Experimental allergic myositis: ultrastructural, histochemical, immunological and immunohistochemical studies.

abstract：:Proliferation indices and mean number of silver-stained nucleolar organizer region-associated proteins (Ag-NORs) are compared in 65 brain tumors, including 34 gliomas, 8 meningiomas, 17 metastatic tumors, and 6 other tumors. Immunocytochemical investigations include labeling with the monoclonal antibody Ki-67 which id...

journal_title：Acta neuropathologica

authors： Maier H,Morimura T,Ofner D,Hallbrucker C,Kitz K,Budka H

更新日期：1990-01-01 00:00:00

abstract：:Brain slices are used extensively for biochemical, electrophysiological and molecular investigations. However, only the time frame for electrophysiological and biochemical investigations has as yet been defined. The goal of the present study was to investigate the time course of nuclear structure in live brain slices....

journal_title：Acta neuropathologica

authors： Kasischke K,Büchner M,Ludolph AC,Riepe MW

更新日期：2001-05-01 00:00:00

abstract：:Vasa vasorum are adventitial vessels that play a role in pathogenesis of atherosclerosis, aneurysm, vasculitides, and graft vascular disease. The existence of vasa vasorum in human intracranial arteries is not yet well defined. The specific aims of this study are to determine whether the human intracranial arteries ha...

journal_title：Acta neuropathologica

authors： Aydin F

更新日期：1998-07-01 00:00:00

abstract：:During corticogenesis, neurons adopt different migration pathways to reach their final position. The precursors of pyramidal neurons migrate radially, whereas most of the GABA-containing interneurons are generated in the ventral telencephalon and migrate tangentially into the neocortex. Then, they use a radial migrati...

journal_title：Acta neuropathologica

authors： Marcorelles P,Laquerrière A,Adde-Michel C,Marret S,Saugier-Veber P,Beldjord C,Friocourt G

更新日期：2010-10-01 00:00:00

abstract：:The immunohistochemical distribution of alpha and beta subunits of S-100 protein (S-100 alpha, S-100 beta, respectively) in 138 cases of human brain tumors was investigated by the avidin-biotin immunoperoxidase method. Brain tumors can be divided into four groups: group 1 [S-100 alpha (+) and/or S-100 beta (+)]; astro...

journal_title：Acta neuropathologica

authors： Hayashi K,Hoshida Y,Horie Y,Takahashi K,Taguchi K,Sonobe H,Ohtsuki Y,Akagi T

更新日期：1991-01-01 00:00:00

abstract：:Laminin alpha2 (merosin)-deficient congenital muscular dystrophy (CMD) patients show progressive muscle fiber necrosis and ineffective muscle regeneration. This is probably due to decreased formation of multi nucleated myotubes resulting from a myoblast fusion defect. When receiving a mechanical signal from muscle mem...

journal_title：Acta neuropathologica

authors： Sakuma K,Nakao R,Inashima S,Hirata M,Kubo T,Yasuhara M

更新日期：2004-09-01 00:00:00

abstract：:Several cases of progressive multifocal leukoencephalopathy (PML) have been associated with simian virus 40 (SV40), rather than with JC virus (JCV), the polyomavirus originally isolated from PML tissue. PML has, therefore, been defined as a demyelinating syndrome with possible multiple viral etiologies. Tissues from t...

journal_title：Acta neuropathologica

authors： Stoner GL,Ryschkewitsch CF

更新日期：1998-09-01 00:00:00

abstract：:Using a 3H-labelled virion DNA probe applied to tissue sections, we have previously identified the precise microscopic anatomical location of herpes simplex virus (HSV) during the acute and latent stages of infection of the mouse trigeminal ganglia and central nervous system (CNS). In the present investigation, we com...

journal_title：Acta neuropathologica

authors： Stroop WG,Schaefer DC

更新日期：1987-01-01 00:00:00

abstract：:An immunoperoxidase technique was used to locate synaptophysin (protein p38), a major integral membrane glycoprotein of synaptic vesicles, in the rat brain. In addition to a diffuse distribution of nerve terminal stainings for synaptophysin appearing as numerous small puncta, the large-sized cells with spindled or pol...

journal_title：Acta neuropathologica

authors： Goto S,Korematsu K,Nagahiro S,Ushio Y

更新日期：1993-01-01 00:00:00

abstract：:The extent of DNA fragmentation analysed using the TUNEL technique was evaluated in post-mortem human brain tissue. Twenty-four patients with clinical and histopathological diagnosis of Alzheimer's disease (AD) and a short post-mortem delay were analysed. We report an increase in the count of TUNEL-labelled cells as t...

journal_title：Acta neuropathologica

authors： Overmyer M,Kraszpulski M,Helisalmi S,Soininen H,Alafuzoff I

更新日期：2000-12-01 00:00:00

abstract：:The very existence of astroblastoma has been a question of considerable controversy, although there appears now to be sufficient documentation to establish it as a tenable entity. Due to the rarity of this tumor, little information exists in the literature as to its natural history, efficacy of therapy and its patholo...

