High serum creatine kinase levels associated with cylindrical spirals at muscle biopsy.

abstract：:Neurofibrillary tangles were induced in the motor neurons of the rabbit spinal cord by the intrathecal injection of colchicine, vinblastine, and vincristine. The tangles stained intensely by immunofluorescence and by the peroxidase-anti-peroxidase procedure using neurofilament antisera raised against chicken brain ant...

journal_title：Acta neuropathologica

authors： Dahl D,Bignami A,Bich NT,Chi NH

更新日期：1980-01-01 00:00:00

abstract：:Excitotoxic stimulation of NMDA receptors results in the activation of a variety of cellular responses. The inducible transcription factor NF-kappaB is known to be involved in excitotoxic responses by neurons. Here, we show that NF-kappaB activation occurs in a biphasic manner in hippocampal slices following a 20-min ...

journal_title：Acta neuropathologica

authors： Caba E,Bahr BA

更新日期：2004-09-01 00:00:00

abstract：:A simple and reproducible method for cryopreservation of brain tissue from patients with Alzheimer's disease is described. Fresh brain slices (1 cm thick) obtained less than 6 h postmortem are placed in sealed plastic bags, sandwiched between 0.3-cm-thick aluminium sheets, and frozen by placing the entire "sandwich" b...

journal_title：Acta neuropathologica

authors： Nochlin D,Mackenzie AP,Bryant EM,Norwood TH,Sumi SM

更新日期：1993-01-01 00:00:00

abstract：:An in vivo method for positively staining dead neurons was developed and compared with an in vitro staining method using acid fuchsin. Neurons previously killed by intracerebral injections of kainic acid were selectively stained by trypan blue within 15 min of its injection in vivo into the central nervous system of r...

journal_title：Acta neuropathologica

authors： Lees GJ

更新日期：1989-01-01 00:00:00

abstract：:Astrocytic alpha-synuclein-immunoreactive inclusions have recently been noted to develop in sporadic Parkinson's disease (PD). Here, the presence of immunoreactive astrocytes is reported in 14 autopsy cases with clinically diagnosed PD and a neuropathological stage of 4 or higher. The labeled astrocytes occur preferen...

journal_title：Acta neuropathologica

authors： Braak H,Sastre M,Del Tredici K

更新日期：2007-09-01 00:00:00

abstract：:Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis and neurodegeneration. However, the mechanisms through which the brain's immune system recognizes and controls viral infections propagating across synaptically linked neuronal circuits have rem...

journal_title：Acta neuropathologica

authors： Fekete R,Cserép C,Lénárt N,Tóth K,Orsolits B,Martinecz B,Méhes E,Szabó B,Németh V,Gönci B,Sperlágh B,Boldogkői Z,Kittel Á,Baranyi M,Ferenczi S,Kovács K,Szalay G,Rózsa B,Webb C,Kovacs GG,Hortobágyi T,West BL,Kö

更新日期：2018-09-01 00:00:00

abstract：:Neurofibromas represent one of the hallmarks of neurofibromatosis 1 (NF1) patients. Tumor progression of neurofibromas to malignant peripheral nerve sheath tumors (MPNST) is a frequent and life threatening complication. To learn more about processes involved in malignant transformation, we evaluated differential gene ...

journal_title：Acta neuropathologica

authors： Holtkamp N,Mautner VF,Friedrich RE,Harder A,Hartmann C,Theallier-Janko A,Hoffmann KT,von Deimling A

更新日期：2004-02-01 00:00:00

abstract：:To identify antigenic differences between gliomas and normal brain, we have immunohistochemically studied the expression of lymphocyte adhesion molecules (ICAM-1, ICAM-2, ICAM-3, VCAM-1, E-selectin and CD58), epidermal growth factor receptor (EGFR) and extracellular matrix proteins (collagen IV, fibronectin, laminin, ...

journal_title：Acta neuropathologica

authors： Mäenpää A,Kovanen PE,Paetau A,Jäáskeläinen J,Timonen T

更新日期：1997-09-01 00:00:00

abstract：:Rat sciatic nerve was assayed for total collagen and total protein both immediately post-mortem and at weekly intervals after death. No significant difference was found in collagen and protein content between corresponding nerve segments assayed fresh and up to 4 weeks post mortem. However, variation was found in peri...

journal_title：Acta neuropathologica

authors： McFarlane KR,Pollock M,Myers DB

更新日期：1980-01-01 00:00:00

abstract：:Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43 proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). However, the pathogenic mechanism of the diseases linked to TDP-43 is largely unknown. We hypothesized that the failu...

journal_title：Acta neuropathologica

authors： Nagano S,Jinno J,Abdelhamid RF,Jin Y,Shibata M,Watanabe S,Hirokawa S,Nishizawa M,Sakimura K,Onodera O,Okada H,Okada T,Saito Y,Takahashi-Fujigasaki J,Murayama S,Wakatsuki S,Mochizuki H,Araki T

