：:Electron microscopy and computerized morphometric techniques were employed to examine pericyte ultrastructure and to assess quantitatively their relationship to endothelial cells in five cases of cerebellar capillary hemangioblastoma. A total of 97 cross-sectioned capillary profiles were studied. Pericyte coverage of ...

journal_title：Acta neuropathologica

authors： Ho KL

更新日期：1985-01-01 00:00:00