journal_title：Acta neuropathologica

authors： Hoag G,Sima AA,Rozdilsky B

更新日期：1986-01-01 00:00:00

abstract：:Rats were given isoniazid either in a single large dose or continuously in drinking water and killed 5--105 days later. The distribution of degenerating fibres in various nerves (sensory and mixed) and in various sites along nerves and spinal roots was studied by light and electron microscopy. It was found that sensor...

journal_title：Acta neuropathologica

authors： Jacobs JM,Miller RH,Cavanagh JB

更新日期：1979-10-01 00:00:00

abstract：:Although it is known that deletions or mutations of the SMN1 gene on chromosome 5 cause decreased levels of the SMN protein in subjects with proximal autosomal recessive spinal muscular atrophy (SMA), the exact sequence of pathological events leading to selective motoneuron cell death is not fully understood yet. In t...

journal_title：Acta neuropathologica

authors： Simic G

更新日期：2008-09-01 00:00:00

abstract：:Interstitial cells are isolated neurons located in the infracortical white matter that are known to express neuropeptides. Twenty-four cases selected for the absence, slight (Braak stages I-II), moderate (Braak stages III-IV), or serious degree (Braak stages V-VI) of cortical neurofibrillary pathology were studied for...

journal_title：Acta neuropathologica

authors： van de Nes JA,Sandmann-Keil D,Braak H

更新日期：2002-10-01 00:00:00

abstract：:Using a four-step immunoperoxidase (PAP) method and the monoclonal antibody MAbA9-C6 (MAbA9-C6), which defines an epitope of the retinal S-antigen (S-Ag), we investigated the S-Ag immunoreactivity in human fetal, newborn, infantile and adult pineal glands and in 13 human pineal parenchymal tumors. S-Ag immunoreactivit...

journal_title：Acta neuropathologica

authors： Perentes E,Rubinstein LJ,Herman MM,Donoso LA

更新日期：1986-01-01 00:00:00

abstract：:The present study used cocultures of rat dorsal root ganglia (DRG) and peritoneal macrophages to define the role of activated complement components during demyelination. The complement cascade was activated in vitro by treatment of the cultures with natural rat serum and lipopolysaccharides. Complement activation was ...

journal_title：Acta neuropathologica

authors： Brück W,Brück Y,Diederich U,Piddlesden SJ

更新日期：1995-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no effective treatments. Numerous RNA-binding proteins (RBPs) have been shown to be altered in ALS, with mutations in 11 RBPs causing familial forms of the disease, and 6 more RBPs showing abnormal expression/distribution in ALS albeit...

journal_title：Acta neuropathologica

authors： Bakkar N,Kovalik T,Lorenzini I,Spangler S,Lacoste A,Sponaugle K,Ferrante P,Argentinis E,Sattler R,Bowser R

更新日期：2018-02-01 00:00:00

abstract：:Recently, 43-kDa TAR DNA-binding protein (TDP-43) was identified as a component of ubiquitinated inclusions (UIs) in sporadic amyotrophic lateral sclerosis (SALS). To clarify whether TDP-43 immunoreactivity is present in neuronal inclusions in familial ALS (FALS), we examined immunohistochemically the brains and spina...

journal_title：Acta neuropathologica

authors： Tan CF,Eguchi H,Tagawa A,Onodera O,Iwasaki T,Tsujino A,Nishizawa M,Kakita A,Takahashi H

更新日期：2007-05-01 00:00:00

abstract：:A case of progressive polyneuropathy associated with Waldenström's macroglobulinaemia is reported. A monoclonal IgM-lambda gradient was detected in the serum and cerebro-spinal fluid. By electro-immunoblot analysis antibodies against myelin-associated glycoprotein were found in the serum and cerebro-spinal fluid. The ...

journal_title：Acta neuropathologica

authors： Meier C,Roberts K,Steck A,Hess C,Miloni E,Tschopp L

更新日期：1984-01-01 00:00:00

abstract：:Stereological estimates of mean volumes, surface areas, and cortical thicknesses were obtained on formalin-fixed brains from 19 men with AIDS and 19 controls. Volumes of neocortex, white matter, central brain nuclei, ventricles and archicortex were estimated using point counting and Cavalieri's unbiased principle for ...

journal_title：Acta neuropathologica

authors： Oster S,Christoffersen P,Gundersen HJ,Nielsen JO,Pakkenberg B,Pedersen C

更新日期：1993-01-01 00:00:00

abstract：:Aluminum was observed in the nucleolus, interchromatin granules, rough endoplasmic reticulum, free ribosomes, euchromatin, and the heterochromatin of the neuron. The association of aluminum with the first four r-RNA-containing cellular components and with the last two DNA-containing chromatins suggests the association...