更新日期：2020-11-01 00:00:00

abstract：:Neuregulins belong to a family of multipotent growth-promoting proteins, and have been shown to have a crucial role in accumulating acetylcholine receptor at neuromuscular junctions. A functional role of neuregulins in muscle regeneration has not yet been identified. Using reverse transcription (RT)-PCR, Western blot ...

journal_title：Acta neuropathologica

authors： Hirata M,Sakuma K,Okajima S,Fujiwara H,Inashima S,Yasuhara M,Kubo T

更新日期：2007-04-01 00:00:00

abstract：:The immunoreactivity to the free radical-related enzymes, nitric oxide synthase (NOS) and superoxide dismutase (SOD), was examined in brain tissue in progressive supranuclear palsy (PSP). To determine the relationship between the immunoexpression of these enzymes and tau-positive, argyrophilic cytoplasmic inclusions, ...

journal_title：Acta neuropathologica

authors： Komori T,Shibata N,Kobayashi M,Sasaki S,Iwata M

更新日期：1998-04-01 00:00:00

abstract：:A 17 year-old male, who was mentally and bodily retarded from the age of 7 years. At the age of 16 years, several neurological signs appeared. Pathologically, there was widespread myelin loss and tissue sponginess in the white matter of the cerebrum and cerebellum, bilaterally and symmetrically. A great many Alzheimer...

journal_title：Acta neuropathologica

authors： Miyakawa T,Murayama E

更新日期：1976-01-01 00:00:00

abstract：:In chronic granulomatous disease (CGD) enzyme-deficient neutrophils and mononuclear cells lack the respiratory burst required for biocidal activity. Recurrent infections lead to granulomas in various organs but brain lesions are rare. In the present case, a 23-year-old male with numerous infections since early childho...

journal_title：Acta neuropathologica

authors： Hadfield MG,Ghatak NR,Laine FJ,Myer EC,Massie FS,Kramer WM

更新日期：1991-01-01 00:00:00

abstract：:A histopathological study was carried out on the brains of eight ex-boxers (ages 56 to 83) using conventional histological staining methods and immunocytochemistry with antibodies to amyloid beta-protein and the PHF-related tau protein. All cases showed a large number of tau-immunoreactive neurofibrillary tangles and ...

journal_title：Acta neuropathologica

authors： Tokuda T,Ikeda S,Yanagisawa N,Ihara Y,Glenner GG

更新日期：1991-01-01 00:00:00

abstract：:We report the case of an 11-year-old male who developed subacute diffuse polyradiculoneuropathy, associated with digestive symptoms and Epstein-Barr virus infection. Parental consanguinity was present. The laboratory findings including bone marrow smear were consistent with hemophagocytic lymphohistiocytosis (HLH). El...

journal_title：Acta neuropathologica

authors： De Armas R,Sindou P,Gelot A,Routon MC,Ponsot G,Vallat JM

更新日期：2004-10-01 00:00:00

abstract：:Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here, we report on DNA methylation-based central nervous system (CNS) tumor diagnostics conducted in our institution between the years 2015 and 2018....

journal_title：Acta neuropathologica

authors： Capper D,Stichel D,Sahm F,Jones DTW,Schrimpf D,Sill M,Schmid S,Hovestadt V,Reuss DE,Koelsche C,Reinhardt A,Wefers AK,Huang K,Sievers P,Ebrahimi A,Schöler A,Teichmann D,Koch A,Hänggi D,Unterberg A,Platten M,Wick

更新日期：2018-08-01 00:00:00

abstract：:The present investigation examined the morphological characteristics of epiplexus macrophages following a single intracisternal injection of the antigen, bacillus Calmette-Guerin (BCG). Three days following injection of BCG (0.5 - 4.0 X 10(8) viable microorganisms), mongrel dogs were perfused with buffered aldehydes. ...

journal_title：Acta neuropathologica

authors： Merchant RE

更新日期：1979-08-01 00:00:00

abstract：:A morphometric study of the basal nucleus of Meynert (bnM) has been performed in a 70-year-old man with a 4-year history of pathologically confirmed progressive supranuclear palsy (PSP). An important neuronal loss (52%) was demonstrated in the bnM. This finding has not been previously documented with morphometric meth...

journal_title：Acta neuropathologica

authors： Tagliavini F,Pilleri G,Gemignani F,Lechi A

更新日期：1983-01-01 00:00:00

abstract：:Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3.3) subgroups were c...