journal_title：Acta neuropathologica

authors： Wen GY,Wisniewski HM

更新日期：1985-01-01 00:00:00

abstract：:In order to further evaluate the parameters whereby intracerebral administration of recombinant α-synuclein (αS) induces pathological phenotypes in mice, we conducted a series of studies where αS fibrils were injected into the brains of M83 (A53T) and M47 (E46K) αS transgenic (Tg) mice, and non-transgenic (nTg) mice. ...

journal_title：Acta neuropathologica

authors： Sacino AN,Brooks M,Thomas MA,McKinney AB,McGarvey NH,Rutherford NJ,Ceballos-Diaz C,Robertson J,Golde TE,Giasson BI

更新日期：2014-05-01 00:00:00

abstract：:Accumulation of mitochondrial DNA (mtDNA) deletions has been proposed to be responsible for the presence of respiratory-deficient neurons in several CNS diseases. Deletions are thought to originate from double-strand breaks due to attack of reactive oxygen species (ROS) of putative inflammatory origin. In epileptogene...

journal_title：Acta neuropathologica

authors： Volmering E,Niehusmann P,Peeva V,Grote A,Zsurka G,Altmüller J,Nürnberg P,Becker AJ,Schoch S,Elger CE,Kunz WS

更新日期：2016-08-01 00:00:00

abstract：:Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis and neurodegeneration. However, the mechanisms through which the brain's immune system recognizes and controls viral infections propagating across synaptically linked neuronal circuits have rem...

journal_title：Acta neuropathologica

authors： Fekete R,Cserép C,Lénárt N,Tóth K,Orsolits B,Martinecz B,Méhes E,Szabó B,Németh V,Gönci B,Sperlágh B,Boldogkői Z,Kittel Á,Baranyi M,Ferenczi S,Kovács K,Szalay G,Rózsa B,Webb C,Kovacs GG,Hortobágyi T,West BL,Kö

更新日期：2018-09-01 00:00:00

abstract：:It is conventionally accepted that during the early stages of Wallerian degeneration of myelinated peripheral nerve fibres Schmidt-Lanterman incisures represent the sites at which the myelin sheath, together with enclosed axoplasm, is segmented into myelin ovoids. This mechanism is considered by some authors to be fac...

journal_title：Acta neuropathologica

authors： Ghabriel MN,Allt G

更新日期：1979-11-01 00:00:00

abstract：:We have investigated relationships between hippocampal/temporal lobe neuropathology and psychosis in subjects with temporal lobe epilepsy, paying particular attention to possible differences in density of hippocampal neurons immunoreactive for calcium-binding proteins. There was a trend for a greater prevalence of lef...

journal_title：Acta neuropathologica

authors： Suckling J,Roberts H,Walker M,Highley JR,Fenwick P,Oxbury J,Esiri MM

更新日期：2000-05-01 00:00:00

abstract：:Granule-containing vacuoles in the cytoplasm of hippocampal neurons are a neuropathological feature of Alzheimer's disease. Granulovacuolar degeneration (GVD) is not disease-specific and can be observed in other neurodegenerative disorders and even in the brains of non-demented elderly people. However, several studies...

journal_title：Acta neuropathologica

authors： Köhler C

更新日期：2016-09-01 00:00:00

abstract：:Glucosylceramide lipidosis results from a defective lysosomal degradation of this glycolipid. Lipid degradation is controlled by two components, the enzyme beta-glucocerebrosidase and a sphingolipid activator protein. While most Gaucher cases are due to mutations within the gene that codes for the lysosomal enzyme, on...

journal_title：Acta neuropathologica

authors： Pàmpols T,Pineda M,Girós ML,Ferrer I,Cusi V,Chabás A,Sanmarti FX,Vanier MT,Christomanou H

更新日期：1999-01-01 00:00:00

abstract：:We studied senile plaques (SP) in the cerebella of six autopsied subjects with Alzheimer-type dementia (ATD) and ten non-ATD autopsied subjects between the ages of 78 and 90. Neither SP nor amyloid angiopathy (AA) was observed in any of the non-ATD subjects. In the four of the six ATD subjects, diffuse plaques in the ...

journal_title：Acta neuropathologica

authors： Yamaguchi H,Hirai S,Morimatsu M,Shoji M,Nakazato Y

更新日期：1989-01-01 00:00:00

abstract：:A 9-year-old male patient developed a germ cell tumor in the right basal ganglia which secreted beta-human chorionic gonadotropin (beta-HCG) and caused precocious puberty. Histology and immunohistochemical staining for placental alkaline phosphatase (PLAP), alpha-fetoprotein (alpha-FP), and beta-HCG showed a mixed pop...

journal_title：Acta neuropathologica

authors： Aguzzi A,Hedinger CE,Kleihues P,Yaşargil MG

更新日期：1988-01-01 00:00:00