journal_title：Acta neuropathologica

authors： Khuong-Quang DA,Buczkowicz P,Rakopoulos P,Liu XY,Fontebasso AM,Bouffet E,Bartels U,Albrecht S,Schwartzentruber J,Letourneau L,Bourgey M,Bourque G,Montpetit A,Bourret G,Lepage P,Fleming A,Lichter P,Kool M,von Deimling

更新日期：2012-09-01 00:00:00

abstract：:The intracellular localization of myoglobin(Mb) mRNA in the skeletal muscles of normal subjects and patients with Duchenne muscular dystrophy(DMD) or amyotrophic lateral sclerosis(ALS) was examined by in situ hybridization using a biotin-labeled cDNA probe. In cross sections of normal muscles, Mb mRNA signals were dem...

journal_title：Acta neuropathologica

authors： Mitsui T,Kawai H,Naruo T,Nishino H,Saito S

更新日期：1993-01-01 00:00:00

abstract：:Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these ...

journal_title：Acta neuropathologica

authors： Dickson DW,Yen SH,Suzuki KI,Davies P,Garcia JH,Hirano A

更新日期：1986-01-01 00:00:00

abstract：:Previous investigators have suggested that proteolysis by calpain, a Ca2+-dependent protease, causes muscle fiber degradation in Duchenne and Becker muscular dystrophies (DMD/BMD). Recent evidence indicates that the nonlysosomal ATP-ubiquitin-dependent proteolytic complex (proteasomes) participates in muscle wasting d...

journal_title：Acta neuropathologica

authors： Kumamoto T,Fujimoto S,Ito T,Horinouchi H,Ueyama H,Tsuda T

更新日期：2000-12-01 00:00:00

abstract：:Mice develop a fatal encephalomyelitis after infection with the Trinidad donkey strain of Venezuelan equine encephalitis (VEE) virus. Adult mice were inoculated intraperitoneally with VEE virus and the brains were examined at different time points. Morphological changes were assessed by histological staining. VEE viru...

journal_title：Acta neuropathologica

authors： Jackson AC,Rossiter JP

更新日期：1997-04-01 00:00:00

abstract：:Mutations in the fused in sarcoma (FUS) gene are linked to a form of familial amyotrophic lateral sclerosis (ALS), ALS6. The FUS protein is a major component of the ubiquitin-positive neuronal cytoplasmic inclusions in both ALS6 and some rare forms of frontotemporal lobar degeneration (FTLD). The latter are now collec...

journal_title：Acta neuropathologica

authors： Aoki N,Higashi S,Kawakami I,Kobayashi Z,Hosokawa M,Katsuse O,Togo T,Hirayasu Y,Akiyama H

更新日期：2012-09-01 00:00:00

abstract：:We studied three siblings and one unrelated patient with cerebrotendinous xanthomatosis (CTX). Of two unrelated patients, we examined biopsies of sural nerve, soleus muscle, and achilles tendon. We also performed neurophysiologic investigations. Another patient died, and a postmortem examination of both brain and spin...

journal_title：Acta neuropathologica

authors： Pop PH,Joosten E,van Spreeken A,Gabreëls-Festen A,Jaspar H,ter Laak H,Vos A

更新日期：1984-01-01 00:00:00

abstract：:The authors describe in biopsies from 6 cases of Werdnig-Hoffmann disease, including 2 of the more benign type, the ultrastructural typical aspects of denervation. They compare their findings with those of other workers. The striking points are the great variation in the diameter of the muscle fibres and the myofibril...

journal_title：Acta neuropathologica

authors： Szliwowski HB,Drochmans P

更新日期：1975-01-01 00:00:00

abstract：:The paper describes the clinical and morphological features of a congenital neurological disease affecting two in-bred litter-mate kittens. The principal neurological features were ataxia and dysmetria. In one of the kittens light microscopy revealed widespread vacuolation of white and grey matter of the brain and spi...

journal_title：Acta neuropathologica

authors： Kelly DF,Gaskell CJ

更新日期：1976-06-15 00:00:00

abstract：:HTLV-III-like particles were observed within a cell process surrounded by a myelin sheath, in the brain of a 4-year-old boy with AIDS encephalopathy. Similar particles were also observed in the mononuclear macrophage-like cells. ...

journal_title：Acta neuropathologica

authors： Kato T,Dembitzer HM,Hirano A,Llena JF

更新日期：1987-01-01 00:00:00

abstract：:A 56-day-old infant with alpha-neuraminidase deficiency, whose clinical features included severe edema of extremities and ascites which resembled those in severe infantile sialidosis, was autopsied. Perforation, whose pathogenesis was unclear, was found on the descending portion of the duodenum. Light and electron mic...

journal_title：Acta neuropathologica

authors： Yamano T,Shimada M,Matsuzaki K,Matsumoto Y,Yoshihara W,Okada S,Inui K,Yutaka T,Yabuuchi H

更新日期：1986-01-01 00:00:00